Increased Oxidative Stress, Altered Trace Elements, and Macro-Minerals Are Associated with Female Obesity
Tóm tắt
Generally female individuals are more prone to obesity due to their lifestyle and physiology. However, female individuals have got little attention in this aspect. This pioneering study designed to find the level of serum malondialdehyde (MDA), non-enzymatic antioxidant (vitamin C), other trace elements (zinc and iron), and macro-minerals (sodium, potassium, and calcium) for female obesity determining its role and action in disease diagnosis along with propagation. For this prospective case-control study, 70 female obese and 70 healthy individuals were evaluated. Serum lipid peroxidation product malondialdehyde (MDA) concentration was measured to determine the level of lipid peroxidation. UV spectrophotometric method was implemented for vitamin C concentration to measure serum ascorbic acid. Atomic absorption spectroscopy (AAS) was implemented to determine serum macro-minerals (Na, K, and Ca), and trace elements (Zn and Fe) were estimated. For statistical analysis, student’s t-test and Pearson’s correlation test were executed. A significantly higher concentration of serum MDA (p < 0.001) and low concentration of antioxidants (vitamin C) (p < 0.001) are observed in patient than control group. We found a lower concentration of trace elements (zinc, iron) and macro-minerals (sodium, potassium, and calcium) in patients compared to control except sodium. The mean concentrations for serum Zn, Fe, Na, K, and Ca were 0.34 ± 0.01, 0.25 ± 0.01, 3828.91 ± 205.09, 90.42 ± 6.45, and 43.04 ± 2.38 mg/L and 0.78 ± 0.08, 0.84 ± 0.08, 2600.97 ± 99.79, 223.79 ± 14.64, and 86.43 ± 2.78 mg/L, respectively, for female obese patients and control subjects (p < 0.001). We can suggest from our study that there is a strong association of female obesity with increased serum concentrations of MDA and reduced non-enzymatic antioxidant vitamin C and different serum trace metals and macro-minerals.
Tài liệu tham khảo
James WPT (2008) The epidemiology of obesity: the size of the problem. J Intern Med 263:336–352
Organization WH (2015) World health statistics 2015. World Health Organization
Kelly T, Yang W, Chen C-S et al (2008) Global burden of obesity in 2005 and projections to 2030. Int J Obes 32:1431
Hickner J (2017) Is obesity a disease? J Fam Pract 66:596–597
Jeffery RW, Utter J (2003) The changing environment and population obesity in the United States. Obes Res 11:12S–22S
Vincent HK, Taylor AG (2006) Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans. Int J Obes 30:400
Zhou T, Prather E, Garrison D, Zuo L (2018) Interplay between ROS and antioxidants during ischemia-reperfusion injuries in cardiac and skeletal muscle. Int J Mol Sci 19:417
Furukawa S, Fujita T, Shimabukuro M et al (2017) Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 114:1752–1761
Kris-Etherton PM, Lichtenstein AH, Howard BV, Steinberg D, Witztum JL, Nutrition Committee of the American Heart Association Council on Nutrition, Physical Activity, and Metabolism (2004) Antioxidant vitamin supplements and cardiovascular disease. Circulation 110:637–641
Farsani GM, Targhi FZ, Pishgahroudsari M et al (2015) High prevalence of zinc deficiency in Iranian morbid obese patients undergoing bariatric surgery. J Minim Invasive Surg Sci 4
Means RT (2004) Hepcidin and cytokines in anaemia. Hematology 9:357–362
Afridi HI, Kazi TG, Kazi N et al (2008) Potassium, calcium, magnesium, and sodium levels in biological samples of hypertensive and nonhypertensive diabetes mellitus patients. Biol Trace Elem Res 124:206
Zemel MB (2002) Regulation of adiposity and obesity risk by dietary calcium: mechanisms and implications. J Am Coll Nutr 21:146S–151S
Zemel MB, Sun X (2008) Dietary calcium and dairy products modulate oxidative and inflammatory stress in mice and humans. J Nutr 138:1047–1052
Sarwar MS, Sarkar RC, Bhowmick R, Dewan SM, Ahmed MU, Hasnat A, Rashid M, Islam MS (2015) Effect of socio-economic status and estimation of lipid peroxidation and antioxidant in preeclamptic pregnant women: a case–control study. Hypertens pregnancy 34:125–135
Nahar Z, Sarwar MS, Islam MS et al (2013) Determination of serum antioxidant vitamins, glutathione and MDA levels in panic disorder patients. Drug Res (Stuttg) 63:424–428
Amin MN, Liza KF, Sarwar MS, Ahmed J, Adnan MT, Chowdhury MI, Hossain MZ, Islam MS (2015) Effect of lipid peroxidation, antioxidants, macro minerals and trace elements on eczema. Arch Dermatol Res 307:617–623
Yanovski SZ, Yanovski JA (2002) Obesity. N Engl J Med 346:591–602. https://doi.org/10.1056/NEJMra012586
Yumuk V, Tsigos C, Fried M, Schindler K, Busetto L, Micic D, Toplak H, Obesity Management Task Force of the European Association for the Study of Obesity (2015) European guidelines for obesity management in adults. Obes Facts 8:402–424
Westerbacka J, Corner A, Tiikkainen M et al (2004) Women and men have similar amounts of liver and intra-abdominal fat, despite more subcutaneous fat in women: implications for sex differences in markers of cardiovascular risk. Diabetologia 47:1360–1369
Maslov LN, Naryzhnaya NV, Boshchenko AA et al (2018) Is oxidative stress of adipocytes a cause or a consequence of the metabolic syndrome? J Clin Transl Endocrinol
Chen L-F, Tian Y-F, Lin C-H et al (2014) Repetitive hyperbaric oxygen therapy provides better effects on brain inflammation and oxidative damage in rats with focal cerebral ischemia. J Formos Med Assoc 113:620–628
Marseglia L, Manti S, D’Angelo G et al (2015) Oxidative stress in obesity: a critical component in human diseases. Int J Mol Sci 16:378–400
Fernández-Sánchez A, Madrigal-Santillán E, Bautista M, Esquivel-Soto J, Morales-González A, Esquivel-Chirino C, Durante-Montiel I, Sánchez-Rivera G, Valadez-Vega C, Morales-González JA (2011) Inflammation, oxidative stress, and obesity. Int J Mol Sci 12:3117–3132
Garcia-Diaz DF, Lopez-Legarrea P, Quintero P, Martinez JA (2014) Vitamin C in the treatment and/or prevention of obesity. J Nutr Sci Vitaminol (Tokyo) 60:367–379
Hartwich J, Goralska J, Siedlecka D et al (2007) Effect of supplementation with vitamin E and C on plasma hsCRP level and cobalt–albumin binding score as markers of plasma oxidative stress in obesity. Genes & nutrition. Springer, In, pp 151–154
Zuo L, Zhou T, Pannell BK, Ziegler AC, Best TM (2015) Biological and physiological role of reactive oxygen species–the good, the bad and the ugly. Acta Physiol 214:329–348
Uddin MG, Hossain MS, Rahman MA, Uddin AHMM, Bhuiyan MS (2017) Elemental zinc is inversely associated with C-reactive protein and oxidative stress in chronic liver disease. Biol Trace Elem Res 178:189–193
Niki E (2009) Lipid peroxidation: physiological levels and dual biological effects. Free Radic Biol Med 47:469–484
Fraga CG, Shigenaga MK, Park J-W et al (1990) Oxidative damage to DNA during aging: 8-hydroxy-2′-deoxyguanosine in rat organ DNA and urine. Proc Natl Acad Sci 87:4533–4537
Selvakumar C, Maheshwari U (2012) Oxidant-Antioxidant disturbance in men classified as obese according to the preliminary WHO guidelines for Asians. J Stress Physiol Biochem:8
Matés JM, Pérez-Gómez C, De Castro IN (1999) Antioxidant enzymes and human diseases. Clin Biochem 32:595–603
Hegde ML, Shanmugavelu P, Vengamma B, Rao TS, Menon RB, Rao RV, Rao KS (2004) Serum trace element levels and the complexity of inter-element relations in patients with Parkinson’s disease. J Trace Elem Med Biol 18:163–171
García OP, Long KZ, Rosado JL (2009) Impact of micronutrient deficiencies on obesity. Nutr Rev 67:559–572
Yerlikaya FH, Toker A, Arıbaş A (2013) Serum trace elements in obese women with or without diabetes. Indian J Med Res 137:339
Plum LM, Rink L, Haase H (2010) The essential toxin: impact of zinc on human health. Int J Environ Res Public Health 7:1342–1365
Kinlaw WB, Levine AS, Morley JE, Silvis SE, McClain C (1983) Abnormal zinc metabolism in type II diabetes mellitus. Am J Med 75:273–277
do Nascimento Marreiro D, Fisberg M, SMF C (2004) Zinc nutritional status and its relationships with hyperinsulinemia in obese children and adolescents. Biol Trace Elem Res 100:137–149
Ahluwalia N, Sun J, Krause D, Mastro A, Handte G (2004) Immune function is impaired in iron-deficient, homebound, older women. Am J Clin Nutr 79:516–521
Arredondo M, Núñez MT (2005) Iron and copper metabolism. Mol Asp Med 26:313–327
Nemeth E, Ganz T (2009) The role of hepcidin in iron metabolism. Acta Haematol 122:78–86
Andrews NC (2004) Anemia of inflammation: the cytokine-hepcidin link. J Clin Invest 113:1251–1253
Adnan MT, Amin MN, Uddin MG et al (2019) Increased concentration of serum MDA, decreased antioxidants and altered trace elements and macro-minerals are linked to obesity among Bangladeshi population. Diabetes Metab Syndr Clin Res Rev 13:933–938
Soetan KO, Olaiya CO, Oyewole OE (2010) The importance of mineral elements for humans, domestic animals and plants-a review. Afr J Food Sci 4:200–222
Stella SY, Kansagra SM (2014) Associations of sodium intake with obesity, body mass index, waist circumference, and weight. Am J Prev Med 46:e53–e55
Rowe JW, Tobin JD, Rosa RM, Andres R (1980) Effect of experimental potassium deficiency on glucose and insulin metabolism. Metabolism 29:498–502
Teramoto T, Kawamori R, Miyazaki S, Teramukai S (2011) Sodium intake in men and potassium intake in women determine the prevalence of metabolic syndrome in Japanese hypertensive patients: OMEGA study. Hypertens Res 34:957
Cai X, Li X, Fan W et al (2016) Potassium and obesity/metabolic syndrome: a systematic review and meta-analysis of the epidemiological evidence. Nutrients 8:183
Bowman SA, Vinyard BT (2004) Fast food consumption of US adults: impact on energy and nutrient intakes and overweight status. J Am Coll Nutr 23:163–168
Melander O, Groop L, Hulthén UL (2000) Effect of salt on insulin sensitivity differs according to gender and degree of salt sensitivity. Hypertension 35:827–831
Hu G, Qiao Q, Tuomilehto J (2002) Nonhypertensive cardiac effects of a high salt diet. Curr Hypertens Rep 4:13–17
Davies KM, Heaney RP, Recker RR, Lappe JM, Barger-Lux MJ, Rafferty K, Hinders S (2000) Calcium intake and body weight. J Clin Endocrinol Metab 85:4635–4638
Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Jones G, Kovacs CS, Mayne ST, Rosen CJ, Shapses SA (2011) The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab 96:53–58
Zemel MB (2001) Calcium modulation of hypertension and obesity: mechanisms and implications. J Am Coll Nutr 20:428S–435S
Goodarzi MO (2018) Genetics of obesity: what genetic association studies have taught us about the biology of obesity and its complications. Lancet Diabetes Endocrinol 6:223–236