Substrate specificity of nonribosomal peptide synthetase modules responsible for the biosynthesis of the oligopeptide moiety of cephabacin inLysobacter lactamgenus
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Challis GL , Ravel J & Townsend CA (2000) Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains. Chem Biol 7: 211â224.
Chang Z , Flatt P , Gerwick WH & Sherman DH (2002) The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide synthase (PKS)ânon-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit. Gene 296: 235â247.
Charbonnier F , Köhler T , Pechère J-C & Ducruix A (2001) Overexpression, refolding and purification of the histidine-tagged outer membrane efflux protein OprM of Pseudomonas aeruginosa. Protein Exp Purif 23: 121â127.
Conti E , Strachelhaus T , Marahiel MA & Brick P (1997) Structural basis for the activation of phenylalanine on the non-ribosomal biosynthesis of gramicidin S. EMBO J 16: 4174â4183.
Edwards DJ , Marquez BL , Nogle LM , McPhail K , Goeger DE , Roberts MA & Gerwick WH (2004) Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine Cyanobacterium Lyngbya majuscule. J Chem Biol 11: 817â833.
Gehring AM , Mori I & Walsh CT (1998) Reconstitution and characterization of the Escherichia coli enterobactin synthetase from EntB, EntE, and EntF. Biochemistry 37: 2648â2659.
Guenzi E , Galli G , Grgurina I , Gross DC & Grandi G (1998) Characterization of the syringomycin synthetase gene cluster. J Biol Chem 273: 32857â32863.
Harada S , Tsubotani S , Ono H & Okazaki H (1984) Cephabacins, new cephem antibiotics of bacterial origin II. Isolation and characterization. J Antibiot 37: 1536â1545.
Kimura H , Miyashita H & Sumino Y (1996) Cloning and expression of isopenicillin N synthetase gene from Lysobacter lactamgenus YK90. J Ferment Bioeng 80: 118â123.
Kimura H , Miyashita H & Sumino Y (1996) Organization and expression in Pseudomonas putida of the gene cluster involved in cephalosporin biosynthesis from Lysobacter lactamgenus YK90. Appl Microbiol Biotechnol 45: 490â501.
Kimura H , Izawa M & Sumino Y (1996) Molecular analysis of the gene cluster involved in cephalosporin biosynthesis from Lysobacter lactamgenus YK90. Appl Microbiol Biotechnol 45: 589â596.
Kleinkauf H & von Döhren H (1996) A non-ribosomal system of peptide biosynthesis. Eur J Biochem 236: 335â351.
Konz D , Klens A , Schorgendorfer K & Marahiel MA (1997) The bacitracin biosynthesis operon of Bacillus licheniformis ATCC 10716: molecular characterization of three multi-modular peptide synthetases. Chem Biol 4: 927â937.
Liras P (1999) Biosynthesis and molecular genetics of cephamycins. Antonie von Leeuwenhoek 75: 109â124.
Makrides SC (1996) Strategies for achieving high-level expression of genes in Escherichia coli. Microbiol Rev 60: 512â538.
Martin JF (1998) New aspects of genes and enzymes for beta-lactam antibiotic biosynthesis. Appl Microbiol Biotechnol 50: 1â15.
Mootz HD & Marahiel MA (1997) The tyrocidine biosynthesis operon of Bacillus brevis: complete nucleotide sequence and biochemical characterization of functional internal adenylation domains. J Bacteriol 179: 6843â6850.
Mootz HD , Schwarzer D & Marahiel MA (2002) Ways of assembling complex natural products on modular nonribosomal peptide synthetases. Chem Bio Chem 3: 490â504.
Nam DH , Chung MH , Lee ES , Sohn YS & Ryu DDY (2001) Membrane transporter genes in cephabacin biosynthetic gene cluster of Lysobacter lactamgenus. J Microbiol Biotechnol 11: 153â159.
Nozaki Y , Okonogi K , Katayama N , Ono H , Harada S , Kondo M & Okazaki H (1984) Cephabacins, new cephem antibiotics of bacterial origin. IV. Antibacterial activities, stability to β-lactamases and mode of action. J Antibiot 37: 1555â1565.
Park MJ , Yon JO , Lim SK , Ryu DDY & Nam DH (2004) Biochemical characterization of an ABC transporter gene involved in cephabacin biosynthesis in Lysobacter lactamgenus. J Microbiol Biotechnol 14: 635â638.
Pavela-Vrancinc M , Dieckmann R & von Döhren H (2004) ATPase activity of non-ribosomal peptide synthetases. Biochim Biophys Acta 1696: 83â91.
Ryu JK & Nam DH (1997) Cloning of isopenicillin N synthetase gene from Lysobacter lactamgenus. J Microbiol Biotechnol 7: 373â377.
Sambrook, 1989, Molecular Cloning. A Laboratory Manual
Scott-Craig JS , Panaccione DG , Pocard JA & Walton JD (1992) The cyclic peptide synthetase catalyzing HC-toxin production in the filamentous fungus Cochliobolus carbonum is encoded by a 15.7 kilo base open reading frame. J Biol Chem 267: 26044â26049.
Sohn YS , Nam DH & Ryu DDY (2001) Biosynthetic pathway of Cephabacins in Lysobacter lactamgenus: molecular and biochemical characterization of the upstream region of the gene clusters for engineering of novel antibiotics. Metabol Eng 3: 380â392.
Stachelhaus T & Marahiel MA (1995) Modular structure of peptide synthetases revealed by dissection of the multifunctional enzyme GrsA. J Biol Chem 270: 6163â6169.
Stachelhaus T , Mootz HD , Bergendahl V & Marahiel MA (1998) Peptide bond formation in nonribosomal peptide biosynthesis. Catalytic role of the condensation domain J Biol Chem 273: 22773â22781.
Stachelhaus T , Mootz HD & Marahiel MA (1999) The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases. Chem Biol 6: 493â505.
Tsubotani S , Hida T , Kasahara F , Wada Y & Harada S (1984) Cephabacins, new cephem antibiotics of bacterial origin. III. Structural determination. J Antibiot 37: 1546â1554.
Tudzynski P , Holter K , Correia T , Arntz C , Grammel N & Keller U (1999) Evidence for an ergot alkaloid gene cluster in Claviceps purpurea. Mol Gen Genet 261: 133â141.
Weber G , Schorgendorfer K , Schneider-Scherzer E & Leitner E (1994) The peptide synthetase catalyzing cyclosporine production in Tolypocladium niveum is encoded by a giant 45.8-kilobase open reading frame. Curr Genet 26: 120â125.
