A Unified Model of Mammalian BCL-2 Protein Family Interactions at the Mitochondria

Molecular Cell - Tập 44 - Trang 517-531 - 2011
Fabien Llambi1, Tudor Moldoveanu1, Stephen W.G. Tait1, Lisa Bouchier-Hayes1, Jamshid Temirov2, Laura L. McCormick1, Christopher P. Dillon1, Douglas R. Green1
1Department of Immunology, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
2Cell and Tissue Imaging, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA

Tài liệu tham khảo

Adler, 2010, Quantifying colocalization by correlation: the Pearson correlation coefficient is superior to the Mander's overlap coefficient, Cytometry A, 77, 733, 10.1002/cyto.a.20896 Brooks, 2007, Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins, Proc. Natl. Acad. Sci. USA, 104, 11649, 10.1073/pnas.0703976104 Certo, 2006, Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members, Cancer Cell, 9, 351, 10.1016/j.ccr.2006.03.027 Chen, 2005, Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function, Mol. Cell, 17, 393, 10.1016/j.molcel.2004.12.030 Chipuk, 2010, The BCL-2 family reunion, Mol. Cell, 37, 299, 10.1016/j.molcel.2010.01.025 Delivani, 2006, Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics, Mol. Cell, 21, 761, 10.1016/j.molcel.2006.01.034 Dewson, 2008, To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions, Mol. Cell, 30, 369, 10.1016/j.molcel.2008.04.005 Ding, 2010, Bcl-2 and Bax interact via the BH1-3 groove-BH3 motif interface and a novel interface involving the BH4 motif, J. Biol. Chem., 285, 28749, 10.1074/jbc.M110.148361 Edlich, 2011, Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol, Cell, 145, 104, 10.1016/j.cell.2011.02.034 Eskes, 2000, Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane, Mol. Cell. Biol., 20, 929, 10.1128/MCB.20.3.929-935.2000 Frank, 2001, The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis, Dev. Cell, 1, 515, 10.1016/S1534-5807(01)00055-7 Friedrich, 2005, Digestive versus regulatory proteases: on calpain action in vivo, Biol. Chem., 386, 609, 10.1515/BC.2005.071 Gavathiotis, 2010, BH3-triggered structural reorganization drives the activation of proapoptotic BAX, Mol. Cell, 40, 481, 10.1016/j.molcel.2010.10.019 Hoppins, 2011, The soluble form of Bax regulates mitochondrial fusion via MFN2 homotypic complexes, Mol. Cell, 41, 150, 10.1016/j.molcel.2010.11.030 Hsu, 1997, Nonionic detergents induce dimerization among members of the Bcl-2 family, J. Biol. Chem., 272, 13829, 10.1074/jbc.272.21.13829 Hsu, 1997, Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis, Proc. Natl. Acad. Sci. USA, 94, 3668, 10.1073/pnas.94.8.3668 Karbowski, 2002, Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis, J. Cell Biol., 159, 931, 10.1083/jcb.200209124 Karbowski, 2006, Role of Bax and Bak in mitochondrial morphogenesis, Nature, 443, 658, 10.1038/nature05111 Kim, 2006, Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies, Nat. Cell Biol., 8, 1348, 10.1038/ncb1499 Kim, 2009, Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis, Mol. Cell, 36, 487, 10.1016/j.molcel.2009.09.030 Ku, 2011, Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX, Cell Res., 21, 627, 10.1038/cr.2010.149 Kuwana, 2002, Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane, Cell, 111, 331, 10.1016/S0092-8674(02)01036-X Kuwana, 2005, BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly, Mol. Cell, 17, 525, 10.1016/j.molcel.2005.02.003 Kvansakul, 2008, Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands, Cell Death Differ., 15, 1564, 10.1038/cdd.2008.83 Leber, 2007, Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes, Apoptosis, 12, 897, 10.1007/s10495-007-0746-4 Leber, 2010, Still embedded together binding to membranes regulates Bcl-2 protein interactions, Oncogene, 29, 5221, 10.1038/onc.2010.283 Letai, 2002, Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics, Cancer Cell, 2, 183, 10.1016/S1535-6108(02)00127-7 Llambi, 2011, Apoptosis and oncogenesis: give and take in the BCL-2 family, Curr. Opin. Genet. Dev., 21, 12, 10.1016/j.gde.2010.12.001 Lopez, 2010, Perturbation of the Bcl-2 network and an induced Noxa/Bcl-xL interaction trigger mitochondrial dysfunction after DNA damage, J. Biol. Chem., 285, 15016, 10.1074/jbc.M109.086231 Martinou, 2011, Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics, Dev. Cell, 21, 92, 10.1016/j.devcel.2011.06.017 Mérino, 2009, The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins, J. Cell Biol., 186, 355, 10.1083/jcb.200905153 Oltersdorf, 2005, An inhibitor of Bcl-2 family proteins induces regression of solid tumours, Nature, 435, 677, 10.1038/nature03579 Petros, 2004, Structural biology of the Bcl-2 family of proteins, Biochim. Biophys. Acta, 1644, 83, 10.1016/j.bbamcr.2003.08.012 Sattler, 1997, Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis, Science, 275, 983, 10.1126/science.275.5302.983 Sheridan, 2008, Bax- or Bak-induced mitochondrial fission can be uncoupled from cytochrome C release, Mol. Cell, 31, 570, 10.1016/j.molcel.2008.08.002 Uren, 2007, Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak, J. Cell Biol., 177, 277, 10.1083/jcb.200606065 Wei, 2000, tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c, Genes Dev., 14, 2060, 10.1101/gad.14.16.2060 Willis, 2005, Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins, Genes Dev., 19, 1294, 10.1101/gad.1304105 Willis, 2007, Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak, Science, 315, 856, 10.1126/science.1133289 Zhai, 2008, Differential regulation of Bax and Bak by anti-apoptotic Bcl-2 family proteins Bcl-B and Mcl-1, J. Biol. Chem., 283, 9580, 10.1074/jbc.M708426200