Manejo de la hemorragia digestiva alta no varicosa: documento de posicionamiento de la Societat Catalana de Digestologia

Gralnek, 2015, Diagnosis and management of nonvariceal upper gastrointestinal hemorrhage: European Society of Gastrointestinal Endoscopy (ESGE) Guideline, Endoscopy., 47, 1, 10.1055/s-0034-1393172 Lanas, 2010, Primer consenso español sobre el tratamiento de la hemorragia digestiva por úlcera péptica, Med Clin (Barc)., 135, 608, 10.1016/j.medcli.2010.07.002 Brożek, 2011, Grading quality of evidence and strength of recommendations in clinical practice guidelines part 3 of 3. The GRADE approach to developing recommendations, Allergy., 66, 588, 10.1111/j.1398-9995.2010.02530.x Sung, 2010, Causes of mortality in patients with peptic ulcer bleeding: a prospective cohort study of 10,428 cases, Am J Gastroenterol., 105, 84, 10.1038/ajg.2009.507 Baradarian, 2004, Early intensive resuscitation of patients with upper gastrointestinal bleeding decreases mortality, Am J Gastroenterol., 99, 619, 10.1111/j.1572-0241.2004.04073.x Gené, 2016, Nasogastric intubation in patients with upper gastrointestinal bleeding?, Gastroenterol Hepatol. Pateron, 2011, Erythromycin infusion or gastric lavage for upper gastrointestinal bleeding: a multicenter randomized controlled trial, Ann Emerg Med., 57, 582, 10.1016/j.annemergmed.2011.01.001 Huang, 2011, Impact of nasogastric lavage on outcomes in acute GI bleeding, Gastrointest Endosc., 74, 971, 10.1016/j.gie.2011.04.045 Laine, 2012, Management of patients with ulcer bleeding, Am J Gastroenterol., 107, 345, 10.1038/ajg.2011.480 Blatchford, 2000, A risk score to predict need for treatment for upper-gastrointestinal haemorrhage, Lancet (London, England)., 356, 1318, 10.1016/S0140-6736(00)02816-6 Dutky, 1989, Factors affecting rapid fluid resuscitation with large-bore introducer catheters, J Trauma., 29, 856, 10.1097/00005373-198906000-00025 Hodge, 1985, Pediatric catheter flow rates, Am J Emerg Med., 3, 403, 10.1016/0735-6757(85)90198-6 Ernst, 1999, Usefulness of the blood urea nitrogen/creatinine ratio in gastrointestinal bleeding, Am J Emerg Med., 17, 70, 10.1016/S0735-6757(99)90021-9 Witting, 2006, ED predictors of upper gastrointestinal tract bleeding in patients without hematemesis, Am J Emerg Med., 24, 280, 10.1016/j.ajem.2005.11.005 Perel, 2013, Colloids versus crystalloids for fluid resuscitation in critically ill patients, Cochrane database Syst Rev., 2, CD000567 Villanueva, 2013, Transfusion for acute upper gastrointestinal bleeding, N Engl J Med., 368, 1362, 10.1056/NEJMoa1211801 Goldstein, 2015, Four-factor prothrombin complex concentrate versus plasma for rapid vitamin K antagonist reversal in patients needing urgent surgical or invasive interventions: a phase 3b, open-label, non-inferiority, randomised trial, Lancet (London, England)., 385, 2077, 10.1016/S0140-6736(14)61685-8 Sarode, 2013, Efficacy and safety of a 4-factor prothrombin complex concentrate in patients on vitamin K antagonists presenting with major bleeding: a randomized, plasma-controlled, phase IIIb study, Circulation., 128, 1234, 10.1161/CIRCULATIONAHA.113.002283 Ageno, 2012, Oral anticoagulant therapy: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines, Chest., 141 Wolf, 2007, Impact of anticoagulation on rebleeding following endoscopic therapy for nonvariceal upper gastrointestinal hemorrhage, Am J Gastroenterol., 102, 290, 10.1111/j.1572-0241.2006.00969.x Shingina, 2011, Systematic review: the presenting international normalised ratio (INR) as a predictor of outcome in patients with upper nonvariceal gastrointestinal bleeding, Aliment Pharmacol Ther., 33, 1010, 10.1111/j.1365-2036.2011.04618.x Aronis, 2015, Who, when, and how to reverse non-vitamin K oral anticoagulants, J Thromb Thrombolysis., 41, 253, 10.1007/s11239-015-1297-0 Grottke, 2016, Efficacy of prothrombin complex concentrates for the emergency reversal of dabigatran-induced anticoagulation, Crit Care., 20, 115, 10.1186/s13054-016-1275-8 Eikelboom, 2015, Idarucizumab, Circulation., 132, 2412, 10.1161/CIRCULATIONAHA.115.019628 Theivanayagam, 2013, Administration of erythromycin before endoscopy in upper gastrointestinal bleeding: a meta-analysis of randomized controlled trials, Saudi J Gastroenterol., 19, 205, 10.4103/1319-3767.118120 Bai, 2011, Meta-analysis: erythromycin before endoscopy for acute upper gastrointestinal bleeding, Aliment Pharmacol Ther., 34, 166, 10.1111/j.1365-2036.2011.04708.x Sreedharan, 2010, Proton pump inhibitor treatment initiated prior to endoscopic diagnosis in upper gastrointestinal bleeding, Cochrane database Syst Rev., 7, CD005415 Neumann, 2013, Comparison of different regimens of proton pump inhibitors for acute peptic ulcer bleeding, Cochrane database Syst Rev., 6, CD007999 Bennett, 2014, Tranexamic acid for upper gastrointestinal bleeding, Cochrane database Syst Rev., 11, CD006640 Tsibouris, 2007, High-dose pantoprazole continuous infusion is superior to somatostatin after endoscopic hemostasis in patients with peptic ulcer bleeding, Am J Gastroenterol., 102, 1192, 10.1111/j.1572-0241.2007.01120.x Barkun, 2010, International consensus recommendations on the management of patients with nonvariceal upper gastrointestinal bleeding, Ann Intern Med., 152, 101, 10.7326/0003-4819-152-2-201001190-00009 Spiegel, 2001, Endoscopy for acute nonvariceal upper gastrointestinal tract hemorrhage: Is sooner better?. A systematic review, Arch Intern Med., 1393, 10.1001/archinte.161.11.1393 Lim, 2011, Urgent endoscopy is associated with lower mortality in high-risk but not low-risk nonvariceal upper gastrointestinal bleeding, Endoscopy., 43, 300, 10.1055/s-0030-1256110 Bjorkman, 2004, Urgent vs. elective endoscopy for acute non-variceal upper-GI bleeding: an effectiveness study, Gastrointest Endosc., 60, 1, 10.1016/S0016-5107(04)01287-8 Kumar, 2016, Initial management and timing of endoscopy in nonvariceal upper GI bleeding, Gastrointest Endosc. Laine, 2016, Clinical Practice. Upper gastrointestinal bleeding due to a peptic ulcer, N Engl J Med., 374, 2367, 10.1056/NEJMcp1514257 Jensen, 2002, Randomized trial of medical or endoscopic therapy to prevent recurrent ulcer hemorrhage in patients with adherent clots, Gastroenterology., 123, 407, 10.1053/gast.2002.34782 Laine, 2009, Endoscopic therapy for bleeding ulcers: an evidence-based approach based on meta-analyses of randomized controlled trials, Clin Gastroenterol Hepatol., 7, 33, 10.1016/j.cgh.2008.08.016 Andriulli, 2005, Proton-pump inhibitors and outcome of endoscopic hemostasis in bleeding peptic ulcers: a series of meta-analyses, Am J Gastroenterol., 100, 207, 10.1111/j.1572-0241.2005.40636.x Calvet, 2004, Addition of a second endoscopic treatment following epinephrine injection improves outcome in high-risk bleeding ulcers, Gastroenterology., 126, 441, 10.1053/j.gastro.2003.11.006 Vergara, 2014, Epinephrine injection versus epinephrine injection and a second endoscopic method in high-risk bleeding ulcers, Cochrane database Syst Rev., 10, CD005584 Laine, 2009, Endoscopic therapy for bleeding ulcers: an evidence-based approach based on meta-analyses of randomized controlled trials, Clin Gastroenterol Hepatol., 7, 33, 10.1016/j.cgh.2008.08.016 Barkun, 2013, Topical hemostatic agents: a systematic review with particular emphasis on endoscopic application in GI bleeding, Gastrointest Endosc., 77, 692, 10.1016/j.gie.2013.01.020 Chen, 2015, Hemostatic powders in gastrointestinal bleeding: a systematic review, Gastrointest Endosc Clin N Am., 25, 535, 10.1016/j.giec.2015.02.008 Imperiale, 2012, Second-look endoscopy for bleeding peptic ulcer disease: a decision-effectiveness and cost-effectiveness analysis, J Clin Gastroenterol., 46, e71, 10.1097/MCG.0b013e3182410351 Chiu, 2013, Second look endoscopy in acute non-variceal upper gastrointestinal bleeding, Best Pract Res Clin Gastroenterol., 27, 905, 10.1016/j.bpg.2013.09.009 El Ouali, 2012, Is routine second-look endoscopy effective after endoscopic hemostasis in acute peptic ulcer bleeding? A meta-analysis, Gastrointest Endosc., 76, 283, 10.1016/j.gie.2012.04.441 Chiu, 2016, High-dose omeprazole infusion compared with scheduled second-look endoscopy for prevention of peptic ulcer rebleeding: a randomized controlled trial, Endoscopy., 48, 717, 10.1055/s-0042-107590 Monteiro, 2016, Upper gastrointestinal bleeding risk scores: Who, when and why?, World J Gastrointest Pathophysiol., 7, 86, 10.4291/wjgp.v7.i1.86 Rockall, 1996, Risk assessment after acute upper gastrointestinal haemorrhage, Gut., 38, 316, 10.1136/gut.38.3.316 Leontiadis, 2006, Proton pump inhibitor treatment for acute peptic ulcer bleeding, Cochrane database Syst Rev., CD002094 Sachar, 2014, Intermittent vs.continuous proton pump inhibitor therapy for high-risk bleeding ulcers: a systematic review and meta-analysis, JAMA Intern Med., 174, 1755, 10.1001/jamainternmed.2014.4056 Sung, 2014, Effects of intravenous and oral esomeprazole in the prevention of recurrent bleeding from peptic ulcers after endoscopic therapy, Am J Gastroenterol., 109, 1005, 10.1038/ajg.2014.105 Lau, 1999, Endoscopic retreatment compared with surgery in patients with recurrent bleeding after initial endoscopic control of bleeding ulcers, N Engl J Med., 340, 751, 10.1056/NEJM199903113401002 Wong, 2011, A comparison of angiographic embolization with surgery after failed endoscopic hemostasis to bleeding peptic ulcers, Gastrointest Endosc., 73, 900, 10.1016/j.gie.2010.11.024 Sung, 2010, Continuation of low-dose aspirin therapy in peptic ulcer bleeding: a randomized trial, Ann Intern Med., 152, 1, 10.7326/0003-4819-152-1-201001050-00179 Derogar, 2013, Discontinuation of low-dose aspirin therapy after peptic ulcer bleeding increases risk of death and acute cardiovascular events, Clin Gastroenterol Hepatol., 11, 38, 10.1016/j.cgh.2012.08.034 Biondi-Zoccai, 2006, A systematic review and meta-analysis on the hazards of discontinuing or not adhering to aspirin among 50,279 patients at risk for coronary artery disease, Eur Heart J., 27, 2667, 10.1093/eurheartj/ehl334 Cea Soriano, 2013, Cardiovascular and upper gastrointestinal bleeding consequences of low-dose acetylsalicylic acid discontinuation, Thromb Haemost., 110, 1298, 10.1160/TH13-04-0326 Witt, 2012, Risk of thromboembolism, recurrent hemorrhage, and death after warfarin therapy interruption for gastrointestinal tract bleeding risks after warfarin interruption for GI bleeding, Arch Intern Med., 10.1001/archinternmed.2012.4261 Lee, 2012, Risks related with withholding and resuming anticoagulation in patients with non-variceal upper gastrointestinal bleeding while on warfarin therapy, Int J Clin Pract., 66, 64, 10.1111/j.1742-1241.2011.02827.x Qureshi, 2014, Restarting anticoagulation and outcomes after major gastrointestinal bleeding in atrial fibrillation, Am J Cardiol., 10.1016/j.amjcard.2013.10.044 Staerk L, Lip GYH, Olesen JB, Fosbøl EL, Pallisgaard JL, Bonde AN, et al. Stroke and recurrent haemorrhage associated with antithrombotic treatment after gastrointestinal bleeding in patients with atrial fibrillation: nationwide cohort study. BMJ. 2015;351(nov16_2):h5876. Chai-Adisaksopha, 2015, Thromboembolic events, recurrent bleeding and mortality after resuming anticoagulant following gastrointestinal bleeding. A meta-analysis, Thromb Haemost., 114, 819, 10.1160/TH15-01-0063 Douketis, 2012, Perioperative management of antithrombotic therapy: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines, Chest., 141 Diener, 2016, Choosing a particular oral anticoagulant and dose for stroke prevention in individual patients with non-valvular atrial fibrillation: part 2, Eur Heart J. Gisbert, 2013, [III Spanish Consensus Conference on Helicobacter pylori infection], Gastroenterol y Hepatol., 36, 340, 10.1016/j.gastrohep.2013.01.011 Lai, 2000, Ulcer-healing drugs are required after eradication of Helicobacter pylori in patients with gastric ulcer but not duodenal ulcer haemorrhage, Aliment Pharmacol Ther., 14, 1071, 10.1046/j.1365-2036.2000.00803.x Salas, 2002, Are proton pump inhibitors the first choice for acute treatment of gastric ulcers?. A meta analysis of randomized clinical trials, BMC Gastroenterol., 2, 17, 10.1186/1471-230X-2-17 Kim, 2015, Diagnostic and treatment approaches for refractory peptic ulcers, Clin Endosc., 48, 285, 10.5946/ce.2015.48.4.285 Amorena Muro, 2009, Analysis of the clinical benefits and cost-effectiveness of performing a systematic second-look gastroscopy in benign gastric ulcer, Gastroenterol y Hepatol., 32, 2, 10.1016/j.gastrohep.2008.07.002 Maniatis, 1997, Endoscopic discrimination of gastric ulcers, J Clin Gastroenterol., 24, 203, 10.1097/00004836-199706000-00004 Lv, 2012, Biopsy from the base and edge of gastric ulcer healing or complete healing may lead to detection of gastric cancer earlier: an 8 years endoscopic follow-up study, Hepatogastroenterology., 59, 947 Sachs, 2006, Review article: the clinical pharmacology of proton pump inhibitors, Aliment Pharmacol Ther., 23, 2, 10.1111/j.1365-2036.2006.02943.x Gisbert, 2004, Meta-analysis. Helicobacter pylori eradication therapy vs. antisecretory non-eradication therapy for the prevention of recurrent bleeding from peptic ulcer, Aliment Pharmacol Ther., 19, 617, 10.1111/j.1365-2036.2004.01898.x Gisbert, 2012, Long-term follow-up of 1,000 patients cured of Helicobacter pylori infection following an episode of peptic ulcer bleeding, Am J Gastroenterol., 107, 1197, 10.1038/ajg.2012.132 Khamaysi, 2015, Nonvariceal upper gastrointestinal bleeding, Gastrointest Endosc Clin N Am., 25, 443, 10.1016/j.giec.2015.03.002 Gisbert, 2006, Accuracy of Helicobacter pylori diagnostic test in patients with bleeding peptic ulcer: a systematic review and meta-analysis, Am J Gastroenterol., 101, 848, 10.1111/j.1572-0241.2006.00528.x Calvet X, Barkun A, Kuipers EJ, Lanas A BMSJ. Is H. pylori Testing Clinically Useful in the Acute Setting of Upper Gastrointestinal Bleeding? A Systematic Review. Gastroenterology. 2009;136 (Suppl 1):A60. Lee, 2000, Rapid urease test lack sensitivity in Helicobacter pylori diagnosis when peptic ulcer disease presents with bleeding, Am J Gastroenterol., 95, 1166, 10.1111/j.1572-0241.2000.02004.x Sánchez-Delgado, 2011, Has H. pylori prevalence in bleeding peptic ulcer been underestimated? A meta-regression, Am J Gastroenterol., 106, 398, 10.1038/ajg.2011.2 Gisbert, 2005, 13C-urea breath test in the management of Helicobacterpylori infection, Dig Liver Dis., 37, 899, 10.1016/j.dld.2005.09.006 Malfertheiner, 2012, Management of Helicobacter pylori infection--the Maastricht IV/Florence Consensus Report, Gut., 61, 646, 10.1136/gutjnl-2012-302084 Calvet, 2010, Accuracy of monoclonal stool test for determining cure of Helicobacter pylori infection after treatment, Helicobacter., 15, 201, 10.1111/j.1523-5378.2010.00757.x Calvet, 2010, Comparative accuracy of 3 monoclonal stool test for diagnosis of Helicobacter pylori infection among patients with dyspepsia, Clin Infect Dis., 50, 323, 10.1086/649860 Bjordal, 2004, Non-steroidal anti-inflammatory drugs, including cyclo-oxygenase-2 inhibitors, in osteoarthritic knee pain: meta-analysis of randomised placebo controlled trials, BMJ., 329, 1317, 10.1136/bmj.38273.626655.63 Chen, 2008, Cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs (etodolac, meloxicam, celecoxib, rofecoxib, etoricoxib, valdecoxib and lumiracoxib) for osteoarthritis and rheumatoid arthritis: a systematic review and economic evaluation, Health Technol Assess., 12, 1, 10.3310/hta12110 Lanas, 2014, Safe prescription recommendations for non steroidal anti-inflammatory drugs: Consensus document ellaborated by nominated experts of three scientific associations (SER-SEC-AEG), Gastroenterol y Hepatol., 37, 107, 10.1016/j.gastrohep.2013.11.014 Scarpignato, 2013, Safe prescribing of non-steroidal anti-inflammatory drugs in patients with osteoarthritis–an expert consensus addressing benefits as well as gastrointestinal and cardiovascular risks, BMC Biol., 11, EE McGettigan, 2011, Cardiovascular risk with non-steroidal anti-inflammatory drugs: systematic review of population-based controlled observational studies, PLoS Med., 8, e1001098, 10.1371/journal.pmed.1001098 Combe, 2009, Cardiovascular safety and gastrointestinal tolerability of etoricoxib vs.diclofenac in a randomized controlled clinical trial (The MEDAL study), Rheumatology (Oxford)., 48, 425, 10.1093/rheumatology/kep005 Castellsague, 2012, Individual NSAIDs and upper gastrointestinal complications: a systematic review and meta-analysis of observational studies (the SOS project), Drug Saf., 35, 1127, 10.1007/BF03261999 Rostom A, Muir K, Dubé C, Jolicoeur E, Boucher M, Joyce J, et al. Gastrointestinal safety of cyclooxygenase-2 inhibitors: A Cochrane Collaboration Systematic Review. Clin Gastroenterol Hepatol. 2007;5(7):818–28.e5. Chan, 2007, Combination of a cyclo-oxygenase-2 inhibitor and a proton-pump inhibitor for prevention of recurrent ulcer bleeding in patients at very high risk: a double-blind, randomised trial, Lancet (London, England)., 369, 1621, 10.1016/S0140-6736(07)60749-1 Chan, 2002, Celecoxib versus diclofenac and omeprazole in reducing the risk of recurrent ulcer bleeding in patients with arthritis, N Engl J Med., 347, 2104, 10.1056/NEJMoa021907 Sung, 2011, Asia-Pacific Working Group consensus on non-variceal upper gastrointestinal bleeding, Gut., 60, 1170, 10.1136/gut.2010.230292 Chan, 2015, Prevention of recurrent ulcer bleeding in arthritis patients with high cardiovascular and high gastrointestinal risks: A 18-month, double-blind, randomized trial, Gastroenterology, 148, s157, 10.1016/S0016-5085(15)30531-X Kushner, 2009, 2009 focused updates: ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction (updating the 2004 guideline and 2007 focused update) and ACC/AHA/SCAI guidelines on percutaneous coronary intervention (updating the 2005 guid, J Am Coll Cardiol., 54, 2205, 10.1016/j.jacc.2009.10.015 Anderson, 2013, 2012 ACCF/AHA focused update incorporated into the ACCF/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Ta, J Am Coll Cardiol., 61, e179, 10.1016/j.jacc.2013.01.014 García Rodríguez, 2011, Risk of upper gastrointestinal bleeding with low-dose acetylsalicylic acid alone and in combination with clopidogrel and other medications, Circulation., 123, 1108, 10.1161/CIRCULATIONAHA.110.973008 Lanas, 2007, Effect of antisecretory drugs and nitrates on the risk of ulcer bleeding associated with nonsteroidal anti-inflammatory drugs, antiplatelet agents, and anticoagulants, Am J Gastroenterol., 102, 507, 10.1111/j.1572-0241.2006.01062.x Abraham, 2010, ACCF/ACG/AHA 2010 expert consensus document on the concomitant use of proton pump inhibitors and thienopyridines: a focused update of the ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID, Am J Gastroenterol., 105, 2533, 10.1038/ajg.2010.445 Kwok, 2011, Effects of proton pump inhibitors on adverse gastrointestinal events in patients receiving clopidogrel: systematic review and meta-analysis, Drug Saf., 34, 47, 10.2165/11584750-000000000-00000 Lin, 2011, Acid suppressants reduce risk of gastrointestinal bleeding in patients on antithrombotic or anti-inflammatory therapy, Gastroenterology., 141, 71, 10.1053/j.gastro.2011.03.049 Gilard, 2008, Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study, J Am Coll Cardiol., 51, 256, 10.1016/j.jacc.2007.06.064 Cuisset, 2009, Comparison of omeprazole and pantoprazole influence on a high 150-mg clopidogrel maintenance dose the PACA (Proton Pump Inhibitors And Clopidogrel Association) prospective randomized study, J Am Coll Cardiol., 54, 1149, 10.1016/j.jacc.2009.05.050 Melloni, 2015, Conflicting results between randomized trials and observational studies on the impact of proton pump inhibitors on cardiovascular events when coadministered with dual antiplatelet therapy: systematic review, Circ Cardiovasc Qual Outcomes., 8, 47, 10.1161/CIRCOUTCOMES.114.001177 Cardoso, 2015, Incidence of cardiovascular events and gastrointestinal bleeding in patients receiving clopidogrel with and without proton pump inhibitors: an updated meta-analysis, Open Hear., 2, e000248, 10.1136/openhrt-2015-000248