Assessment of hepatic excretory function in chronic liver disease by hepatobiliary scintigraphy

Springer Science and Business Media LLC - Tập 3 - Trang 139-142 - 1989
Hisao Itoh1, Norio Takahashi1, Reiko Shimono2, Takafumi Sugawara2, Masashi Kawamura2, Takaharu Tsuda2, Masaaki Kataoka2, Atsushi Iio2, Ken Hamamoto2, Kanji Ohshima3, Koichi Akamatsu3
1Department of Radiology, Matsunami General Hospital, Gifu, Japan
2Department of Radiology, Ehime University School of Medicine, Ehime
3The Third Department of Internal Medicine, Ehime University School of Medicine, Ehime

Tóm tắt

Hepatobiliary scintigraphy was performed in 23 normal subjects and 47 patients with chronic liver disease (chronic hepatitis; n=27, liver cirrhosis; n=20) to evaluate its availability as a test of liver function. After intravenous administration of Tc-99m N-pyriodxyl-5-methyl-tryptophan, the data were acquired for 60 min and the time-activity curves of ROIs (the heart and liver) were generated. In two compartment model simulation, the early blood clearance rate (kl), late blood clearance rate (km), hepatic uptake rate (ku), hepatic excretion rate (ke), and hepatic excretion T 1/2 were calculated. There was no significant difference in those fourk values in normal and chronic hepatitis. However, in liver cirrhosis each of them, exceptkm, was lower than in normal subjects. Thekl value correlated closely with the indocyanine green plasma clearance test, whereas theke and T 1/2 values were closely correlated with the level of serum bilirubins. Only hepatobiliary scintigraphy showed the excretory function of the liver quantitatively and theke value was helpful in detecting hepatic excretory dysfunction early in chronic liver disease before serum bilirubins increased.

Tài liệu tham khảo

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