Infections and vaccinations preceding childhood Guillain-Barré syndrome: a prospective study
Tóm tắt
We performed a prospective, multicentre study in children with Guillain-Barré syndrome (GBS), diagnosed according to international criteria, to investigate the frequency and aetiology of antecedent diseases. All infections and vaccinations occurring within a 6-week period prior to the onset of GBS were documented. Stool cultures, standardised serological investigations and PCR analyses for 24 different infective agents were performed. Serological findings were regarded as significant if specific immunoglobulin (Ig)M or IgA antibodies were detected, if the IgM enzyme immunoassay or immunfluorescence assay findings were confirmed by immunoblot, if complement fixation test titres rose fourfold or if geometric titres were more than threefold higher than in uninfected control persons. Ninety-five children with GBS were included in the study over a 40-month period. Preceding events were reported in 82%. Microbiological studies carried out on 84 patients resulted in a probable diagnosis in 46 (55%). Coxsackieviruses (15%), Chlamydia pneumoniae (8%), cytomegalovirus (7%) and Mycoplasma pneumoniae (7%) were the most frequently involved agents. Serological evidence of a Campylobacter jejuni infection was found in six patients (7%). Eight children had been vaccinated during the 6 weeks preceding the onset of GBS; in six of these children concomitant infectious diseases were reported, and in one child the time between vaccination and GBS was extremely short. We conclude that, in contrast to adults, Campylobacter spp. does not seem to play a major role in childhood GBS in German-speaking countries. The aetiology of antecedent diseases is distributed over a wide spectrum of paediatric infectious diseases. Most of the children who had been vaccinated showed concomitant infectious diseases, thus obscuring the causative role for GBS.
Tài liệu tham khảo
Aldous MB, Grayston JT, Wang SP, Foy HM (1992) Seroepidemiology of Chlamydia pneumoniae TWAR infection in Seattle families, 1966–1979. J Infect Dis 166:646–649
Ang CW, Jacobs BC, Brandenburg AH, Laman JD, van der Meche FG, Osterhaus AD, van Doorn PA (2000) Cross-reactive antibodies against GM2 and CMV-infected fibroblasts in Guillain-Barre syndrome. Neurology 54:1453–1458
Asbury AK (2000) New concepts of Guillain-Barre syndrome. J Child Neurol 15:183–191
Asbury AK, Cornblath DR (1990) Assessment of current diagnostic criteria for Guillain-Barre syndrome. Ann Neurol 27[Suppl]:S21–S24
Baer W, Fricke G, Goossens H (1989) Distribution of serotypes and biotypes of thermophilic campylobacters in the Federal Republic of Germany: a comparison with other countries. Zentralbl Bakteriol 271:127–134
Blaser MJ, Duncan DJ (1984) Human serum antibody response to Campylobacter jejuni infection as measured in an enzyme-linked immunosorbent assay. Infect Immun 44:292–298
Dal Molin G, Longo B, Not T, Poli A, Campello C (2005) A population based seroepidemiological survey of Chlamydia pneumoniae infections in schoolchildren. J Clin Pathol 58:617–620
da Silveira CM, Salisbury DM, de Quadros CA (1997) Measles vaccination and Guillain-Barre syndrome. Lancet 349:14–16
Enders U, Karch H, Toyka KV, Michels M, Zielasek J, Pette M, Heesemann J, Hartung HP (1993) The spectrum of immune responses to Campylobacter jejuni and glycoconjugates in Guillain-Barre syndrome and in other neuroimmunological disorders. Ann Neurol 34:136–144
Foy HM, Kenny GE, Cooney MK, Allan ID (1979) Long-term epidemiology of infections with Mycoplasma pneumoniae. J Infect Dis 139:681–687
Goddard EA, Lastovica AJ, Argent AC (1997) Campylobacter 0:41 isolation in Guillain-Barre syndrome. Arch Dis Child 76:526–528
Godschalk PC, Heikema AP, Gilbert M, Komagamine T, Ang CW, Glerum J, Brochu D, Li J, Yuki N, Jacobs BC, van Belkum A, Endtz HP (2004) The crucial role of Campylobacter jejuni genes in anti-ganglioside antibody induction in Guillain-Barre syndrome. J Clin Invest 114:1659–1665
Gruenewald R, Ropper AH, Lior H, Chan J, Lee R, Molinaro VS (1991) Serologic evidence of Campylobacter jejuni/coli enteritis in patients with Guillain-Barre syndrome. Arch Neurol 48:1080–1082
Hadden RD, Karch H, Hartung HP, Zielasek J, Weissbrich B, Schubert J, Weishaupt A, Cornblath DR, Swan AV, Hughes RAC, Toyka KV, Plasma/Exchange Guillain Barré Syndrome Trial Group (2001) Preceding infections, immune factors, and outcome in Guillain-Barre syndrome. Neurology 56:758–765
Hahn AF (1998) Guillain-Barre syndrome. Lancet 352:635–641
Hughes RAC (1990) Guillain-Barre syndrome. Springer, Berlin Heidelberg New York
Hughes R, Rees J, Smeeton N, Winer J (1996) Vaccines and Guillain-Barre syndrome. Br Med J 312:1475–1476
Hung KL, Wang HS, Liou WY, Mak SC, Chi CS, Shen EY, Lin MI, Wang PJ, Shen YZ, Chang KP (1994) Guillain-Barre syndrome in children: a cooperative study in Taiwan. Brain Dev 16:204–208
Ismail EA, Shabani IS, Badawi M, Sanaa H, Madi S, Al-Tawari A, Nadi H, Zaki M, Al-saleh Q (1998) An epidemiologic, clinical, and therapeutic study of childhood Guillain-Barre syndrome in Kuwait: is it related to the oral polio vaccine? J Child Neurol 13:488–492
Jacobs BC, Rothbarth PH, van der Meche F, Herbrink P, Schmitz PI, de Klerk MA, van Doorn PA (1998) The spectrum of antecedent infections in Guillain-Barre syndrome: a case-control study. Neurology 51:1110–1115
Kendall EJ, Tanner EI (1982) Campylobacter enteritis in general practice. J Hyg (London) 88:155–163
Kinnunen E, Farkkila M, Hovi T, Juntunen J, Weckstrom P (1989) Incidence of Guillain-Barre syndrome during a nationwide oral poliovirus vaccine campaign. Neurology 39:1034–1036
Kogon A, Spigland I, Frothingham TE, Elveback L, Williams C, Hall CE, Fox JP (1969) The virus watch program: a continuing surveillance of viral infections in metropolitan New York families. VII. Observations on viral excretion, seroimmunity, intrafamilial spread and illness association in coxsackie and echovirus infections. Am J Epidemiol 89:51–61
Korinthenberg R, Schulte Moenting JS (1996) Natural history and treatment effects in Guillain-Barre syndrome: a multicentre study. Arch Dis Child 74:281–287
Lasky T, Terracciano GJ, Magder L, Koski CL, Ballesteros M, Nash D, Clark S, Haber P, Stolley PD, Schonberger LB, Chen RT (1998) The Guillain-Barre syndrome and the 1992–1993 and 1993–1994 influenza vaccines. N Engl J Med 339: 1797–1802
Liu GF, Wu ZL, Wu HS, Wang QY, Zhao-Ri GT, Wang CY, Liang ZX, Cui SL, Zheng JD (2003) A case-control study on children with Guillain-Barre syndrome in North China. Biomed Environ Sci 16: 105-111
Mauch H, Lütticken R, Gatermann S (2000) MIQ. German quality standards in microbiology – Qualitätsstandards in der mikrobiologisch-serologischen Diagnostik. Infektionen des Darmes. Urban & Fischer, München, Jena
Mead PS, Slutsker L, Dietz V, McCaig LF, Bresee JS, Shapiro C, Griffin PM, Tauxe RV (1999) Food-related illness and death in the United States. Emerg Infect Dis 5:607–625
Monto AS, Bryan ER, Rhodes LM (1974) The Tecumseh study of respiratory illness. VII. Further observations on the occurrence of respiratory syncytial virus and Mycoplasma pneumoniae infections. Am J Epidemiol 100:458–468
Mori M, Kuwabara S, Miyake M, Noda M, Kuroki H, Kanno H, Ogawara K, Hattori T (2000) Haemophilus influenzae infection and Guillain-Barre syndrome. Brain 123:2171–2178
Nachamkin I, Allos BM, Ho TW (2000) Campylobacter jejunI infection and association with Guillain-Barré syndrome. In: Nachamkin I, Blaser MJ (eds) Campylobacter, 2nd edn. ASM Press,Washington D.C.
Nachamkin I, Liu J, Li M, Ung H, Moran AP, Prendergast MM, Sheikh K (2002) Campylobacter jejuni from patients with Guillain-Barre syndrome preferentially expresses a GD(1a)-like epitope. Infect Immun 70:5299–5303
Ogawara K, Kuwabara S, Mori M, Hattori T, Koga M, Yuki N (2000) Axonal Guillain-Barre syndrome: relation to anti-ganglioside antibodies and Campylobacter jejuni infection in Japan. Ann Neurol 48:624–631
Patja A, Paunio M, Kinnunen E, Junttila O, Hovi T, Peltola H (2001) Risk of Guillain-Barre syndrome after measles-mumps-rubella vaccination. J Pediatr 138:250–254
Prendergast MM, Lastovica AJ, Moran AP (1998) Lipopolysaccharides from Campylobacter jejuni O:41 strains associated with Guillain-Barre syndrome exhibit mimicry of GM1 ganglioside. Infect Immun 66:3649–3655
Rantala H, Cherry JD, Shields WD, Uhari M (1994) Epidemiology of Guillain-Barre syndrome in children: relationship of oral polio vaccine administration to occurrence. J Pediatr 124:220–223
Rees JH, Soudain SE, Gregson NA, Hughes RA (1995) Campylobacter jejuni infection and Guillain-Barre syndrome. N Engl J Med 333:1374–1379
Rose NR, Hamilton RG, Detrick B (2002) Manual of clinical laboratory immunology, 6th edn. ASM Press, Washington D.C.
Safranek TJ, Lawrence DN, Kurland LT, Culver DH, Wiederholt WC, Hayner NS, Osterholm MT, O’Brien P, Hughes JM (1991) Reassessment of the association between Guillain-Barre syndrome and receipt of swine influenza vaccine in 1976–1977: results of a two-state study. Expert Neurology Group. Am J Epidemiol 133:940–951
Stratton KR, Howe CH Johnston RB (1994) Adverse events associated with childhood vaccines. Evidence bearing on causality. National Academy Press, Washington D.C., pp 19–33
Uhari M, Rantala H, Niemela M (1989) Cluster of childhood Guillain-Barre cases after an oral poliovaccine campaign. Lancet 2:440–441
Winer JB (2001) Guillain Barre syndrome. Mol Pathol 54:381–385
Winer JB, Hughes RA, Anderson MJ, Jones DM, Kangro H, Watkins RP (1988) A prospective study of acute idiopathic neuropathy. II. Antecedent events. J Neurol Neurosurg Psychiatry 51:613–618
Yow MD, White NH, Taber LH, Frank AL, Gruber WC, May RA, Norton HJ (1987) Acquisition of cytomegalovirus infection from birth to 10 years: a longitudinal serologic study. J Pediatr 110:37–42