Molecular signatures define alopecia areata subtypes and transcriptional biomarkers

Alkhalifah, 2010, Alopecia areata update: part II. Treatment, J. Am. Acad. Dermatol., 62, 191, 10.1016/j.jaad.2009.10.031 Bertolini, 2014, Abnormal interactions between perifollicular mast cells and CD8+ T-cells may contribute to the pathogenesis of alopecia areata, PLoS ONE, 9, e94260, 10.1371/journal.pone.0094260 Betz, 2015, Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci, Nat. Commun., 6, 5966, 10.1038/ncomms6966 Bindea, 2013, Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer, Immunity, 39, 782, 10.1016/j.immuni.2013.10.003 Carroll, 2002, Gene array profiling and immunomodulation studies define a cell-mediated immune response underlying the pathogenesis of alopecia areata in a mouse model and humans, J. Investig. Dermatol., 119, 392, 10.1046/j.1523-1747.2002.01811.x Castellana, 2014, Macrophages contribute to the cyclic activation of adult hair follicle stem cells, PLoS Biol., 12, e1002002, 10.1371/journal.pbio.1002002 Chen, 2015, Master regulators of infiltrate recruitment in autoimmune disease identified through network-based molecular deconvolution, Cell Syst., 1, 326, 10.1016/j.cels.2015.11.001 Claudy, 1983, PUVA treatment of alopecia areata, Arch. Dermatol., 119, 975, 10.1001/archderm.1983.01650360021007 Craiglow, 2014, Killing two birds with one stone: oral tofacitinib reverses alopecia universalis in a patient with plaque psoriasis, J. Investig. Dermatol., 134, 2988, 10.1038/jid.2014.260 Elston, 1997, Eosinophils in fibrous tracts and near hair bulbs: a helpful diagnostic feature of alopecia areata, J. Am. Acad. Dermatol., 37, 101, 10.1016/S0190-9622(97)70219-6 Gilhar, 2012, Alopecia Areata, N. Engl. J. Med., 366, 1515, 10.1056/NEJMra1103442 Gregersen, 2009, Recent advances in the genetics of autoimmune disease, Annu. Rev. Immunol., 27, 363, 10.1146/annurev.immunol.021908.132653 Higgins, 2015, Use of ruxolitinib to successfully treat chronic mucocutaneous candidiasis caused by gain-of-function signal transducer and activator of transcription 1 (STAT1) mutation, J. Allergy Clin. Immunol., 135, 551, 10.1016/j.jaci.2014.12.1867 Ito, 2008, Maintenance of hair follicle immune privilege is linked to prevention of NK cell attack, J. Investig. Dermatol., 128, 1196, 10.1038/sj.jid.5701183 Ito, 2009, Combination therapy with oral PUVA and corticosteroid for recalcitrant alopecia areata, Arch. Dermatol. Res., 301, 373, 10.1007/s00403-009-0936-8 Jabbari, 2015, Reversal of alopecia areata following treatment with the JAK1/2 inhibitor baricitinib, EBioMedicine, 2, 351, 10.1016/j.ebiom.2015.02.015 Kaufman, 2010, An unexpected twist in alopecia areata pathogenesis: are NK cells protective and CD49b+ T cells pathogenic?, Exp. Dermatol., 19, e347, 10.1111/j.1600-0625.2010.01106.x McElwee, 2005, Transfer of CD8(+) cells induces localized hair loss whereas CD4(+)/CD25(−) cells promote systemic alopecia areata and CD4(+)/CD25(+) cells blockade disease onset in the C3H/HeJ mouse model, J. Investig. Dermatol., 124, 947, 10.1111/j.0022-202X.2005.23692.x Petukhova, 2010, Genome-wide association study in alopecia areata implicates both innate and adaptive immunity, Nature, 466, 113, 10.1038/nature09114 Pieri, 2015, Ruxolitinib-induced reversal of alopecia universalis in a patient with essential thrombocythemia, Am. J. Hematol., 90, 82, 10.1002/ajh.23871 Rashighi, 2014, CXCL10 is critical for the progression and maintenance of depigmentation in a mouse model of vitiligo, Sci. Transl. Med., 6, 10.1126/scitranslmed.3007811 Smyth, 2004, Linear models and empirical bayes methods for assessing differential expression in microarray experiments, Stat. Appl. Genet. Mol. Biol., 3, 10.2202/1544-6115.1027 Suárez-Fariñas, 2015, Alopecia areata profiling shows TH1, TH2, and IL-23 cytokine activation without parallel TH17/TH22 skewing, J. Allergy Clin. Immunol., 136, 1277, 10.1016/j.jaci.2015.06.032 Subramanya, 2010, Transcriptional profiling in alopecia areata defines immune and cell cycle control related genes within disease-specific signatures, Genomics, 96, 146, 10.1016/j.ygeno.2010.05.002 Whiting, 2003, Histopathologic features of alopecia areata: a new look, Arch. Dermatol., 139, 1555, 10.1001/archderm.139.12.1555 Whiting, 2003, Histopathologic features of alopecia areata, Arch. Dermatol., 139, 1555, 10.1001/archderm.139.12.1555 Xing, 2014, Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition, Nat. Med., 20, 1043, 10.1038/nm.3645