Circulating MicroRNAs Associate With Diabetic Nephropathy and Systemic Microvascular Damage and Normalize After Simultaneous Pancreas–Kidney Transplantation

Paneni, 2013, Diabetes and vascular disease: Pathophysiology, clinical consequences, and medical therapy: Part I, Eur Heart J, 34, 2436, 10.1093/eurheartj/eht149 Tooke, 1996, Microvasculature in diabetes, Cardiovasc Res, 32, 764, 10.1016/S0008-6363(96)00091-0 American Diabetes Association. Available at: www.diabetes.org. Accessed March 28, 2014. Khairoun, 2013, Microvascular damage in type 1 diabetic patients is reversed in the first year after simultaneous pancreas–kidney transplantation, Am J Transplant, 13, 1272, 10.1111/ajt.12182 Choudhury, 2010, Diabetic nephropathy—A multifaceted target of new therapies, Discov Med, 10, 406 Tousoulis, 2013, Diabetes mellitus-associated vascular impairment: Novel circulating biomarkers and therapeutic approaches, J Am Coll Cardiol, 62, 667, 10.1016/j.jacc.2013.03.089 Guay, 2013, Circulating microRNAs as novel biomarkers for diabetes mellitus, Nat Rev Endocrinol, 9, 513, 10.1038/nrendo.2013.86 Bijkerk, 2014, Hematopoietic microRNA-126 protects against renal ischemia/reperfusion injury by promoting vascular integrity, J Am Soc Nephrol, 25, 1710, 10.1681/ASN.2013060640 Anand, 2010, MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis, Nat Med, 16, 909, 10.1038/nm.2186 Creemers, 2012, Circulating microRNAs: Novel biomarkers and extracellular communicators in cardiovascular disease?, Circ Res, 110, 483, 10.1161/CIRCRESAHA.111.247452 Kato, 2013, MicroRNAs: Potential mediators and biomarkers of diabetic complications, Free Radic Biol Med, 64, 85, 10.1016/j.freeradbiomed.2013.06.009 Marang-van de Mheen, 2008, Pancreas-kidney transplantations with primary bladder drainage followed by enteric conversion: Graft survival and outcomes, Transplantation, 85, 517, 10.1097/TP.0b013e31816361f7 Djaberi, 2013, Non-invasive assessment of microcirculation by sidestream dark field imaging as a marker of coronary artery disease in diabetes, Diab Vasc Dis Res, 10, 123, 10.1177/1479164112446302 Vasylyeva, 2007, Novel roles of the IGF-IGFBP axis in etiopathophysiology of diabetic nephropathy, Diabetes Res Clin Pract, 76, 177, 10.1016/j.diabres.2006.09.012 Silverstein, 2009, Inflammation in chronic kidney disease: Role in the progression of renal and cardiovascular disease, Pediatr Nephrol, 24, 1445, 10.1007/s00467-008-1046-0 Muntner, 2004, The prevalence of nontraditional risk factors for coronary heart disease in patients with chronic kidney disease, Ann Intern Med, 140, 9, 10.7326/0003-4819-140-1-200401060-00006 Pritchard, 2012, Blood cell origin of circulating microRNAs: A cautionary note for cancer biomarker studies, Cancer Prev Res (Phila), 5, 492, 10.1158/1940-6207.CAPR-11-0370 Neal, 2011, Circulating microRNA expression is reduced in chronic kidney disease, Nephrol Dial Transplant, 26, 3794, 10.1093/ndt/gfr485 Argyropoulos, 2013, Urinary microRNA profiling in the nephropathy of type 1 diabetes, PLoS ONE, 8, e54662, 10.1371/journal.pone.0054662 Nielsen, 2012, Circulating levels of microRNA from children with newly diagnosed type 1 diabetes and healthy controls: Evidence that miR-25 associates to residual beta-cell function and glycaemic control during disease progression, Exp Diabetes Res, 2012, 896362 Zampetaki, 2010, Plasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes, Circ Res, 107, 810, 10.1161/CIRCRESAHA.110.226357 Pan, 2014, Platelet-secreted microRNA-223 promotes endothelial cell apoptosis induced by advanced glycation end products via targeting the insulin-like growth factor 1 receptor, J Immunol, 192, 437, 10.4049/jimmunol.1301790 Brett, 2011, The microRNA cluster miR-106b∼25 regulates adult neural stem/progenitor cell proliferation and neuronal differentiation, Aging (Albany NY), 3, 108, 10.18632/aging.100285 Khairoun, 2013, Renal ischemia-reperfusion induces a dysbalance of angiopoietins, accompanied by proliferation of pericytes and fibrosis, Am J Physiol Renal Physiol, 305, F901, 10.1152/ajprenal.00542.2012 Sessa, 2012, The miR-126 regulates angiopoietin-1 signaling and vessel maturation by targeting p85beta, Biochim Biophys Acta, 1823, 1925, 10.1016/j.bbamcr.2012.07.011 Katare, 2011, Transplantation of human pericyte progenitor cells improves the repair of infarcted heart through activation of an angiogenic program involving micro-RNA-132, Circ Res, 109, 894, 10.1161/CIRCRESAHA.111.251546 Santovito, 2014, Plasma exosome microRNA profiling unravels a new potential modulator of adiponectin pathway in diabetes: Effect of glycemic control, J Clin Endocrinol Metab, 99, E1681, 10.1210/jc.2013-3843 Jung, 2014, Association between serum adipocytokine levels and microangiopathies in patients with type 2 diabetes mellitus, J Diabetes Investig, 5, 333, 10.1111/jdi.12144 de Boer, 2013, Aspirin treatment hampers the use of plasma microRNA-126 as a biomarker for the progression of vascular disease, Eur Heart J, 34, 3451, 10.1093/eurheartj/eht007