Mackay, 1958, Primary biliary cirrhosis showing a high titer of autoantibody, N Engl J Med, 258, 185, 10.1056/NEJM195801232580407
Walker, 1965, Serological tests in the diagnosis of primary biliary cirrhosis, Lancet, 1, 827, 10.1016/S0140-6736(65)91372-3
James, 1983, Primary biliary cirrhosis, Ann Intern Med, 99, 500, 10.7326/0003-4819-99-4-500
Kaplan, 1996, Primary biliary cirrhosis, N Engl J Med, 335, 1570, 10.1056/NEJM199611213352107
Strassburg, 2000, Autoimmune tests in primary biliary cirrhosis, Baillieres Clin Gastroenterol, 14, 585, 10.1053/bega.2000.0105
Mackay, 2000, Autoimmunity and primary biliary cirrhosis, Baillieres Clin Gastroenterol, 14, 519, 10.1053/bega.2000.0101
Kim, 2000, Variant forms of cholestatic diseases involving small bile ducts in adults, Am J Gastroenterol, 95, 1130, 10.1111/j.1572-0241.2000.01999.x
Neuberger, 1997, Primary biliary cirrhosis, Lancet, 350, 875, 10.1016/S0140-6736(97)05419-6
Joplin, 1999, Immunopathology of primary biliary cirrhosis, Eur J Gastroenterol Hepatol, 11, 587, 10.1097/00042737-199906000-00002
Sasaki, 2000, The immunopathology of primary biliary cirrhosis, Arch Immunol Ther Exp (Warsz), 48, 1
Parikh-Patel, 2001, Risk factors for primary biliary cirrhosis in a cohort of patients from the United States, Hepatology, 33, 16, 10.1053/jhep.2001.21165
Surh, 1990, Comparative epitope mapping of murine monoclonal and human autoantibodies to human PDH-E2, the major mitochondrial autoantigen of primary biliary cirrhosis, J Immunol, 144, 2647, 10.4049/jimmunol.144.7.2647
Leung, 1992, Characterization and epitope mapping of human monoclonal antibodies to PDC-E2, the immunodominant autoantigen of primary biliary cirrhosis, J Autoimmun, 5, 367, 10.1016/0896-8411(92)90187-U
Prud'Homme, 1993, Short analytical review. Cyclosporine, tolerance, and autoimmunity, Clin Immunol Immunopathol, 66, 185, 10.1006/clin.1993.1024
Cha, 1994, Heterogeneity of combinatorial human autoantibodies against PDC-E2 and biliary epithelial cells in patients with primary biliary cirrhosis, Hepatology, 20, 574, 10.1002/hep.1840200305
Leung, 1996, Mitochondrial antibodies, 494
Storch, 1982, Fluorescent patterns of antibodies to mitochondria endoplasmic reticulum and ribosomes, Acta Histochem, 71, 67, 10.1016/S0065-1281(82)80014-7
Lindenborn-Fotinos, 1982, Mitochondrial antibodies in primary biliary cirrhosis. VI. association of the complement fixing antigen with a component of the mitochondrial F-ATPase complex, Clin Exp Immunol, 50, 267
Weber, 1986, Characterization and clinical relevance of a new complement-fixing antibody - anti-M8 - in patients with primary biliary cirrhosis, Hepatology, 6, 533, 10.1002/hep.1840060402
Miyachi, 1980, Precipitating antibodies to mitochondrial antigens in patients with primary biliary cirrhosis, Clin Exp Immunol, 39, 599
Plebani, 1989, Two new serum immunoassays (RIA and EIA) for the determination of M2 antimitochondrial antibodies in primary biliary cirrhosis, Clin Chim Acta, 181, 201, 10.1016/0009-8981(89)90189-7
Manns, 1982, A mitochondrial antigen-antibody system in cholestatic liver disease detected by radioimmunoassay, Hepatology, 2, 1, 10.1002/hep.1840020102
Baum, 1981, The complex nature of mitochondrial antibodies and their relation to primary biliary cirrhosis, Semin Liver Dis, 1, 309, 10.1055/s-2008-1040734
Mouritsen, 1985, Enzyme-linked immunosorbent assay for determination of anti-mitochondrial antibodies, Acta Pathol Micobiol Immunol Scand, 93, 205
Kaplan, 1984, An enzyme-linked immunosorbent assay (ELISA) for detecting antimitochondrial antibodies, Hepatology, 4, 727, 10.1002/hep.1840040428
Kenna, 1984, A simple enzyme-linked immunosorbent assay for the detection of anti-mitochondrial antibodies, J Immunol Methods, 73, 401, 10.1016/0022-1759(84)90415-0
Van de Water, 1989, Detection of autoantibodies to recombinant mitochondrial proteins in patients with primary biliary cirrhosis, N Engl J Med, 320, 1377, 10.1056/NEJM198905253202104
Leung, 1995, Autoantibodies to BCOADC-E2 in patients with primary biliary cirrhosis recognize a conformational epitope, Hepatology, 22, 505
Teoh, 1991, An automated microassay for enzyme inhibitory effects of M2 antibodies in primary biliary cirrhosis, Liver, 11, 287, 10.1111/j.1600-0676.1991.tb00531.x
Teoh, 1994, Enzyme inhibitory autoantibodies to pyruvate dehydrogenase complex in primary biliary cirrhosis, Hepatology, 20, 1220, 10.1002/hep.1840200518
Makinen, 1983, Anticentromere antibodies in primary biliary cirrhosis, Arthritis Rheum, 26, 914, 10.1002/art.1780260714
Fritzler, 1985, Antinuclear, anticytoplasmic and anti-Sjögren's syndrome antigen-A (SS-A/Ro) antibodies in female blood donors, Clin Immunol Immunopathol, 36, 120, 10.1016/0090-1229(85)90045-5
Invernizzi, 2001, Autoantibodies against nuclear pore complexes are associated with more active and severe liver disease in primary biliary cirrhosis, J Hepatol, 34, 366, 10.1016/S0168-8278(00)00040-4
Miyakawa, 2001, Detection of antimitochondrial autoantibodies in immunofluorescent AMA-negative patients with primary biliary cirrhosis using recombinant autoantigens, Hepatology, 34, 243, 10.1053/jhep.2001.26514
Fritzler, 1986, Autoantibody testing, Meth Achiev Exp Pathol, 12, 224
Meheus, 1999, Multicenter validation of recombinant, natural and synthetic antigens used in a single multiparameter assay for the detection of specific anti-nuclear antibodies in connective tissue disorders, Clin Exp Rheumatol, 17, 205
Fritzler, 2002, Specificity of autoantibodies to SS-A/Ro on a transfected and overexpressed human 60 kDa Ro autoantigen substrate, J Clin Lab Anal, 16, 103, 10.1002/jcla.10026
Vignali, 2000, Multiplexed particle-based flow cytometric assays, J Immunol Methods, 21, 243, 10.1016/S0022-1759(00)00238-6
Fulton, 1997, Advanced multiplexed analysis with FlowMetrix systems, Clin Chem, 43, 1749, 10.1093/clinchem/43.9.1749
Robinson, 2002, Autoantigen microarrays for multiplex characterization of autoantibody responses, Nat Med, 8, 295, 10.1038/nm0302-295
Surh, 1988, The predominance of IgG3 and IgM isotype antimitochondrial autoantibodies against recombinant fused mitochondrial polypeptide in patients with primary biliary cirrhosis, Hepatology, 8, 290, 10.1002/hep.1840080217
Reynoso-Paz, 2000, Evidence for a locally driven mucosal response and the presence of mitochondrial antigens in saliva in primary biliary cirrhosis, Hepatology, 31, 24, 10.1002/hep.510310106
Mutimer, 1989, Frequency of IgG and IgM autoantibodies to four specific M2 mitochondrial autoantigens in primary biliary cirrhosis, Hepatology, 10, 403, 10.1002/hep.1840100402
Miyakawa, 1999, Serial changes of serum and anti-M2 proteins in patients with primary biliary cirrhosis, Hepatol Res, 13, 143, 10.1016/S1386-6346(98)00088-6
Miyakawa, 1998, Combination assays for IgG class anti-pyruvate dehydrogenase (PDC)-E2 by ELISA using recombinant autoantigen to diagnose primary biliary cirrhosis, Hepatol Res, 12, 140, 10.1016/S1386-6346(98)00054-0
Moteki, 1998, The association between autoantibodies to enzyme and diseases–with special reference to antibodies to pyruvate dehydrogenase complex (PDH), Rinsho Byori, 46, 317
Leung, 1992, Use of designer recombinant mitochondrial antigens in the diagnosis of primary biliary cirrhosis, Hepatology, 15, 367, 10.1002/hep.1840150302
Joshi, 2002, Antimitochondrial antibody profiles, Am J Gastroenterol, 97, 999, 10.1111/j.1572-0241.2002.05620.x
Smolen, 1997, Standards of care, Arthritis Rheum, 40, 410, 10.1002/art.1780400303
Tan, 2002, A critical evaluation of enzyme immunoassay kits for the detection of antinuclear antibodies of defined specificities. II. Potential for quantitation of antibody content, J Rheumatol, 29, 68
Tan, 1999, A critical evaluation of enzyme immunoassays for the detection of antinuclear antibodies of defined specificities. I. Precision, sensitivity and specificity, Arthritis Rheum, 42, 455, 10.1002/1529-0131(199904)42:3<455::AID-ANR10>3.0.CO;2-3
Smolen, 1997, Reference sera for antinuclear antibodies, Arthritis Rheum, 40, 413, 10.1002/art.1780400304
Smolen, 1999, Reference sera for antinuclear antibodies.2. Further definition of antibody specificities in international antinuclear antibody reference sera by immunofluorescence and Western blotting, Arthritis Rheum, 40, 413, 10.1002/art.1780400304
Molden, 1984, Standardization of the immunofluorescence test for autoantibody to nuclear antigens (ANA), Am J Clin Pathol, 82, 57, 10.1093/ajcp/82.1.57
Berg, 1967, Mitochondrial antibodies in primary biliary cirrhosis. I. Localizattion of the antigen to mitochondrial membranes, J Exp Med, 126, 277, 10.1084/jem.126.2.277
Lohr, 1993, Autoreactive liver-infiltrating T cells in primary biliary cirrhosis recognize inner mitochondrial epiotpes and the pyruvate dehydrogenase complex, J Hepatol, 18, 322, 10.1016/S0168-8278(05)80276-4
Berg, 1992, Antimitochondrial antibodies in primary biliary cirrhosis and other disorders, Dig Dis, 10, 85, 10.1159/000171347
Gershwin, 1987, Identification and specificity of a cDNA encoding the 70 KD mitochondrial antigen recognized in primary biliary cirrhosis, J Immunol, 138, 3525, 10.4049/jimmunol.138.10.3525
Van de Water, 1988, The autoepitope of the 74-kD mitochondrial autoantigen of primary biliary cirrhosis corresponds to the functional site of dihydrolipoamide acetyltransferase, J Exp Med, 167, 1791, 10.1084/jem.167.6.1791
Fussey, 1988, Identification and analysis of the major M2 autoantigens in primary biliary cirrhosis, Proc Natl Acad Sci USA, 85, 8654, 10.1073/pnas.85.22.8654
Yeaman, 1988, Primary biliary cirrhosis, Lancet, 1, 1067, 10.1016/S0140-6736(88)91894-6
Coppel, 1988, Primary structure of the human M2 mitochondrial autoantigen of primary biliary cirrhosis, Proc Natl Acad Sci USA, 85, 7317, 10.1073/pnas.85.19.7317
Surh, 1989, Reactivity of primary biliary cirrhosis sera with a human fetal liver cDNA clone of branched-chain α-keto acid dehydrogenase-dihydrolipoamide acyltransfererase, Hepatology, 9, 63, 10.1002/hep.1840090110
Surh, 1989, Antimitochondrial autoantibodies in primary biliary cirrhosis recognize cross-reactive epitope(s) on protein X and dihydrolipoamide acetyltransferase of pyruvate dehydrogenase complex, Hepatology, 10, 127, 10.1002/hep.1840100202
Leung, 1997, Antimitochondrial antibodies in primary biliary cirrhosis, Semin Liver Dis, 17, 61, 10.1055/s-2007-1007183
Maeng, 1994, Expression, purification, and characterization of the dihydrolipoamide dehydrogenase-binding protein of the pyruvate dehydrogenase complex from Saccharomyces serevisiae, Biochemistry, 33, 13801, 10.1021/bi00250a034
De Marucci, 1985, An immunologically distinct polypeptide associated with mammalian pyruvate dehydrogenase multienzyme complex, Eur J Biochem, 149, 641, 10.1111/j.1432-1033.1985.tb08972.x
Harris, 1997, Dihydrolipoamide dehydrogenase-binding protein of the human pyruvate dehydrogenase complex. DNA-derived amino acid sequence, expression, and reconstitution of the pyruvate dehdrogenase complex, J Biol Chem, 272, 19746, 10.1074/jbc.272.32.19746
Fregeau, 1990, Inhibition of pyruvate dehydrogenase complex activity by antibodies specific for E1α, a nonlipoic acid containing mitochondrial enzyme, J Immunol, 144, 1671, 10.4049/jimmunol.144.5.1671
Yeaman, 1986, The mammalian 2-oxo-acid dehydrogenases. A complex family, Trends Biochem Sci, 11, 293, 10.1016/0968-0004(86)90033-2
Njemini, 2002, The prevalence of autoantibodies in an elderly sub-Saharan African population, Clin Exp Immunol, 127, 99, 10.1046/j.1365-2249.2002.01713.x
Gordon, 1995, Antibodies to carbonic anhydrase in patients with immune cholangiopathies, Gastroenterol, 108, 1802, 10.1016/0016-5085(95)90143-4
Christensen, 1980, Clinical pattern and course of disease in primary biliary cirrhosis based on an analysis of 236 patients, Gastroenterol, 78, 236, 10.1016/0016-5085(80)90571-5
Surh, 1990, Structural requirement for autoreactivity on human pyruvate dehydorgenase-E2, the major autoantigen of primary biliary cirrhosis. Implications for a conformational epitope, J Immunol, 144, 3367, 10.4049/jimmunol.144.9.3367
Quinn, 1993, Lipoylated and unlipoylated domains of human PDC-E2 as autoantigens in primary biliary cirrhosis, Hepatology, 18, 1384, 10.1002/hep.1840180616
Leung, 1990, Site-directed mutagenesis of lysine within the imunodominant autoepitope of PDC-E2, Hepatology, 12, 1321, 10.1002/hep.1840120612
Sasaki, 2000, Comparative immunoreactivity of anti-trifluoroacetyl (TFA) antibody and anti-lipoic acid antibody in primary biliary cirrhosis, J Autoimmun, 15, 51, 10.1006/jaut.2000.0390
Migliaccio, 2001, Heterogeneous response of antimitochondrial autoantibodies and bile duct apical staining monoclonal antibodies to pyruvate dehydrogenase complex E2, Hepatology, 33, 792, 10.1053/jhep.2001.23783
Caldwell, 1992, Antimitochondrial antibodies in kindreds of patients with primary biliary cirrhosis, Hepatology, 16, 899, 10.1002/hep.1840160408
Palmer, 2002, The immunology of primary biliary cirrhosis, Clin Exp Immunol, 129, 191, 10.1046/j.1365-2249.2002.01948.x
Van de Water, 1995, Heterogeneity of autoreactive T cell lones specific for the E2 component of the pyruvate dehydrogenase complex in primary biliary cirrhosis, J Exp Med, 181, 723, 10.1084/jem.181.2.723
Dubel, 1999, Autoepitope mapping and reactivity of autoantibodies to the dihydrolipoamide dehydrogenase-binding protein (E3BP) and the glycine cleavage proteins in primary biliary cirrhosis, Hepatology, 29, 1013, 10.1002/hep.510290403
Koike, 1998, Immunoreactivity of porcine heart dihydrolipoamide acetyl- and succinyl-transferases (PDC-E2, OGDC-E2) with primary biliary cirrhosis sera, Hepatology, 27, 1467, 10.1002/hep.510270602
Iwayama, 1991, Specific reactivity of recombinant human PDC-E1α in primary biliary cirrhosis, J Autoimmun, 4, 769, 10.1016/0896-8411(91)90172-9
Moteki, 1996, Epitope mapping and reactivity of autoantibodies to the E2 component of 2-oxoglutarate dehydrogenase complex in primary biliary cirrhosis using recombinant 2-oxoglutarate dehydrogenase complex, Hepatology, 23, 436, 10.1002/hep.510230307
Ikuno, 2001, A comparative study of antibody expressions in primary biliary cirrhosis and autoimmune cholangitis using phage display, Hepatology, 34, 478, 10.1053/jhep.2001.27013
Shigematsu, 2000, Fine specificity of T cells reactive to human PDC-E2 163-176 peptide, the immunodominant autoantigen in primary biliary cirrhosis, Hepatology, 32, 901, 10.1053/jhep.2000.18714
Shimoda, 1995, HLA DRB4 0101-restricted immunodominant T cell autoepitope of pyruvate dehydrogenase complex in primary biliary cirrhosis, J Exp Med, 181, 1835, 10.1084/jem.181.5.1835
Van de Water, 1997, The role of T cells in primary biliary cirrhosis, Semin Liver Dis, 17, 105, 10.1055/s-2007-1007188
Akbar, 2001, Peripheral blood T-cell responses to pyruvate dehydrogenase complex in primary biliary cirrhosis, Eur J Clin Invest, 31, 639, 10.1046/j.1365-2362.2001.00847.x
Shimoda, 1998, Identification and precursor frequncy analysis of a common T cell epitope motif in mitochondrial autoantigens in primary biliary cirrhosis, J Clin Invest, 102, 1831, 10.1172/JCI4213
Ichiki, 2001, Analysis of T-cell receptor β of the T-cell clones reactive to human PDC-E2 163-176 peptide in the context of HLA-DR53 in patients with primary biliary cirrhosis, Hepatology, 26, 728
Berg, 1987, Immunobiology of primary biliary cirrhosis, Baillieres Clin Gastroenterol, 1, 675, 10.1016/0950-3528(87)90053-4
Sternsdorf, 1995, Two nuclear dot-associated proteins, PML and Sp100, are often co-immunogenic inpatients with primary biliary cirrhosis, Scand J Immunol, 42, 257, 10.1111/j.1365-3083.1995.tb03652.x
Lozano, 1988, Autoantibodies against nuclear envelope-associated proteins in primary biliary cirrhosis, Hepatology, 8, 930, 10.1002/hep.1840080438
Lassoued, 1990, Antinuclear antibodies directed to a 200-kilodalton polypeptide of the nuclear envelope in primary biliary cirrhosis. A clinical and immunological study of a series of 150 patients with primary biliary cirrhosis, Gastroenterology, 99, 181, 10.1016/0016-5085(90)91246-3
Nickowitz, 1994, Autoantibodies against integral membrane proteins of the nuclear envelope in patients with primary biliary cirrhosis, Gastroenterology, 106, 193, 10.1016/S0016-5085(94)95333-3
Remmel, 1996, Clinical significance of different antinuclear antibody patterns in the course of primary biliary cirrhosis, Hepatogastroenterology, 43, 1135
Itoh, 1998, Autoantibodies against a 210 kDa glycoprotein of the nuclear pore complex as a prognostic marker in patients with primary biliary cirrhosis, J Gastroenterol Hepatol, 13, 257, 10.1111/j.1440-1746.1998.01553.x
Zuchner, 1997, Prevalence, kinetics, and therapeutic modulation of autoantibodies against Sp100 and promyelocytic leukemia protein in a large cohort of patients with primary biliary cirrhosis, Hepatology, 26, 1123
Ruffatti, 1985, Nuclear membrane-staining antinuclear antibody in patients with primary biliary cirrhosis, J Clin Immunol, 5, 357, 10.1007/BF00918255
Worman, 1991, Autoantibodies against nuclear envelope proteins in liver disease, Hepatology, 14, 1269, 10.1002/hep.1840140649
Konstantinov, 1996, Nuclear envelope protein autoantibodies, 561
Dubel, 1998, Persistence of gp210 and multiple nuclear dots antibodies does not correlate with recurrence of primary biliary cirrhosis 6 years after liver transplantation, J Hepatol, 28, 169, 10.1016/S0168-8278(98)80220-1
Courvalin, 1997, Nuclear envelope protein autoantibodies in primary biliary cirrhosis, Semin Liver Dis, 17, 79, 10.1055/s-2007-1007185
Hansen, 1991, High prevalence of autoimmune liver disease in patients with multiple nuclear dot, anti-centromere, and mitotic spindle antibodies, Scand J Gastroenterol, 26, 707, 10.3109/00365529108998588
Muratori, 2002, Anti-multiple nuclear dots (anti-MND) and anti-SP100 antibodies in hepatic and rheumatological disorders, Clin Exp Immunol, 127, 172, 10.1046/j.1365-2249.2002.01719.x
Bernstein, 1984, Antinuclear antibodies in primary biliary cirrhosis, Lancet, 1, 508, 10.1016/S0140-6736(84)92869-1
Hirakata, 1988, Coexistence of CREST syndrome and primary biliary cirrhosis. Serological studies of two cases, J Rheumatol, 15, 1166
Bernstein, 1982, Anticentromere antibody in primary biliary cirrhosis, Ann Rheum Dis, 41, 612, 10.1136/ard.41.6.612
Bernstein, 1984, Diversity of autoantibodies in primary biliary cirrhosis and chronic active hepatitis, Clin Exp Immunol, 55, 553
Strassburg, 2000, Autoimmunity in liver diseases, Clin Rev Allergy Immunol, 18, 127, 10.1385/CRIAI:18:2:127
Evans, 1991, PBC 95K, a 95-kilodalton nuclear-autoantigen in primary biliary cirrhosis, Arthritis Rheum, 34, 731, 10.1002/art.1780340614
Szostecki, 1987, Autoimmune sera recognize a 100 kD nuclear protein antigen (sp-100), Clin Exp Immunol, 68, 108
Reeves, 1987, Autoantibodies in sera of certain patients with systemic lupus erythematosus, J Exp Med, 165, 750, 10.1084/jem.165.3.750
Dagenais, 1988, A novel autoantibody causing a peripheral fluorescent antinuclear antibody pattern is specific for nuclear pore complexes, Arthritis Rheum, 31, 1322, 10.1002/art.1780311017
Senécal, 1993, Autoantibodies to nuclear lamins and to intermediate filament proteins, J Rheumatol, 20, 211
Senécal, 1999, Strong association of autoantibodies to human nuclear lamin B1 with lupus anticoagulant antibodies in systemic lupus erythematosus, Arthritis Rheum, 42, 1347, 10.1002/1529-0131(199907)42:7<1347::AID-ANR7>3.0.CO;2-#
Miyachi K, Shibata M, Onozuka Y, Kikuchi F, Imai N, Horigome T. Primary biliary cirrhosis sera recognize not only gp210 but also proteins of the p62 complex bearing N-acetyl glucosamine residues from rat liver nuclear envelope. Anti-p62 complex antibody in PBC. Mol Biol Rep 1996;23:227–34.
Courvalin, 1990, The 21-kD nuclear envelope polypeptide recognized by human autoantibodies in primary biliary cirrhosis is the major glycoprotein of the nuclear pore, J Clin Invest, 86, 279, 10.1172/JCI114696
Nickowitz, 1993, Autoantibodies from patients with primary biliary cirrhosis recognize a restricted region within the cytoplasmic tail of nuclear pore membrane glycoprotein Gp210, J Exp Med, 178, 2237, 10.1084/jem.178.6.2237
Wesierska-Gadek, 1996, Autoantibodies against nucleoporin p62 constitute a novel marker of primary biliary cirrhosis, Gastroenterology, 110, 840, 10.1053/gast.1996.v110.pm8608894
Weseierska-Gadek, 1988, Antibodies to nuclear lamins in autoimmune liver disease, Clin Immunol Immunopathol, 49, 107, 10.1016/0090-1229(88)90100-6
Courvalin, 1990, Identification and characterization of autoantibodies against the nuclear envelope lamin B receptor from patients with primary biliary cirrhosis, J Exp Med, 172, 961, 10.1084/jem.172.3.961
Bandin, 1996, Specificity and sensitivity of gp210 autoantibodies detected using an enzyme-linked immunosorbent assay and a synthetic polypeptide in the diagnosis of primary biliary cirrhosis, Hepatology, 23, 1020, 10.1002/hep.510230512
Doniach, 1966, Tissue antibodies in primary biliary cirrhosis, active chronic (lupoid) hepatitis, cryptogenic cirrhosis and other liver diseases and their clinical implications, Clin Exp Immunol, 1, 237
Luettig, 1998, The antinuclear autoantibodies Sp100 and gp210 persist after orthotopic liver transplantation in patients with primary biliary cirrhosis, J Hepatol, 28, 824, 10.1016/S0168-8278(98)80233-X
Mattalia, 1997, Persistence of autoantibodies against recombinant mitochondrial and nuclear pore proteins after orthotopic liver transplantation, J Autoimmun, 10, 491, 10.1006/jaut.1997.0156
McHugh, 1990, Autoantibodies to mitochondrial and centromere antigens in primary biliary cirrhosis and systemic sclerosis, Clin Exp Immunol, 81, 244, 10.1111/j.1365-2249.1990.tb03325.x
Akimoto, 1999, Clinical and immunological characterization of patients with systemic sclerosis overlapping primary biliary cirrhosis, J Dermatol, 26, 18, 10.1111/j.1346-8138.1999.tb03503.x
Moroi, 1980, Autoantibody to centromere (kinetochore) in scleroderma sera, Proc Natl Acad Sci USA, 77, 1627, 10.1073/pnas.77.3.1627
Fritzler, 1984, Speckled pattern antinuclear antibodies resembling anticentromere antibodies, Arthritis Rheum, 27, 92, 10.1002/art.1780270114
Szostecki, 1990, Isolation and characterization of cDNA encoding a human nuclear antigen predominantly recognized by autoantibodies from patients with primary biliary cirrhosis, J Immunol, 145, 4338, 10.4049/jimmunol.145.12.4338
de Thé, 1990, The t(15;17) translocation of acute promyelocytic leukemia fuses with the retinoic acid receptor α gene to a novel putative transcribed locus, Nature, 347, 558, 10.1038/347558a0
Blüthner, 1999, Identification of major linear eiptopes on the sp100 nuclear PBC autoantigen by the gene-fragment phage-display technology, Autoimmunity, 29, 33, 10.3109/08916939908995970
Strassburg, 1996, Identification of cyclin A as a molecular target of antinuclear antibodies (ANA) in hepatic and non-hepatic diseases, J Hepatol, 25, 859, 10.1016/S0168-8278(96)80290-X
Sobajima, 1999, High mobility group (HMG) non-histone proteins HMG1 and HMG2 are significant target atnigens of perinuclear anti-neutrophil cytoplasmic antibodies in autoimmune hepatitis, Gut, 44, 867, 10.1136/gut.44.6.867
Mackay, 2000, The peculiar autoimmunity of primary biliary cirrhosis, Immunol Rev, 174, 226, 10.1034/j.1600-0528.2002.017410.x
Wiik, 2001, Methods for the detection of anti-neutrophil cytoplasmic antibodies. Recommendations for clinical use of ANCA serology and laboratory efforts to optimize the informative value of ANCA test results, Springer Semin Immunopathol, 23, 217, 10.1007/s002810100076
Ayer, 1994, Antibodies to high mobility group (HMG) proteins in systemic sclerosis, J Rheumatol, 21, 2071
Ayer, 1994, Antibodies to HMG proteins in patients with drug-induced autoimmunity, Arthritis Rheum, 37, 98, 10.1002/art.1780370115
Burlingame, 1993, Autoantibodies to chromatin components in juvenile rheumatoid arthritis, Arthritis Rheum, 36, 836, 10.1002/art.1780360615
Neuer, 1992, Autoantibodies to the chromosomal protein HMG-17 in juvenile rheumatoid arthritis, Arthritis Rheum, 35, 472, 10.1002/art.1780350418
Tzioufas, 1993, Autoantibodies to HMG-17 nucleosomal protein in autoimmune rheumatic diseases.Correlation with systemic lupus erythematosus clinical activity and with antibodies to double-stranded DNA, Arthritis Rheum, 36, 955, 10.1002/art.1780360712
Invernizzi, 1998, Antibody to carbonic anhydrase II is present in primary biliary cirrhosis (PBC) irrespective of antimitochondrial antibody status, Clin Exp Immunol, 114, 448, 10.1046/j.1365-2249.1998.00735.x
Akisawa, 1999, The ability of anti-carbonic anhydrase II antibody to distinguish autoimmune cholangitis from primary biliary cirrhosis in Japanese patients, J Gastroenterol, 34, 366, 10.1007/s005350050275
Itoh, 1992, Antibodies to carbonic anhydrase in systemic lupus erythematosus and other rheumatic diseases, Arthritis Rheum, 35, 73, 10.1002/art.1780350112
Anagaki, 1991, A novel autoantibody reactive with carbonic anhydrase in sera from patients with systemic lupus erythematosus and Sjögren's syndrome, J Dermatol Sci, 2, 147, 10.1016/0923-1811(91)90060-B
Kino-Ohsaki, 1996, Serum antibodies to carbonic anhydrase I and II in patients with idiopathic chronic pancreatitis and Sjögren's syndrome, Gastroenterology, 110, 1579, 10.1053/gast.1996.v110.pm8613065
Mouritsen, 1986, High prevalence of anti-mitochondrial antibodies among patients with some well-defined connective tissue diseases, Clin Exp Immunol, 66, 68
Triger, 1982, What does the antimitochondrial antibody mean?, Gut, 23, 814, 10.1136/gut.23.10.814
Celis, 1987, Anti-mitochondrial protein antibodies in a serum from a patient with systemic lupus erythematosus, Electrophoresis, 8, 238, 10.1002/elps.1150080507
Tsianos, 1990, Sjögren's syndrome in patients with primary biliary cirrhosis, Hepatology, 11, 730, 10.1002/hep.1840110504
Hansen, 1988, Clinical and immunological features of Sjögren's syndrome in patients with primary biliary cirrhosis with an emphasis on focal sialadenitis, Acta Med Scand, 224, 611, 10.1111/j.0954-6820.1988.tb19634.x
Webb, 1975, Liver disease in rheumatoid arthritis and Sjögren's syndrome. Prospective study using biochemical and serological markers of hepatic dysfunction, Ann Rheum Dis, 34, 70, 10.1136/ard.34.1.70
Skopouli, 1994, Liver involvement in primary Sjögren's syndrome, Br J Rheumatol, 33, 745, 10.1093/rheumatology/33.8.745
Lindgren, 1994, Autoimmune liver disease in patients with primary Sjögren's syndrome, J Hepatol, 20, 354, 10.1016/S0168-8278(94)80007-3
Furuya, 1995, Primary biliary cirrhosis in patients with Sjögren's syndrome, Nippon Rinsho, 53, 2536
Fujikura, 1990, Sjögren's syndrome and primary biliary cirrhosis, J Rheumatol, 17, 1453
Culp, 1998, Autoimmune associations in primary biliary cirrhosis, Semin Immunol, 10, 5
Manthorpe, 1979, Auto-antibodies in Sjögren's syndrome. With special reference to liver-cell membrane antibody (LMA), Scand J Rheumatol, 8, 168, 10.3109/03009747909114450
Dorner, 1994, Serologic characteristics in primary biliary cirrhosis associated with sicca syndrome, Scand J Gastroenterol, 29, 655, 10.3109/00365529409092488
Gentric, 1990, Serological arguments for classifying Raynaud's phenomenon as idiopathic, J Rheumatol, 17, 1177
Reimer, 1990, Autoantibodies against nuclear, nucleolar, and mitochondrial antigens in systemic sclerosis (scleroderma), Rheum Dis Clin North Am, 16, 169, 10.1016/S0889-857X(21)01047-4
Fujimoto, 1995, Autoantibodies to pyruvate dehydrogenase complex in patients with systemic sclerosis - possible role of anti-E1α antibody as a serologic indicator for development of primary biliary cirrhosis, Arthritis Rheum, 38, 985, 10.1002/art.1780380715
Zurgil, 1992, Anti-mitochondrial (pyruvate dehydrogenase) autoantibodies in autoimmune rheumatic diseases, J Clin Immunol, 12, 201, 10.1007/BF00918090
Gupta, 1984, Precipitating autoantibodies to mitochondrial proteins in progressive systemic sclerosis, Clin Exp Immunol, 58, 68
Fregeau, 1988, Autoanibodies to mitochondria in systemic sclerosis, Arthritis Rheum, 31, 386, 10.1002/art.1780310310
Powell, 1987, Primary biliary cirrhosis and the CREST syndrome, Q J Med, 237, 75
Palmer, 2000, Secretory autoantibodies in primary biliary cirrhosis (PBC), Clin Exp Immunol, 122, 423, 10.1046/j.1365-2249.2000.01403.x
Akimoto, 1998, Immunological features of patients with primary biliary cirrhosis (PBC) overlapping systemic sclerosis, J Gastroenterol Hepatol, 13, 897, 10.1111/j.1440-1746.1998.tb00758.x
Reimer, 1984, Anti-native DNA antibodies from autoimmune sera also bind to DNA in mitochondria, J Immunol, 133, 2532, 10.4049/jimmunol.133.5.2532
Kastaros, 2001, Lupus associated anti-guanosine antibodies, Arthritis Rheum, 44, S281
La Rosa, 1998, Anti-mitochondrial M5 type antibody represents one of the serological markers for anti-phospholipid syndrome distinct from anti-cardiolipin and anti-beta2-glycoprotein I antibodies, Clin Exp Immunol, 112, 144, 10.1046/j.1365-2249.1998.00562.x
Verrier Jones, 1991, Williams CN et al. Antimitochondrial antibodies and antiphospholipid antibodies, J Rheumatol, 18, 478
Quaranta, 1999, Autoantibodies in human chronic graft-versus-host disease after hematopoietic cell transplantation, Clin Immunol, 91, 106, 10.1006/clim.1998.4666
Stahle, 1999, Anti-mitochondrial flavoprotein autoantibodies of patients with myocarditis and dilated cardiomyopathy (anti-M7), Clin Exp Immunol, 115, 404, 10.1046/j.1365-2249.1999.00832.x
Shikuwa, 2000, Primary biliary cirrhosis associated with idiopathic retroperitoneal fibrosis, J Gastroenterol, 35, 646, 10.1007/s005350070067
Homberg, 1982, A new antimitochondria antibody (anti-M6) in iproniazid-induced hepatitis, Clin Exp Immunol, 47, 93
Pons, 1996, Human anti-mitochondria autoantibodies appearing in iproniazid- induced immunoallergic hepatitis recognize human liver monoamine oxidase B, Biochem Biophys Res Commun, 218, 118, 10.1006/bbrc.1996.0021
Mattalia, 1998, Van de WJ, Calvo PL et al. Characterization of antimitochondrial antibodies in health adults, Hepatology, 27, 656, 10.1002/hep.510270303
Koizumi, 2000, Positive rate of anti-mitochondrial antibody in Japanese corporate workers, Rinsho Byori, 48, 966
Tanaka, 2000, Mucosal immunity and primary biliary cirrhosis, Hepatology, 32, 910, 10.1053/jhep.2000.19254
Malmborg, 1998, Penetration and co-localization in MDCK cell mitochondria of IgA derived from patients with primary biliary cirrhosis, J Autoimmun, 11, 573, 10.1006/jaut.1998.0220
Nakajima, 1999, Detection of IgA, IgM, and IgG subclasses of anti-M2 antibody by immunoblotting in autoimmune cholangitis, J Gastroenterol, 34, 607, 10.1007/s005350050380
Mitchison, 1986, Positive antimitochondrial antibody but normal alkaline phosphatase, Hepatology, 6, 1279, 10.1002/hep.1840060609
Metcalf, 1996, Natural history of early primary biliary cirrhosis, Lancet, 348, 1399, 10.1016/S0140-6736(96)04410-8
Howel, 2000, An exploratory population-based case-control study of primary biliary cirrhosis, Hepatology, 31, 1055, 10.1053/he.2000.7050
Tsuneyama, 1995, Abnormal expression of the E2 component of the pyruvate dehydrogenase complex on the luminal surface of biliary epithelium occurs before major histocompatability complex class II and BB1/B7 expression, Hepatology, 21, 1031
Joplin, 1995, Subcellular localization of pyruvate dehydrogenase dihydrolipoamide acetyltransferease in human, J Pathol, 176, 381, 10.1002/path.1711760409
Van de Water, 1993, Molecular mimicry in primary biliary cirrhosis. Evidence of biliary epithelial expression of a molecule cross-reactive with pyruvate dehydrogenase complex-E2, J Clin Invest, 91, 2653, 10.1172/JCI116504
Nishio, 1997, Comparative studies of antimitochondrial antibodies in sera and bile in primary biliary cirrhosis, Hepatology, 25, 1085, 10.1002/hep.510250506
Joplin, 1992, Membrane dihydrolipoamide acetyltransferase (E2) on human biliary epithelial cells in primary biliary cirrhosis, Lancet, 339, 93, 10.1016/0140-6736(92)91001-O
Joplin, 1997, Ductular expression of autoantigens in primary biliary cirrhosis, Semin Liver Dis, 17, 97, 10.1055/s-2007-1007187
Joplin, 1997, The human biliary epithelial cell plasma membrane antigen in primary biliary cirrhosis, Gastroenterology, 113, 1727, 10.1053/gast.1997.v113.pm9352878
Van de Water, 1989, Molecular definitions, autoepitopes, and enzymatic activities of the mitochondrial autoantigens of primary biliary cirrhosis, Semin Liver Dis, 9, 132, 10.1055/s-2008-1040504
Hubscher, 1993, Primary biliary cirrhosis. Histological evidence of disease recurrence after liver transplantation, J Hepatol, 18, 173, 10.1016/S0168-8278(05)80244-2
Van de Water, 1996, Immunohistochemical evidence of disease recurrence after liver transpantation, Hepatology, 24, 1079, 10.1002/hep.510240517
Haagsma, 1987, Subtypes of antimitochondrial antibodies in primary biliary cirrhosis before and after orthotopic liver transplantation, Hepatology, 7, 129, 10.1002/hep.1840070125
Gouw, 1994, Is there recurrence of primary biliary cirrhosis after liver transplantation? A clinicopathologic study in long-term survivors, J Hepatol, 20, 500, 10.1016/S0168-8278(05)80497-0
Rosen, 1995, Novel packages of viral and self-antigens are generated during apoptosis, J Exp Med, 181, 1557, 10.1084/jem.181.4.1557
Rosen, 2001, Clearing the way to mechanisms of autoimmunity, Nat Med, 7, 664, 10.1038/89034
Odin, 2001, Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis, J Clin Invest, 108, 223, 10.1172/JCI200110716
Koga, 1997, Nuclear DNA fragmentation and expression of Bcl-2 in primary biliary cirrhosis, Hepatology, 25, 1077, 10.1002/hep.510250505
Harada, 1997, Enhanced apoptosis realtes to bile duct loss in primary biliary cirrhosis, Hepatology, 26, 1399, 10.1002/hep.510260604
Graham, 1998, Bile ducts in primary biliary cirrhosis are ‘primed’ for apoptosis, Eur J Gastroenterol Hepatol, 10, 553, 10.1097/00042737-199807000-00005
Matsumura, 2002, Contribution to antimitochondrial antibody production, Hepatology, 35, 14, 10.1053/jhep.2002.30280
Rowley, 1996, Diabetic sera react with the glutamic acid decarboxylase molecule in a dimeric-oligomeric form, Clin Exp Immunol, 106, 323, 10.1046/j.1365-2249.1996.d01-827.x
Pollard, 1997, The autoimmunity-inducing xenobiotic mercury interacts with the autoantigen fibrillarin and modifies its molecular and antigenic properties, J Immunol, 158, 3521, 10.4049/jimmunol.158.7.3521
Krams, 1989, Immunization of experimental animals with dihydrolipoamide acetyltransferase, as a purified recombinant polypeptide, generate mtiochondrial antibodies but not primary bilairy cirrhosis, Hepatology, 9, 411, 10.1002/hep.1840090311
Jones, 2002, Investigation of a mechanism for accelerated breakdown of immune tolerance to the primary biliary cirrhosis-associated autoantigen, pyruvate dehydrogenase complex, Lab Invest, 82, 211, 10.1038/labinvest.3780413
Krams, 1989, Generation of biliary lesions after transfer of human lymphocytes into severe combined immunodeficient (SCID) mice, J Exp Med, 170, 1919, 10.1084/jem.170.6.1919
Lacerda, 1995, Anti-mitochondrial antibody-negative primary biliary cirrhosis, Am J Gastroenterol, 90, 247
Invernizzi, 1997, Comparison of the clinical features and clinical course of antimitochondrial antibody-positive and-negative primary biliary cirrhosis, Hepatology, 25, 1090, 10.1002/hep.510250507
Goodman, 1995, Autoimmune cholangitis, Dig Dis Sci, 40, 1232, 10.1007/BF02065530
Brunner, 1987, A cholangitis with antinuclear antibodies (immunocholangitis) resembling chronic non-supparative cholangitis, Dtsch Med Wochenschr, 112, 1454, 10.1055/s-2008-1068269
Ben-Ari, 1993, Autoimmune cholangiopathy, Hepatology, 18, 10, 10.1002/hep.1840180103
Taylor, 1994, Primary autoimmune cholangitis. An alternative to antimitochondrial antibody-negative primary biliary cirrhosis, Am J Surg Pathol, 18, 91, 10.1097/00000478-199401000-00009
Michieletti, 1994, Antimitochondrial antibody negative primary biliary cirrhosis, Gut, 35, 260, 10.1136/gut.35.2.260
Vierling, 1999, Autoimmune cholangiopathy, Clin Liver Dis, 3, 571, 10.1016/S1089-3261(05)70085-4
Kinoshita, 1999, Autoimmune cholangitis and primary biliary cirrhosis–an autoimmune enigma, Liver, 19, 122, 10.1111/j.1478-3231.1999.tb00021.x
Sherlock, 1998, Ludwig symposium on biliary disorders. Autoimmune cholangitis, Mayo Clin Proc, 73, 184, 10.4065/73.2.184
Neuberger, 1999, PBC and AMA–what is the connection?, Hepatology, 29, 271, 10.1002/hep.510290126
Heathcote, 1997, Autoimmune cholangitis, Gut, 40, 440, 10.1136/gut.40.4.440
Tsuneyama, 1995, Abnormal expression of PDC-E2 on the apical surface of biliary epithelial cells in pateints with antimitochondrial antibody-negative primary biliary cirrhosis, Hepatology, 22, 1440
Shibata, 2001, A case of autoimmune hepatitis with a high titer of antimitochondrial antibody and normal gamma-globulinemia, J Gastroenterol Hepatol, 16, 830, 10.1046/j.1440-1746.2001.02413.x
Cho, 1999, Negative conversion of antimitochondrial antibody in primary biliary cirrhosis, J Korean Med Sci, 14, 102, 10.3346/jkms.1999.14.1.102
Ishibashi, 2001, Are primary biliary cirrhosis and autoimmune cholangitis reflective of the pendulum of a clock and therefore represent a ‘phase’ of the same disease?, J Gastroenterol Hepatol, 16, 121, 10.1111/j.1440-1746.2001.02408.x
Mackay, 2000, Autoimmune disease overlaps and the liver, J Gastroenterol Hepatol, 15, 3, 10.1046/j.1440-1746.2000.02041.x
Manns, 1994, Immunogenetics of chronic liver diseases, Gastroenterology, 106, 1676, 10.1016/0016-5085(94)90427-8
Zhang, 1993, Anti-idiotype antibodies to antimitochondrial antibodies in sera of patients with primary biliary cirrhosis, J Autoimmun, 1, 93, 10.1006/jaut.1993.1008
Ramakrishna, 2000, Familial intrahepatic cholestatic cirrhosis with positive antimitochondrial antibody, J Clin Gastroenterol, 30, 255, 10.1097/00004836-200004000-00010
Bach, 1994, Familial primary biliary cirrhosis, J Hepatol, 20, 698, 10.1016/S0168-8278(05)80137-0
Jones, 1999, Familial primary biliary cirrhosis reassessed, J Hepatol, 30, 402, 10.1016/S0168-8278(99)80097-X
Kato, 1981, Familial primary biliary cirrhosis. Immunological and genetic study, Am J Gastroenterol, 75, 188
Tsuji, 1999, Familial primary biliary cirrhosis in Hiroshima, J Autoimmun, 13, 171, 10.1006/jaut.1999.0299
Metcalf, 1997, The geoepidemiology of primary biliary cirrhosis, Semin Liver Dis, 17, 13, 10.1055/s-2007-1007179
Triger, 1984, Epidemiology of primary biliary cirrhosis, Liver, 4, 195, 10.1111/j.1600-0676.1984.tb00927.x
Uibo, 1999, The epidemiology of primary biliary cirrhosis, Hepatogastroenterology, 46, 3048
Alarcon-Segovia, 1973, Features of Sjogren's syndrome in primary biliary cirrhosis, Ann Intern Med, 79, 31, 10.7326/0003-4819-79-1-31
Yap, 1996, Primary biliary cirrhosis–an uncommon disease in Singapore, Singapore Med J, 37, 48
Howel, 2000, An exploratory population-based case-control study of primary biliary cirrhosis, Hepatology, 31, 1055, 10.1053/he.2000.7050
Burroughs, 1992, Molecular mimicry in liver disease, Nature, 358, 377, 10.1038/358377a0
Gershwin, 2000, Primary biliary cirrhosis, Immunol Rev, 174, 210, 10.1034/j.1600-0528.2002.017402.x
Fritzler, 1991, The diversity and origin of rheumatologic autoantibodies, Clin Microbiol Rev, 4, 256, 10.1128/CMR.4.3.256
Nishio, 2000, The pyruvate dehydrogenase complex as a target autoantigen in primary biliary cirrhosis, Baillieres Clin Gastroenterol, 14, 535, 10.1053/bega.2000.0102
Butler, 1995, Detection of M2 antibodies in patients with recurrent urinary tract infection using an ELISA and purified PBC specific antigens. Evidence for a molecular mimicry mechanism in the pathogenesis of primary biliary cirrhosis?, Biochem Mol Biol Int, 35, 473
Butler, 1993, M2 mitochondrial antibodies and urinary rough mutant bacteria in patients with primary biliary cirrhosis and in patients with recurrent bacteriuria, J Hepatol, 17, 408, 10.1016/S0168-8278(05)80225-9
Morreale, 1989, Significant bacteriuria has prognostic significance in primary biliary cirrhosis, J Hepatol, 9, 149, 10.1016/0168-8278(89)90045-7
Burroughs, 1984, Bacteriuria and primary biliary cirrhosis, Gut, 25, 133, 10.1136/gut.25.2.133
Rosenstein, 1984, Recurrent bacteriuria and primary biliary cirrhosis, J Clin Pathol, 37, 1055, 10.1136/jcp.37.9.1055
Hopf, 1989, Relation between Escerichia coli R (rough)-forms in gut, lipid A in liver, and primary biliary cirrhosis, Lancet, 2, 1419, 10.1016/S0140-6736(89)92034-5
Floreani, 1989, No specific association between primary biliary cirrhosis and bacteriuria?, J Hepatol, 8, 201, 10.1016/0168-8278(89)90008-1
O'Donohue, 1997, Urinary tract infections in primary biliary cirrhosis and other chronic liver diseases, Eur J Clin Microbiol Infect Dis, 16, 743, 10.1007/BF01709256
Burlingame, 1996, Autoantibody to the nucleosome subunit (H2A-H2B)-DNA is an early and ubiquitous feature of lupus-like conditions, Mol Biol Rep, 23, 159, 10.1007/BF00351164
Moteki, 1996, Use of a designer triple expression hybrid clone for three different lipoyl domains for the detection of antimitochondrial autoantibodies, Hepatology, 24, 97, 10.1002/hep.510240117
Akisawa, 1997, Identification of an autoantibody against alpha-enolase in primary biliary cirrhosis, J Hepatol, 26, 845, 10.1016/S0168-8278(97)80251-6
Alderuccio, 1986, Identification and characterization of mitochondria autoantigens in progressive systemic sclerosis, J Immunol, 137, 1855, 10.4049/jimmunol.137.6.1855
Varga, 1993, Myopathy with mitochondrial alterations in patients with primary biliary cirrhosis and antimitochondrial antibodies, Arthritis Rheum, 36, 1468, 10.1002/art.1780361020
Gilburd, 1994, Antimitochondrial (pyruvate dehydrogenase) antibodies in leprosy, J Clin Immunol, 14, 14, 10.1007/BF01541171