TCF-1 deficiency influences the composition of intestinal microbiota and enhances susceptibility to colonic inflammation

Ding T, Schloss PD (2014) Dynamics and associations of microbial community types across the human body. Nature 509:357–360 Donaldson GP, Lee SM, Mazmanian SK (2016) Gut biogeography of the bacterial microbiota. Nat Rev Microbiol 14:20–32 Fulde M, Sommer F, Chassaing B, van Vorst K, Dupont A, Hensel M, Basic M, Klopfleisch R, Rosenstiel P, Bleich A et al (2018) Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition. Nature 560:489–493 Harly C, Kenney D, Ren G, Lai B, Raabe T, Yang Q, Cam MC, Xue HH, Zhao K, Bhandoola A (2019) The transcription factor TCF-1 enforces commitment to the innate lymphoid cell lineage. Nat Immunol 20:1150–1160 Held W, Clevers H, Grosschedl R (2003) Redundant functions of TCF-1 and LEF-1 during T and NK cell development, but unique role of TCF-1 for Ly49 NK cell receptor acquisition. Eur J Immunol 33:1393–1398 Kato LM, Kawamoto S, Maruya M, Fagarasan S (2014) Gut TFH and IgA: key players for regulation of bacterial communities and immune homeostasis. Immunol Cell Biol 92:49–56 Kawamoto S, Tran TH, Maruya M, Suzuki K, Doi Y, Tsutsui Y, Kato LM, Fagarasan S (2012) The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut. Science 336:485–489 Kubinak JL, Petersen C, Stephens WZ, Soto R, Bake E, O’Connell RM, Round JL (2015) MyD88 signaling in T cells directs IgA-mediated control of the microbiota to promote health. Cell Host Microbe 17:153–163 Mielke LA, Groom JR, Rankin LC, Seillet C, Masson F, Putoczki T, Belz GT (2013) TCF-1 controls ILC2 and NKp46+RORgammat+ innate lymphocyte differentiation and protection in intestinal inflammation. J Immunol 191:4383–4391 Odamaki T, Kato K, Sugahara H, Hashikura N, Takahashi S, Xiao JZ, Abe F, Osawa R (2016) Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study. BMC Microbiol 16:90 Saleh M, Elson CO (2011) Experimental inflammatory bowel disease: insights into the host-microbiota dialog. Immunity 34:293–302 Verbeek S, Izon D, Hofhuis F, Robanus-Maandag E, te Riele H, van de Wetering M, Oosterwegel M, Wilson A, MacDonald HR, Clevers H (1995) An HMG-box-containing T-cell factor required for thymocyte differentiation. Nature 374:70–74 Xing S, Gai K, Li X, Shao P, Zeng Z, Zhao X, Zhao X, Chen X, Paradee WJ, Meyerholz DK et al (2019) Tcf1 and Lef1 are required for the immunosuppressive function of regulatory T cells. J Exp Med 216:847–866 Xu L, Cao Y, Xie Z, Huang Q, Bai Q, Yang X, He R, Hao Y, Wang H, Zhao T et al (2015) The transcription factor TCF-1 initiates the differentiation of T(FH) cells during acute viral infection. Nat Immunol 16:991–999 Yang Q, Li F, Harly C, Xing S, Ye L, Xia X, Wang H, Wang X, Yu S, Zhou X et al (2015) TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow. Nat Immunol 16:1044–1050