Functional role of metalloproteins in genome stability

Frontiers in Biology - Tập 11 - Trang 119-131 - 2016
Chunqiang Zhang1, Fan Zhang1, Ping Zhou2, Caiguo Zhang3
1Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming, China
2Department of Nephrology, Jiangxi Provincial People’s Hospital Nanchang, Nanchang, China
3Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, USA

Tóm tắt

Cells contain a large number of metalloproteins that commonly harbor at least one metal ion cofactor. In metalloproteins, metal ions are usually coordinated by oxygen, sulfur, or nitrogen centers belonging to amino acid residues in the protein. The presence of the metal ion in metalloproteins allows them to take part in diverse biological processes, such as genome stability, metabolic catalysis, and cell cycle progression. Clinically, alteration of the function of metalloproteins in mammals is genetically associated with diseases characterized by DNA damage and repair defects. The present review focuses on the current perspectives of metal ion homeostasis in different organisms and summarizes the most recent understanding on magnesium, copper, iron, and manganese-containing proteins and their functional involvement in the maintenance of genome stability.

Tài liệu tham khảo

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