Acrylonitrile: a suspected human carcinogen

Internationales Archiv für Arbeitsmedizin - Tập 54 - Trang 317-324 - 1984
Willem Koerselman1, Maurits van der Graaf1
1Biological Science Shop, State University of Utrecht, AG Utrecht, The Netherlands

Tóm tắt

The literature on carcinogenicity of acrylonitrile (an important intermediate in the chemical industry) is reviewed. The three main conclusions are: (1) Acrylonitrile has genotoxic effects in various tests in microorganisms and in mammal cells. (2) Chronic exposure to acrylonitrile causes tumours in rats. (3) Results of epidemiological studies indicate that acrylonitrile may be a human carcinogen. From this it is clear that acrylonitrile is very probably carcinogenic to humans. Therefore the authors plead for a reduction of acrylonitrile standards to the lowest practicable limit.

Tài liệu tham khảo

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