Interleukin-31 is associated with uremic pruritus in patients receiving hemodialysis

Mathur, 2010, A longitudinal study of uremic pruritus in hemodialysis patients, Clin J Am Soc Nephrol, 5, 1410, 10.2215/CJN.00100110 Pisoni, 2006, Pruritus in hemodialysis patients: international results from the dialysis outcomes and practice patterns study (DOPPS), Nephrol Dial Transplant, 21, 3495, 10.1093/ndt/gfl461 Pauli-Magnus, 2000, Naltrexone does not relieve uremic pruritus: results of a randomized, double-blind, placebo-controlled crossover study, J Am Soc Nephrol, 11, 514, 10.1681/ASN.V113514 Ko, 2011, Narrowband ultraviolet B phototherapy for patients with refractory uremic pruritus: a randomized controlled trial, Br J Dermatol, 165, 633, 10.1111/j.1365-2133.2011.10448.x Dyachenko, 2006, Hemodialysis-related pruritus and associated cutaneous manifestations, Int J Dermatol, 45, 664, 10.1111/j.1365-4632.2005.02592.x Yosipovitch, 2001, A questionnaire for the assessment of pruritus: validation in uremic patients, Acta Derm Venereol, 81, 108, 10.1080/00015550152384236 Fallahzadeh, 2011, Interleukin-2 serum levels are elevated in patients with uremic pruritus: a novel finding with practical implications, Nephrol Dial Transplant, 26, 3338, 10.1093/ndt/gfr053 Kimmel, 2006, The role of micro-inflammation in the pathogenesis of uremic pruritus in hemodialysis patients, Nephrol Dial Transplant, 21, 749, 10.1093/ndt/gfi204 Dillon, 2004, Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice, Nat Immunol, 5, 752, 10.1038/ni1084 Takaoka, 2005, Expression of IL-31 gene transcripts in NC/Nga mice with atopic dermatitis, Eur J Pharmacol, 516, 180, 10.1016/j.ejphar.2005.04.040 Takaoka, 2006, Involvement of IL-31 on scratching behavior in NC/Nga mice with atopic-like dermatitis, Exp Dermatol, 15, 161, 10.1111/j.1600-0625.2006.00405.x Raap, 2008, Correlation of IL-31 serum levels with severity of atopic dermatitis, J Allergy Clin Immunol, 122, 421, 10.1016/j.jaci.2008.05.047 Ezzat, 2011, Serum measurement of interleukin-31 (IL-31) in pediatric atopic dermatitis: elevated levels correlate with severity scoring, J Eur Acad Dermatol Venereol, 25, 334, 10.1111/j.1468-3083.2010.03794.x Neis, 2006, Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis, J Allergy Clin Immunol, 118, 930, 10.1016/j.jaci.2006.07.015 Dambacher, 2007, Interleukin 31 mediates MAP kinase and STAT1/3 activation in intestinal epithelial cells and its expression is upregulated in inflammatory bowel disease, Gut, 56, 1257, 10.1136/gut.2006.118679 Cornelissen, 2012, Signaling by IL-31 and functional consequences, Eur J Cell Biol, 91, 552, 10.1016/j.ejcb.2011.07.006 2006, Clinical practice guidelines for hemodialysis adequacy, update 2006, Am J Kidney Dis, 48, S2 Furue, 2013, Verbalizing extremes of the visual analog scale for pruritus: a consensus statement, Acta Derm Venereol, 93, 214, 10.2340/00015555-1446 Ada, 2005, Treatment of uremic pruritus with narrowband ultraviolet B phototherapy: an open pilot study, J Am Acad Dermatol, 53, 149, 10.1016/j.jaad.2004.12.052 Ko, 2013, Postprandial blood glucose is associated with generalized pruritus in patients with type 2 diabetes, Eur J Dermatol, 23, 688, 10.1684/ejd.2013.2100 Daugirdas, 1995, Simplified equations for monitoring Kt/V, PCRn, eKt/V, and ePCRn, Adv Ren Replac Ther, 2, 295, 10.1016/S1073-4449(12)80028-8 Benedetti, 2009, Using generalized additive models to detect and estimate threshold associations, Int J Biostatistics, 5, 26, 10.2202/1557-4679.1172 Morton, 1996, Pruritus and skin hydration during dialysis, Nephrol Dial Transplant, 11, 2031, 10.1093/oxfordjournals.ndt.a027092 Massry, 1968, Intractable pruritus as a manifestation of secondary hyperparathyroidism in uremia: disappearance of itching after subtotal parathyroidectomy, N Engl J Med, 279, 697, 10.1056/NEJM196809262791308 Graf, 1979, Disappearance of uremic pruritus after lowering dialysate magnesium concentration, Br Med J, 2, 1478, 10.1136/bmj.2.6203.1478-a Narita, 2006, Etiology and prognostic significance of severe uremic pruritus in chronic hemodialysis patients, Kidney Int, 69, 1626, 10.1038/sj.ki.5000251 Kato, 2008, Aspects of immune dysfunction in end-stage renal disease, Clin J Am Soc Nephrol, 3, 1526, 10.2215/CJN.00950208 Stenvinkel, 2005, IL-10, IL-6, and TNF-alpha: central factors in the altered cytokine network of uremia–the good, the bad, and the ugly, Kidney Int, 67, 1216, 10.1111/j.1523-1755.2005.00200.x Pertosa, 2000, Clinical relevance of cytokine production in hemodialysis, Kidney Int Suppl, 76, S104, 10.1046/j.1523-1755.2000.07613.x Stenvinkel, 2002, Inflammation in end-stage renal disease: sources, consequences, and therapy, Semin Dial, 15, 329, 10.1046/j.1525-139X.2002.00083.x Balaskas, 1998, Histamine and serotonin in uremic pruritus: effect of ondansetron in CAPD-pruritic patients, Nephron, 78, 395, 10.1159/000044967 Chen, 2010, Elevated C-reactive protein level in hemodialysis patients with moderate/severe uremic pruritus: a potential mediator of high overall mortality, QJM, 103, 837, 10.1093/qjmed/hcq036 Sonkoly, 2006, IL-31: a new link between T cells and pruritus in atopic skin inflammation, J Allergy Clin Immunol, 117, 411, 10.1016/j.jaci.2005.10.033 Schulz, 2007, A common haplotype of the IL-31 gene influencing gene expression is associated with nonatopic eczema, J Allergy Clin Immunol, 120, 1097, 10.1016/j.jaci.2007.07.065 Goldsmith, 2012 Grimstad, 2009, Anti-interleukin-31-antibodies ameliorate scratching behavior in NC/Nga mice: a model of atopic dermatitis, Exp Dermatol, 18, 35, 10.1111/j.1600-0625.2008.00766.x Ko, 2013, Uremic pruritus, dialysis adequacy, and metabolic profiles in hemodialysis patients: a prospective 5-year cohort study, PloS One, 8, e71404, 10.1371/journal.pone.0071404 Ridker, 2000, C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women, N Engl J Med, 342, 836, 10.1056/NEJM200003233421202 Chiu, 2008, Association of uremic pruritus with inflammation and hepatitis infection in hemodialysis patients, Nephrol Dial Transplant, 23, 3685, 10.1093/ndt/gfn303