Cerebrospinal fluid IL-1β is elevated in tuberculous meningitis patients but not associated with mortality

Wilkinson, 2017, Tuberculous meningitis, Nat Rev Neurol, 13, 581, 10.1038/nrneurol.2017.120 Prasad, 2016, Corticosteroids for managing tuberculous meningitis, Cochrane Database Syst Rev, 4, CD002244 van Laarhoven, 2019, Immune cell characteristics and cytokine responses in adult HIV-negative tuberculous meningitis: an observational cohort study, Sci Rep, 9, 884, 10.1038/s41598-018-36696-3 Marais, 2017, Inflammasome activation underlying central nervous system deterioration in HIV-associated tuberculosis, J Infect Dis, 215, 677 Fox, 2010, The serum and cerebrospinal fluid pharmacokinetics of anakinra after intravenous administration to non-human primates, J Neuroimmunol, 223, 138, 10.1016/j.jneuroim.2010.03.022 Sibley, 2012, Sustained response and prevention of damage progression in patients with neonatal-onset multisystem inflammatory disease treated with anakinra: a cohort study to determine three- and five-year outcomes, Arthritis Rheum, 64, 2375, 10.1002/art.34409 Michael, 2016, The interleukin-1 balance during encephalitis is associated with clinical severity, blood-brain barrier permeability, neuroimaging changes, and disease outcome, J Infect Dis, 213, 1651, 10.1093/infdis/jiv771 Thuong, 2017, Leukotriene A4 hydrolase genotype and HIV infection influence intracerebral inflammation and survival from tuberculous meningitis, J Infect Dis, 215, 1020, 10.1093/infdis/jix050 Sharma, 2017, Cytokines do play a role in pathogenesis of tuberculous meningitis: a prospective study from a tertiary care center in India, J Neurol Sci, 379, 131, 10.1016/j.jns.2017.06.001 van Laarhoven, 2017, Clinical parameters, routine inflammatory markers, and LTA4H genotype as predictors of mortality among 608 patients with tuberculous meningitis in Indonesia, J Infect Dis, 215, 1029, 10.1093/infdis/jix051 Rohlwink, 2019, Standardized approaches for clinical sampling and endpoint ascertainment in tuberculous meningitis studies, Wellcome Open Res, 4, 204, 10.12688/wellcomeopenres.15497.1 Assarsson, 2014, Homogenous 96-plex PEA immunoassay exhibiting high sensitivity, specificity, and excellent scalability, PloS One, 9, 10.1371/journal.pone.0095192 van Laarhoven, 2018, Cerebral tryptophan metabolism and outcome of tuberculous meningitis: an observational cohort study, Lancet Infect Dis, 18, 526, 10.1016/S1473-3099(18)30053-7 Võsa, 2018, Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis, bioRxiv, 447367 Keeley, 2020, Anakinra in the treatment of protracted paradoxical inflammatory reactions in HIV-associated tuberculosis in the United Kingdom: a report of two cases, Int J STD AIDS, 31, 808, 10.1177/0956462420915394 van Laarhoven, 2018, Cerebral tryptophan metabolism and outcome of tuberculous meningitis: an observational cohort study, Lancet Infect Dis, 10.1016/S1473-3099(18)30053-7