Exogenous IFN-β has antiviral and anti-inflammatory properties in primary bronchial epithelial cells from asthmatic subjects exposed to rhinovirus

Masoli, 2004, The global burden of asthma: executive summary of the GINA Dissemination Committee report, Allergy, 59, 469, 10.1111/j.1398-9995.2004.00526.x Jackson, 2010, The role of viruses in acute exacerbations of asthma, J Allergy Clin Immunol, 125, 1178, 10.1016/j.jaci.2010.04.021 Johnston, 1995, Community study of role of viral infections in exacerbations of asthma in 9-11 year old children, BMJ, 310, 1225, 10.1136/bmj.310.6989.1225 Kumar, 2009, The role of viruses in the development and exacerbation of atopic disease, Ann Allergy Asthma Immunol, 103, 181, 10.1016/S1081-1206(10)60178-0 Leung, 2010, Multiplex molecular detection of respiratory pathogens in children with asthma exacerbation, Chest, 137, 348, 10.1378/chest.09-1250 Pattemore, 1992, Viruses as precipitants of asthma symptoms. I. Epidemiology, Clin Exp Allergy, 22, 325, 10.1111/j.1365-2222.1992.tb03094.x Nicholson, 1993, Respiratory viruses and exacerbations of asthma in adults, BMJ, 307, 982, 10.1136/bmj.307.6910.982 Chen, 2006, Rhinovirus induces airway epithelial gene expression through double-stranded RNA and IFN-dependent pathways, Am J Respir Cell Mol Biol, 34, 192, 10.1165/rcmb.2004-0417OC Proud, 2008, Gene expression profiles during in vivo human rhinovirus infection: insights into the host response, Am J Respir Crit Care Med, 178, 962, 10.1164/rccm.200805-670OC Corne, 2002, Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study, Lancet, 359, 831, 10.1016/S0140-6736(02)07953-9 Mallia, 2006, How viral infections cause exacerbation of airway diseases, Chest, 130, 1203, 10.1378/chest.130.4.1203 Contoli, 2006, Role of deficient type III interferon-lambda production in asthma exacerbations, Nat Med, 12, 1023, 10.1038/nm1462 Wark, 2005, Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus, J Exp Med, 201, 937, 10.1084/jem.20041901 1987, J Interferon Res, 7, 429, 10.1089/jir.1987.7.429 Pestka, 2004, Interferons, interferon-like cytokines, and their receptors, Immunol Rev, 202, 8, 10.1111/j.0105-2896.2004.00204.x Pestka, 2007, The interferons: 50 years after their discovery, there is much more to learn, J Biol Chem, 282, 20047, 10.1074/jbc.R700004200 Novick, 1994, The human interferon alpha/beta receptor: characterization and molecular cloning, Cell, 77, 391, 10.1016/0092-8674(94)90154-6 Stark, 1998, How cells respond to interferons, Annu Rev Biochem, 67, 227, 10.1146/annurev.biochem.67.1.227 Stark, 2007, How cells respond to interferons revisited: from early history to current complexity, Cytokine Growth Factor Rev, 18, 419, 10.1016/j.cytogfr.2007.06.013 Alexopoulou, 2001, Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3, Nature, 413, 732, 10.1038/35099560 Takeuchi, 2008, MDA5/RIG-I and virus recognition, Curr Opin Immunol, 20, 17, 10.1016/j.coi.2008.01.002 Hurd, 1991, Workshop summary and guidelines: investigative use of bronchoscopy, lavage, and bronchial biopsies in asthma and other airway diseases, J Allergy Clin Immunol, 88, 808, 10.1016/0091-6749(91)90189-U Bucchieri, 2002, Asthmatic bronchial epithelium is more susceptible to oxidant-induced apoptosis, Am J Respir Cell Mol Biol, 27, 179, 10.1165/ajrcmb.27.2.4699 Papi, 1999, Rhinovirus infection induces expression of its own receptor intercellular adhesion molecule 1 (ICAM-1) via increased NF-kappaB-mediated transcription, J Biol Chem, 274, 9707, 10.1074/jbc.274.14.9707 Grunberg, 2001, Rhinovirus-induced airway inflammation in asthma: effect of treatment with inhaled corticosteroids before and during experimental infection, Am J Respir Crit Care Med, 164, 1816, 10.1164/ajrccm.164.10.2102118 Hansbro, 2008, Understanding the mechanisms of viral induced asthma: new therapeutic directions, Pharmacol Ther, 117, 313, 10.1016/j.pharmthera.2007.11.002 Bochkov, 2010, Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthma, Mucosal Immunol, 3, 69, 10.1038/mi.2009.109 Lopez-Souza, 2009, In vitro susceptibility to rhinovirus infection is greater for bronchial than for nasal airway epithelial cells in human subjects, J Allergy Clin Immunol, 123, 1384, 10.1016/j.jaci.2009.03.010 Uller, 2010, Double-stranded RNA induces disproportionate expression of thymic stromal lymphopoietin versus interferon-beta in bronchial epithelial cells from donors with asthma, Thorax, 65, 626, 10.1136/thx.2009.125930 Jakiela, 2008, Basal cells of differentiated bronchial epithelium are more susceptible to rhinovirus infection, Am J Respir Cell Mol Biol, 38, 517, 10.1165/rcmb.2007-0050OC Bossios, 2005, Rhinovirus infection induces cytotoxicity and delays wound healing in bronchial epithelial cells, Respir Res, 6, 114, 10.1186/1465-9921-6-114 Wark, 2007, IFN-gamma-induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations, J Allergy Clin Immunol, 120, 586, 10.1016/j.jaci.2007.04.046 Spurrell, 2005, Human airway epithelial cells produce IP-10 (CXCL10) in vitro and in vivo upon rhinovirus infection, Am J Physiol Lung Cell Mol Physiol, 289, L85, 10.1152/ajplung.00397.2004 Schroth, 1999, Rhinovirus replication causes RANTES production in primary bronchial epithelial cells, Am J Respir Cell Mol Biol, 20, 1220, 10.1165/ajrcmb.20.6.3261 Simon, 2003, Clinical and immunological effects of low-dose IFN-alpha treatment in patients with corticosteroid-resistant asthma, Allergy, 58, 1250, 10.1046/j.1398-9995.2003.00424.x Monto, 2002, Epidemiology of viral respiratory infections, Am J Med, 112, 4S, 10.1016/S0002-9343(01)01058-0 Hayden, 1983, Intranasal interferon alpha 2 for prevention of rhinovirus infection and illness, J Infect Dis, 148, 543, 10.1093/infdis/148.3.543 Douglas, 1986, Prophylactic efficacy of intranasal alpha 2-interferon against rhinovirus infections in the family setting, N Engl J Med, 314, 65, 10.1056/NEJM198601093140201 Farr, 1984, Intranasal interferon-alpha 2 for prevention of natural rhinovirus colds, Antimicrob Agents Chemother, 26, 31, 10.1128/AAC.26.1.31 Hayden, 1986, Prevention of natural colds by contact prophylaxis with intranasal alpha 2-interferon, N Engl J Med, 314, 71, 10.1056/NEJM198601093140202 Monto, 1986, Intranasal interferon-alpha 2b for seasonal prophylaxis of respiratory infection, J Infect Dis, 154, 128, 10.1093/infdis/154.1.128 Hayden, 1984, Intranasal interferon-alpha 2 treatment of experimental rhinoviral colds, J Infect Dis, 150, 174, 10.1093/infdis/150.2.174 Hayden, 1988, Intranasal recombinant alfa-2b interferon treatment of naturally occurring common colds, Antimicrob Agents Chemother, 32, 224, 10.1128/AAC.32.2.224 Sperber, 1988, Tolerance and efficacy of intranasal administration of recombinant beta serine interferon in healthy adults, J Infect Dis, 158, 166, 10.1093/infdis/158.1.166 Wiselka, 1991, Prophylactic intranasal alpha 2 interferon and viral exacerbations of chronic respiratory disease, Thorax, 46, 706, 10.1136/thx.46.10.706 Hayden, 1985, Prophylactic efficacy and tolerance of low-dose intranasal interferon-alpha 2 in natural respiratory viral infections, Antiviral Res, 5, 111, 10.1016/0166-3542(85)90037-3 Virgolini, 1997, Inhalation scintigraphy with iodine-123-labeled interferon gamma-1b: pulmonary deposition and dose escalation study in healthy volunteers, J Nucl Med, 38, 1475 Krasnowska, 1992, Inhaled natural human interferon alpha induces bronchospastic reactions in asthmatics, Arch Immunol Ther Exp (Warsz), 40, 75