SIRT1 downregulation mediated Manganese-induced neuronal apoptosis through activation of FOXO3a-Bim/PUMA axis

Bouabid, 2015, Manganese neurotoxicity: behavioral disorders associated with dysfunctions in the basal ganglia and neurochemical transmission, J. Neurochem., 136, 677, 10.1111/jnc.13442 Bowman, 2011, Role of manganese in neurodegenerative diseases, J. Trace Elem. Med. Biol., 25, 191, 10.1016/j.jtemb.2011.08.144 Brunet, 2004, Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase, Science, 303, 2011, 10.1126/science.1094637 Caito, 2010, SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress, FASEB J., 24, 3145, 10.1096/fj.09-151308 Chen, 2016, Arsenic trioxide mediates HAPI microglia inflammatory response and the secretion of inflammatory cytokine IL-6 via Akt/NF-kappaB signaling pathway, Regul. Toxicol. Pharmacol., 81, 480, 10.1016/j.yrtph.2016.09.027 Duan, 2015, NiO nanoparticles induce apoptosis through repressing SIRT1 in human bronchial epithelial cells, Toxicol. Appl. Pharmacol., 286, 80, 10.1016/j.taap.2015.03.024 El-Hady, 2018, neurotoxic outcomes of subchronic manganese chloride exposure via contaminated water in adult male rats and the potential benefits of ebselen, Biol. Trace Elem. Res., 4-5, 1 Gao, 2011, Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity, J. Biol. Chem., 286, 22227, 10.1074/jbc.M111.228874 Hirata, 1998, Activation of JNK pathway and induction of apoptosis by manganese in PC12 cells, J. Neurochem., 71, 1607, 10.1046/j.1471-4159.1998.71041607.x Hirata, 2004, Anti-apoptotic and pro-apoptotic effect of NEPP11 on manganese-induced apoptosis and JNK pathway activation in PC12 cells, Brain Res., 1021, 241, 10.1016/j.brainres.2004.06.064 Hori, 2013, Regulation of FOXOs and p53 by SIRT1 modulators under oxidative stress, PLoS One, 8, 10.1371/journal.pone.0073875 Huo, 2017, Betulinic acid derivative B10 inhibits glioma cell proliferation through suppression of SIRT1, acetylation of FOXO3a and upregulation of Bim/PUMA, Biomed Pharmacother, 92, 347, 10.1016/j.biopha.2017.05.074 Kuwana, 2002, Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane, Cell, 111, 331, 10.1016/S0092-8674(02)01036-X Lai, 2013, Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of manganese superoxide dismutase via the SIRT1/FoxO3a pathway, Circulation, 127, 1692, 10.1161/CIRCULATIONAHA.112.001212 Lin, 2016, Transcriptional activation of follistatin by Nrf2 protects pulmonary epithelial cells against silica nanoparticle-induced oxidative stress, Sci. Rep., 6, 21133, 10.1038/srep21133 Lindsten, 2000, The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues, Mol. Cell, 6, 1389, 10.1016/S1097-2765(00)00136-2 Liu, 2017, Downregulation of Mfn2 participates in manganese-induced neuronal apoptosis in rat striatum and PC12 cells, Neurochem. Int., 108, 40, 10.1016/j.neuint.2017.02.008 Ma, 2015, Involvement of dysregulated Wip1 in manganese-induced p53 signaling and neuronal apoptosis, Toxicol. Lett., 235, 17, 10.1016/j.toxlet.2014.12.019 Mao, 2016, Arsenic trioxide mediates HAPI microglia inflammatory response and subsequent neuron apoptosis through p38/JNK MAPK/STAT3 pathway, Toxicol. Appl. Pharmacol., 303, 79, 10.1016/j.taap.2016.05.003 Qi, 2017, Salidroside inhibits HMGB1 acetylation and release through upregulation of SirT1 during inflammation, Oxidative Med. Cell. Longev., 2017, 9821543, 10.1155/2017/9821543 Qi, 2018, Mitochondrial fission is required for angiotensin II-induced cardiomyocyte apoptosis mediated by a Sirt1-p53 signaling pathway, Front. Pharmacol., 9, 176, 10.3389/fphar.2018.00176 Ramos, 2014, Anatomical region differences and age-related changes in copper, zinc, and manganese levels in the human brain, Biol. Trace Elem. Res., 161, 190, 10.1007/s12011-014-0093-6 Shi, 2015, KHSRP participates in manganese-induced neurotoxicity in rat striatum and PC12 cells, J. Mol. Neurosci., 55, 454, 10.1007/s12031-014-0367-7 Singh, 2017, SIRT1 ameliorates oxidative stress induced neural cell death and is down-regulated in Parkinson's disease, BMC Neurosci., 18, 46, 10.1186/s12868-017-0364-1 Sooyeon, 2016, Deacetylation of mitofusin-2 by sirtuin-1: a critical event in cell survival after ischemia, Mol. Cell. Oncol., 3 Wan, 2014, Pivotal roles of p53 transcription-dependent and -independent pathways in manganese-induced mitochondrial dysfunction and neuronal apoptosis, Toxicol. Appl. Pharmacol., 281, 294, 10.1016/j.taap.2014.10.013 Wang, 2016, hnRNP A1 antagonizes cellular senescence and senescence-associated secretory phenotype via regulation of SIRT1 mRNA stability, Aging Cell, 15, 1063, 10.1111/acel.12511 Yan, 2018, Yap regulates gastric cancer survival and migration via SIRT1/Mfn2/mitophagy, Oncol. Rep., 39, 1671 Yao, 2014, SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism, Am. J. Physiol. Lung Cell. Mol. Physiol., 306, L816, 10.1152/ajplung.00323.2013 Yin, 2018, Manganese exposure facilitates microglial JAK2-STAT3 signaling and consequent secretion of TNF-a and IL-1beta to promote neuronal death, Neurotoxicology, 64, 195, 10.1016/j.neuro.2017.04.001 Zhang, 2017, miR-181a increases FoxO1 acetylation and promotes granulosa cell apoptosis via SIRT1 downregulation, Cell Death Dis., 8, 10.1038/cddis.2017.467 Zhang, 2017, miR-200a-3p promotes b-Amyloid-induced neuronal apoptosis through down-regulation of SIRT1 in Alzheimer's disease, J. Biosci., 42, 397, 10.1007/s12038-017-9698-1 Zhao, 2017, Antimony trichloride induces a loss of cell viability via reactive oxygen species-dependent autophagy in A549 cells, Int. J. Biochem. Cell Biol., 93, 32, 10.1016/j.biocel.2017.10.007 Zhou, 2017, SIRT1/PGC-1alpha signaling promotes mitochondrial functional recovery and reduces apoptosis after intracerebral hemorrhage in rats, Front. Mol. Neurosci., 10, 443, 10.3389/fnmol.2017.00443