Imaging angiogenesis in atherosclerosis in large arteries with 68Ga-NODAGA-RGD PET/CT: relationship with clinical atherosclerotic cardiovascular disease

Springer Science and Business Media LLC - 2021
Matthieu Dietz1, Christel H. Kamani1, Emmanuel Deshayes2, Vincent Dunet3, Periklis Mitsakis1, George Coukos4, Marie Nicod Lalonde1, Niklaus Schaefer1, John O. Prior1
1Nuclear Medicine and Molecular Imaging Department, Lausanne University Hospital, Lausanne, Switzerland
2Nuclear Medicine Department, Montpellier Cancer Institute (ICM), University of Montpellier, Montpellier Cedex 5, France
3Department of Diagnostic and Interventional Radiology, Lausanne University Hospital, Lausanne, Switzerland
4Ludwig Institute for Cancer Research and Department of Oncology, Lausanne University Hospital, Lausanne, Switzerland

Tóm tắt

Integrin alpha-V-beta-3 (αvβ3) pathway is involved in intraplaque angiogenesis and inflammation and represents a promising target for molecular imaging in cardiovascular diseases such as atherosclerosis. The aim of this study was to assess the clinical correlates of arterial wall accumulation of 68Ga-NODAGA-RGD, a specific αvβ3 integrin ligand for PET. The data of 44 patients who underwent 68Ga-NODAGA-RGD PET/CT scans were retrospectively analyzed. Tracer accumulation in the vessel wall of major arteries was analyzed semi-quantitatively by blood-pool-corrected target-to-background ratios. Tracer uptake was compared with clinically documented atherosclerotic cardiovascular disease, cardiovascular risk factors and calcified plaque burden. Data were compared using the Mann–Whitney U test, Pearson correlation and Spearman correlation. 68Ga-NODAGA-RGD arterial uptake was significantly higher in patients with previous clinically documented atherosclerotic cardiovascular disease (mean TBR 2.44 [2.03–2.55] vs. 1.81 [1.56–1.96], p = 0.001) and showed a significant correlation with prior cardiovascular or cerebrovascular event (r = 0.33, p = 0.027), BMI (ρ = 0.38, p = 0.01), plaque burden (ρ = 0.31, p = 0.04) and hypercholesterolemia (r = 0.31, p = 0.04). 68Ga-NODAGA-RGD holds promise as a non-invasive marker of disease activity in atherosclerosis, providing information about intraplaque angiogenesis.

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