The comparative cardiovascular effects of sevoflurane with halothane and isoflurane
Tóm tắt
Using closed chest dogs, the cardiovascular effects of sevoflurane were compared with those of halothane and isoflurane in equipotent doses of 1.0, 1.5, 2.0, 2.5 and 3.0 MAC. They were evaluated by the changes of arterial blood pressure, central venous pressure, pulmonary artery pressure, maximum rate of left ventricular pressure rise (LV dp/dt), cardiac output and coronary sinus blood flow. The suppression of left cardiac function by sevoflurane was less than that of halothane, but was greater than that of isoflurane. Heart rate, systemic vascular resistance with sevoflurane were slightly lower than that of isoflurane. The coronary sinus blood flows with sevoflurane and isoflurane were significantly (P<0.05 at 1.0 MAC,P<0.005 at 2.0 MAC) higher than halothane. There was no significant difference on coronary sinus flow between sevoflurane and isoflurane, The depth of anesthesia could be quickly changed by adjustment of inspired sevoflurane concentration in comparison with the other two anesthetics.
Tài liệu tham khảo
Gelman G, Fowlers KC, Smith LR: Regional blood flow during isoflurane and halothane anesthesia. Anesth Analg 63:557–565, 1984
Moffitt EA, Sethna DH, Bussell JA, Raymond M, Matloff JM, Gray RJ: Myocardial metabolism and hemodynamic responses to halothane or morphine anesthesia for coronary artery surgery. Anesth Analg 61:979–985, 1982
Bruckner JB, Kielmann D, Hess W: Sevoflurane: Effects on the circulation and myocardial oxygen consumption in comparison with halothane. In proceedings of the Central European congress of Anesthesiology, Innsbruck, Austria, 1979
Kazama T, Ideda K: Comparison of MAC and the rate of rise of alveolar concentration of sevoflurane with halothane and isoflurane in the dog. Anesthesiology (3, 1988 in press)
Wallin RF, Regan BM, Napoli MD, Stern IJ: Sevoflurane: a new inhalational anesthetic agent. Anesth Analg 54:758–766, 1975
Imamura S, Ikeda K: Comparison of epinephrine-induced arrhythmogenic effect of sevoflurane with isoflurane and halothane. J. of Anesthesia 1:62–68, 1987
Gibbons RT, Steffey EP, Eger EI II: The effect of spontaneous versus controlled ventilation on the rate of rise of alveolar halothane concentration in dogs. Anesth Analg 56:32–34, 1977
Mathey DG, Chatterjee K, Tyberg JV, Lekven J, Brundage B, Parmley WW: Coronary sinus reflux: A source of error in the measurement of ther modilution coronary sinus flow. Circulation 57:778–786, 1978
Weisse AB, Regan TJ: A comparison of thermodilution coronary sinus blood flows and krypton myocardial blood flows in the in tact dog. Cardiovascular Research 8:526–533, 1974
Tarnow J, Eberlein HJ, Oser G, Patschke D, Schneider E, Schweichel E, Wilde J: Influence of modern in halation anaesthetics on hemodynamics, myocardial contractility, left ventricular volumes and myocardial oxygen supply. Anaesthesist 26:220–230, 1977
Reiz S, Balfour E, Sorensen MB, Ariola S Jr, Friedman A, Truedsson H: Isofluranea powerful coronary vasodilator in patients with coronary artery disease. Anesthesiology 59:91–97, 1983
Wolfson B, Hetrick WD, Lake CL, Siker ES: Anesthetic indices-further DATA. Anesthesiology 48:187–190, 1978