Regulation of Keap1–Nrf2 signaling: The role of epigenetics

Current Opinion in Toxicology - Tập 1 - Trang 134-138 - 2016
David Cheng1, Renyi Wu1, Yue Guo1, Ah-Ng Tony Kong1
1Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA

Tài liệu tham khảo

Guo, 2015, Epigenetic regulation of Keap1-Nrf2 signaling, Free Radic Biol Med, 88, 337, 10.1016/j.freeradbiomed.2015.06.013 Suzuki, 2015, Molecular basis of the Keap1-Nrf2 system, Free Radic Biol Med, 88, 93, 10.1016/j.freeradbiomed.2015.06.006 Kobayashi, 2006, Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species, Adv Enzyme Regul, 46, 113, 10.1016/j.advenzreg.2006.01.007 Sporn, 2012, NRF2 and cancer: the good, the bad and the importance of context, Nat Rev Cancer, 12, 564, 10.1038/nrc3278 Wolffe, 1999, Epigenetics: regulation through repression, Science, 286, 481, 10.1126/science.286.5439.481 Jaenisch, 2003, Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals, Nat Genet, 33, 245, 10.1038/ng1089 Yu, 2010, Nrf2 expression is regulated by epigenetic mechanisms in prostate cancer of TRAMP mice, PLoS One, 5, e8579, 10.1371/journal.pone.0008579 Khor, 2014, Epigenetic DNA methylation of antioxidative stress regulator NRF2 in human prostate cancer, Cancer Prev Res, 7, 1186, 10.1158/1940-6207.CAPR-14-0127 Cheng, 2013, Gestational diabetes mellitus impairs Nrf2-mediated adaptive antioxidant defenses and redox signaling in fetal endothelial cells in utero, Diabetes, 62, 4088, 10.2337/db13-0169 Kang, 2014, Epigenetic modification of Nrf2 in 5-fluorouracil-resistant colon cancer cells: involvement of TET-dependent DNA demethylation, Cell Death Dis, 5, e1183, 10.1038/cddis.2014.149 Li, 2014, The polycomb group protein EZH2 inhibits lung cancer cell growth by repressing the transcription factor Nrf2, FEBS Lett, 588, 3000, 10.1016/j.febslet.2014.05.057 Chase, 2011, Aberrations of EZH2 in cancer, Clin Cancer Res, 17, 2613, 10.1158/1078-0432.CCR-10-2156 Mercado, 2011, Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress, Biochem Biophys Res Commun, 406, 292, 10.1016/j.bbrc.2011.02.035 Zhang, 2015, Low long non-coding RNA HOTAIR expression is associated with down-regulation of Nrf2 in the spermatozoa of patients with asthenozoospermia or oligoasthenozoospermia, Int J Clin Exp Pathol, 8, 14198 Ayers, 2015, miRNA influences in NRF2 pathway interactions within cancer models, J Nucleic Acids, 2015 Zhang, 2015, MicroRNAs: new players in cancer prevention targeting Nrf2, oxidative stress and inflammatory pathways, Curr Pharmacol Rep, 1, 21, 10.1007/s40495-014-0013-7 Narasimhan, 2012, Identification of novel microRNAs in post-transcriptional control of Nrf2 expression and redox homeostasis in neuronal, SH-SY5Y cells, PLoS One, 7, e51111, 10.1371/journal.pone.0051111 Yang, 2011, MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism, Breast Cancer Res Treat, 129, 983, 10.1007/s10549-011-1604-1 Singh, 2013, MicroRNA-93 regulates NRF2 expression and is associated with breast carcinogenesis, Carcinogenesis, 34, 1165, 10.1093/carcin/bgt026 Shah, 2013, Understanding the role of NRF2-regulated miRNAs in human malignancies, Oncotarget, 4, 1130, 10.18632/oncotarget.1181 Papp, 2012, The NRF2-related interactome and regulome contain multifunctional proteins and fine-tuned autoregulatory loops, FEBS Lett, 586, 1795, 10.1016/j.febslet.2012.05.016 Gao, 2016, miR-214 protects erythroid cells against oxidative stress by targeting ATF4 and EZH2, Free Radic Biol Med, 92, 39, 10.1016/j.freeradbiomed.2016.01.005 He, 2015, Lysine Methyltransferase SETD7 (SET7/9) Regulates ROS Signaling through mitochondria and NFE2L2/ARE pathway, Sci Rep, 5, 14368, 10.1038/srep14368 Barbano, 2013, Aberrant Keap1 methylation in breast cancer and association with clinicopathological features, Epigenetics, 8, 105, 10.4161/epi.23319 Hanada, 2012, Methylation of the KEAP1 gene promoter region in human colorectal cancer, BMC Cancer, 12, 66, 10.1186/1471-2407-12-66 Zhang, 2010, Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth, Mol Cancer Ther, 9, 336, 10.1158/1535-7163.MCT-09-0589 Ma, 2015, Functional role of NRF2 in cervical carcinogenesis, PLoS One, 10, e0133876, 10.1371/journal.pone.0133876 Wang, 2008, Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues, Biochem Biophys Res Commun, 373, 151, 10.1016/j.bbrc.2008.06.004 Wang, 2015, Hypermethylation of the Keap1 gene inactivates its function, promotes Nrf2 nuclear accumulation, and is involved in arsenite-induced human keratinocyte transformation, Free Radic Biol Med, 89, 209, 10.1016/j.freeradbiomed.2015.07.153 Liu, 2016, Genistein mediates the selective radiosensitizing effect in NSCLC A549 cells via inhibiting methylation of the keap1 gene promoter region, Oncotarget, 7, 27267, 10.18632/oncotarget.8403 Palsamy, 2012, Promoter demethylation of Keap1 gene in human diabetic cataractous lenses, Biochem Biophys Res Commun, 423, 542, 10.1016/j.bbrc.2012.05.164 Gao, 2015, Human agerelated cataracts: epigenetic suppression of the nuclear factor erythroid 2related factor 2mediated antioxidant system, Mol Med Rep, 11, 1442, 10.3892/mmr.2014.2849 Liu, 2014, Promoter DNA demethylation of Keap1 gene in diabetic cardiomyopathy, Int J Clin Exp Pathol, 7, 8756 Mishra, 2014, Epigenetic modifications of Keap1 regulate its interaction with the protective factor Nrf2 in the development of diabetic retinopathy, Invest Ophthalmol Vis Sci, 55, 7256, 10.1167/iovs.14-15193 Eades, 2011, miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells, J Biol Chem, 286, 40725, 10.1074/jbc.M111.275495 Wang, 2012, Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage, Free Radic Biol Med, 52, 928, 10.1016/j.freeradbiomed.2011.12.006 Abu-Alainin, 2016, UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis, J Pathol, 238, 423, 10.1002/path.4665