Interneurones are probably not involved in the presynaptic dopaminergic control of dopamine release in rabbit caudate nucleus

Rolf Jackisch1, Anton Zymstein1, Georg Hertting1, Klaus Starke1
1Pharmakologisches Institut, Universität Freiburg, Freiburg i. Br., Federal Republic of Germany

Tóm tắt

Slices of rabbit caudate nucleus were preincubated with 3H-dopamine and then superfused. The influence of apomorphine and haloperidol on the overflow of tritium evoked by 20 mmol/l potassium was investigated in the presence and in the absence of tetrodotoxin. The potassium-evoked overflow was largely calcium-dependent and consisted mainly of 3H-dopamine. The dopamine receptor agonist apomorphine 0.01–1.0 μmol/l reduced, whereas the antagonist haloperidol 0.1 μmol/l enhanced the potassium-evoked overflow of tritium. The effects of apomorphine and haloperidol were as pronounced in the presence as in the absence of tetrodotoxin 0.3 μmol/l. It is concluded that the presynaptic dopaminergic modulation of dopamine release is not mediated by a tetrodotoxin-sensitive interneuronal pathway.

Tài liệu tham khảo

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