Molecular Definition of Breast Tumor Heterogeneity

Cancer Cell - Tập 11 - Trang 259-273 - 2007
Michail Shipitsin1,2, Lauren L. Campbell1,3, Pedram Argani4, Stanislawa Weremowicz5,6, Noga Bloushtain-Qimron1, Jun Yao1,7, Tatiana Nikolskaya8,9, Tatiana Serebryiskaya8,9, Rameen Beroukhim1,2, Min Hu1,7, Marc K. Halushka4, Saraswati Sukumar4, Leroy M. Parker1,7, Karen S. Anderson1,2, Lyndsay N. Harris1,2, Judy E. Garber1,7, Andrea L. Richardson5,6, Stuart J. Schnitt5,10, Yuri Nikolsky8, Rebecca S. Gelman11,12
1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115 USA
2Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA
3Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA
4Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
5Department of Pathology, Harvard Medical School, Boston, MA 02115 USA
6Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115 USA
7Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
8GeneGo, Inc., St. Joseph, MI 49085, USA
9Vavilov Institute for General Genetics, Moscow B333, 117809, Russia
10Department of Pathology, Beth-Israel Deaconess Medical Center, Boston, MA 02115, USA
11Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, 02115, USA
12Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA

Tài liệu tham khảo

Abraham, 2005, Prevalence of CD44+/CD24-/low cells in breast cancer may not be associated with clinical outcome but may favor distant metastasis, Clin. Cancer Res., 11, 1154, 10.1158/1078-0432.1154.11.3 Al-Hajj, 2003, Prospective identification of tumorigenic breast cancer cells, Proc. Natl. Acad. Sci. USA, 100, 3983, 10.1073/pnas.0530291100 Allinen, 2004, Molecular characterization of the tumor microenvironment in breast cancer, Cancer Cell, 6, 17, 10.1016/j.ccr.2004.06.010 Arteaga, 2006, Inhibition of TGFbeta signaling in cancer therapy, Curr. Opin. Genet. Dev., 16, 30, 10.1016/j.gde.2005.12.009 Asselin-Labat, 2006, Steroid hormone receptor status of mouse mammary stem cells, J. Natl. Cancer Inst., 98, 1011, 10.1093/jnci/djj267 Bates, 2005, The epithelial-mesenchymal transition (EMT) and colorectal cancer progression, Cancer Biol. Ther., 4, 365, 10.4161/cbt.4.4.1655 Baumann, 2005, CD24 expression causes the acquisition of multiple cellular properties associated with tumor growth and metastasis, Cancer Res., 65, 10783, 10.1158/0008-5472.CAN-05-0619 Bircan, 2006, CD24 expression in ductal carcinoma in situ and invasive ductal carcinoma of breast: An immunohistochemistry-based pilot study, Pathol. Res. Pract., 202, 569, 10.1016/j.prp.2006.05.004 Blanpain, 2004, Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche, Cell, 118, 635, 10.1016/j.cell.2004.08.012 Bocker, 2002, Common adult stem cells in the human breast give rise to glandular and myoepithelial cell lineages: A new cell biological concept, Lab. Invest., 82, 737, 10.1097/01.LAB.0000017371.72714.C5 Chang, 2005, Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival, Proc. Natl. Acad. Sci. USA, 102, 3738, 10.1073/pnas.0409462102 Clarke, 2006, Stem cells and cancer: Two faces of eve, Cell, 124, 1111, 10.1016/j.cell.2006.03.011 Clarke, 2005, A putative human breast stem cell population is enriched for steroid receptor-positive cells, Dev. Biol., 277, 443, 10.1016/j.ydbio.2004.07.044 Clayton, 2004, Growth and differentiation of progenitor/stem cells derived from the human mammary gland, Exp. Cell Res., 297, 444, 10.1016/j.yexcr.2004.03.029 Dean, 2005, Tumour stem cells and drug resistance, Nat. Rev. Cancer, 5, 275, 10.1038/nrc1590 Dontu, 2003, In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells, Genes Dev., 17, 1253, 10.1101/gad.1061803 Eckfeldt, 2005, The molecular repertoire of the ‘almighty’ stem cell, Nat. Rev. Mol. Cell Biol., 6, 726, 10.1038/nrm1713 Eisen, 1998, Cluster analysis and display of genome-wide expression patterns, Proc. Natl. Acad. Sci. USA, 95, 14863, 10.1073/pnas.95.25.14863 Ekins, 2006, A combined approach to drug metabolism and toxicity assessment, Drug Metab. Dispos., 34, 495, 10.1124/dmd.105.008458 Glinsky, 2005, Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer, J. Clin. Invest., 115, 1503, 10.1172/JCI23412 Hu, 2005, Distinct epigenetic changes in the stromal cells of breast cancers, Nat. Genet., 37, 899, 10.1038/ng1596 Ivanova, 2002, A stem cell molecular signature, Science, 298, 601, 10.1126/science.1073823 James, 2005, TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells, Development, 132, 1273, 10.1242/dev.01706 Jarvinen, 2006, Identification of target genes in laryngeal squamous cell carcinoma by high-resolution copy number and gene expression microarray analyses, Oncogene, 25, 6997, 10.1038/sj.onc.1209690 Kristiansen, 2003, CD24 expression is a new prognostic marker in breast cancer, Clin. Cancer Res., 9, 4906 LaFramboise, 2005, Allele-specific amplification in cancer revealed by SNP array analysis, PLoS Comput. Biol., 1, e65, 10.1371/journal.pcbi.0010065 Lee, 2006, Application of transcriptional and biological network analyses in mouse germ-cell transcriptomes, Genomics, 88, 18, 10.1016/j.ygeno.2006.03.008 Liu, 2006, Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells, Cancer Res., 66, 6063, 10.1158/0008-5472.CAN-06-0054 Lynch, 2006, Breast cancer, stem cells and prospects for therapy, Breast Cancer Res., 8, 211, 10.1186/bcr1513 Moses, 1996, Regulation of differentiation by TGF-beta, Curr. Opin. Genet. Dev., 6, 581, 10.1016/S0959-437X(96)80087-6 Muraoka-Cook, 2005, Dual role of transforming growth factor beta in mammary tumorigenesis and metastatic progression, Clin. Cancer Res., 11, 937s, 10.1158/1078-0432.937s.11.2 Ney, 1993, Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner, Mol. Cell. Biol., 13, 5604, 10.1128/MCB.13.9.5604 Nikolsky, 2005, A novel method for generation of signature networks as biomarkers from complex high throughput data, Toxicol. Lett., 158, 20, 10.1016/j.toxlet.2005.02.004 Nikolsky, 2005, Biological networks and analysis of experimental data in drug discovery, Drug Discov. Today, 10, 653, 10.1016/S1359-6446(05)03420-3 Osada, 2005, Histone modification in the TGFbetaRII gene promoter and its significance for responsiveness to HDAC inhibitor in lung cancer cell lines, Mol. Carcinog., 44, 233, 10.1002/mc.20135 Patrawala, 2005, Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2− cancer cells are similarly tumorigenic, Cancer Res., 65, 6207, 10.1158/0008-5472.CAN-05-0592 Polyak, 2006, Pregnancy and breast cancer: The other side of the coin, Cancer Cell, 9, 151, 10.1016/j.ccr.2006.02.026 Polyak, 2006, Roots and stems: Stem cells in cancer, Nat. Med., 12, 296, 10.1038/nm1379 Polyak, 1994, Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals, Cell, 78, 59, 10.1016/0092-8674(94)90572-X Ponti, 2005, Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties, Cancer Res., 65, 5506, 10.1158/0008-5472.CAN-05-0626 Porter, 2003, Molecular markers in ductal carcinoma in situ of the breast, Mol. Cancer Res., 1, 362 Ramalho-Santos, 2002, “Stemness”: Transcriptional profiling of embryonic and adult stem cells, Science, 298, 597, 10.1126/science.1072530 Roberts, 2003, The two faces of transforming growth factor beta in carcinogenesis, Proc. Natl. Acad. Sci. USA, 100, 8621, 10.1073/pnas.1633291100 Russo, 2005, The protective role of pregnancy in breast cancer, Breast Cancer Res., 7, 131, 10.1186/bcr1029 Schedin, 2006, Pregnancy-associated breast cancer and metastasis, Nat. Rev. Cancer, 6, 281, 10.1038/nrc1839 Siegel, 2003, Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer, Nat. Rev. Cancer, 3, 807, 10.1038/nrc1208 Soreghan, 2005, Using proteomics and network analysis to elucidate the consequences of synaptic protein oxidation in a PS1 + AbetaPP mouse model of Alzheimer's disease, J. Alzheimers Dis., 8, 227, 10.3233/JAD-2005-8302 Sotiriou, 2006, Gene expression profiling in breast cancer: Understanding the molecular basis of histologic grade to improve prognosis, J. Natl. Cancer Inst., 98, 262, 10.1093/jnci/djj052 Stingl, 1998, Phenotypic and functional characterization in vitro of a multipotent epithelial cell present in the normal adult human breast, Differentiation, 63, 201, 10.1111/j.1432-0436.1998.00201.x Stingl, 2005, Epithelial progenitors in the normal human mammary gland, J. Mammary Gland Biol. Neoplasia, 10, 49, 10.1007/s10911-005-2540-7 van de Vijver, 2002, A gene-expression signature as a predictor of survival in breast cancer, N. Engl. J. Med., 347, 1999, 10.1056/NEJMoa021967 Wang, 2005, Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer, Lancet, 365, 671, 10.1016/S0140-6736(05)70933-8 Weissman, 2005, Normal and neoplastic stem cells, Novartis Found. Symp., 265, 35, 10.1002/0470091452.ch4 Wicha, 2006, Cancer stem cells: An old idea—A paradigm shift, Cancer Res., 66, 1883, 10.1158/0008-5472.CAN-05-3153 Zhang, 2004, Defective expression of transforming growth factor beta receptor type II is associated with CpG methylated promoter in primary non-small cell lung cancer, Clin. Cancer Res., 10, 2359, 10.1158/1078-0432.CCR-0959-3 Zhao, 1995, RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: Growth factor-stimulated kinase function and nuclear translocation, Mol. Cell. Biol., 15, 4353, 10.1128/MCB.15.8.4353 Zhao, 2005, CpG methylation at promoter site -140 inactivates TGFbeta2 receptor gene in prostate cancer, Cancer, 104, 44, 10.1002/cncr.21135