A pilot study of vitamin E versus vitamin E and pioglitazone for the treatment of nonalcoholic steatohepatitis

Clinical Gastroenterology and Hepatology - Tập 2 - Trang 1107-1115 - 2004
Arun J. Sanyal1, Pouneh S. Mofrad1, Melissa J. Contos2, Carol Sargeant1, Velimir A. Luketic1, Richard K. Sterling1, R. Todd Stravitz1, Mitchell L. Shiffman1, John Clore3, Alan S. Mills2
1Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
2Department of Pathology, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
3Division of Endocrinology, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA

Tài liệu tham khảo

Clark, 2003, The prevalence and etiology of elevated aminotransferase levels in the United States, Am J Gastroenterol, 98, 960, 10.1111/j.1572-0241.2003.07486.x Sanyal, 2002, AGA technical review on nonalcoholic fatty liver disease, Gastroenterology, 123, 1705, 10.1053/gast.2002.36572 Harrison, 2003, The natural history of nonalcoholic fatty liver disease, Am J Gastroenterol, 98, 2042, 10.1111/j.1572-0241.2003.07659.x Matteoni, 1999, Nonalcoholic fatty liver disease, Gastroenterology, 116, 1413, 10.1016/S0016-5085(99)70506-8 Marchesini, 1999, Association of nonalcoholic fatty liver disease with insulin resistance, Am J Med, 107, 450, 10.1016/S0002-9343(99)00271-5 Sanyal, 2001, Nonalcoholic steatohepatitis, Gastroenterology, 120, 1183, 10.1053/gast.2001.23256 Reaven, 2004, Obesity, insulin resistance, and cardiovascular disease, Recent Prog Horm Res, 59, 207, 10.1210/rp.59.1.207 McLaughlin, 2003, Use of metabolic markers to identify overweight individuals who are insulin resistant, Ann Intern Med, 139, 802, 10.7326/0003-4819-139-10-200311180-00007 Reaven, 2003, The insulin resistance syndrome, Curr Atheroscler Rep, 5, 364, 10.1007/s11883-003-0007-0 Diraison, 2003, Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease, Diabetes Metab, 29, 478, 10.1016/S1262-3636(07)70061-7 Turcotte, 2001, Increased fatty acid uptake and altered fatty acid metabolism in insulin-resistant muscle of obese Zucker rats, Diabetes, 50, 1389, 10.2337/diabetes.50.6.1389 Sumida, 2003, Serum thioredoxin levels as a predictor of steatohepatitis in patients with nonalcoholic fatty liver disease, J Hepatol, 38, 32, 10.1016/S0168-8278(02)00331-8 Oliveira, 2002, Oxidative stress in the pathogenesis of nonalcoholic fatty liver disease, in rats fed with a choline-deficient diet, J Cell Mol Med, 6, 399, 10.1111/j.1582-4934.2002.tb00518.x 1998, Executive summary of the clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults, Arch Intern Med, 158, 1855, 10.1001/archinte.158.17.1855 Lavine, 2000, Vitamin E treatment of nonalcoholic steatohepatitis in children, J Pediatr, 136, 734, 10.1067/mpd.2000.106566 Fujiwara, 1998, Troglitazone, a new antidiabetic agent possessing radical scavenging ability, improved decreased skin blood flow in diabetic rats, Life Sci, 63, 2039, 10.1016/S0024-3205(98)00482-2 DeFronzo, 1985, Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus, J Clin Invest, 76, 149, 10.1172/JCI111938 Brunt, 1999, Nonalcoholic steatohepatitis, Am J Gastroenterol, 94, 2467, 10.1111/j.1572-0241.1999.01377.x DeFronzo, 1979, Glucose clamp technique, Am J Physiol, 237, E214 Frayn, 1983, Calculation of substrate oxidation rates in vivo from gaseous exchange, J Appl Physiol, 55, 628, 10.1152/jappl.1983.55.2.628 Pasquali, 2003, Obesity and reproductive disorders in women, Hum Reprod Update, 9, 359, 10.1093/humupd/dmg024 Lord, 2003, Insulin-sensitising drugs (metformin, troglitazone, rosiglitazone, pioglitazone, D-chiro-inositol) for polycystic ovary syndrome, Cochrane Database Syst Rev, 3, CD003053 Neuschwander-Tetri, 2003, Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone, Hepatology, 38, 1008, 10.1053/jhep.2003.50420 Promrat, 2004, A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis, Hepatology, 39, 188, 10.1002/hep.20012 Ito, 2003, Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates myocardial ischemia/reperfusion injury in a rat model, Lab Invest, 83, 1715, 10.1097/01.LAB.0000106724.29121.DA Berg, 2002, ACRP30/adiponectin, Trends Endocrinol Metab, 13, 84, 10.1016/S1043-2760(01)00524-0 Yamauchi, 2001, The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance, J Biol Chem, 276, 41245, 10.1074/jbc.M103241200 Mofrad, 2003, Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values, Hepatology, 37, 1286, 10.1053/jhep.2003.50229 Clarke, 2001, Nonalcoholic steatosis and steatohepatitis. I. Molecular mechanism for polyunsaturated fatty acid regulation of gene transcription, Am J Physiol, 281, G865 Assimacopoulos-Jeannet, 1995, In vivo effects of hyperinsulinemia on lipogenic enzymes and glucose transporter expression in rat liver and adipose tissues, Metabolism, 44, 228, 10.1016/0026-0495(95)90270-8 Matsuzawa, 1995, Pathophysiology and pathogenesis of visceral fat obesity, Ann N Y Acad Sci, 748, 399, 10.1111/j.1749-6632.1994.tb17336.x Capeau, 2003, Insulin signaling, Med Sci (Paris), 19, 834, 10.1051/medsci/20031989834 Chavez, 2003, Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes, Arch Biochem Biophys, 419, 101, 10.1016/j.abb.2003.08.020 Marchesini, 2001, Nonalcoholic fatty liver disease, Diabetes, 50, 1844, 10.2337/diabetes.50.8.1844 Pessayre, 2001, Mitochondria in steatohepatitis, Semin Liver Dis, 21, 57, 10.1055/s-2001-12929 Pessayre, 2002, Nonalcoholic steatosis and steatohepatitis. V. Mitochondrial dysfunction in steatohepatitis, Am J Physiol, 282, G193 Roychoudhury, 2003, Antioxidant vitamins do not prevent cardiovascular disease, J Fam Pract, 52, 751 Clarke, 2002, Antioxidant vitamins and risk of cardiovascular disease. Review of large-scale randomised trials, Cardiovasc Drugs Ther, 16, 411, 10.1023/A:1022134418372