Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria

Cell - Tập 87 - Trang 629-638 - 1996
Hong-Gang Wang1, Ulf R Rapp2, John C Reed1
1The Burnham Institute, Program on Apoptosis and Cell Death Research, La Jolla, California 92037, USA
2Institute of Medical Radiation and Cell Research, Bayerische Julius-Maximilians-Universität, D097078 Wurzburg, Germany

Tài liệu tham khảo

Baffy, 1993, Apoptosis is induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production, J. Biol. Chem., 268, 6511, 10.1016/S0021-9258(18)53280-4 Bernardi, 1994, Recent progress on regulation of the mitochondrial permeability transition pore, a cyclosporin-sensitive pore in the inner mitochondrial membrane, J. Bioenerget. Biomembranes, 26, 509, 10.1007/BF00762735 Blagosklonny, 1996, Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway, Cancer Res., 56, 1851 Borner, 1994, The protein bcl-2α does not require membrane attachment, but two conserved domains to suppress apoptosis, J. Cell Biol., 126, 1059, 10.1083/jcb.126.4.1059 Borner, 1996, Diminished cell proliferation associated with the death-protective activity of Bcl-2, J. Biol. Chem., 271, 12695, 10.1074/jbc.271.22.12695 Boulakia, 1996, Bcl-2 and adenovirus E1B 19 kDA protein prevent E1A-induced processing of CPP32 and cleavage of poly(ADP-ribose) polymerase, Oncogene, 12, 29 Bruder, 1992, Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase, Genes Dev., 6, 545, 10.1101/gad.6.4.545 Daum, 1994, The ins and outs of Raf kinases, Trends Biochem. Sci., 19, 474, 10.1016/0968-0004(94)90133-3 Estojak, 1995, Correlation of two-hybrid affinity data with in vitro measurements, Mol. Cell. Biol., 15, 5820, 10.1128/MCB.15.10.5820 Faux, 1996, Molecular glue, Cell, 85, 9, 10.1016/S0092-8674(00)81075-2 González-Garcia, 1994, bcl-XL is the major bcl-X mRNA form expressed during murine development and its product localizes to mitochondria, Development, 120, 3033, 10.1242/dev.120.10.3033 Hall, 1994, A biochemical function for Ras—at last, Science, 264, 1413, 10.1126/science.8197454 Han, 1993, C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation, Nature, 363, 133, 10.1038/363133a0 Hanada, 1995, Structure-function analysis of bcl-2 protein, J. Biol. Chem., 270, 11962, 10.1074/jbc.270.20.11962 Hase, 1984, The 70-kd protein of the yeast mitochondrial outer membrane is targeted and anchored via its extreme amino terminus, EMBO J., 3, 3157, 10.1002/j.1460-2075.1984.tb02274.x Hockenbery, 1993, Bcl-2 functions in an antioxidant pathway to prevent apoptosis, Cell, 75, 241, 10.1016/0092-8674(93)80066-N Hunter, 1996, Functional dissection of the human Bcl-2 protein, Mol. Cell. Biol., 16, 877, 10.1128/MCB.16.3.877 Jelinek, 1996, Ras-induced activation of Raf-1 is dependent on tyrosine phosphorylation, Mol. Cell. Biol., 16, 1027, 10.1128/MCB.16.3.1027 Kane, 1993, Bcl-2 inhibition of neural cell death, Science, 262, 1274, 10.1126/science.8235659 Kolch, 1991, Raf-1 protein kinase is required for growth of induced NIH/3T3 cells, Nature, 349, 426, 10.1038/349426a0 Krajewski, 1993, Investigations of the subcellular distribution of the bcl-2 oncoprotein, Cancer Res., 53, 4701 Kyriakis, 1992, Raf-1 activates MAP kinase-kinase, Nature, 358, 417, 10.1038/358417a0 Leevers, 1994, Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane, Nature, 369, 411, 10.1038/369411a0 Lithgow, 1994, The protein product of the oncogene bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum, and the outer mitochondrial membrane, Cell Growth Differ., 3, 411 Liu, 1996, Induction of apoptotic program in cell-free extracts, Cell, 86, 147, 10.1016/S0092-8674(00)80085-9 Lu, 1994, Genetic and molecular analyses of mutations involved in Drosophila raf signal transduction, EMBO J., 13, 2592, 10.1002/j.1460-2075.1994.tb06549.x Mazel, 1996, Regulation of cell division cycle progression by bcl-2 expression, J. Exp. Med., 183, 2219, 10.1084/jem.183.5.2219 Morrison, 1993, Identification of the major phosphorylation sites of the Raf-1 kinase, J. Biol. Chem., 268, 17309, 10.1016/S0021-9258(19)85336-X Muchmore, 1996, X-ray and NMR structure of human Bcl-XL, an inhibitor of programmed cell death, Nature, 381, 335, 10.1038/381335a0 Newmeyer, 1994, Cell-free apoptosis in Xenopus egg extracts, Cell, 79, 353, 10.1016/0092-8674(94)90203-8 Nguyen, 1994, Role of membrane anchor domain of bcl-2 in suppression of apoptosis caused by E1B-defective adenovirus, J. Biol. Chem., 269, 16521, 10.1016/S0021-9258(19)89417-6 Oltvai, 1993, Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death, Cell, 74, 609, 10.1016/0092-8674(93)90509-O Oltvai, 1994, Checkpoints of dueling dimers foil death wishes, Cell, 79, 189, 10.1016/0092-8674(94)90188-0 Pietenpol, 1994, Paradoxical inhibition of solid tumor cell growth by bcl-2, Cancer Res., 54, 3714 Ryan, 1994, c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle, Proc. Natl. Acad. Sci. USA, 91, 5878, 10.1073/pnas.91.13.5878 Sato, 1994, Interactions among members of the bcl-2 protein family analyzed with a yeast two-hybrid system, Proc. Natl. Acad. Sci. USA, 91, 9238, 10.1073/pnas.91.20.9238 Sedlak, 1995, Multiple Bcl-2 family members demonstrate selective dimerizations with Bax, Proc. Natl. Acad. Sci. USA, 92, 7834, 10.1073/pnas.92.17.7834 Stokoe, 1994, Activation of Raf as a result of recruitment to the plasma membrane, Science, 264, 1463, 10.1126/science.7811320 Takayama, 1995, Cloning and functional analysis of BAG-1, Cell, 80, 279, 10.1016/0092-8674(95)90410-7 Tanaka, 1993, Structure–function analysis of the apoptosis-suppressing bcl-2 oncoprotein, J. Biol. Chem., 268, 10920, 10.1016/S0021-9258(18)82073-7 Tsuda, 1993, A protein kinase similar to MAP kinase activator acts downstream of the Raf kinase in Drosophila, Cell, 72, 407, 10.1016/0092-8674(93)90117-9 Wang, 1994, Apoptosis regulation by interaction of bcl-2 protein and Raf-1 kinase, Oncogene, 9, 2751 Wang, 1995, R-ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 suppressible mechanism, J. Cell Biol., 129, 1103, 10.1083/jcb.129.4.1103 Wang, 1996, Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1, Proc. Natl. Acad. Sci. USA, 93, 7063, 10.1073/pnas.93.14.7063 Weil, 1996, Constitutive expression of the machinery for programmed cell death, J. Cell Biol., 133, 1053, 10.1083/jcb.133.5.1053 Yang, 1995, The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2, J. Cell Biol., 128, 1173, 10.1083/jcb.128.6.1173 Zamzami, 1996, Mitochondrial control of nuclear apoptosis, J. Exp. Med., 183, 1533, 10.1084/jem.183.4.1533 Zha, 1996, Pro-apoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2, J. Biol. Chem., 271, 7440, 10.1074/jbc.271.13.7440 Zhang, 1993, Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1, Nature, 364, 308, 10.1038/364308a0