Emerging role of 18F-FDG PET/CT in Castleman disease: a review

Insights into Imaging - Tập 12 - Trang 1-11 - 2021
Benjamin Koa1,2, Austin J. Borja1,3, Mahmoud Aly1, Sayuri Padmanabhan1, Joseph Tran1, Vincent Zhang1, Chaitanya Rojulpote1, Sheila K. Pierson4, Mark-Avery Tamakloe4, Johnson S. Khor4, Thomas J. Werner1, David C. Fajgenbaum4, Abass Alavi1, Mona-Elisabeth Revheim1,5,6
1Department of Radiology, University of Pennsylvania, Philadelphia, USA
2Drexel University College of Medicine, Philadelphia, USA
3Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
4Department of Medicine, Division of Translational Medicine and Human Genetics, University of Pennsylvania, Philadelphia, USA
5Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway
6Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway

Tóm tắt

Castleman disease (CD) describes a group of rare hematologic conditions involving lymphadenopathy with characteristic histopathology and a spectrum of clinical abnormalities. CD is divided into localized or unicentric CD (UCD) and multicentric CD (MCD) by imaging. MCD is further divided based on etiological driver into human herpesvirus-8-associated MCD, POEMS-associated MCD, and idiopathic MCD. There is notable heterogeneity across MCD, but increased level of pro-inflammatory cytokines, particularly interleukin-6, is an established disease driver in a portion of patients. FDG-PET/CT can help determine UCD versus MCD, evaluate for neoplastic conditions that can mimic MCD clinico-pathologically, and monitor therapy responses. CD requires more robust characterization, earlier diagnosis, and an accurate tool for both monitoring and treatment response evaluation; FDG-PET/CT is particularly suited for this. Moving forward, future prospective studies should further characterize the use of FDG-PET/CT in CD and specifically explore the utility of global disease assessment and dual time point imaging. Trial registration ClinicalTrials.gov, NCT02817997, Registered 29 June 2016, https://clinicaltrials.gov/ct2/show/NCT02817997

Tài liệu tham khảo

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