A new biotechnological source of rosmarinic acid and surface flavonoids: Hairy root cultures of Dracocephalum kotschyi Boiss

Amirghofran, 2000, Evaluation of the immunomodulatory effects of five herbal plants, Journal of Ethnopharmacology, 72, 167, 10.1016/S0378-8741(00)00234-8 Anusuya, 2011, Antitumor initiating potential of rosmarinic acid in 7,12-dimethylbenz(a)anthracene-induced hamster buccal pouch carcinogenesis, Journal of Environmental Pathology, Toxicology and Oncology, 30, 199, 10.1615/JEnvironPatholToxicolOncol.v30.i3.30 Brown, 2001, Flavonoids act as negative regulators of auxin transport in vivo in Arabidopsis, Plant Physiology, 126, 524, 10.1104/pp.126.2.524 Bulgakov, 2008, Functions of rol genes in plant secondary metabolism, Biotechnology Advances, 26, 318, 10.1016/j.biotechadv.2008.03.001 Chen, 2001, The effect of yeast elicitor on the growth and secondary metabolism of hairy root cultures of Salvia miltiorrhiza, Enzyme and Microbial Technology, 28, 100, 10.1016/S0141-0229(00)00284-2 Chung, 2009, Flavonoid glucosides from the hairy roots of Catharanthus roseus, Journal of Natural Products, 72, 613, 10.1021/np800378q Danihelová, 2012, Lipophilization of flavonoids for their food, therapeutic and cosmetic applications, Acta Chimica Slovenica, 5, 59, 10.2478/v10188-012-0010-6 Ebrahim Sajjadi, 1998, Antihyperlipidemic effect of hydroalcoholic extract and polyphenolic fraction from Dracocephalum kotschyi Boiss, Pharmaceutica Acta Helvetiae, 73, 167, 10.1016/S0031-6865(98)00016-8 Fattahi, 2011, The effect of pre-sowing treatments and light on seed germination of Dracocephalum kotschyi Boiss: an endangered medicinal plant in Iran, Horticulture, Environment, and Biotechnology, 52, 559, 10.1007/s13580-011-0057-0 Fattahi, 2013, Identification and quantification of leaf surface flavonoids in wild-growing populations of Dracocephalum kotschyi by LC–DAD–ESI-MS, Food Chemistry, 141, 139, 10.1016/j.foodchem.2013.03.019 Georgiev, 2011, Sonication-assisted Agrobacterium rhizogenes-mediated transformation of Verbascum xanthophoeniceum Griseb. for bioactive metabolite accumulation, Plant Cell Reports, 30, 859, 10.1007/s00299-010-0981-y Georgiev, 2007, Hairy root type plant in vitro systems as sources of bioactive substances, Applied Microbiology and Biotechnology, 74, 1175, 10.1007/s00253-007-0856-5 Georgiev, 2012, Genetically transformed roots: from plant disease to biotechnological resource, Trends in Biotechnology, 30, 528, 10.1016/j.tibtech.2012.07.001 Giri, 2000, Transgenic hairy roots: recent trends and applications, Biotechnology Advances, 18, 1, 10.1016/S0734-9750(99)00016-6 Gohari, 2003, Flavonoid constituents of Dracocephalum kotschyi growing in Iran and their trypanocidal activity, Journal of Natural Medicines, 57, 250 Goli, 2013, Novel oilseed of Dracocephalum kotschyi with high n−3 to n−6 polyunsaturated fatty acid ratio, Industrial Crops and Products, 43, 188, 10.1016/j.indcrop.2012.07.036 Golshani, 2004, Antinociceptive effects of the essential oil of Dracocephalum kotschyi in the mouse writhing test, Journal of Pharmaceutical Sciences, 7, 76 Greenham, 2003, Identification of lipophilic flavones and flavonols by comparative HPLC, TLC and UV spectral analysis, Phytochemical Analysis, 14, 100, 10.1002/pca.693 Honda, 2004, Two new monoterpene glycosides and trypanocidal terpenoids from Dracocephalum kotschyi, Chemical & Pharmaceutical Bulletin, 52, 1249, 10.1248/cpb.52.1249 Hwang, 2006, Baicalin production in transformed hairy root clones of Scutellaria baicalensis, Biotechnology and Bioprocess Engineering, 11, 105, 10.1007/BF02931892 Jahaniani, 2005, Xanthomicrol is the main cytotoxic component of Dracocephalum kotschyii and a potential anti-cancer agent, Phytochemistry, 66, 1581, 10.1016/j.phytochem.2005.04.035 Jalali, 1999 Kovács, 2004, HPLC determination of flavonoids in hairy-root cultures of Scutellaria baicalensis Georgi, Chromatographia, 60, 81, 10.1365/s10337-004-0266-0 Lamien-Meda, 2010, Investigation of antioxidant and rosmarinic acid variation in the Sage collection of the genebank in Gatersleben, Journal of Agricultural and Food Chemistry, 58, 3813, 10.1021/jf903993f Lee, 2008, Rosmarinic acid production in hairy root cultures of Agastache rugosa Kuntze, World Journal of Microbiology and Biotechnology, 24, 969, 10.1007/s11274-007-9560-y Li, 2001, Flavonoids from Glycyrrhiza pallidiflora hairy root cultures, Phytochemistry, 58, 595, 10.1016/S0031-9422(01)00268-0 Li, 2000, Flavonoid constituents from Glycyrrhiza glabra hairy root cultures, Phytochemistry, 55, 447, 10.1016/S0031-9422(00)00337-X Li, 2002, Flavonoids from Glycyrrhiza pallidiflora hairy root cultures, Phytochemistry, 60, 351, 10.1016/S0031-9422(02)00093-6 Li, 2005, Rosmarinic acid production by Coleus forskohlii hairy root cultures, Plant Cell, Tissue and Organ Culture, 80, 151, 10.1007/s11240-004-9541-x Mallol, 2001, Ginsenoside production in different phenotypes of Panax ginseng transformed roots, Phytochemistry, 57, 365, 10.1016/S0031-9422(01)00062-0 Medina-Bolivar, 2007, Production and secretion of resveratrol in hairy root cultures of peanut, Phytochemistry, 68, 1992, 10.1016/j.phytochem.2007.04.039 Mirjalili, 2009, Morphology and withanolide production of Withania coagulans hairy root cultures, Engineering in Life Sciences, 9, 197, 10.1002/elsc.200800081 Park, 2012, Overexpression of phenylalanine ammonia-lyase improves flavones production in transgenic hairy root cultures of Scutellaria baicalensis, Process Biochemistry, 47, 2575, 10.1016/j.procbio.2012.09.026 Moghaddam, 2012, Antiproliferative activity of flavonoids influence of the sequential methoxylation state of the flavonoid structure, Phytotherapy Research, 26, 1023, 10.1002/ptr.3678 Morris, 1986, Genes specifying auxin and cytokinin biosynthesis in phytopathogens, Annual Review of Plant Biology, 73, 509, 10.1146/annurev.pp.37.060186.002453 Moyano, 1999, Effect of Agrobacterium rhizogenes T-DNA on alkaloid production in Solanaceae plants, Phytochemistry, 52, 1287, 10.1016/S0031-9422(99)00421-5 Mozaffarian, 1998 Nair, 2013, Elicitation of pharmacologically active phenolic compounds from Rauvolfia serpentina Benth. Ex. Kurtz., Industrial Crops and Products, 45, 406, 10.1016/j.indcrop.2013.01.008 Murashige, 1962, A revised medium for rapid growth and bio assays with tobacco tissue cultures, Physiologia Plantarum, 15, 473, 10.1111/j.1399-3054.1962.tb08052.x Peer, 2007, Flavonoids and auxin transport: modulators or regulators?, Trends in Plant Science, 12, 556, 10.1016/j.tplants.2007.10.003 Rechinger, 1986 Seito, 2011, Antiproliferative activity of three methoxylated flavonoids isolated from Zeyheria montana Mart (Bignoniaceae) leaves, Phytotherapy Research, 25, 1447, 10.1002/ptr.3438 Sivanandhan, 2012, Chitosan enhances withanolides production in adventitious root cultures of Withania somnifera (L.) Dunal, Industrial Crops and Products, 37, 124, 10.1016/j.indcrop.2011.11.022 Srivastava, 2013, Production of industrially important cosmaceutical and pharmaceutical derivatives of betuligenol by Atropa belladonna hairy root mediated biotransformation, Industrial Crops and Products, 44, 171, 10.1016/j.indcrop.2012.11.016 Staszków, 2011, LC/MS profiling of flavonoid glycoconjugates isolated from hairy roots, suspension root cell cultures and seedling roots of Medicago truncatula, Metabolomics, 7, 604, 10.1007/s11306-011-0287-2 Swarup, 2007, Antiviral and anti-inflammatory effects of rosmarinic acid in an experimental murine model of Japanese encephalitis, Antimicrobial Agents and Chemotherapy, 51, 3367, 10.1128/AAC.00041-07 Tada, 1996, Rosmarinic acid and related phenolics in hairy root cultures of Ocimum basilicum, Phytochemistry, 42, 431, 10.1016/0031-9422(96)00005-2 Tepe, 2008, Antioxidant potentials and rosmarinic acid levels of the methanolic extracts of Salvia virgata (Jacq) Salvia staminea (Montbret & Aucher ex Bentham) and Salvia verbenaca (L.) from Turkey, Bioresource Technology, 99, 1584, 10.1016/j.biortech.2007.04.008 Vervliet, 1975, Characterization of different plaque-forming and defective temperate phages in Agrobacterium strains, Journal of General Virology, 26, 33, 10.1099/0022-1317-26-1-33 Vieira, 2001, Genetic diversity of Ocimum gratissimum L. based on volatile oil constituents flavonoids and RAPD markers, Biochemical Systematics and Ecology, 29, 287, 10.1016/S0305-1978(00)00062-4 Wang, 2006, Genetic transformation of Echinacea purpurea with Agrobacterium rhizogenes and bioactive ingredient analysis in transformed cultures, Colloids and Surfaces B, 53, 101, 10.1016/j.colsurfb.2006.08.003 Washida, 2004, Auxins affected ginsenoside production and growth of hairy roots in Panax hybrid, Biological and Pharmaceutical Bulletin, 27, 657, 10.1248/bpb.27.657 Yang, 2010, Characterization of reference genes for quantitative real-time PCR analysis in various tissues of Salvia miltiorrhiza, Molecular Biology Reports, 37, 507, 10.1007/s11033-009-9703-3 Zhang, 2009, Enhanced flavonoid production in hairy root cultures of Glycyrrhiza uralensis Fisch by combining the over-expression of chalcone isomerase gene with the elicitation treatment, Plant Cell Reports, 28, 1205, 10.1007/s00299-009-0721-3 Zhou, 1997, Flavonoids and phenylethanoids from hairy root cultures of Scutellaria baicalensis, Phytochemistry, 44, 83, 10.1016/S0031-9422(96)00443-8