Secreted Ly-6/uPAR-related protein-1 (SLURP1) is a pro-differentiation factor that stalls G1-S transition during corneal epithelial cell cycle progression

Norman, 2004, Postnatal gene expression in the normal mouse cornea by SAGE, Invest Ophthalmol Vis Sci, 45, 429, 10.1167/iovs.03-0449 Stephens, 2013, The Ets transcription factor EHF as a regulator of cornea epithelial cell identity, J Biol Chem, 288, 34304, 10.1074/jbc.M113.504399 Loughner, 2016, Organization, evolution and functions of the human and mouse Ly6/uPAR family genes, Hum Genom, 10, 10, 10.1186/s40246-016-0074-2 Adermann, 1999, Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily, Protein Sci, 8, 810, 10.1110/ps.8.4.810 Swamynathan, 2015, Corneal expression of SLURP-1 by age, sex, genetic strain, and ocular surface health, Invest Ophthalmol Vis Sci, 56, 7888, 10.1167/iovs.15-18206 Swamynathan, 2012, Klf4 regulates the expression of Slurp1, which functions as an immunomodulatory peptide in the mouse cornea, Invest Ophthalmol Vis Sci, 53, 8433, 10.1167/iovs.12-10759 Matsumoto, 2012, Localization of acetylcholine-related molecules in the retina: implication of the communication from photoreceptor to retinal pigment epithelium, PLoS One, 7, 10.1371/journal.pone.0042841 Horiguchi, 2009, Expression of SLURP-1, an endogenous alpha7 nicotinic acetylcholine receptor allosteric ligand, in murine bronchial epithelial cells, J Neurosci Res, 87, 2740, 10.1002/jnr.22102 Narumoto, 2010, Down-regulation of secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related peptide-1 (SLURP-1), an endogenous allosteric alpha7 nicotinic acetylcholine receptor modulator, in murine and human asthmatic conditions, Biochem Biophys Res Commun, 398, 713, 10.1016/j.bbrc.2010.07.006 Moriwaki, 2009, Primary sensory neuronal expression of SLURP-1, an endogenous nicotinic acetylcholine receptor ligand, Neurosci Res, 64, 403, 10.1016/j.neures.2009.04.014 Mastrangeli, 2003, ARS Component B: structural characterization, tissue expression and regulation of the gene and protein (SLURP-1) associated with Mal de Meleda, Eur J Dermatol, 13, 560 Moriwaki, 2007, Immune system expression of SLURP-1 and SLURP-2, two endogenous nicotinic acetylcholine receptor ligands, Life Sci, 80, 2365, 10.1016/j.lfs.2006.12.028 Arredondo, 2007, SLURP-1 and -2 in normal, immortalized and malignant oral keratinocytes, Life Sci, 80, 2243, 10.1016/j.lfs.2007.01.003 Kawashima, 2007, Expression and function of genes encoding cholinergic components in murine immune cells, Life Sci, 80, 2314, 10.1016/j.lfs.2007.02.036 Favre, 2007, SLURP1 is a late marker of epidermal differentiation and is absent in Mal de Meleda, J Invest Dermatol, 127, 301, 10.1038/sj.jid.5700551 Arredondo, 2005, Biological effects of SLURP-1 on human keratinocytes, J Invest Dermatol, 125, 1236, 10.1111/j.0022-202X.2005.23973.x Lyukmanova, 2018, Human secreted proteins SLURP-1 and SLURP-2 control the growth of epithelial cancer cells via interactions with nicotinic acetylcholine receptors, Br J Pharmacol, 175, 1973, 10.1111/bph.14194 Arredondo, 2007, Overexpression of SLURP-1 and -2 alleviates the tumorigenic action of tobacco-derived nitrosamine on immortalized oral epithelial cells, Biochem Pharmacol, 74, 1315, 10.1016/j.bcp.2007.06.026 Chimienti, 2003, Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda, Hum Mol Genet, 12, 3017, 10.1093/hmg/ddg320 Grando, 2008, Basic and clinical aspects of non-neuronal acetylcholine: biological and clinical significance of non-canonical ligands of epithelial nicotinic acetylcholine receptors, J Pharmacol Sci, 106, 174, 10.1254/jphs.FM0070087 Eckl, 2003, Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates, Hum Genet, 112, 50, 10.1007/s00439-002-0838-8 Fischer, 2001, Mutations in the gene encoding SLURP-1 in Mal de Meleda, Hum Mol Genet, 10, 875, 10.1093/hmg/10.8.875 Hu, 2003, A recurrent mutation in the ARS (component B) gene encoding SLURP-1 in Turkish families with mal de Meleda: evidence of a founder effect, J Invest Dermatol, 120, 967, 10.1046/j.1523-1747.2003.12248.x Marrakchi, 2003, Novel mutations in the gene encoding secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related protein-1 (SLURP-1) and description of five ancestral haplotypes in patients with Mal de Meleda, J Invest Dermatol, 120, 351, 10.1046/j.1523-1747.2003.12062.x Ward, 2003, Identification of recurrent mutations in the ARS (component B) gene encoding SLURP-1 in two families with mal de Meleda, J Invest Dermatol, 120, 96, 10.1046/j.1523-1747.2003.12020.x Adeyo, 2014, Palmoplantar keratoderma along with neuromuscular and metabolic phenotypes in Slurp1-deficient mice, J Invest Dermatol, 134, 1589, 10.1038/jid.2014.19 Niederkorn, 2010, History and physiology of immune privilege, Ocul Immunol Inflamm, 18, 19, 10.3109/09273940903564766 Azar, 2006, Corneal angiogenic privilege: angiogenic and antiangiogenic factors in corneal avascularity, vasculogenesis, and wound healing (an American Ophthalmological Society thesis), Trans Am Ophthalmol Soc, 104, 264 Hazlett, 2010, Reviews for immune privilege in the year 2010: immune privilege and infection, Ocul Immunol Inflamm, 18, 237, 10.3109/09273948.2010.501946 Barabino, 2012, Ocular surface immunity: homeostatic mechanisms and their disruption in dry eye disease, Prog Retin Eye Res, 31, 271, 10.1016/j.preteyeres.2012.02.003 Clements, 2011, Inflammatory corneal neovascularization: etiopathogenesis, Semin Ophthalmol, 26, 235, 10.3109/08820538.2011.588652 Yamanaka, 2010, Fibrosis in the anterior segments of the eye, Endocr Metab Immune Disord - Drug Targets, 10, 331, 10.2174/1871530311006040331 Gronert, 2010, Resolution, the grail for healthy ocular inflammation, Exp Eye Res, 91, 478, 10.1016/j.exer.2010.07.004 Ambati, 2006, Corneal avascularity is due to soluble VEGF receptor-1, Nature, 443, 993, 10.1038/nature05249 Cursiefen, 2006, Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision, Proc Natl Acad Sci U S A, 103, 11405, 10.1073/pnas.0506112103 Swamynathan, 2014, SLURP-1 modulates corneal homeostasis by serving as a soluble scavenger of urokinase-type plasminogen activator, Invest Ophthalmol Vis Sci, 55, 6251, 10.1167/iovs.14-15107 Swamynathan, 2017, Inhibition of HUVEC tube formation via suppression of NFkappaB suggests an anti-angiogenic role for SLURP1 in the transparent cornea, Exp Eye Res, 164, 118, 10.1016/j.exer.2017.08.007 Swamynathan, 2019, The secreted Ly6/uPAR-related protein-1 suppresses neutrophil binding, chemotaxis, and transmigration through human umbilical vein endothelial cells, Sci Rep, 9, 5898, 10.1038/s41598-019-42437-x Campbell, 2019, The secreted Ly-6/uPAR related protein-1 (SLURP1) stabilizes epithelial cell junctions and suppresses TNF-alpha-induced cytokine production, Biochem Biophys Res Commun, 517, 729, 10.1016/j.bbrc.2019.07.123 Argueso, 2006, Mucin characteristics of human corneal-limbal epithelial cells that exclude the rose bengal anionic dye, Invest Ophthalmol Vis Sci, 47, 113, 10.1167/iovs.05-0735 Schneider, 2012, NIH Image to ImageJ: 25 years of image analysis, Nat Methods, 9, 671, 10.1038/nmeth.2089 Lyukmanova, 2014, Human SLURP-1 and SLURP-2 proteins acting on nicotinic acetylcholine receptors reduce proliferation of human colorectal adenocarcinoma HT-29 cells, Acta Naturae, 6, 60, 10.32607/20758251-2014-6-4-60-66 Foulsham, 2018, When clarity is crucial: regulating ocular surface immunity, Trends Immunol, 39, 288, 10.1016/j.it.2017.11.007 Latres, 2000, Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis, EMBO J, 19, 3496, 10.1093/emboj/19.13.3496 Hannon, 1994, p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest, Nature, 371, 257, 10.1038/371257a0 Reynisdottir, 1995, Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta, Genes Dev, 9, 1831, 10.1101/gad.9.15.1831 Tiwari, 2020, KLF4 coordinates corneal epithelial apical-basal polarity and plane of cell division and is downregulated in ocular surface squamous neoplasia, Invest Ophthalmol Vis Sci, 61, 15, 10.1167/iovs.61.5.15 Li, 2021, IL-36alpha/IL-36RA/IL-38 signaling mediates inflammation and barrier disruption in human corneal epithelial cells under hyperosmotic stress, Ocul Surf, 22, 163, 10.1016/j.jtos.2021.08.012 Sakiyama, 2016, Hereditary palmoplantar keratoderma "clinical and genetic differential diagnosis, J Dermatol, 43, 264, 10.1111/1346-8138.13219 Mueller, 1983, Biochemical and immunological characterization of desmoplakins I and II, the major polypeptides of the desmosomal plaque, J Mol Biol, 163, 647, 10.1016/0022-2836(83)90116-X Yao, 2020, More than meets the eye: palmoplantar keratoderma and arrhythmogenic right ventricular cardiomyopathy in a patient with loss of the DSP gene, JAAD Case Rep, 6, 804, 10.1016/j.jdcr.2020.06.025 Abi Zamer, 2019, Novel mutation in the DSG1 gene causes autosomal-dominant striate palmoplantar keratoderma in a large Syrian family, Ann Hum Genet, 83, 472, 10.1111/ahg.12335 Xue, 2019, A novel heterozygous missense mutation of DSP in a Chinese Han pedigree with palmoplantar keratoderma, J Cosmet Dermatol, 18, 371, 10.1111/jocd.12533 Baudouin, 2019, Reconsidering the central role of mucins in dry eye and ocular surface diseases, Prog Retin Eye Res, 71, 68, 10.1016/j.preteyeres.2018.11.007 Martinez-Carrasco, 2021, Membrane-associated mucins of the human ocular surface in health and disease, Ocul Surf, 21, 313, 10.1016/j.jtos.2021.03.003