Performance-driven, pulmonary delivery of systemically acting drugs

Drug Discovery Today: Technologies - Tập 2 - Trang 39-46 - 2005
Rita Vanbever1
1Université catholique de Louvain, School of Pharmacy, Department of Pharmaceutical Technology, UCL 73.20 avenue, E. Mounier 73, 1200 Brussels, Belgium

Tài liệu tham khảo

Nerbrink, 2003, A history of the development of therapy by jet nebulization, 1 Sangwan, 2001, Aerosolized protein delivery in asthma: gamma camera analysis of regional deposition and perfusion, J. Aerosol Med., 14, 185, 10.1089/08942680152484117 Valente, 2003, Recent advances in the development of an inhaled insulin product, BioDrugs, 17, 9, 10.2165/00063030-200317010-00002 Heinemann, 2001, Alternative routes of administration as an approach to improve insulin therapy: update on dermal, oral, nasal and pulmonary insulin delivery, Curr. Pharm. Des., 7, 1327, 10.2174/1381612013397384 Matsukawa, 1997, Size-dependent dextran transport across rat alveolar epithelial cell monolayers, J. Pharm. Sci., 86, 305, 10.1021/js960352x Hastings, 1992, Clearance of different-sized proteins from the alveolar space in humans and rabbits, J. Appl. Physiol., 73, 1310, 10.1152/jappl.1992.73.4.1310 Hinds, 1999 Adjei, 1990, Pulmonary delivery of peptide drugs: effect of particle size on bioavailability of leuprolide acetate in healthy male volunteers, Pharm. Res., 7, 565, 10.1023/A:1015853824722 Codrons, 2004, Impact of formulation and methods of pulmonary delivery on absorption of parathyroid hormone (1–34) from rat lungs, J. Pharm. Sci., 93, 1241, 10.1002/jps.20053 Colthorpe, 1995, The influence of regional deposition on the pharmacokinetics of pulmonary-delivered human growth hormone in rabbits, Pharm. Res., 12, 356, 10.1023/A:1016292232513 Pillai, 1996, The effect of pulmonary-delivered insulin on blood glucose levels using two nebulizer systems, J. Aerosol Med., 9, 227, 10.1089/jam.1996.9.227 Qi, 2004, Delivery of therapeutic levels of heparin and low-molecular-weight heparin through a pulmonary route, Proc. Natl. Acad. Sci. USA, 101, 9867, 10.1073/pnas.0402891101 Richards, 1988, Effect of methacholine induced bronchoconstriction on the pulmonary distribution and plasma pharmacokinetics of inhaled sodium cromoglycate in subjects with normal and hyperreactive airways, Thorax, 43, 611, 10.1136/thx.43.8.611 Martin, 1993, Diffusion and dissolution, 324 Patton, 1996, Mechanisms of macromolecule absorption by the lungs, Adv. Drug Deliv. Rev., 19, 3, 10.1016/0169-409X(95)00113-L Mathias, 1996, Respiratory epithelial cell culture models for evaluation of ion and drug transport, Adv. Drug Deliv. Rev., 22, 215, 10.1016/S0169-409X(96)00420-6 Oberdorster, 1986, Bronchial and alveolar absorption of inhaled 99mTc-DTPA, Am. Rev. Respir. Dis., 134, 944, 10.1164/arrd.1986.134.5.944 Schanker, 1986, Species comparison of drug absorption from the lung after aerosol inhalation or intratracheal injection, Drug Metab. Dispos., 14, 79 Moller, 2004, Mucociliary and long-term particle clearance in the airways of healthy nonsmoker subjects, J. Appl. Physiol., 97, 2200, 10.1152/japplphysiol.00970.2003 Dunbar, 1998, Dispersion and characterization of pharmaceutical dry powder aerosols, Kona, 16, 7, 10.14356/kona.1998007 Dunbar, 2002, In vitro and in vivo dose delivery characteristics of large porous particles for inhalation, Int. J. Pharm., 245, 179, 10.1016/S0378-5173(02)00349-6 Schuster, 1997, The AERX aerosol delivery system, Pharm. Res., 14, 354, 10.1023/A:1012058323754 Patton, 2004, Clinical pharmacokinetics and pharmacodynamics of inhaled insulin, Clin. Pharmacokinet., 43, 781, 10.2165/00003088-200443120-00002 Suarez, 2001, Facilitation of pulmonary insulin absorption by H-MAP: pharmacokinetics and pharmacodynamics in rats, Pharm. Res., 18, 1677, 10.1023/A:1013362227548 Milstein, 1998, Partially unfolded proteins efficiently penetrate cell membranes – implications for oral drug delivery, J. Control. Release, 53, 259, 10.1016/S0168-3659(97)00259-9 Garcia-Contreras, 2001, Immediate and short-term cellular and biochemical responses to pulmonary single-dose studies of insulin and H-MAP, Pharm. Res., 18, 1685, 10.1023/A:1013314311619 Pfutzner, 2002, Technosphere/insulin – a new approach for effective delivery of human insulin via the pulmonary route, Diabetes Technol. Ther., 4, 589, 10.1089/152091502320798204 Pfutzner, 2003, Pilot study with technosphere/PTH(1–34) – a new approach for effective pulmonary delivery of parathyroid hormone (1–34), Horm. Metab. Res., 35, 319, 10.1055/s-2003-41309 Bitonti, 2004, Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway, Proc. Natl. Acad. Sci. USA, 101, 9763, 10.1073/pnas.0403235101 Gumbleton, 2003, Targeting caveolae for vesicular drug transport, J. Control. Release, 87, 139, 10.1016/S0168-3659(02)00358-9 McIntosh, 2002, Targeting endothelium and its dynamic caveolae for tissue-specific transcytosis in vivo: a pathway to overcome cell barriers to drug and gene delivery, Proc. Natl. Acad. Sci. USA, 99, 1996, 10.1073/pnas.251662398 John, 2001, Evidence for the role of alveolar epithelial gp60 in active transalveolar albumin transport in the rat lung, J. Physiol., 533, 547, 10.1111/j.1469-7793.2001.0547a.x Tiruppathi, 2004, Albumin mediates the transcytosis of myeloperoxidase by means of caveolae in endothelial cells, Proc. Natl. Acad. Sci. USA, 101, 7699, 10.1073/pnas.0401712101 Lombry, 2004, Alveolar macrophages are a primary barrier to pulmonary absorption of macromolecules, Am. J. Physiol. Lung Cell Mol. Physiol., 286, L1002, 10.1152/ajplung.00260.2003 Kim, 2004, Net absorption of IgG via FcRn-mediated transcytosis across rat alveolar epithelial cell monolayers, Am. J. Physiol. Lung Cell Mol. Physiol., 287, L616, 10.1152/ajplung.00121.2004 Spiekermann, 2002, Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung, J. Exp. Med., 196, 303, 10.1084/jem.20020400 Leach, 2003, Modifying the pulmonary absorption and retention of proteins through PEGylation, Respir. Drug Deliv. IX, 1, 69 Niven, 1995, The pulmonary absorption of aerosolized and intratracheally instilled rhG-CSF and monoPEGylated rhG-CSF, Pharm. Res., 12, 1343, 10.1023/A:1016281925554 Batycky, R. et al. [Advanced Inhalation Research] (2004) Inhalable epinephrine. WO 2004/002551 A2 Simons, 2004, First-aid treatment of anaphylaxis to food: focus on epinephrine, J. Allergy Clin. Immunol., 113, 837 Duplay, D. et al. (2005) Physicians’ Desk Reference (59th edn) Thomson PDR Dershwitz, 2000, Pharmacokinetics and pharmacodynamics of inhaled versus intravenous morphine in healthy volunteers, Anesthesiology, 93, 619, 10.1097/00000542-200009000-00009 Claessens, P. et al. (2000) Compendium 2000 (18ème édition edn) Cefalu, 2004, Evolving strategies for insulin delivery and therapy, Drugs, 64, 1149, 10.2165/00003495-200464110-00001 Balwani, G. et al. [Aradigm Corporation] (2003) Compositions methods and systems for pulmonary delivery of recombinant human interferon alpha-2B. WO 03/102014 A2 Blizzard, C.D. et al. [Advanced Inhalation Research and Eli Lilly] (2003) Method for administration of growth hormone via pulmonary delivery. WO 03/079991 A2 Jackson, B. et al. [Advanced Inhalation Research] (2003) hGH (human growth hormone) formulations for pulmonary administration. WO 03/079993 A2 Bosquillon, 2004, Pulmonary delivery of growth hormone using dry powders and visualization of its local fate in rats, J. Control. Release, 96, 233, 10.1016/j.jconrel.2004.01.027 Welty-Wolf, 1997, Aerosolized manganese SOD decreases hyperoxic pulmonary injury in primates. II. Morphometric analysis, J. Appl. Physiol., 83, 559, 10.1152/jappl.1997.83.2.559 Lombry, 2005, Alveolar macrophages inhibit the immune response to pulmonary antigen delivery, J. Aerosol Med., 18, 114 Lombry, 2002, Confocal imaging of rat lungs following intratracheal delivery of dry powders or solutions of fluorescent probes, J. Control. Release, 83, 331, 10.1016/S0168-3659(02)00174-8 Hastings, 1995, Cellular uptake of albumin from lungs of anesthetized rabbits, Am. J. Physiol., 269, L453 Williams, 1984, Endocytosis in alveolar type II cells: effect of charge and size of tracers, Proc. Natl. Acad. Sci. USA, 81, 6054, 10.1073/pnas.81.19.6054