Altered T cell signalling in ageing
Tóm tắt
Từ khóa
Tài liệu tham khảo
Adibzadeh, 1995, Long-term culture of monoclonal human T lymphocytes: models for immunosenescence?, Mech. Ageing Dev., 83, 171, 10.1016/0047-6374(95)01625-A
Akiba, 1999, CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells, J. Immunol., 162, 7058, 10.4049/jimmunol.162.12.7058
Altman, 2000, Protein kinase C theta: a new essential superstar on the T-cell stage, Immunol. Today, 21, 567, 10.1016/S0167-5699(00)01749-7
Arlinger, 1999, Interleukin/interferon signaling—a 1999 perspective, Immunologist, 7, 139
Becker, 2000, Differential expression of CD28 and CD94/NKG2 on T cells with identical TCR beta variable regions in primary melanoma and sentinel lymph node, Eur. J. Immunol., 30, 3699, 10.1002/1521-4141(200012)30:12<3699::AID-IMMU3699>3.0.CO;2-2
Beier, 2000, Induction, binding specificity and function of human ICOS, Eur. J. Immunol., 30, 3707, 10.1002/1521-4141(200012)30:12<3707::AID-IMMU3707>3.0.CO;2-Q
Bernstein, 1998, Effect of age on cytokine production in humans, Age, 21, 137, 10.1007/s11357-998-0024-6
Bining, 1997, Cytokine production by subsets of CD4 memory T cells differing in P-glycoprotein expression: Effects of aging, J. Gerontol. Ser. A—Biol. Sci. Med., 52, B137, 10.1093/gerona/52A.3.B137
Boucher, 1998, CD28 expression in T cell aging and human longevity, Exp. Gerontol., 33, 267, 10.1016/S0531-5565(97)00132-0
Boussiotis, 1997, Induction of T cell clonal anergy results in resistance, whereas CD28-mediated costimulation primes for susceptibility to Fas- and Bax-mediated programmed cell death, J. Immunol., 159, 3156, 10.4049/jimmunol.159.7.3156
Buonfiglio, 2000, The T cell activation molecule H4 and the CD28-like molecule ICOS are identical, Eur. J. Immunol., 30, 3463, 10.1002/1521-4141(2000012)30:12<3463::AID-IMMU3463>3.0.CO;2-5
Chambers, 1997, Co-stimulation in T cell responses, Curr. Opin. Immunol., 9, 396, 10.1016/S0952-7915(97)80087-8
Chopra, 1989, Interleukin 2, interleukin 2 receptor, and interferon-gamma synthesis and mRNA expression in phorbol myristate acetate and calcium ionophore A23187-stimulated T cells from elderly humans, Clin. Immunol. Immunopathol., 53, 297, 10.1016/0090-1229(89)90058-5
Coles, 2000, Memory CD8 T lymphocytes express inhibitory MHC-specific Ly49 receptors, Eur. J. Immunol., 30, 236, 10.1002/1521-4141(200001)30:1<236::AID-IMMU236>3.0.CO;2-X
Conconi, 1997, Proteasome inactivation upon aging and on oxidation-effect of HSP 90, Mol. Biol. Rep., 24, 45, 10.1023/A:1006852506884
Coyle, 2000, The CD28-related molecule ICOS is required for effective T cell-dependent immune responses, Immunity, 13, 95, 10.1016/S1074-7613(00)00011-X
De Benedette, 1999, Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus, J. Immunol., 163, 4833, 10.4049/jimmunol.163.9.4833
Di Pietro, 1998, Age-related defect of phospholipase C activity, differential expression of the beta(2) isoform in active T lymphocytes from aged humans, Hum. Immunol., 59, 25, 10.1016/S0198-8859(97)00228-0
Di Pietro, 2000, Age-dependent variations in the expression of PLC isoforms upon mitogenic stimulation of peripheral blood T cells from healthy donors, Br. J. Haematol., 111, 1209
Dobber, 1994, Mel14(+) CD4(+) T cells from aged mice display functional and phenotypic characteristics of memory cells, Int. Immunol., 6, 1227, 10.1093/intimm/6.8.1227
Douek, 1998, Changes in thymic function with age and during the treatment of HIV infection, Nature, 396, 690, 10.1038/25374
Dustin, 2000, The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling, Nat. Immunol., 1, 23, 10.1038/76877
Effros, 1994, Decline in CD28(+) T cells in centenarians and in long-term T cell cultures: A possible cause for both in vivo and in vitro immunosenescence, Exp. Gerontol., 29, 601, 10.1016/0531-5565(94)90073-6
Eisenbraun, 2000, Altered composition of the immunological synapse in an anergic, age-dependent memory T cell subset, J. Immunol., 164, 6105, 10.4049/jimmunol.164.12.6105
Engwerda, 1994, Aged T cells are hyporesponsive to costimulation mediated by CD28, J. Immunol., 152, 3740, 10.4049/jimmunol.152.8.3740
Engwerda, 1996, An age-related decrease in rescue from T cell death following costimulation mediated by CD28, Cell Immunol., 170, 141, 10.1006/cimm.1996.0144
Enioutina, 2000, Enhancement of common mucosal immunity in aged mice following their supplementation with various antioxidants, Vaccine, 18, 2381, 10.1016/S0264-410X(00)00008-6
Faasen, 1989, Diminished heat shock protein synthesis following mitogen stimulation of lymphocytes from aged donors, Exp. Cell. Res., 183, 326, 10.1016/0014-4827(89)90393-5
Fagnoni, 1996, Expansion of cytotoxic CD8(+) CD28(−) T cells in healthy ageing people, including centenarians, Immunology, 88, 501, 10.1046/j.1365-2567.1996.d01-689.x
Fernandez-Gutierrez, 1999, Early lymphocyte activation in elderly humans: Impaired T and T-dependent B cell responses, Exp. Gerontol., 34, 217, 10.1016/S0531-5565(98)00068-0
Fiorentini, 1999, Generation of CD28(−) cells from long-term-stimulated CD8(+)CD28(+) T cells: a possible mechanism accounting for the increased number of CD8(+)CD28(−) T cells in HIV-1-infected patients, J. Leukocyte Biol., 65, 641, 10.1002/jlb.65.5.641
Fischer, 1999, Function and dysfunction of CD4(+) T cells in the immune response to melanoma, Cancer Immunol. Immunother., 48, 363, 10.1007/s002620050587
Freeman, 2000, Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation, J. Exp. Med., 192, 1027, 10.1084/jem.192.7.1027
Froelich, 1988, Phytohemagglutinin-induced proliferation by aged lymphocytes: reduced expression of high affinity interleukin 2 receptors and interleukin 2 secretion, Life Sci., 43, 1583, 10.1016/0024-3205(88)90529-2
Fülöp, 1993, Age-dependent changes in transmembrane signalling -identification of G-proteins in human lymphocytes and polymorphonuclear leukocytes, Cell Signal., 5, 593, 10.1016/0898-6568(93)90054-P
Fülöp, 1995, Cellular distribution of protein kinase C isozymes in CD3-mediated stimulation of human T lymphocytes with aging, FEBS Lett., 375, 69, 10.1016/0014-5793(95)01179-I
Fülöp, 1999, Age-related impairment of p56(Lck) and ZAP-70 activities in human T lymphocytes activated through the TcR/CD3 complex, Exp. Gerontol., 34, 197, 10.1016/S0531-5565(98)00061-8
Fülöp, T., Douziech, N., Goulet, A.C., Desgeorges, S., Linteau, A., Lacombe, G., Dupuis, G., 2001. Cyclodextrin modulation of T lymphocyte signal transduction with aging, Mech. Ageing Dev. (in press).
Gaglia, 2000, Intercellular adhesion molecule 1 is critical for activation of CD28-deficient T cells, J. Immunol., 165, 6091, 10.4049/jimmunol.165.11.6091
Garcia, 1997, Differential tyrosine phosphorylation of zeta chain dimers in mouse CD4 T lymphocytes: Effect of age, Cell Immunol., 175, 51, 10.1006/cimm.1996.1040
Garcia, 1998, Increased Zap-70 association with CD3 zeta in CD4 T cells from old mice, Cell Immunol., 190, 91, 10.1006/cimm.1998.1394
Garcia, 2001, Single-cell analyses reveal two defects in peptide-specific activation of naive T cells from aged mice, J. Immunol., 166, 3151, 10.4049/jimmunol.166.5.3151
Geginat, 2000, CD28 and LFA-1 contribute to cyclosporin A-resistant T cell growth by stabilizing the IL-2 mRNA through distinct signaling pathways, Eur. J. Immunol., 30, 1136, 10.1002/(SICI)1521-4141(200004)30:4<1136::AID-IMMU1136>3.0.CO;2-3
Gesbert, 1998, Recent advances in the understanding of interleukin-2 signal transduction, J. Clin. Immunol., 18, 307, 10.1023/A:1023223614407
Ginaldi, 2000, Immunophenotypical changes of T lymphocytes in the elderly, Gerontology, 46, 242, 10.1159/000022167
Godfrey, 1994, Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor, J. Exp. Med., 180, 757, 10.1084/jem.180.2.757
Gorgas, 1997, Diminished activation of the MAP kinase pathway in CD3-stimulated T lymphocytes from old mice, Mech. Ageing Dev., 94, 71, 10.1016/S0047-6374(96)01857-X
Gramaglia, 2000, The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion, J. Immunol., 165, 3043, 10.4049/jimmunol.165.6.3043
Granelli-Piperno, 1990, The effect of immunosuppressive agents on the induction of nuclear factors that bind to sites on the interleukin 2 promoter, J. Exp. Med., 172, 1869, 10.1084/jem.172.6.1869
Guerra, 2000, Killer inhibitory receptor (CD158b) modulates the lytic activity of tumor-specific T lymphocytes infiltrating renal cell carcinomas, Blood, 95, 2883, 10.1182/blood.V95.9.2883.009k22_2883_2889
Guidi, 1998, Changes in the amount and level of phosphorylation of p56lck in PBL from aging humans, Mech. Ageing Dev., 102, 177, 10.1016/S0047-6374(97)00144-9
Hara, 1988, Age-related changes of expression of IL-2 receptor subunits and kinetics of IL-2 internalization in T cells after mitogenic stimulation, Mech. Ageing Dev., 45, 167, 10.1016/0047-6374(88)90106-6
Haynes, 1999, Interleukin 2, but not other common gamma chain-binding cytokines, can reverse the defect in generation of CD4 effector T cells from naive T cells of aged mice, J. Exp. Med., 190, 1013, 10.1084/jem.190.7.1013
Hoshino, 1993, Tissue-specific distribution and age-dependent increase of human CD11b+ T-cells, J. Immunol., 151, 2237, 10.4049/jimmunol.151.4.2237
Hutloff, 1999, ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28, Nature, 397, 263, 10.1038/16717
Jackola, 1995, Diminished cell-cell binding by lymphocytes from healthy, elderly humans: Evidence for altered activation of LFA-1 function with age, J. Gerontol. Ser. A—Biol. Sci. Med., 50, B368, 10.1093/gerona/50A.6.B368
Keller, 2000, Possible involvement of proteasome inhibition in aging: implications for oxidative stress, Mech. Ageing Dev., 113, 61, 10.1016/S0047-6374(99)00101-3
Kirchhoff, 2000, TCR-mediated up-regulation of c-FLIPshort correlates with resistance toward CD95-mediated apoptosis by blocking death-inducing signaling complex activity, J. Immunol., 165, 6293, 10.4049/jimmunol.165.11.6293
Kirchhoff, 2000, Up-regulation of c-FLIPshort and reduction of activation-induced cell death in CD28-co-stimulated human T cells, Eur. J. Immunol., 30, 2765, 10.1002/1521-4141(200010)30:10<2765::AID-IMMU2765>3.0.CO;2-W
Kirk, 1998, Analysis of Raf-1 activation in response to TCR activation and costimulation in murine T-lymphocytes: Effect of age, Cell Immunol., 190, 33, 10.1006/cimm.1998.1382
Kirk, 1999, Age-sensitive and -insensitive pathways leading to JNK activation in mouse CD4(+) T-cells, Cell Immunol., 197, 83, 10.1006/cimm.1999.1568
Kirk, 1999, Age-related decline in activation of JNK by TCR- and CD28-mediated signals in murine T-lymphocytes, Cell Immunol., 197, 75, 10.1006/cimm.1999.1567
Kunitomi, 2000, Vascular endothelial cells provide T cells with costimulatory signals via the OX40/gp34 system, J. Leukocyte Biol., 68, 111, 10.1189/jlb.68.1.111
Kurashima, 1997, Age-related changes of cytokine production by murine helper T cell subpopulations, Pathobiology, 65, 155, 10.1159/000164117
Kurt, 2000, TCR V-beta usage and clonality of T cells isolated from progressing and rejected tumor sites before and after in vitro culture, Int. Immunol., 12, 639, 10.1093/intimm/12.5.639
Labalette, 1999, Peripheral human CD8(+)CD28(+) T lymphocytes give rise to CD28(−) progeny, but IL-4 prevents loss of CD28 expression, Int. Immunol., 11, 1327, 10.1093/intimm/11.8.1327
Leupin, 2000, Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes, Curr. Biol., 10, 277, 10.1016/S0960-9822(00)00362-6
Li, 2000, Impaired signal transduction in mitogen activated rat splenic lymphocytes during aging, Mech. Ageing Dev., 113, 85, 10.1016/S0047-6374(99)00096-2
Linton, 1996, Antigen-independent changes in naive CD4 T cells with aging, J. Exp. Med., 184, 1891, 10.1084/jem.184.5.1891
Lio, 1998, Interleukin 12-release by mitogen-stimulated mononuclear cells in the elderly, Mech. Ageing Dev., 102, 211, 10.1016/S0047-6374(98)00016-5
Liu, 1997, Reductions in the activation of ERK and JNK are associated with decreased IL-2 production in T cells from elderly humans stimulated by the TCR/CD3 complex and costimulatory signals, Cell Immunol., 182, 79, 10.1006/cimm.1997.1226
Livak, 1996, T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells, Mol. Cell. Biol., 16, 609, 10.1128/MCB.16.2.609
Marelli-Berg, 1999, Recently activated T cells are costimulation-dependent in vitro, Cell Immunol., 195, 18, 10.1006/cimm.1999.1521
Marti, 2001, Negative-feedback regulation of CD28 costimulation by a novel mitogen-activated protein kinase phosphatase, MKP6, J. Immunol., 166, 197, 10.4049/jimmunol.166.1.197
Mattila, 1990, The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes, EMBO J., 9, 4425, 10.1002/j.1460-2075.1990.tb07893.x
McFarland, 2000, Identification of a human recent thymic emigrant phenotype, Proc. Natl. Acad. Sci. USA, 97, 4215, 10.1073/pnas.070061597
Miller, 1987, Diminished calcium influx in lectin-stimulated T cells from old mice, J. Cell. Physiol., 132, 337, 10.1002/jcp.1041320220
Miller, 1994, Lack of B7-2 expression in the germinal centers of aged mice, Aging: Immunol. Infect. Dis., 5, 249
Minami, 1993, Association of p56(lck) with IL-2 receptor beta-chain is critical for the IL-2-induced activation of p56(lck), EMBO J., 12, 759, 10.1002/j.1460-2075.1993.tb05710.x
Miyazaki, 1994, Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits, Science, 266, 1045, 10.1126/science.7973659
Nam, 1998, Age-dependent remodeling of peripheral blood CD4(+) CD8(+) T lymphocytes in Cynomolgus monkeys, Dev. Comp. Immunol., 22, 239, 10.1016/S0145-305X(97)00058-X
Namekawa, 2000, Killer cell activating receptors function as costimulatory molecules on CD4(+)CD28(Null) T cells clonally expanded in rheumatoid arthritis, J. Immunol., 165, 1138, 10.4049/jimmunol.165.2.1138
Northrop, 1994, NF-AT components define a family of transcription factors targeted in T-cell activation, Nature, 369, 497, 10.1038/369497a0
O'Leary, 1988, Expression of the human T cell antigen receptor complex in advanced age, Mech. Ageing Dev., 45, 239, 10.1016/0047-6374(88)90006-1
Pahlavani, 1996, The age-related changes in DNA binding activity of AP-1, NF-kappa B, and OCT-1 transcription factors in lymphocytes from rats, Age, 19, 45, 10.1007/BF02434070
Pahlavani, 1999, Age-related decline in activation of calcium/calmodulin-dependent phosphatase calcineurin and kinase CaMK-IV in rat T cells, Mech. Ageing Dev., 112, 59, 10.1016/S0047-6374(99)00077-9
Pahlavani, 1995, The age-related decline in the induction of IL-2 transcription is correlated to changes in the transcription factor NFAT, Cell. Immunol., 165, 84, 10.1006/cimm.1995.1190
Pahlavani, 1998, Activation of p21(ras)/MAPK signal transduction molecules decreases with age in mitogen-stimulated T cells from rats, Cell Immunol., 185, 39, 10.1006/cimm.1998.1274
Pawelec, 1996, Interleukin 10 protects activated human T lymphocytes against growth factor withdrawal-induced cell death but only anti-fas antibody can prevent activation-induced cell death, Cytokine, 8, 877, 10.1006/cyto.1996.0117
Pawelec, 1997, Human T cell clones as a model for immunosenescence, Immunol. Rev., 160, 31, 10.1111/j.1600-065X.1997.tb01025.x
Pawelec, 1998, Extrathymic T cell differentiation in vitro from human CD34(+) stem cells, J. Leukocyte Biol., 64, 733, 10.1002/jlb.64.6.733
Pawelec, 2000, Longevity in vitro of human CD4+ T helper cell clones derived from young donors and elderly donors, or from progenitor cells: age-associated differences in cell surface molecule expression and cytokine secretion, Biogerontology, 1, 247, 10.1023/A:1010086229931
Ponnappan, 1999, Decreased proteasome-mediated degradation in T cells from the elderly: A role in immune senescence, Cell Immunol., 192, 167, 10.1006/cimm.1998.1418
Potestio, 1999, Age-related changes in the expression of CD95 (APO1/FAS) on blood lymphocytes, Exp. Gerontol., 34, 659, 10.1016/S0531-5565(99)00041-8
Poynter, 1998, Peroxisome proliferator-activated receptor alpha activation modulates cellular redox status, represses nuclear factor-kappa B signaling, and reduced inflammatory cytokine production in aging, J. Biol. Chem., 273, 32833, 10.1074/jbc.273.49.32833
Pucci, 1998, Inhibition of IL-2 production by Nil-2-a in murine T cells, Int. Immunol., 10, 1435, 10.1093/intimm/10.10.1435
Quadri, 1996, Age-related tyrosine-specific protein phosphorylation defect in human T lymphocytes activated through CD3, CD4, CD8 or the IL-2 receptor, Mech. Ageing Dev., 88, 125, 10.1016/0047-6374(96)01715-0
Russ, 1998, P-glycoprotein plays an insignificant role in the presentation of antigenic peptides to CD8+ T cells, Cancer Res., 58, 4688
Russell, 1995, Mutation of Jak3 in a patient with SCID: Essential role of Jak3 in lymphoid development, Science, 270, 797, 10.1126/science.270.5237.797
Salkind, 1994, Influence of age on the production of Fos and Jun by influenza virus-exposed T cells, J. Leukocyte Biol., 56, 817, 10.1002/jlb.56.6.817
Sallusto, 1999, Two subsets of memory T lymphocytes with distinct homing potentials and effector functions, Nature, 401, 708, 10.1038/44385
Schnaider, 2000, The Hsp90-specific inhibitor geldanamycin selectively disrupts kinase-mediated signaling events of T-lymphocyte activation, Cell Stress Chaper., 5, 52, 10.1379/1466-1268(2000)005<0052:THSIGS>2.0.CO;2
Schrum, 2000, Enhanced surface TCR replenishment mediated by CD28 leads to greater TCR engagement during primary stimulation, Int. Immunol., 12, 833, 10.1093/intimm/12.6.833
Schuh, 1998, The interleukin 2 receptor alpha chain/CD25 promoter is a target for nuclear factor of activated T cells, J. Exp. Med., 188, 1369, 10.1084/jem.188.7.1369
Sikora, 1992, Loss of transcription factor AP-1 DNA binding activity during lymphocyte aging in vivo, FEBS Lett., 312, 179, 10.1016/0014-5793(92)80930-F
Sitte, 2000, Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part I-effects of proliferative senescence, FASEB J., 14, 2495, 10.1096/fj.00-0209com
Song, 1992, Expression of c-fos, c-jun and jun-b in peripheral blood lymphocytes from young and elderly adults, Mech. Ageing Dev., 65, 149, 10.1016/0047-6374(92)90031-8
Sosinowski, 2000, Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling, J. Exp. Med., 191, 463, 10.1084/jem.191.3.463
Spencer, 1997, Constitutive activation of NF-kappa B in an animal model of aging, Int. Immunol., 9, 1581, 10.1093/intimm/9.10.1581
Steffens, 2000, Evaluation of thymopoiesis using T cell receptor excision circles (TRECs): Differential correlation between adult and pediatric TRECs and naive phenotypes, Clin. Immunol., 97, 95, 10.1006/clim.2000.4938
Steger, 1996, Morphologically and functionally intact dendritic cells can be derived from the peripheral blood of aged individuals, Clin. Exp. Immunol., 105, 544, 10.1046/j.1365-2249.1996.d01-790.x
Straten, 1999, In situ T cells in melanoma, Cancer Immunol. Immunother., 48, 386, 10.1007/s002620050591
Tafuri, 2001, ICOS is essential for effective T-helper-cell responses, Nature, 409, 105, 10.1038/35051113
Tamir, 2000, Age-dependent alterations in the assembly of signal transduction complexes at the site of T cell/APC interaction, J. Immunol., 165, 1243, 10.4049/jimmunol.165.3.1243
Tamura, 2000, Molecular mechanism of the impairment in activation signal transduction in CD4(+) T cells from old mice, Int. Immunol., 12, 1205, 10.1093/intimm/12.8.1205
Tinkle, 1998, Decreased association of p56(lck) with CD4 may account for lowered tyrosine kinase activity in mitogen-activated human T lymphocytes during aging, Cell Immunol., 186, 154, 10.1006/cimm.1998.1313
Tortorella, 1997, Age-related impairment of T cell proliferative responses related to the decline of CD28(+) T cell subsets, Arch. Gerontol. Geriatr., 26, 55, 10.1016/S0167-4943(97)00033-2
Trebilcock, 1996, Evidence for lowered induction of nuclear factor kappa B in activated human T lymphocytes during aging, Gerontology, 42, 137, 10.1159/000213785
Trebilcock, 1996, Induction and regulation of NF kappa B during aging: Role of protein kinases, Clin. Immunol. Immunopathol., 79, 87, 10.1006/clin.1996.0054
Tugores, 1992, Human T-cell activation through the activation-inducer molecule/CD69 enhances the activity of transcription factor-AP-1, J. Immunol., 148, 2300, 10.4049/jimmunol.148.7.2300
Utsuyama, 1993, Influence of age on the signal transduction of T cells in mice, Int. Immunol., 9, 1177, 10.1093/intimm/5.9.1177
Utsuyama, 1997, Impairment of signal transduction in T cells from old mice, Mech. Ageing Dev., 93, 131, 10.1016/S0047-6374(96)01837-4
Vallejo, 1998, Aging-related deficiency of CD28 expression in CD4+ T cells is associated with the loss of gene-specific nuclear factor binding activity, J. Biol. Chem., 273, 8119, 10.1074/jbc.273.14.8119
Vallejo, 1999, Modulation of CD28 expression: Distinct regulatory pathways during activation and replicative senescence, J. Immunol., 162, 6572, 10.4049/jimmunol.162.11.6572
Van Gool, 1999, Blocking CD40-CD154 and CD80/CD86-CD28 interactions during primary allogeneic stimulation results in T cell anergy and high IL-10 production, Eur. J. Immunol., 29, 2367, 10.1002/(SICI)1521-4141(199908)29:08<2367::AID-IMMU2367>3.0.CO;2-3
Venable, 1999, Phospholipase D in cellular senescence Bba, Mol. Cell. Biol. Lipids, 1439, 291, 10.1016/S1388-1981(99)00101-8
Wakikawa, 1997, Altered expression of various receptors on T cells in young and old mice after mitogenic stimulation: A flow cytometric analysis, Mech. Ageing Dev., 94, 113, 10.1016/S0047-6374(97)01880-0
Walker, 1998, Down-regulation of CD28 via Fas (CD95): Influence of CD28 on T-cell apoptosis, Immunology, 94, 41, 10.1046/j.1365-2567.1998.00490.x
Weyand, 1998, Functional properties of CD4+CD28− T cells in the aging immune system, Mech. Ageing Dev., 102, 131, 10.1016/S0047-6374(97)00161-9
Whisler, 1991, Characterization of intracellular ionized calcium responsiveness and inisitol phosphate production among resting and stimulated peripheral blood T cells from elderly humans, Aging: Immunol. Infect. Dis., 3, 27
Whisler, 1993, Reduced activation of transcriptional factor-AP-1 among peripheral blood T-cells from elderly humans after PHA stimulation-restorative effect of phorbol diesters, Cell Immunol., 152, 96, 10.1006/cimm.1993.1270
Whisler, 1995, Differential expression of the alpha- and beta-isoforms of protein kinase C in peripheral blood T and B cells from young and elderly adults, Mech. Ageing Dev., 77, 197, 10.1016/0047-6374(94)01526-R
Whisler, 1996, Age-related decreases in IL-2 production by human T cells are associated with impaired activation of nuclear transcriptional factors AP-1 and NF-AT, Cell Immunol., 169, 185, 10.1006/cimm.1996.0109
Whisler, 1996, Age-related reductions in the activation of mitogen-activated protein kinases p44(mapk)/ERK1 and p42(mapk)/ERK2 in human T cells stimulated via ligation of the T cell receptor complex, Cell Immunol., 168, 201, 10.1006/cimm.1996.0067
Whisler, 1997, Expression and catalytic activities of protein tyrosine kinases (PTKs) Fyn and Lck in peripheral blood T cells from elderly humans stimulated through the T cell receptor (TCR)/CD3 complex, Mech. Ageing Dev., 98, 57, 10.1016/S0047-6374(97)00073-0
Whisler, 1998, Phosphorylation and coupling of zeta-chains to activated T-cell receptor (TCR)/CD3 complexes from peripheral blood T-cells of elderly humans, Mech. Ageing Dev., 105, 115, 10.1016/S0047-6374(98)00084-0
Whisler, 1999, Age-related impairments in TCR/CD3 activation of ZAP-70 are associated with reduced tyrosine phosphorylations of zeta-chains and p59(Fyn)/p56(Lck) in human T cells, Mech. Ageing Dev., 111, 49, 10.1016/S0047-6374(99)00074-3
Witkowski, 1999, Calcium signal abnormalities in murine T lymphocytes that express the multidrug transporter P-glycoprotein, Mech. Ageing Dev., 107, 165, 10.1016/S0047-6374(98)00147-X
Witkowski, 1996, Reciprocal expression of P-glycoprotein and TAP1 accompanied by higher expression of MHC class I antigens in T cells of old mice, J. Gerontol. Ser. A—Biol. Sci. Med., 51, B76, 10.1093/gerona/51A.1.B76
Yang, 1999, Cluster formation by protein kinase C theta during murine T cell activation: Effect of age, Cell Immunol., 195, 28, 10.1006/cimm.1999.1517
Young, 2001, Preliminary studies on the effect of dehydroepiandrosterone (DHEA) on both constitutive and phytohaemagglutinin (PHA)-inducible IL-6 and IL-2 mRNA expression and cytokine production in human spleen mononuclear cell suspensions in vitro, Clin. Exp. Immunol., 123, 28, 10.1046/j.1365-2249.2001.01445.x