Effect of dietary nitrate on blood pressure, endothelial function, and insulin sensitivity in type 2 diabetes

Haffner, 1998, Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction, N. Engl. J. Med., 339, 229, 10.1056/NEJM199807233390404 Newman, 1993, Ankle-arm index as a marker of atherosclerosis in the Cardiovascular Health Study. Cardiovascular Heart Study (CHS) Collaborative Research Group, Circulation, 88, 837, 10.1161/01.CIR.88.3.837 Wannamethee, 1999, Nonfasting serum glucose and insulin concentrations and the risk of stroke, Stroke, 30, 1780, 10.1161/01.STR.30.9.1780 Almdal, 2004, The independent effect of type 2 diabetes mellitus on ischemic heart disease, stroke, and death: a population-based study of 13 000 men and women with 20 years of follow-up, Arch. Intern. Med, 164, 1422, 10.1001/archinte.164.13.1422 Chen, 2011, Cardiovascular outcomes in Framingham participants with diabetes: the importance of blood pressure, Hypertension, 57, 891, 10.1161/HYPERTENSIONAHA.110.162446 Ignarro, 1989, Endothelium-derived nitric oxide: actions and properties, FASEB J, 3, 31, 10.1096/fasebj.3.1.2642868 Woodman, 2006, Basal production of nitric oxide (NO) and non-NO vasodilators in the forearm microcirculation in type 2 diabetes: associations with blood pressure and HDL cholesterol, Diabetes Res. Clin. Pract, 71, 59, 10.1016/j.diabres.2005.05.008 Scherrer, 2000, Defective nitric oxide synthesis: a link between metabolic insulin resistance, sympathetic overactivity and cardiovascular morbidity, Eur. J. Endocrinol., 142, 315, 10.1530/eje.0.1420315 Morris, 1995, Responses of the skin microcirculation to acetylcholine and sodium nitroprusside in patients with NIDDM, Diabetologia, 38, 1337, 10.1007/BF00401767 Henry, 2004, Type 2 diabetes is associated with impaired endothelium-dependent, flow-mediated dilation, but impaired glucose metabolism is not: the Hoorn Study, Atherosclerosis, 174, 49, 10.1016/j.atherosclerosis.2004.01.002 Su, 2008, The relationship between endothelial dysfunction and oxidative stress in diabetes and prediabetes, Int. J. Clin. Pract., 62, 877, 10.1111/j.1742-1241.2008.01776.x Tan, 2002, Advanced glycation end products and endothelial dysfunction in type 2 diabetes, Diabetes Care, 25, 1055, 10.2337/diacare.25.6.1055 Bucala, 1991, Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes, J. Clin. Invest., 87, 432, 10.1172/JCI115014 Deshmukh, 2010, Nitric oxide increases cyclic GMP levels, AMP-activated protein kinase (AMPK)α1-specific activity and glucose transport in human skeletal muscle, Diabetologia, 53, 1142, 10.1007/s00125-010-1716-x Kingwell, 2002, Nitric oxide synthase inhibition reduces glucose uptake during exercise in individuals with type 2 diabetes more than in control subjects, Diabetes, 51, 2572, 10.2337/diabetes.51.8.2572 Steinberg, 1996, Obesity/insulin resistance is associated with endothelial dysfunction: implications for the syndrome of insulin resistance, J. Clin. Invest., 97, 2601, 10.1172/JCI118709 Sandeman, 1991, Microvascular vasodilatation in feet of newly diagnosed non-insulin dependent diabetic patients, BMJ, 302, 1122, 10.1136/bmj.302.6785.1122 Morris, 1996, Skin blood flow responses to the iontophoresis of acetylcholine and sodium nitroprusside in man: possible mechanisms, J. Physiol., 496, 531, 10.1113/jphysiol.1996.sp021704 Joshipura, 2001, The effect of fruit and vegetable intake on risk for coronary heart disease, Ann. Intern. Med., 134, 1106, 10.7326/0003-4819-134-12-200106190-00010 Joshipura, 1999, Fruit and vegetable intake in relation to risk of ischemic stroke, J. Am. Med. Assoc, 282, 1233, 10.1001/jama.282.13.1233 Carter, 2010, Fruit and vegetable intake and incidence of type 2 diabetes mellitus: systematic review and meta-analysis, Br. Med. J., 341, c4229, 10.1136/bmj.c4229 Lundberg, 2006, Cardioprotective effects of vegetables: is nitrate the answer?, Nitric Oxide, 15, 359, 10.1016/j.niox.2006.01.013 Carlstrom, 2010, Dietary inorganic nitrate reverses features of metabolic syndrome in endothelial nitric oxide synthase-deficient mice, Proc. Natl. Acad. Sci. USA, 107, 17716, 10.1073/pnas.1008872107 Gilchrist, 2010, Vegetables and diabetes: is nitrate the answer?, Br. Med. J, 341, 10.1136/bmj.c5306 Larsen, 2006, Effects of dietary nitrate on blood pressure in healthy volunteers, N. Engl. J. Med., 355, 2792, 10.1056/NEJMc062800 Webb, 2008, Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite, Hypertension, 51, 784, 10.1161/HYPERTENSIONAHA.107.103523 Kapil, 2010, Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO, Hypertension, 56, 274, 10.1161/HYPERTENSIONAHA.110.153536 Zhang, 1998, Generation of nitric oxide by a nitrite reductase activity of xanthine oxidase: a potential pathway for nitric oxide formation in the absence of nitric oxide synthase activity, Biochem. Biophys. Res. Commun., 249, 767, 10.1006/bbrc.1998.9226 Duncan, 1995, Chemical generation of nitric oxide in the mouth from the enterosalivary circulation of dietary nitrate, Nat. Med, 1, 546, 10.1038/nm0695-546 Gilchrist, 2010, Dietary nitrate—good or bad?, Nitric Oxide, 22, 104, 10.1016/j.niox.2009.10.005 ECETOC, 1988 Corretti, 2002, Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force, J. Am. Coll. Cardiol., 39, 257, 10.1016/S0735-1097(01)01746-6 Hannemann, 2002, Vascular function in women with previous gestational diabetes mellitus, J. Vasc. Res., 39, 311, 10.1159/000065543 Middlebrooke, 2006, Six months of aerobic exercise does not improve microvascular function in type 2 diabetes mellitus, Diabetologia, 49, 2263, 10.1007/s00125-006-0361-x DeFronzo, 1979, Glucose clamp technique: a method for quantifying insulin secretion and resistance, Am. J. Physiol., 237, E214 Muniyappa, 2008, Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage, Am. J. Physiol. Endocrinol. Metab., 294, E15, 10.1152/ajpendo.00645.2007 Harper, 1995, A comparison of the effects of low- and conventional-dose thiazide diuretic on insulin action in hypertensive patients with NIDDM, Diabetologia, 38, 853, 10.1007/s001250050363 Higuchi, 1999, Flow-injection spectrophotometric determination of nitrite and nitrate in biological samples, Anal. Sci., 15, 129, 10.2116/analsci.15.129 Bateman, 2002, Optimization of nitric oxide chemiluminescence operating conditions for measurement of plasma nitrite and nitrate, Clin. Chem., 48, 570, 10.1093/clinchem/48.3.570 Fotherby, 1993, Reproducibility of ambulatory and clinic blood pressure measurements in elderly hypertensive subjects, J. Hypertens., 11, 573, 10.1097/00004872-199305000-00014 Yan, 1994, Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins, J. Biol. Chem., 269, 9889, 10.1016/S0021-9258(17)36966-1 Golovchenko, 2000, Hyperinsulinemia enhances transcriptional activity of nuclear factor-κB induced by angiotensin II, hyperglycemia, and advanced glycosylation end products in vascular smooth muscle cells, Circ. Res., 87, 746, 10.1161/01.RES.87.9.746 Kawamura, 1994, Pathophysiological concentrations of glucose promote oxidative modification of low density lipoprotein by a superoxide-dependent pathway, J. Clin. Invest., 94, 771, 10.1172/JCI117396 Kenjale, 2011, Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease, J. Appl. Physiol., 110, 1582, 10.1152/japplphysiol.00071.2011 Kelly, 2013, Effects of short-term dietary nitrate supplementation on blood pressure, O2 uptake kinetics, and muscle and cognitive function in older adults, Am. J. Physiol. Regul. Integr. Comp. Physiol, 304, R73, 10.1152/ajpregu.00406.2012 Sobko, 2010, Dietary nitrate in Japanese traditional foods lowers diastolic blood pressure in healthy volunteers, Nitric Oxide, 22, 136, 10.1016/j.niox.2009.10.007 Lyons, 1997, Impaired nitric oxide-mediated vasodilatation and total body nitric oxide production in healthy old age, Clin. Sci., 93, 519, 10.1042/cs0930519 Svetkey, 1999, Effects of dietary patterns on blood pressure: subgroup analysis of the Dietary Approaches to Stop Hypertension (DASH) randomized clinical trial, Arch. Intern. Med., 159, 285, 10.1001/archinte.159.3.285 Bailey, 2010, Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans, J. Appl. Physiol., 109, 135, 10.1152/japplphysiol.00046.2010 Appel, 1997, A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group, N. Engl. J. Med., 336, 1117, 10.1056/NEJM199704173361601 Larsen, 2011, Dietary inorganic nitrate improves mitochondrial efficiency in humans, Cell Metab., 13, 149, 10.1016/j.cmet.2011.01.004 Zhen, 2008, Upregulation of endothelial and inducible nitric oxide synthase expression by reactive oxygen species, Am. J. Hypertens., 21, 28, 10.1038/ajh.2007.14 Vanhatalo, 2010, Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incremental exercise, Am. J. Physiol. Regul. Integr. Comp. Physiol, 299, R1121, 10.1152/ajpregu.00206.2010