Activin A Stimulates Interleukin 8 and Vascular Endothelial Growth Factor Release From Cultured Human Endometrial Stromal Cells: Possible Implications for the Pathogenesis of Endometriosis

Jones KL, de Kretser DM, Patella S, Phillips DJ. Activin A and follistatin in systemic inflammation. Mol Cel Endoc. 2004; 225(1–2):119–125. Phillips DJ, de Kretser DM, Hedger MP. Activin and related proteins in inflammation: not just interested bystanders. Cytokine Growth Factor Rev. 2009;20(2):153–164. Bertolino P, Deckers M, Lebrin F, ten Dijke P. Transforming growth factor-beta signal transduction in angiogenesis and vascular disorders. Chest. 2005;128(6 suppl):585S–590S. Hedger MP, Winnall WR, Phillips DJ, de Kretser DM. The regulation and functions of activin and follistatin in inflammation and immunity. Vitam Horm. 2011;85:255–297. Yoshino O, Izumi G, Shi J, et al. Activin-A is induced by interleu-kin-1β and tumor necrosis factor-α and enhances the mRNA expression of interleukin-6 and protease-activated receptor-2 and proliferation of stromal cells from endometrioma. Fertil Steril. 2011;96(1):118–121. Florio P, Gabbanini M, Borges LE, et al. Activins and related proteins in the establishment of pregnancy. Reprod Sci. 2010;17(4): 320–330. Jones RL, Stoikos C, Findlay JK, Salomonsen LA. TGF-β super-family expression and actions in the endometrium and placenta. Reproduction. 2006;132(2):217–232. Salamonsen LA, Lathbury LJ. Endometrial leukocytes and menstruation. Hum Reprod Update. 2000;6(l):16–27. Harrison CA, Gray PC, Vale WW, Robertson DM. Antagonists of activin signaling: mechanisms and potencial biological applications. Trends Endocrinol Metabol. 2005;16(2):73–78. Leung PH, Salamonsen LA, Findlay JK. Immunolocalization of inhibin and activin subunits in human endometrium across the menstrual cycle. Hum Reprod. 1998;13(12):3469–3477. Jones RL, Salamonsen LA, Critchley HO, Rogers PA, Affandi B, Findlay JK. Inhibin and activin subunits are differentially expressed in endometrial cells and leukocytes during the menstrual cycle, in early pregnancy and in women using progestin-only contraception. Mol Hum Reprod. 2000;6(12): 1107–1117. Jones RL, Salamonsen LA, Findlay JK. Activin A promotes human endometrial stromal cell decidualization in vitro. J Clin Endocrinol Metab. 2002;87(8):4001–4004. Tierney EP, Giudice LC. Role of activin A as a mediator of in vitro endometrial stromal cell decidualization via the cyclic adenosine monophosphate pathway. Fertil Steril. 2004;81(suppl 1): 899–903. Carvalho L, Podgaec S, Bellodi-Privato M, Falcone T, Abraão MS. Role of eutopic endometrium in pelvic endometriosis. J Minim Invasive Gynecol. 2011;18(4):419–427. Giudice LC. Clinical practice. Endometriosis. N Engl J Med. 2010;362(25):2389–2398. Bulun SE. Endometriosis. N Engl J Med. 2009;360(3):268–279. Taylor RN, Yu J, Torres PB, et al. Mechanistic and therapeutic implications of angiogenesis in endometriosis. Reprod Sci. 2009;16(2):140–146. Yoshinaga K, Mimori K, Inoue H, et al. Activin A enhances MMP-7 activity via the transcriptional factor AP-1 in an esophageal squamous cell carcinoma cell line. Int J Oncol. 2008;33(3):453-459. Ogawa K, Funaba M, Mathews LS, Mizutani T. Activin A stimulates type IV collagenase (matrix metalloproteinase-2) production in mouse peritoneal macrophages. J Immunol. 2000;165(6): 2997–3003. Ferrari A, Petraglia F, Gurpide E. Corticotropin releasing factor decidualizes human endometrial stromal cells in vitro. Interaction with progestin. J Steroid Biochem Mol Biol. 1995;54(5–6): 251–255. Mangioni S, Vigano P, Florio P, et al. Effect of activin A on tumor necrosis factor-alpha/intercellular adhesion molecule-1 pathway in endometrial stromal cells. Eur J Obstet Gynecol Reprod Biol. 2005;123(2):218–223. Jones RL, Findlay JK, Farnworth PG, Robertson DM, Wallace E, Salamonsen LA. Activin A and inhibin A differentially regulate human uterine matrix metalloproteinases: potential interactions during decidualization and trophoblast invasion. Endocrinology. 2006;147(2):724–732. Florio P, Bruni L, Galleri L, et al. Evaluation of endometrial activin A secretion for prediction of pregnancy after intrauterine insemination. Fertil Steril. 2010;93(7):2316–2320. Reis FM, Nascimento LL, Tsigkou A, Ferreira MC, Luisi S, Petraglia F. Activin A and follistatin in menstrual blood: low concentrations in women with dysfunctional uterine bleeding. Reprod Sci. 2007;14(4):383–389. Koch AE, Volin MV, Woods JM, et al. Regulation of angiogenesis by the C-X-C chemokines interleukin-8 and epithelial neutrophil activating peptide 78 in the rheumatoid joint. Arthritis Rheum. 2001 ;44(l):31–40. Arici A. Local cytokines in endometrial tissue: the role of interleukin-8 in the pathogenesis of endometriosis. Ann N Y Acad Sci. 2002;955:101–109. Mueller MD, Vigne JL, Minchenko A, Lebovic DI, Leitman DC, Taylor RN. Regulation of vascular endothelial growth factor (VEGF) gene transcription by estrogen receptors alpha and beta. Proc Natl Acad Sci USA. 2000;97(20): 10972–10977. Li XF, Gregory J, Ahmed A. Immunolocalisation of vascular endothelial growth factor in human endometrium. Growth Factors. 1994;ll(4):277–282. Rocha AL, Carrarelli P, Novembri R, et al. Altered expression of activin, cripto, and follistatin in the endometrium of women with endometrioma. Fertil Steril. 2011;95(7):2241–2246. Giudice LC. Growth factors and growth modulators in human uterine endometrium: their potential relevance to reproductive medicine. Fertil Steril. 1994;61(1):1–17. Cohen T, Nahari D, Cerem LW, Neufeld G, Levi BZ. Interleukin 6 induces the expression of vascular endothelial growth factor. J Biol Chem. 1996;271(2):736–741. Keenan JA, Chen TT, Chadwell NL, Tony DS, Caudle MR. Interferon gamma(IFN-g) and interleukin-6 (IL-6) in peritoneal fluid and macrophage- conditioned media of women with endometriosis. Am J Reprod Immunol. 1994;32(3):180–183.