Complete biosynthesis of the potential medicine icaritin by engineered Saccharomyces cerevisiae and Escherichia coli

Science Bulletin - Tập 66 - Trang 1906-1916 - 2021
Pingping Wang1, Chaojing Li1,2, Xiaodong Li1,2, Wenjun Huang3, Yan Wang1, Jiali Wang1,4, Yanjun Zhang3, Xiaoman Yang5, Xing Yan1,2, Ying Wang2,5, Zhihua Zhou1,2
1CAS-Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, 200032, China
2University of Chinese Academy of Sciences, Beijing, 100049, China
3Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan 430074, China
4School of Life Sciences, Henan University, Kaifeng 475001, China
5Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, Center of Economic Botany/Core Botanical Gardens, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China