Substrate specificity of nonribosomal peptide synthetase modules responsible for the biosynthesis of the oligopeptide moiety of cephabacin inLysobacter lactamgenus

FEMS Microbiology Letters - Tập 255 Số 1 - Trang 121-128 - 2006
Atanas V. Demirev1, Chu-Hee Lee2, Bharat P. Jaishy1,3, Doo-Hyun Nam1,3, Dewey D. Y. Ryu4,1
1Department of Biotechnology
2Institute of Medical Research,
3Division of Pharmacy, Yeungnam University, Gyongsan, Korea
4Biochemical Engineering Program, University of California, Davis, CA, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Challis GL , Ravel J & Townsend CA (2000) Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains. Chem Biol 7: 211–224.

Chang Z , Flatt P , Gerwick WH & Sherman DH (2002) The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide synthase (PKS)–non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit. Gene 296: 235–247.

Charbonnier F , Köhler T , Pechère J-C & Ducruix A (2001) Overexpression, refolding and purification of the histidine-tagged outer membrane efflux protein OprM of Pseudomonas aeruginosa. Protein Exp Purif 23: 121–127.

Conti E , Strachelhaus T , Marahiel MA & Brick P (1997) Structural basis for the activation of phenylalanine on the non-ribosomal biosynthesis of gramicidin S. EMBO J 16: 4174–4183.

Edwards DJ , Marquez BL , Nogle LM , McPhail K , Goeger DE , Roberts MA & Gerwick WH (2004) Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine Cyanobacterium Lyngbya majuscule. J Chem Biol 11: 817–833.

Gehring AM , Mori I & Walsh CT (1998) Reconstitution and characterization of the Escherichia coli enterobactin synthetase from EntB, EntE, and EntF. Biochemistry 37: 2648–2659.

Guenzi E , Galli G , Grgurina I , Gross DC & Grandi G (1998) Characterization of the syringomycin synthetase gene cluster. J Biol Chem 273: 32857–32863.

Harada S , Tsubotani S , Ono H & Okazaki H (1984) Cephabacins, new cephem antibiotics of bacterial origin II. Isolation and characterization. J Antibiot 37: 1536–1545.

Kimura H , Miyashita H & Sumino Y (1996) Cloning and expression of isopenicillin N synthetase gene from Lysobacter lactamgenus YK90. J Ferment Bioeng 80: 118–123.

Kimura H , Miyashita H & Sumino Y (1996) Organization and expression in Pseudomonas putida of the gene cluster involved in cephalosporin biosynthesis from Lysobacter lactamgenus YK90. Appl Microbiol Biotechnol 45: 490–501.

Kimura H , Izawa M & Sumino Y (1996) Molecular analysis of the gene cluster involved in cephalosporin biosynthesis from Lysobacter lactamgenus YK90. Appl Microbiol Biotechnol 45: 589–596.

Kleinkauf H & von Döhren H (1996) A non-ribosomal system of peptide biosynthesis. Eur J Biochem 236: 335–351.

Konz D , Klens A , Schorgendorfer K & Marahiel MA (1997) The bacitracin biosynthesis operon of Bacillus licheniformis ATCC 10716: molecular characterization of three multi-modular peptide synthetases. Chem Biol 4: 927–937.

Liras P (1999) Biosynthesis and molecular genetics of cephamycins. Antonie von Leeuwenhoek 75: 109–124.

Makrides SC (1996) Strategies for achieving high-level expression of genes in Escherichia coli. Microbiol Rev 60: 512–538.

Martin JF (1998) New aspects of genes and enzymes for beta-lactam antibiotic biosynthesis. Appl Microbiol Biotechnol 50: 1–15.

Mootz HD & Marahiel MA (1997) The tyrocidine biosynthesis operon of Bacillus brevis: complete nucleotide sequence and biochemical characterization of functional internal adenylation domains. J Bacteriol 179: 6843–6850.

Mootz HD , Schwarzer D & Marahiel MA (2002) Ways of assembling complex natural products on modular nonribosomal peptide synthetases. Chem Bio Chem 3: 490–504.

Nam DH , Chung MH , Lee ES , Sohn YS & Ryu DDY (2001) Membrane transporter genes in cephabacin biosynthetic gene cluster of Lysobacter lactamgenus. J Microbiol Biotechnol 11: 153–159.

Nozaki Y , Okonogi K , Katayama N , Ono H , Harada S , Kondo M & Okazaki H (1984) Cephabacins, new cephem antibiotics of bacterial origin. IV. Antibacterial activities, stability to β-lactamases and mode of action. J Antibiot 37: 1555–1565.

Park MJ , Yon JO , Lim SK , Ryu DDY & Nam DH (2004) Biochemical characterization of an ABC transporter gene involved in cephabacin biosynthesis in Lysobacter lactamgenus. J Microbiol Biotechnol 14: 635–638.

Pavela-Vrancinc M , Dieckmann R & von Döhren H (2004) ATPase activity of non-ribosomal peptide synthetases. Biochim Biophys Acta 1696: 83–91.

Ryu JK & Nam DH (1997) Cloning of isopenicillin N synthetase gene from Lysobacter lactamgenus. J Microbiol Biotechnol 7: 373–377.

Sambrook, 1989, Molecular Cloning. A Laboratory Manual

Scott-Craig JS , Panaccione DG , Pocard JA & Walton JD (1992) The cyclic peptide synthetase catalyzing HC-toxin production in the filamentous fungus Cochliobolus carbonum is encoded by a 15.7 kilo base open reading frame. J Biol Chem 267: 26044–26049.

Sohn YS , Nam DH & Ryu DDY (2001) Biosynthetic pathway of Cephabacins in Lysobacter lactamgenus: molecular and biochemical characterization of the upstream region of the gene clusters for engineering of novel antibiotics. Metabol Eng 3: 380–392.

Stachelhaus T & Marahiel MA (1995) Modular structure of peptide synthetases revealed by dissection of the multifunctional enzyme GrsA. J Biol Chem 270: 6163–6169.

Stachelhaus T , Mootz HD , Bergendahl V & Marahiel MA (1998) Peptide bond formation in nonribosomal peptide biosynthesis. Catalytic role of the condensation domain J Biol Chem 273: 22773–22781.

Stachelhaus T , Mootz HD & Marahiel MA (1999) The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases. Chem Biol 6: 493–505.

Tsubotani S , Hida T , Kasahara F , Wada Y & Harada S (1984) Cephabacins, new cephem antibiotics of bacterial origin. III. Structural determination. J Antibiot 37: 1546–1554.

Tudzynski P , Holter K , Correia T , Arntz C , Grammel N & Keller U (1999) Evidence for an ergot alkaloid gene cluster in Claviceps purpurea. Mol Gen Genet 261: 133–141.

Weber G , Schorgendorfer K , Schneider-Scherzer E & Leitner E (1994) The peptide synthetase catalyzing cyclosporine production in Tolypocladium niveum is encoded by a giant 45.8-kilobase open reading frame. Curr Genet 26: 120–125.