MicroRNA-24 aggravates atherosclerosis by inhibiting selective lipid uptake from HDL cholesterol via the post-transcriptional repression of scavenger receptor class B type I

Song, 2017, Effect of circular ANRIL on the inflammatory response of vascular endothelial cells in a rat model of coronary atherosclerosis, Cell. Physiol. Biochem., 42, 1202, 10.1159/000478918 Sattler, 2014, HDL-bound sphingosine 1-phosphate (S1P) predicts the severity of coronary artery atherosclerosis, Cell. Physiol. Biochem., 34, 172, 10.1159/000362993 Rader, 2012, The not-so-simple HDL story: is it time to revise the HDL cholesterol hypothesis?, Nat. Med., 18, 1344, 10.1038/nm.2937 Haase, 2012, LCAT, HDL cholesterol and ischemic cardiovascular disease: a Mendelian randomization study of HDL cholesterol in 54,500 individuals, J. Clin. Endocrinol. Metab., 97, E248, 10.1210/jc.2011-1846 Mo, 2016, A high-density lipoprotein-mediated drug delivery system, Adv. Drug Deliv. Rev., 106, 132, 10.1016/j.addr.2016.04.030 Acton, 1996, Identification of scavenger receptor SR-BI as a high density lipoprotein receptor, Science, 271, 518, 10.1126/science.271.5248.518 Wang, 1998, Liver-specific overexpression of scavenger receptor BI decreases levels of very low density lipoprotein ApoB, low density lipoprotein ApoB, and high density lipoprotein in transgenic mice, J. Biol. Chem., 273, 32920, 10.1074/jbc.273.49.32920 Varban, 1998, Targeted mutation reveals a central role for SR-BI in hepatic selective uptake of high density lipoprotein cholesterol, Proc. Natl. Acad. Sci. U. S. A., 95, 4619, 10.1073/pnas.95.8.4619 Ueda, 2000, Relationship between expression levels and atherogenesis in scavenger receptor class B, type I transgenics, J. Biol. Chem., 275, 20368, 10.1074/jbc.M000730200 Van Eck, 2003, Differential effects of scavenger receptor BI deficiency on lipid metabolism in cells of the arterial wall and in the liver, J. Biol. Chem., 278, 23699, 10.1074/jbc.M211233200 Matveev, 1999, Co-expression of scavenger receptor-BI and caveolin-1 is associated with enhanced selective cholesteryl ester uptake in THP-1 macrophages, J. Lipid Res., 40, 1647, 10.1016/S0022-2275(20)33410-6 Van Eck, 2004, Dual role for scavenger receptor class B, type I on bone marrow-derived cells in atherosclerotic lesion development, Am. J. Pathol., 165, 785, 10.1016/S0002-9440(10)63341-X Chen, 2016, Regulation of miR-24 on vascular endothelial cell function and its role in the development of cardiovascular disease, Sheng Li Xue Bao, 68, 201 Vickers, 2011, MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins, Nat. Cell Biol., 13, 423, 10.1038/ncb2210 Ng, 2014, Inhibition of microRNA-24 expression in liver prevents hepatic lipid accumulation and hyperlipidemia, Hepatology, 60, 554, 10.1002/hep.27153 He, 2014, MicroRNA-590 attenuates lipid accumulation and pro-inflammatory cytokine secretion by targeting lipoprotein lipase gene in human THP-1 macrophages, Biochimie, 106, 81, 10.1016/j.biochi.2014.08.003 Ren, 2017, TGF-beta down-regulates apolipoprotein M expression through the TAK-1-JNK-c-Jun pathway in HepG2 cells, Lipids, 52, 109, 10.1007/s11745-016-4227-9 Pittman, 1986, Methods for assessment of tissue sites of lipoprotein degradation, Methods Enzymol., 129, 612, 10.1016/0076-6879(86)29094-1 Rinninger, 1994, Selective uptake of high-density lipoprotein-associated cholesteryl esters by human hepatocytes in primary culture, Hepatology, 19, 1100 Hu, 2016, VNN1 promotes atherosclerosis progression in apoE-/- mice fed a high-fat/high-cholesterol diet, J. Lipid Res., 57, 1398, 10.1194/jlr.M065565 O, 1993, Effects of fasting on phosphatidylcholine biosynthesis in hamster liver: regulation of cholinephosphotransferase activity by endogenous argininosuccinate, Biochem. J., 289, 727, 10.1042/bj2890727 Tang, 2012, PAPP-A negatively regulates ABCA1, ABCG1 and SR-B1 expression by inhibiting LXRalpha through the IGF-I-mediated signaling pathway, Atherosclerosis, 222, 344, 10.1016/j.atherosclerosis.2012.03.005 Zhang, 2012, An involvement of SR-B1 mediated PI3K-Akt-eNOS signaling in HDL-induced cyclooxygenase 2 expression and prostacyclin production in endothelial cells, Biochem. Biophys. Res. Commun., 420, 17, 10.1016/j.bbrc.2012.02.103 Ren, 2017, ApoA-I/SR-BI modulates S1P/S1PR2-mediated inflammation through the PI3K/Akt signaling pathway in HUVECs, J. Physiol. Biochem., 73, 287, 10.1007/s13105-017-0553-5 Jiang, 2017, Leonurine prevents atherosclerosis via promoting the expression of ABCA1 and ABCG1 in a ppargamma/lxralpha signaling pathway-dependent manner, Cell. Physiol. Biochem., 43, 1, 10.1159/000484031 Ioriya, 2002, Effect of SMP-500, a novel ACAT inhibitor, on hepatic cholesterol disposition in rats, Lipids, 37, 395, 10.1007/s1145-002-0907-1 Lv, 2014, MicroRNA-19b promotes macrophage cholesterol accumulation and aortic atherosclerosis by targeting ATP-binding cassette transporter A1, Atherosclerosis, 236, 215, 10.1016/j.atherosclerosis.2014.07.005 Ceolotto, 2017, miR-30c–5p regulates macrophage-mediated inflammation and pro-atherosclerosis pathways, Cardiovasc. Res., 113, 1627, 10.1093/cvr/cvx157 Chen, 2017, MircroRNA-19a promotes vascular inflammation and foam cell formation by targeting HBP-1 in atherogenesis, Sci. Rep., 7, 12089, 10.1038/s41598-017-12167-z Out, 2004, Scavenger receptor class B type I is solely responsible for the selective uptake of cholesteryl esters from HDL by the liver and the adrenals in mice, J. Lipid Res., 45, 2088, 10.1194/jlr.M400191-JLR200 Brundert, 2005, Scavenger receptor class B type I mediates the selective uptake of high-density lipoprotein-associated cholesteryl ester by the liver in mice, Arterioscler. Thromb. Vasc. Biol., 25, 143, 10.1161/01.ATV.0000149381.16166.c6 Huszar, 2000, Increased LDL cholesterol and atherosclerosis in LDL receptor-deficient mice with attenuated expression of scavenger receptor B1, Arterioscler. Thromb. Vasc. Biol., 20, 1068, 10.1161/01.ATV.20.4.1068 Ji, 2011, Scavenger receptor SR-BI in macrophage lipid metabolism, Atherosclerosis, 217, 106, 10.1016/j.atherosclerosis.2011.03.017 Yang, 2014, GABA and topiramate inhibit the formation of human macrophage-derived foam cells by modulating cholesterol-metabolism-associated molecules, Cell. Physiol. Biochem., 33, 1117, 10.1159/000358681 Zhang, 2003, Inactivation of macrophage scavenger receptor class B type I promotes atherosclerotic lesion development in apolipoprotein E-deficient mice, Circulation, 108, 2258, 10.1161/01.CIR.0000093189.97429.9D Ahras, 2008, Scavenger receptor class B type I localizes to a late endosomal compartment, J. Lipid Res., 49, 1569, 10.1194/jlr.M800055-JLR200 Zhang, 2014, MicroRNA-27a/b regulates cellular cholesterol efflux, influx and esterification/hydrolysis in THP-1 macrophages, Atherosclerosis, 234, 54, 10.1016/j.atherosclerosis.2014.02.008 Xie, 2016, MicroRNA-27 prevents atherosclerosis by suppressing lipoprotein lipase-induced lipid accumulation and inflammatory response in apolipoprotein E knockout mice, PLoS One, 11 Lv, 2015, Diosgenin inhibits atherosclerosis via suppressing the MiR-19b-induced downregulation of ATP-binding cassette transporter A1, Atherosclerosis, 240, 80, 10.1016/j.atherosclerosis.2015.02.044 Treguier, 2004, Transcription factor sterol regulatory element binding protein 2 regulates scavenger receptor Cla-1 gene expression, Arterioscler. Thromb. Vasc. Biol., 24, 2358, 10.1161/01.ATV.0000147896.69299.85 Rhainds, 2003, The role of human and mouse hepatic scavenger receptor class B type I (SR-BI) in the selective uptake of low-density lipoprotein-cholesteryl esters, Biochemistry, 42, 7527, 10.1021/bi026949a