High-dose ACE inhibition: Can it improve renoprotection?

Rudberg, 1990, Enalapril reduces microalbuminuria in young normotensive type 1 (insulin-dependent) diabetic patients irrespective of its hypotensive effect, Diabetologia, 33, 470, 10.1007/BF00405108

Lufft, 1998, Antiproteinuric efficacy of fosinopril after renal transplantation is determined by the extent of vascular and tubulointerstitial damage, Clin Transplant, 12, 409

Peters, 1998, Targeting TGF-β overexpression in renal disease: Maximizing the antifibrotic action of angiotensin II blockade, Kidney Int, 54, 1570, 10.1046/j.1523-1755.1998.00164.x

Packer, 1999, Comparative effects of low and high doses of the angiotensin-converting enzyme inhibitor, lisinopril, on morbidity and mortality in chronic heart failure. ATLAS Study Group, Circulation, 100, 2312, 10.1161/01.CIR.100.23.2312

Haas, 2002, Antiproteinuric versus antihypertensive effects of high-dose ACE inhibitor therapy, Am J Kidney Dis, 40, 458, 10.1053/ajkd.2002.34883

Palla, 1994, Effect of increasing doses of lisinopril on proteinuria of normotensive patients with IgA nephropathy and normal renal function, Int J Clin Pharmacol Res, 14, 35

Laverman GD, Navis GJ, Henning RH, de Jong PE, de Zeeuw D: Combined effects of ACEi and AT1 blockade in proteinuric patients. Kidney Int (in press)

Laverman, 2001, Optimal antiproteinuric dose of losartan in nondiabetic patients with nephrotic range proteinuria, Am J Kidney Dis, 38, 1381, 10.1053/ajkd.2001.29262

Andersen, 2002, Optimal dose of losartan for renoprotection in diabetic nephropathy, Nephrol Dial Transplant, 17, 1413, 10.1093/ndt/17.8.1413

Weinberg, 2002, The effect of high-dose angiotensin II receptor blockade beyond maximal recommended doses in reducing urinary protein secretion, JRAAS, 2, S196

Bos, 2000, The role of patient factors in therapy resistance to antiproteinuric intervention in non-diabetic and diabetic nephropathy, Kidney Int Suppl, 75, S32, 10.1046/j.1523-1755.2000.07506.x

Bos, 2002, Addition of AT1 receptor blockade fails to overcome resistance to ACE inhibition in adriamycin nephrosis, Kidney Int, 61, 473, 10.1046/j.1523-1755.2002.00154.x

Zoja, 2002, Effect of combining ACE inhibitor and statin in severe experimental nephropathy, Kidney Int, 61, 1635, 10.1046/j.1523-1755.2002.00332.x