A novel self-nanoemulsifying formulation for sunitinib: Evaluation of anticancer efficacy

Tian, 2013, Calycosin induces apoptosis by upregulation of RASD1 in human breast cancer cells MCF-7, Horm. Metab. Res., 45, 593, 10.1055/s-0033-1341510 Veiseh, 2014, Cellular heterogeneity profiling by hyaluronan probes reveals an invasive but slow-growing breast tumor subset, Proc. Natl. Acad. Sci. U. S. A., 111, 1731, 10.1073/pnas.1402383111 Assi, 2013, Epidemiology and prognosis of breast cancer in young women, J. Thorac. Dis., 5, 2 Bray, 2012, Global cancer transitions according to the Human Development Index (2008–2030): a population-based study, Lancet Oncol., 13, 790, 10.1016/S1470-2045(12)70211-5 Marslin, 2015, Delivery as nanoparticles reduces imatinib mesylate-induced cardiotoxicity and improves anticancer activity, Int. J. Nanomed., 10, 3163 Chen, 2013, Synthesis and biological evaluation of sunitinib analogues to improve aqueous solubility, Adv. Mat. Res., 749, 350 Sato, 2015, Elacridar enhances the cytotoxic effects of sunitinib and prevents multidrug resistance in renal carcinoma cells, Eur. J. Pharmacol., 746, 258, 10.1016/j.ejphar.2014.11.021 Kappers, 2011, The vascular endothelial growth factor receptor inhibitor sunitinib causes a preeclampsia-like syndrome with activation of the endothelin system, Hypertension, 58, 295, 10.1161/HYPERTENSIONAHA.111.173559 Gotink, 2014, Acquired tumor cell resistance to sunitinib causes resistance in a HT-29 human colon cancer xenograft mouse model without affecting sunitinib biodistribution or the tumor microvasculature, Oncoscience, 1, 844, 10.18632/oncoscience.106 Demetri, 2006, Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial, Lancet, 368, 1329, 10.1016/S0140-6736(06)69446-4 Joosten, 2015, Resistance to sunitinib in renal cell carcinoma: from molecular mechanisms to predictive markers and future perspectives, Biochim. Biophys. Acta, 1855, 1 Cao, 2016, Future options of anti-angiogenic cancer therapy, Chin. J. Cancer, 35, 1, 10.1186/s40880-016-0084-4 Chu, 2007, Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib, Lancet, 370, 2011, 10.1016/S0140-6736(07)61865-0 Yuasa, 2013, Early onset recall pneumonitis during targeted therapy with sunitinib, BMC Cancer, 13, 1, 10.1186/1471-2407-13-3 Zhang, 2011, Effect of sunitinib combined with ionizing radiation on endothelial cells, J. Radiat. Res., 52, 1, 10.1269/jrr.10013 Schwandt, 2009, Management of side effects associated with sunitinib therapy for patients with renal cell carcinoma, Onco Targets Ther., 2, 51 Joensuu, 2007, Cardiac toxicity of sunitinib, Lancet, 370, 1978, 10.1016/S0140-6736(07)61840-6 Yamamoto, 2014, Association of toxicity of sorafenib and sunitinib for human keratinocytes with inhibition of signal transduction and activator of transcription 3 (STAT3), PLoS One, 9, 1, 10.1371/journal.pone.0102110 Chinchar, 2014, Sunitinib significantly suppresses the proliferation, migration, apoptosis resistance, tumor angiogenesis and growth of triple-negative breast cancers but increases breast cancer stem cells, Vasc. Cell, 6, 1, 10.1186/2045-824X-6-12 Meng, 2015, An improved synthesis of sunitinib malate via a solvent-free decarboxylation process, Res. Chem. Intermed., 41, 8941, 10.1007/s11164-015-1939-z Silay, 2007, Sunitinib malate and sorafenib may be beneficial at the treatment of advanced bladder cancer due to their anti-angiogenic effects, Med. Hypotheses, 69, 892, 10.1016/j.mehy.2007.01.065 Ramazani, 2015, Sunitinib microspheres based on [PDLLA-PEG-PDLLA]-b-PLLA multi-block copolymers for ocular drug delivery, Eur. J. Pharm. Biopharm., 95, 368, 10.1016/j.ejpb.2015.02.011 Abdel-Aziz, 2014, Chloroquine synergizes sunitinib cytotoxicity via modulating autophagic, apoptotic and angiogenic machineries, Chem. Biol. Interact., 217, 28, 10.1016/j.cbi.2014.04.007 Papaetis, 2009, Sunitinib, BioDrugs, 23, 377, 10.2165/11318860-000000000-00000 Raymond, 2011, Sunitinib malate for the treatment of pancreatic neuroendocrine tumors, N. Engl. J. Med., 364, 501, 10.1056/NEJMoa1003825 Jeong, 2011, Sunitinib inhibits papillary thyroid carcinoma with RET/PTC rearrangement but not BRAF mutation, Cancer Biol. Ther., 12, 458, 10.4161/cbt.12.5.16303 Schlumberger, 2012, Endocrine tumours: approach to the patient with advanced differentiated thyroid cancer, Eur. J. Endocrinol., 166, 5, 10.1530/EJE-11-0631 Kollmannsberger, 2012, Sunitinib therapy for metastatic renal cell carcinoma: recommendations for management of side effects, Can. Urol. Assoc. J., 1, 541, 10.5489/cuaj.67 Navid, 2008, Stability of sunitinib in oral suspension, Ann. Pharmacother., 42, 962, 10.1345/aph.1K654 Fratto, 2010, New perspectives: role of sunitinib in breast cancer, Clin. Ter., 162, 251 Bergh, 2012, First-line treatment of advanced breast cancer with sunitinib in combination with docetaxel versus docetaxel alone: results of a prospective, randomized phase III study, J. Clin. Oncol., 30, 921, 10.1200/JCO.2011.35.7376 Bachelot, 2014, Sunitinib in combination with trastuzumab for the treatment of advanced breast cancer: activity and safety results from a phase II study, BMC Cancer, 14, 166, 10.1186/1471-2407-14-166 Parisi, 2015, Controlled release of sunitinib in targeted cancer therapy: smart magnetically responsive hydrogels as restricted access materials, RSC Adv., 5, 65308, 10.1039/C5RA12229E Kassem, 2012, Chapter 9 – sunitinib malate, 10.1016/B978-0-12-397220-0.00009-X Donskov, 2015, Sunitinib-associated hypertension and neutropenia as efficacy biomarkers in metastatic renal cell carcinoma patients, Br. J. Cancer, 113, 1571, 10.1038/bjc.2015.368 Kollmannsberger, 2007, Sunitinib therapy for metastatic renal cell carcinoma: recommendations for management of side effects, Can. Urol. Assoc. J., 1, S41 Salem, 2008, Effect of sunitinib on growth and function of FRTL-5 thyroid cells, Thyroid, 18, 631, 10.1089/thy.2007.0336 Lankhorst, 2014, Treatment of hypertension and renal injury induced by the angiogenesis inhibitor sunitinib, Hypertension, 64, 1282, 10.1161/HYPERTENSIONAHA.114.04187 Joseph, 2016, Sunitinib loaded chitosan nanoparticles formulation and its evaluation, Int. J. Biol. Macromol., 82, 952, 10.1016/j.ijbiomac.2015.10.079 Ebos, 2007, Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy, Proc. Natl. Acad. Sci. U. S. A., 104, 17069, 10.1073/pnas.0708148104 Acharya, 2011, PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effect, Adv. Drug Deliv. Rev., 63, 170, 10.1016/j.addr.2010.10.008 Verma, 2013, Formulation by design of felodipine loaded liquid and solid self nanoemulsifying drug delivery systems using Box-Behnken design, Drug Dev. Ind. Pharm., 40, 1358, 10.3109/03639045.2013.819884 Rahi, 2016, Nanostructured materials in electroanalysis of pharmaceuticals, Anal. Biochem., 497, 39, 10.1016/j.ab.2015.12.018 Rahi, 2016, Label-free electrochemical aptasensing of the human prostate-specific antigen using gold nanospears, Talanta, 156, 218, 10.1016/j.talanta.2016.05.029 Rahi, 2015, Zepto-molar electrochemical detection of Brucella genome based on gold nanoribbons covered by gold nanoblooms, Sci. Rep., 5, 1, 10.1038/srep18060 Sattarahmady, 2016, Albumin coated arginine-capped magnetite nanoparticles as a paclitaxel vehicle: physicochemical characterizations and in vitro evaluation, J. Drug Deliv. Sci. Technol., 36, 68, 10.1016/j.jddst.2016.07.004 Dash, 2015, Design, optimization and evaluation of glipizide solid self-nanoemulsifying drug delivery for enhanced solubility and dissolution, Saudi Pharm. J., 23, 528, 10.1016/j.jsps.2015.01.024 Nazari-Vanani, 2017, In vivo evaluation of a self-nanoemulsifying drug delivery system for curcumin, Biomed. Pharmacother., 88, 715, 10.1016/j.biopha.2017.01.102 Wang, 2015, Preparation and evaluation of nattokinase-loaded self-double-emulsifying drug delivery system, Asian J. of Pharm. Sci., 10, 386, 10.1016/j.ajps.2015.04.005 Chourasia, 2015, Self double emulsifying drug delivery system: a comprehensive review, World J. Pharm. Pharm. Sci., 4, 433 Ahmed, 2014, Design and optimization of self-nanoemulsifying drug delivery system to enhance Quercetin hepatoprotective activity in paracetamol-induced hepatotoxicity, J. Pharm. Sci., 103, 602, 10.1002/jps.23834 Sinha, 2010, Formulation design and development of self-nanoemulsifying drug delivery systems containing a hydrophobic selective β1-adrenoreceptor blocker, Int. J. Biomed. Nanosci. Nanotechnol., 6, 154 Panyam, 2003, Biodegradable nanoparticles for drug and gene delivery to cells and tissue, Adv. Drug Deliv. Rev., 55, 329, 10.1016/S0169-409X(02)00228-4 Shrivastava, 2014, Applications of self emulsifying drug delivery systems in novel drug delivery-a review, Afr. J. Basic Appl. Sci., 6, 6 Soni, 2014, Self nanoemulsion: advance from of drug delivery system, World J. Pharm. Pharm. Sci., 3, 410 Yin, 2016, Sunitinib-loaded tumor penetrating peptide-functionalized nanomicelles in oral squamous cell carcinoma, J. Biomater. Tissue Eng., 6, 509, 10.1166/jbt.2016.1489 Jubeli, 2015, Embolization biomaterial reinforced with nanotechnology for an in-situ release of anti-angiogenic agent in the treatment of hyper-vascularized tumors and arteriovenous malformations, Eur. J. Pharm. Biopharm., 96, 396, 10.1016/j.ejpb.2015.09.006 Chakravarty, 2015, Hollow mesoporous silica nanoparticles for tumor vasculature targeting and PET image-guided drug delivery, Nanomedicine (Lond.), 10, 1233, 10.2217/nnm.14.226 Murphy, 2011, Targeted nanogels: a versatile platform for drug delivery to tumors, Mol. Cancer Ther., 10, 972, 10.1158/1535-7163.MCT-10-0729 Parisi, 2015, Controlled release of sunitinib in targeted cancer therapy: smart magnetically responsive hydrogels as restricted access materials, RSC Adv., 5, 65308, 10.1039/C5RA12229E Buchy, 2015, Synthesis and cytotoxic activity of self-assembling squalene conjugates of 3-[(pyrrol-2-yl)methylidene]-2,3-dihydro-1H-indol-2-one anticancer agents, Eur. J. Org. Chem., 2015, 202, 10.1002/ejoc.201403088 Maafi, 2015, Actinometric and Φ-order photodegradation properties of anti-cancer Sunitinib, Proc. Natl. Acad. Sci. U. S. A., 110, 34 Mahmoud, 2014, In vitro and in vivo evaluation of self-nanoemulsifying drug delivery systems of cilostazol for oral and parenteral administration, Int. J. Pharm., 476, 60, 10.1016/j.ijpharm.2014.09.045 Yuan, 2009, Surfactant selection for accurate size control of microcapsules using membrane emulsification, Colloid. Surf. A Physicochem. Eng. Asp., 347, 97, 10.1016/j.colsurfa.2008.12.033 Beig, 2012, Accounting for the solubility-permeability interplay in oral formulation development for poor water solubility drugs: the effect of PEG-400 on carbamazepine absorption, Eur. J. Pharm. Biopharm., 81, 386, 10.1016/j.ejpb.2012.02.012 Tadros, 2013, 1 Sanka, 2016, Optimization of solid-self nanoemulsifying drug delivery system for solubility and release profile of clonazepam using simplex lattice design, J. Drug Deliv. Sci. Technol., 33, 114, 10.1016/j.jddst.2016.04.003