Genomic Studies Across the Lifespan Point to Early Mechanisms Determining Subcortical Volumes

Quentin Le Grand1, Claudia L. Satizabal2,3,4,5, Muralidharan Sargurupremraj1,2, Aniket Mishra1, Aicha Soumaré1, Alexandre Laurent6,7,8, Fabrice Crivello6,7,8, Ami Tsuchida6,7,8, Jean Shin9,10, Mélissa Macalli1, Baljeet Singh11, Alexa S. Beiser4,5,12, Charles DeCarli11, Evan Fletcher11, Tomas Paus13,14,15, Mark Lathrop16, Hieab H.H. Adams17,18, Joshua C. Bis19, Sudha Seshadri2,3,4,5, Christophe Tzourio1,20
1University of Bordeaux, INSERM, Bordeaux Population Health Center, UMR1219, Bordeaux, France
2Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, Texas
3Department of Population Health Sciences, UT Health San Antonio, San Antonio, Texas
4Framingham Heart Study, Framingham, Massachusetts
5Department of Neurology, Boston University School of Medicine, Boston, Massachusetts
6University of Bordeaux, Institute of Neurodegenerative Diseases, UMR5293, Neurofunctional imaging group, Bordeaux, France
7CNRS, Institute of Neurodegenerative Diseases, UMR5293, Neurofunctional imaging group, Bordeaux, France
8CEA, Institute of Neurodegenerative Diseases, UMR5293, Neurofunctional imaging group, Bordeaux, France
9Department of Physiology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
10Department of Nutritional Sciences, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
11Imaging of Dementia and Aging Laboratory, Department of Neurology, University of California Davis, Davis, California
12Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts
13Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
14Department of Psychology, University of Toronto, Toronto, Ontario, Canada
15Department of Psychiatry, Centre Hospitalier Universitaire Sainte-Justine, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada
16McGill Genome Center, McGill University, Montreal, Quebec, Canada
17Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
18Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
19Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington
20Bordeaux University Hospital, Department of Medical Informatics, Bordeaux, France

Tài liệu tham khảo

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