The Oxidation State of DJ-1 Regulates its Chaperone Activity Toward α-Synuclein

Trojanowski, 2003, Parkinson's disease and related alpha-synucleinopathies are brain amyloidoses, Ann. NY Acad. Sci., 991, 107, 10.1111/j.1749-6632.2003.tb07468.x

Uversky, 2001, Evidence for a partially folded intermediate in alpha-synuclein fibril formation, J. Biol. Chem., 276, 10737, 10.1074/jbc.M010907200

Conway, 2000, Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid, Biochemistry, 39, 2552, 10.1021/bi991447r

Iwai, 1995, Non-A beta component of Alzheimer's disease amyloid (NAC) is amyloidogenic, Biochemistry, 34, 10139, 10.1021/bi00032a006

Kayed, 2003, Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis, Science, 300, 486, 10.1126/science.1079469

Volles, 2003, Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease, Biochemistry, 42, 7871, 10.1021/bi030086j

Bucciantini, 2002, Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases, Nature, 416, 507, 10.1038/416507a

Volles, 2002, Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism, Biochemistry, 41, 4595, 10.1021/bi0121353

Munishkina, 2004, The effect of macromolecular crowding on protein aggregation and amyloid fibril formation, J. Mol. Recognit., 17, 456, 10.1002/jmr.699

Uversky, 2001, Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular link between Parkinson's disease and heavy metal exposure, J. Biol. Chem., 276, 44284, 10.1074/jbc.M105343200

Giasson, 2003, Initiation and synergistic fibrillization of tau and alpha-synuclein, Science, 300, 636, 10.1126/science.1082324

Goers, 2003, Polycation-induced oligomerization and accelerated fibrillation of human alpha-synuclein in vitro, Protein Sci., 12, 702, 10.1110/ps.0230903

Antony, 2003, Cellular polyamines promote the aggregation of alpha-synuclein, J. Biol. Chem., 278, 3235, 10.1074/jbc.M208249200

Perrin, 2001, Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins, J. Biol. Chem., 276, 41958, 10.1074/jbc.M105022200

Manning-Bog, 2002, The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice, J. Biol. Chem., 277, 1641, 10.1074/jbc.C100560200

Uversky, 2001, Pesticides directly accelerate the rate of alpha-synuclein fibril formation: a possible factor in Parkinson's disease, FEBS Letters, 500, 105, 10.1016/S0014-5793(01)02597-2

Uversky, 2002, Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta- and gamma-synucleins, J. Biol. Chem., 277, 11970, 10.1074/jbc.M109541200

Hashimoto, 2001, beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor, Neuron, 32, 213, 10.1016/S0896-6273(01)00462-7

Park, 2003, Beta-synuclein inhibits formation of alpha-synuclein protofibrils: a possible therapeutic strategy against Parkinson's disease, Biochemistry, 42, 3696, 10.1021/bi020604a

Conway, 2001, Kinetic stabilization of the alpha-synuclein protofibril by a dopamine- alpha-synuclein adduct, Science, 294, 1346, 10.1126/science.1063522

Zhu, 2004, The flavonoid baicalein inhibits fibrillation of alpha-synuclein and disaggregates existing fibrils, J. Biol. Chem., 279, 26846, 10.1074/jbc.M403129200

Li, 2004, Rifampicin inhibits alpha-synuclein fibrillation and disaggregates fibrils, Chem. Biol., 11, 1513, 10.1016/j.chembiol.2004.08.025

Lindersson, 2004, Proteasomal inhibition by alpha -synuclein filaments and oligomers, J. Biol. Chem., 10.1074/jbc.M306390200

Cuervo, 2004, Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy, Science, 305, 1292, 10.1126/science.1101738

Lee, 2004, Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway, J. Neurosci., 24, 1888, 10.1523/JNEUROSCI.3809-03.2004

Auluck, 2002, Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease, Science, 295, 865, 10.1126/science.1067389

Rekas, 2004, Interaction of the molecular chaperone alphaB-crystallin with alpha-synuclein: effects on amyloid fibril formation and chaperone activity, J. Mol. Biol., 340, 1167, 10.1016/j.jmb.2004.05.054

Hague, 2003, Early-onset Parkinson's disease caused by a compound heterozygous DJ-1 mutation, Ann. Neurol., 54, 271, 10.1002/ana.10663

Bonifati, 2003, Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism, Science, 299, 256, 10.1126/science.1077209

Moore, 2003, A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization, J. Neurochem., 87, 1558, 10.1111/j.1471-4159.2003.02265.x

Bonifati, 2004, Linking DJ-1 to neurodegeneration offers novel insights for understanding the pathogenesis of Parkinson's disease, J. Mol. Med., 82, 163, 10.1007/s00109-003-0512-1

Honbou, 2003, The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease, J. Biol. Chem., 278, 31380, 10.1074/jbc.M305878200

Wilson, 2003, The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease, Proc. Natl Acad. Sci. USA, 100, 9256, 10.1073/pnas.1133288100

Lee, 2003, Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain, J. Biol. Chem., 278, 44552, 10.1074/jbc.M304517200

Tao, 2003, Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease, J. Biol. Chem., 278, 31372, 10.1074/jbc.M304221200

Quigley, 2003, The 1.6-Å crystal structure of the class of chaperones represented by Escherichia coli Hsp31 reveals a putative catalytic triad, Proc. Natl Acad. Sci. USA, 100, 3137, 10.1073/pnas.0530312100

Bonifati, 2002, Deciphering Parkinson's disease–PARK8, Lancet Neurol., 1, 83, 10.1016/S1474-4422(02)00036-4

Bonifati, 2002, Localization of autosomal recessive early-onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset, Ann. Neurol., 51, 253, 10.1002/ana.10106

Mitsumoto, 2001, DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin, Free Radic. Res., 35, 885, 10.1080/10715760100301381

Mitsumoto, 2001, Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response to sublethal levels of paraquat, Free Radic. Res., 35, 301, 10.1080/10715760100300831

Beal, 2003, Mitochondria, oxidative damage, and inflammation in Parkinson's disease, Ann. NY Acad. Sci., 991, 120, 10.1111/j.1749-6632.2003.tb07470.x

Jenner, 2003, Oxidative stress in Parkinson's disease, Ann. Neurol., 53, S26, 10.1002/ana.10483

Lotharius, 2002, Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein, Nature Rev. Neurosci., 3, 932, 10.1038/nrn983

Yokota, 2003, Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition, Biochem. Biophys. Res. Commun., 312, 1342, 10.1016/j.bbrc.2003.11.056

Kinumi, 2004, Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cells, Biochem. Biophys. Res. Commun., 317, 722, 10.1016/j.bbrc.2004.03.110

Canet-Aviles, 2004, The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization, Proc. Natl Acad. Sci. USA, 101, 9103, 10.1073/pnas.0402959101

Miller, 2003, L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the uniquitin-proteasome system, J. Biol. Chem., 278, 36588, 10.1074/jbc.M304272200

Eerola, 2003, Assessment of a DJ-1 (PARK7) polymorphism in Finnish PD, Neurology, 61, 1000, 10.1212/01.WNL.0000083992.28066.7E

Morris, 2003, Polymorphism in the human DJ-1 gene is not associated with sporadic dementia with Lewy bodies or Parkinson's disease, Neurosci. Letters, 352, 151, 10.1016/j.neulet.2003.08.037

Neumann, 2004, Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease, Acta Neuropathol. (Berl), 107, 489, 10.1007/s00401-004-0834-2

Shendelman, 2004, DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation, PLoS. Biol., 2, e362, 10.1371/journal.pbio.0020362

Naiki, 1989, Fluorometric determination of amyloid fibrils in vitro using the fluorescent dye, thioflavin T, Anal. Biochem., 177, 244, 10.1016/0003-2697(89)90046-8

Le Vine, 1995, Thioflavine T interaction with amyloid beta-sheet structures, Amyloid, 2, 1, 10.3109/13506129509031881

Wilson, 2004, The 1.8-A resolution crystal structure of YDR533Cp from Saccharomyces cerevisiae: a member of the DJ-1/ThiJ/PfpI superfamily, Proc. Natl Acad. Sci. USA, 101, 1531, 10.1073/pnas.0308089100

Meulener, 2005, DJ-1 is present in a large molecular complex in human brain tissue and interacts with alpha-synuclein, J. Neurochem., 93, 1524, 10.1111/j.1471-4159.2005.03145.x

Giasson, 2000, Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions, Science, 290, 985, 10.1126/science.290.5493.985

Nielsen, 2001, Effect of environmental factors on the kinetics of insulin fibril formation: elucidation of the molecular mechanism, Biochemistry, 40, 6036, 10.1021/bi002555c

Zhu, 2003, Lipid binding inhibits alpha-synuclein fibril formation, J Biol Chem, 278, 16873, 10.1074/jbc.M210136200

Andrade, 1993, Evaluation of secondary structure proteins from UV circular dichroism spectra using an unsupervised learning neural network, Protein Eng, 6, 383, 10.1093/protein/6.4.383