Mitochondrial regulation of oxygen sensing

Adelman, 2000, Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses, Genes Dev., 14, 3191, 10.1101/gad.853700

Agani, 2000, The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia, J. Biol. Chem., 275, 35863, 10.1074/jbc.M005643200

Aragones, 2001, Evidence for the involvement of diacylglycerol kinase in the activation of hypoxia-inducible transcription factor 1 by low oxygen tension, J. Biol. Chem., 276, 10548, 10.1074/jbc.M006180200

Aw, 1982, Secondary bioenergetic hypoxia. Inhibition of sulfation and glucuronidation reactions in isolated hepatocytes at low O2 concentration, J. Biol. Chem., 257, 8997, 10.1016/S0021-9258(18)34232-7

Bunn, 1996, Oxygen sensing and molecular adaptation to hypoxia, Physiol. Rev., 76, 839, 10.1152/physrev.1996.76.3.839

Bruick, 2003, Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor, Genes Dev., 17, 2614, 10.1101/gad.1145503

Bruick, 2001, A conserved family of prolyl-4-hydroxylases that modify HIF, Science, 294, 1337, 10.1126/science.1066373

Brunelle, 2005, Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation, Cell Metab., 1, 409, 10.1016/j.cmet.2005.05.002

Carmeliet, 1998, Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis, Nature, 394, 485, 10.1038/28867

Chan, 2002, Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha, J. Biol. Chem., 277, 40112, 10.1074/jbc.M206922200

Chandel, 1996, Molecular oxygen modulates cytochrome c oxidase function, J. Biol. Chem., 271, 18672, 10.1074/jbc.271.31.18672

Chandel, 1998, Mitochondrial reactive oxygen species trigger hypoxia-induced transcription, Proc. Natl Acad. Sci. USA, 95, 5015, 10.1073/pnas.95.20.11715

Chandel, 2000, Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing, J. Biol. Chem., 275, 25130, 10.1074/jbc.M001914200

Dirmeier, 2002, Exposure of yeast cells to anoxia induces transient oxidative stress. Implications for the induction of hypoxic genes, J. Biol. Chem., 277, 34773, 10.1074/jbc.M203902200

Duranteau, 1998, Intracellular signaling by reactive oxygen species during hypoxia in cardiomyocytes, J. Biol. Chem., 273, 11619, 10.1074/jbc.273.19.11619

Emerling, 2005, Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling, Mol. Cell Biol., 25, 4853, 10.1128/MCB.25.12.4853-4862.2005

Enomoto, 2002, Hypoxic induction of hypoxia-inducible factor-1alpha and oxygen-regulated gene expression in mitochondrial DNA-depleted HeLa cells, Biochem. Biophys. Res. Commun., 297, 346, 10.1016/S0006-291X(02)02186-1

Epstein, 2001, C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation, Cell, 107, 43, 10.1016/S0092-8674(01)00507-4

Fandrey, 1994, Role of hydrogen peroxide in hypoxia-induced erythropoietin production, Biochem. J., 303, 507, 10.1042/bj3030507

Forsythe, 1996, Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1, Mol. Cell Biol., 16, 4604, 10.1128/MCB.16.9.4604

Gleadle, 1995, Diphenylene iodonium inhibits the induction of erythropoietin and other mammalian genes by hypoxia. Implications for the mechanism of oxygen sensing, Eur. J. Biochem., 234, 92, 10.1111/j.1432-1033.1995.092_c.x

Goldberg, 1988, Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein, Science, 242, 1412, 10.1126/science.2849206

Graeber, 1996, Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours, Nature, 379, 88, 10.1038/379088a0

Grishko, 2001, Hypoxia promotes oxidative base modifications in the pulmonary artery endothelial cell VEGF gene, FASEB J., 15, 1267, 10.1096/fj.00-0755fje

Guzy, 2005, Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing, Cell Metab., 1, 401, 10.1016/j.cmet.2005.05.001

Hagen, 2003, Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha, Science, 302, 1975, 10.1126/science.1088805

Hirota, 2001, Rac1 activity is required for the activation of hypoxia-inducible factor 1, J. Biol. Chem., 276, 21166, 10.1074/jbc.M100677200

Hirsila, 2003, Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor, J. Biol. Chem., 278, 30772, 10.1074/jbc.M304982200

Hon, W.C., Wilson, M.I., Harlos, K., Claridge, T.D., Schoefield, C.J., Pugh, C.W., Maxwell, P.H., Ratcliffe, P.J., Stuart, D.I., Jones, E.Y., 2002. Structured basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL Nature 417, 975–978.

Hsia, 2003, Differential regulation of cell motility and invasion by FAK, J. Cell Biol., 160, 753, 10.1083/jcb.200212114

Ivan, 2001, HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing, Science, 292, 464, 10.1126/science.1059817

Iyer, 1998, Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha, Genes Dev., 12, 149, 10.1101/gad.12.2.149

Jaakkola, 2001, Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation, Science, 292, 468, 10.1126/science.1059796

Jiang, 1996, Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension, Am. J. Physiol., 271, C1172, 10.1152/ajpcell.1996.271.4.C1172

Jiang, 1997, Transactivation and inhibitory domains of hypoxia-inducible factor 1α modulation of transcriptional activity by oxygen tension, J. Biol. Chem., 272, 19253, 10.1074/jbc.272.31.19253

Kaelin, 2002, How oxygen makes its presence felt, Genes Dev., 16, 1441, 10.1101/gad.1003602

Killilea, 2000, Free radical production in hypoxic pulmonary artery smooth muscle cells, Am. J. Physiol. Lung Cell Mol. Physiol., 279, L408, 10.1152/ajplung.2000.279.2.L408

King, 1988, Injection of mitochondria into human cells leads to a rapid replacement of the endogenous mitochondrial DNA, Cell, 52, 811, 10.1016/0092-8674(88)90423-0

Lando, 2002, FIH-1 is a an asparaginyl hydroxylase that regulates the transcriptional activity of hypoxia inducible factor, Genes Dev., 16, 466, 10.1101/gad.991402

Lando, 2002, Asparagine hydroxylation of the HIF transactivation domain: a hypoxic switch, Science, 295, 858, 10.1126/science.1068592

Liu, 2001, Increased production of reactive oxygen species (ROS) by pulmonary arterial smooth muscle is required for hypoxic pulmonary vasoconstriction (HPV), Am. J. Respir. Crit. Care Med., 163, A395

Mahon, 2001, FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity, Genes Dev., 15, 2675, 10.1101/gad.924501

Maltepe, 1997, Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT, Nature, 386, 403, 10.1038/386403a0

Mansfield, 2005, Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation, Cell Metab., 1, 393, 10.1016/j.cmet.2005.05.003

Masson, 2001, Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation, EMBO J., 20, 5197, 10.1093/emboj/20.18.5197

Mateo, 2003, Regulation of hypoxia-inducible factor-1alpha by nitric oxide through mitochondria-dependent and -independent pathways, Biochem. J., 376, 537, 10.1042/bj20031155

Maxwell, 1999, The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis, Nature, 399, 271, 10.1038/20459

Michelakis, 2002, Diversity in mitochondrial function explains differences in vascular oxygen sensing, Circ. Res., 90, 1307, 10.1161/01.RES.0000024689.07590.C2

Minden, 1995, Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs, Cell, 81, 1147, 10.1016/S0092-8674(05)80019-4

Ohh, 2000, Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein, Nat. Cell Biol., 2, 423, 10.1038/35017054

Pugh, 1997, Activation of hypoxia-inducible factor-1; definition of regulatory domains within the subunit, J. Biol. Chem., 272, 11205, 10.1074/jbc.272.17.11205

Ryan, 1998, HIF-1 alpha is required for solid tumor formation and embryonic vascularization, EMBO J., 17, 3005, 10.1093/emboj/17.11.3005

Sanjuan-Pla, 2005, A targeted antioxidant reveals the importance of mitochondrial reactive oxygen species in the hypoxic signaling of HIF-1 alpha, FEBS Lett., 579, 2669, 10.1016/j.febslet.2005.03.088

Saraste, 1999, Oxidative phosphorylation at the fin de siecle, Science, 283, 1488, 10.1126/science.283.5407.1488

Sato, 2005, Mitochondrial reactive oxygen species and c-Src play a critical role in hypoxic response in vascular smooth muscle cells, Cardiovasc. Res., 10.1016/j.cardiores.2005.04.017

Schroedl, 2002, Hypoxic but not anoxic stabilization of HIF-1alpha requires mitochondrial reactive oxygen species, Am. J. Physiol. (Lung Cell Mol. Physiol.), 283, L922, 10.1152/ajplung.00014.2002

Semenza, 1999, Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1, Annu. Rev. Cell Dev. Biol., 15, 551, 10.1146/annurev.cellbio.15.1.551

Semenza, 2003, Targeting HIF-1 for cancer therapy, Nat. Rev. Cancer, 3, 721, 10.1038/nrc1187

Srinivas, 1998, Hypoxia-inducible factor 1alpha (HIF-1alpha) is a non-heme iron protein. Implications for oxygen sensing, J. Biol. Chem., 273, 18019, 10.1074/jbc.273.29.18019

Srinivas, 2001, Oxygen sensing and HIF-1 activation does not require an active mitochondrial respiratory chain electron-transfer pathway, J. Biol. Chem., 276, 21995, 10.1074/jbc.C100177200

Tarpey, 2001, Methods of detection of vascular reactive species: nitric oxide, superoxide, hydrogen peroxide, and peroxynitrite, Circ. Res., 89, 224, 10.1161/hh1501.094365

Tiranti, 1998, Mutations of SURF-1 in leigh disease associated with cytochrome c oxidase deficiency, Am. J. Hum. Genet., 63, 1609, 10.1086/302150

Turcotte, 2003, HIF-1alpha mRNA and protein upregulation involves Rho GTPase expression during hypoxia in renal cell carcinoma, J. Cell Sci., 116, 2247, 10.1242/jcs.00427

Vaux, 2001, Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain, Blood, 98, 296, 10.1182/blood.V98.2.296

Wang, 1995, Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension, Proc. Natl Acad. Sci. USA, 92, 5510, 10.1073/pnas.92.12.5510

Wilson, 1988, The oxygen dependence of mitochondrial oxidative phosphorylation measured by a new optical method for measuring oxygen concentration, J. Biol. Chem., 263, 2712, 10.1016/S0021-9258(18)69126-4

Wood, 1999, Systemic hypoxia promotes leukocyte-endothelial adherence via reactive oxidant generation, J. Appl. Physiol., 87, 1734, 10.1152/jappl.1999.87.5.1734

Yu, 1999, Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha, J. Clin. Invest., 103, 691, 10.1172/JCI5912

Yu, 2001, HIF-1 binding to VHL is regulated by stimulus-sensitive proline hydroxylation, Proc. Natl Acad. Sci., 98, 9630, 10.1073/pnas.181341498

Zhong, 2000, Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics, Cancer Res., 60, 1541

Zundel, 2000, Loss of PTEN facilitates HIF-1-mediated gene expression, Genes Dev., 14, 391, 10.1101/gad.14.4.391