Defective translational control facilitates vesicular stomatitis virus oncolysis

Anand, 2002, Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer, Nat. Genet., 31, 301, 10.1038/ng904 Asano, 1999, Conserved bipartite motifs in yeast eIF5 and eIF2Bepsilon, GTPase-activating and GDP-GTP exchange factors in translation initiation, mediate binding to their common substrate eIF2, EMBO J., 18, 1673, 10.1093/emboj/18.6.1673 Ashe, 2001, A novel eIF2B-dependent mechanism of translational control in yeast as a response to fusel alcohols, EMBO J., 20, 6464, 10.1093/emboj/20.22.6464 Balachandran, 2000, Vesicular stomatitis virus therapy of tumors, IUBMB Life, 50, 135, 10.1080/713803696 Balachandran, 2000, Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection, Immunity, 13, 129, 10.1016/S1074-7613(00)00014-5 Balachandran, 2001, Oncolytic activity of vesicular stomatitis virus is effective against tumors exhibiting aberrant p53, Ras, or myc function and involves the induction of apoptosis, J. Virol., 75, 3474, 10.1128/JVI.75.7.3474-3479.2001 Barber, 2001, Host defense, viruses and apoptosis, Cell Death Differ., 8, 113, 10.1038/sj.cdd.4400823 Bergmann, 2001, A genetically engineered influenza A virus with ras-dependent oncolytic properties, Cancer Res., 61, 8188 Clemens, 1997, The double-stranded RNA-dependent protein kinase PKR, J. Interferon Cytokine Res., 17, 503, 10.1089/jir.1997.17.503 Dever, 1993, Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast, Proc. Natl. Acad. Sci. USA, 90, 4616, 10.1073/pnas.90.10.4616 Fabian, 1997, Subunit assembly and guanine nucleotide exchange activity of eukaryotic initiation factor-2B expressed in Sf9 cells, J. Biol. Chem., 272, 12359, 10.1074/jbc.272.19.12359 Farassati, 2001, Oncogenes in Ras signalling pathway dictate host-cell permissiveness to herpes simplex virus 1, Nat. Cell Biol., 3, 745, 10.1038/35087061 Fernandez, 2002, Genetically engineered vesicular stomatitis virus in gene therapy, J. Virol., 76, 895, 10.1128/JVI.76.2.895-904.2002 Flowers, 1996, Cloning and characterization of complementary and genomic DNAs encoding the epsilon-subunit of rat translation initiation factor-2B, Biochim. Biophys. Acta, 1307, 318, 10.1016/0167-4781(96)00055-3 Gomez, 2002, Characterization of the minimal catalytic domain within eIF2B, EMBO J., 21, 5292, 10.1093/emboj/cdf515 Hahn, 1999, Creation of human tumour cells with defined genetic elements, Nature, 400, 464, 10.1038/22780 Harding, 2000, Perk is essential for translational regulation and cell survival during the unfolded protein response, Mol. Cell, 5, 897, 10.1016/S1097-2765(00)80330-5 Hershey, 1991, Translational control in mammalian cells, Annu. Rev. Biochem., 60, 717, 10.1146/annurev.bi.60.070191.003441 Hinnebusch, 1994, The eIF-2 alpha kinases, Semin. Cell Biol., 5, 417, 10.1006/scel.1994.1049 Kim, 2000, Human breast cancer cells contain elevated levels and activity of the protein kinase, PKR, Oncogene, 19, 3086, 10.1038/sj.onc.1203632 Kimball, 1999, Eukaryotic initiation factor eIF2, Int. J. Biochem. Cell Biol., 31, 25, 10.1016/S1357-2725(98)00128-9 Kimball, 1998, Regulation of guanine nucleotide exchange through phosphorylation of eukaryotic initiation factor eIF2alpha. Role of the alpha- and delta- subunits of eiF2b, J. Biol. Chem., 273, 12841, 10.1074/jbc.273.21.12841 Lawson, 1995, Recombinant vesicular stomatitis viruses from DNA, Proc. Natl. Acad. Sci. USA, 92, 4477, 10.1073/pnas.92.10.4477 Lee, 1999, Azidothymidine and interferon-alpha induce apoptosis in herpesvirus-associated lymphomas, Cancer Res., 59, 5514 Obuchi, 2003, Development of recombinant vesicular stomatitis viruses that exploit defects in host defense to augment specific oncolytic activity, J. Virol., 77, 8843, 10.1128/JVI.77.16.8843-8856.2003 Pavitt, 1997, Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2, Mol. Cell. Biol., 17, 1298, 10.1128/MCB.17.3.1298 Pavitt, 1998, eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange, Genes Dev., 12, 514, 10.1101/gad.12.4.514 Proud, 2001, Regulation of eukaryotic initiation factor eIF2B, Prog. Mol. Subcell. Biol., 26, 95, 10.1007/978-3-642-56688-2_4 Ron, 2002, Translational control in the endoplasmic reticulum stress response, J. Clin. Invest., 110, 1383, 10.1172/JCI0216784 Savinova, 1999, Abnormal levels and minimal activity of the dsRNA-activated protein kinase, PKR, in breast carcinoma cells, Int. J. Biochem. Cell Biol., 31, 175, 10.1016/S1357-2725(98)00140-X Sonenberg, 1993, Translation factors as effectors of cell growth and tumorigenesis, Curr. Opin. Cell Biol., 5, 955, 10.1016/0955-0674(93)90076-3 Stark, 1998, How cells respond to interferons, Annu. Rev. Biochem., 67, 227, 10.1146/annurev.biochem.67.1.227 Stojdl, 2000, Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus, Nat. Med., 6, 821, 10.1038/77558 Strong, 1998, The molecular basis of viral oncolysis, EMBO J., 17, 3351, 10.1093/emboj/17.12.3351 Vazquez de Aldana, 1994, Mutations in the GCD7 subunit of yeast guanine nucleotide exchange factor eIF-2B overcome the inhibitory effects of phosphorylated eIF-2 on translation initiation, Mol. Cell. Biol., 14, 3208, 10.1128/MCB.14.5.3208 Vojtechova, 2003, Initiation factor eIF2B not p70 S6 kinase is involved in the activation of the PI-3K signalling pathway induced by the v-src oncogene, FEBS Lett., 543, 81, 10.1016/S0014-5793(03)00415-0 Williams, 2001, Characterization of the initiation factor eIF2B and its regulation in Drosophila melanogaster, J. Biol. Chem., 276, 3733, 10.1074/jbc.M008041200 Zimmer, 2000, Translational control of malignancy, Anticancer Res., 20, 1343