CXCR4/CXCL12 Mediate Autocrine Cell- Cycle Progression in NF1-Associated Malignant Peripheral Nerve Sheath Tumors

Balkwill, 2004, The significance of cancer cell expression of the chemokine receptor CXCR4, Semin. Cancer Biol., 14, 171, 10.1016/j.semcancer.2003.10.003 Bertolini, 2002, CXCR4 neutralization, a novel therapeutic approach for non-Hodgkin’s lymphoma, Cancer Res., 62, 3106 Bian, 2007, Preferential expression of chemokine receptor CXCR4 by highly malignant human gliomas and its association with poor patient survival, Neurosurgery, 61, 570, 10.1227/01.NEU.0000290905.53685.A2 Burger, 1999, Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells, Blood, 94, 3658, 10.1182/blood.V94.11.3658 Cichowski, 1999, Mouse models of tumor development in neurofibromatosis type 1, Science, 286, 2172, 10.1126/science.286.5447.2172 Cross, 1995, Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B, Nature, 378, 785, 10.1038/378785a0 Cui, 2008, Neurofibromin regulation of ERK signaling modulates GABA release and learning, Cell, 135, 549, 10.1016/j.cell.2008.09.060 Ferner, 2007, Neurofibromatosis 1, Eur. J. Hum. Genet., 15, 131, 10.1038/sj.ejhg.5201676 Ghadimi, 2012, Survivin is a viable target for the treatment of malignant peripheral nerve sheath tumors, Clin. Cancer Res., 18, 2545, 10.1158/1078-0432.CCR-11-2592 Hoppler, 2007, Wnt signalling: variety at the core, J. Cell Sci., 120, 385, 10.1242/jcs.03363 Johannessen, 2008, TORC1 is essential for NF1-associated malignancies, Curr. Biol., 18, 56, 10.1016/j.cub.2007.11.066 Johansson, 2008, Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors, Mol. Cancer Ther., 7, 1237, 10.1158/1535-7163.MCT-07-2335 Johnson, 1999, Cyclins and cell cycle checkpoints, Annu. Rev. Pharmacol. Toxicol., 39, 295, 10.1146/annurev.pharmtox.39.1.295 Joseph, 2008, The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells, Cancer Cell, 13, 129, 10.1016/j.ccr.2008.01.003 Kijima, 2002, Regulation of cellular proliferation, cytoskeletal function, and signal transduction through CXCR4 and c-Kit in small cell lung cancer cells, Cancer Res., 62, 6304 Koshiba, 2000, Expression of stromal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer: a possible role for tumor progression, Clin. Cancer Res., 6, 3530 Laverdiere, 2005, Messenger RNA expression levels of CXCR4 correlate with metastatic behavior and outcome in patients with osteosarcoma, Clin. Cancer Res., 11, 2561, 10.1158/1078-0432.CCR-04-1089 Le, 2007, Tumor microenvironment and neurofibromatosis type I: connecting the GAPs, Oncogene, 26, 4609, 10.1038/sj.onc.1210261 Le, 2009, Cell of origin and microenvironment contribution for NF1-associated dermal neurofibromas, Cell Stem Cell, 4, 453, 10.1016/j.stem.2009.03.017 Le, 2011, Susceptible stages in Schwann cells for NF1-associated plexiform neurofibroma development, Cancer Res., 71, 4686, 10.1158/0008-5472.CAN-10-4577 Lee, 2003, Regulators of G1 cyclin-dependent kinases and cancers, Cancer Metastasis Rev., 22, 435, 10.1023/A:1023785332315 Li, 2004, Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis, Cancer Cell, 6, 459, 10.1016/j.ccr.2004.09.027 Liu, 2002, Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism, Cell, 108, 837, 10.1016/S0092-8674(02)00685-2 Mantripragada, 2008, High-resolution DNA copy number profiling of malignant peripheral nerve sheath tumors using targeted microarray-based comparative genomic hybridization, Clin. Cancer Res., 14, 1015, 10.1158/1078-0432.CCR-07-1305 Müller, 2001, Involvement of chemokine receptors in breast cancer metastasis, Nature, 410, 50, 10.1038/35065016 Obaya, 2002, Regulation of cyclin-Cdk activity in mammalian cells, Cell. Mol. Life Sci., 59, 126, 10.1007/s00018-002-8410-1 Oh, 2001, CXC chemokine receptor 4 expression and function in human astroglioma cells, J. Immunol., 166, 2695, 10.4049/jimmunol.166.4.2695 Peled, 2012, Development of novel CXCR4-based therapeutics, Expert Opin. Investig. Drugs, 21, 341, 10.1517/13543784.2012.656197 Righi, 2011, CXCL12/CXCR4 blockade induces multimodal antitumor effects that prolong survival in an immunocompetent mouse model of ovarian cancer, Cancer Res., 71, 5522, 10.1158/0008-5472.CAN-10-3143 Rubin, 2005, Neurofibromatosis type 1 - a model for nervous system tumour formation?, Nat. Rev. Cancer, 5, 557, 10.1038/nrc1653 Schrader, 2002, CXCR4/CXCL12 expression and signalling in kidney cancer, Br. J. Cancer, 86, 1250, 10.1038/sj.bjc.6600221 Sehgal, 1998, CXCR-4, a chemokine receptor, is overexpressed in and required for proliferation of glioblastoma tumor cells, J. Surg. Oncol., 69, 99, 10.1002/(SICI)1096-9098(199810)69:2<99::AID-JSO10>3.0.CO;2-M Sengupta, 2012, CXCR4 activation defines a new subgroup of Sonic hedgehog-driven medulloblastoma, Cancer Res., 72, 122, 10.1158/0008-5472.CAN-11-1701 Serra, 2000, Schwann cells harbor the somatic NF1 mutation in neurofibromas: evidence of two different Schwann cell subpopulations, Hum. Mol. Genet., 9, 3055, 10.1093/hmg/9.20.3055 Sherr, 1995, D-type cyclins, Trends Biochem. Sci., 20, 187, 10.1016/S0968-0004(00)89005-2 Singh, 2004, CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion, Lab. Invest., 84, 1666, 10.1038/labinvest.3700181 Srivastava, 1998, Potential mechanism(s) involved in the regulation of glycogen synthesis by insulin, Mol. Cell. Biochem., 182, 135, 10.1023/A:1006857527588 Taichman, 2002, Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone, Cancer Res., 62, 1832 Tonsgard, 2006, Clinical manifestations and management of neurofibromatosis type 1, Semin. Pediatr. Neurol., 13, 2, 10.1016/j.spen.2006.01.005 Vogel, 1999, Mouse tumor model for neurofibromatosis type 1, Science, 286, 2176, 10.1126/science.286.5447.2176 Wang, 2008, Blockade of SDF-1/CXCR4 signalling inhibits pancreatic cancer progression in vitro via inactivation of canonical Wnt pathway, Br. J. Cancer, 99, 1695, 10.1038/sj.bjc.6604745 Wang, 2012, ERK inhibition rescues defects in fate specification of Nf1-deficient neural progenitors and brain abnormalities, Cell, 150, 816, 10.1016/j.cell.2012.06.034 Warrington, 2007, Spatiotemporal differences in CXCL12 expression and cyclic AMP underlie the unique pattern of optic glioma growth in neurofibromatosis type 1, Cancer Res., 67, 8588, 10.1158/0008-5472.CAN-06-2220 Zeelenberg, 2003, The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases, Cancer Res., 63, 3833 Zheng, 2008, Induction of abnormal proliferation by nonmyelinating schwann cells triggers neurofibroma formation, Cancer Cell, 13, 117, 10.1016/j.ccr.2008.01.002 Zhou, 2002, CXCR4 is a major chemokine receptor on glioma cells and mediates their survival, J. Biol. Chem., 277, 49481, 10.1074/jbc.M206222200 Zhu, 2001, Neurofibromin, a tumor suppressor in the nervous system, Exp. Cell Res., 264, 19, 10.1006/excr.2000.5138 Zhu, 2002, Neurofibromas in NF1: Schwann cell origin and role of tumor environment, Science, 296, 920, 10.1126/science.1068452 Zou, 2009, Dual targeting of AKT and mammalian target of rapamycin: a potential therapeutic approach for malignant peripheral nerve sheath tumor, Mol. Cancer Ther., 8, 1157, 10.1158/1535-7163.MCT-08-1008 2008, Comprehensive genomic characterization defines human glioblastoma genes and core pathways, Nature, 455, 1061, 10.1038/nature07385 Courtois-Cox, 2006, A negative feedback signaling network underlies oncogene-induced senescence, Cancer Cell, 10, 459, 10.1016/j.ccr.2006.10.003 Dalgliesh, 2010, Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes, Nature, 463, 360, 10.1038/nature08672 Jones, 2008, Core signaling pathways in human pancreatic cancers revealed by global genomic analyses, Science, 321, 1801, 10.1126/science.1164368 Kan, 2010, Diverse somatic mutation patterns and pathway alterations in human cancers, Nature, 466, 869, 10.1038/nature09208 Morin, 2011, Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma, Nature, 476, 298, 10.1038/nature10351 Orimo, 2005, Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion, Cell, 121, 335, 10.1016/j.cell.2005.02.034 Parsons, 2008, An integrated genomic analysis of human glioblastoma multiforme, Science, 321, 1807, 10.1126/science.1164382 Parsons, 2011, The genetic landscape of the childhood cancer medulloblastoma, Science, 331, 435, 10.1126/science.1198056 Wegner, 1998, Genomic organization and functional characterization of the chemokine receptor CXCR4, a major entry co-receptor for human immunodeficiency virus type 1, J. Biol. Chem., 273, 4754, 10.1074/jbc.273.8.4754 Wood, 2007, The genomic landscapes of human breast and colorectal cancers, Science, 318, 1108, 10.1126/science.1145720