TRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses

Ahn, 2014, Self-DNA, STING-dependent signaling and the origins of autoinflammatory disease, Curr. Opin. Immunol., 31, 121, 10.1016/j.coi.2014.10.009 Bell, 2012, TRIM16 acts as an E3 ubiquitin ligase and can heterodimerize with other TRIM family members, PLoS ONE, 7, e37470, 10.1371/journal.pone.0037470 Boyle, 2013, The role of ‘eat-me’ signals and autophagy cargo receptors in innate immunity, Curr. Opin. Microbiol., 16, 339, 10.1016/j.mib.2013.03.010 Chan, 2016, Viral evasion of intracellular DNA and RNA sensing, Nat. Rev. Microbiol., 14, 360, 10.1038/nrmicro.2016.45 Chen, 2009, Nonproteolytic functions of ubiquitin in cell signaling, Mol. Cell, 33, 275, 10.1016/j.molcel.2009.01.014 Dai, 2014, Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway, PLoS Pathog., 10, e1003989, 10.1371/journal.ppat.1003989 Ding, 2008, Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome, Autophagy, 4, 141, 10.4161/auto.5190 Finley, 2009, Recognition and processing of ubiquitin-protein conjugates by the proteasome, Annu. Rev. Biochem., 78, 477, 10.1146/annurev.biochem.78.081507.101607 Gao, 2015, Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases, Proc. Natl. Acad. Sci. USA, 112, E5699, 10.1073/pnas.1516465112 Gao, 2013, Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses, Science, 341, 903, 10.1126/science.1240933 Gao, 2013, Cyclic [G(2′,5′)pA(3′,5′)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase, Cell, 153, 1094, 10.1016/j.cell.2013.04.046 Hansen, 2014, Listeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathway, EMBO J., 33, 1654, 10.15252/embj.201488029 Herzner, 2015, Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA, Nat. Immunol., 16, 1025, 10.1038/ni.3267 Isogai, 2011, Crystal structure of the ubiquitin-associated (UBA) domain of p62 and its interaction with ubiquitin, J. Biol. Chem., 286, 31864, 10.1074/jbc.M111.259630 Jing, 2015, Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca2+ influx, Nat. Cell Biol., 17, 1339, 10.1038/ncb3234 Kawai, 2011, Toll-like receptors and their crosstalk with other innate receptors in infection and immunity, Immunity, 34, 637, 10.1016/j.immuni.2011.05.006 Kirkin, 2009, A role for ubiquitin in selective autophagy, Mol. Cell, 34, 259, 10.1016/j.molcel.2009.04.026 Korolchuk, 2009, Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates, Mol. Cell, 33, 517, 10.1016/j.molcel.2009.01.021 Kuma, 2007, LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: caution in the interpretation of LC3 localization, Autophagy, 3, 323, 10.4161/auto.4012 Lahaye, 2013, The capsids of HIV-1 and HIV-2 determine immune detection of the viral cDNA by the innate sensor cGAS in dendritic cells, Immunity, 39, 1132, 10.1016/j.immuni.2013.11.002 Lam, 2014, Adenovirus detection by the cGAS/STING/TBK1 DNA sensing cascade, J. Virol., 88, 974, 10.1128/JVI.02702-13 Lee, 2010, Enhancement of proteasome activity by a small-molecule inhibitor of USP14, Nature, 467, 179, 10.1038/nature09299 Li, 2013, Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization, Immunity, 39, 1019, 10.1016/j.immuni.2013.10.019 Li, 2013, Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects, Science, 341, 1390, 10.1126/science.1244040 Liang, 2014, Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responses, Cell Host Microbe, 15, 228, 10.1016/j.chom.2014.01.009 Liu, 2016, Post-Translational Modification Control of Innate Immunity, Immunity, 45, 15, 10.1016/j.immuni.2016.06.020 Liu, 2015, A selective autophagy pathway takes an unconventional route, Autophagy, 11, 2381, 10.1080/15548627.2015.1110669 Liu, 2014, Activated STING in a vascular and pulmonary syndrome, N. Engl. J. Med., 371, 507, 10.1056/NEJMoa1312625 Ma, 2013, Autophagy and cellular immune responses, Immunity, 39, 211, 10.1016/j.immuni.2013.07.017 Meng, 2015, Reversible ubiquitination shapes NLRC5 function and modulates NF-κB activation switch, J. Cell Biol., 211, 1025, 10.1083/jcb.201505091 Mijaljica, 2012, Receptor protein complexes are in control of autophagy, Autophagy, 8, 1701, 10.4161/auto.21332 Münz, 2010, Selective macroautophagy for immunity, Immunity, 32, 298, 10.1016/j.immuni.2010.03.002 Novak, 2010, Nix is a selective autophagy receptor for mitochondrial clearance, EMBO Rep., 11, 45, 10.1038/embor.2009.256 Ozato, 2008, TRIM family proteins and their emerging roles in innate immunity, Nat. Rev. Immunol., 8, 849, 10.1038/nri2413 Paludan, 2013, Immune sensing of DNA, Immunity, 38, 870, 10.1016/j.immuni.2013.05.004 Qin, 2016, TRIM9 short isoform preferentially promotes DNA and RNA virus-induced production of type I interferon by recruiting GSK3β to TBK1, Cell Res., 26, 613, 10.1038/cr.2016.27 Radivojac, 2010, Identification, analysis, and prediction of protein ubiquitination sites, Proteins, 78, 365, 10.1002/prot.22555 Rajsbaum, 2014, Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response, Immunity, 40, 880, 10.1016/j.immuni.2014.04.018 Robert, 2014, Deciphering key features in protein structures with the new ENDscript server, Nucleic Acids Res., 42, W320, 10.1093/nar/gku316 Schoggins, 2014, Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity, Nature, 505, 691, 10.1038/nature12862 Sho, 2011, TRIM29 negatively regulates p53 via inhibition of Tip60, Biochim. Biophys. Acta, 1813, 1245, 10.1016/j.bbamcr.2011.03.018 Storek, 2015, cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infection, J. Immunol., 194, 3236, 10.4049/jimmunol.1402764 Sun, 2013, Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway, Science, 339, 786, 10.1126/science.1232458 Sutton, 2014, TRIM16 inhibits proliferation and migration through regulation of interferon beta 1 in melanoma cells, Oncotarget, 5, 10127, 10.18632/oncotarget.2466 Takeuchi, 2010, Pattern recognition receptors and inflammation, Cell, 140, 805, 10.1016/j.cell.2010.01.022 Versteeg, 2013, The E3-ligase TRIM family of proteins regulates signaling pathways triggered by innate immune pattern-recognition receptors, Immunity, 38, 384, 10.1016/j.immuni.2012.11.013 Wang, 2014, The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING, Immunity, 41, 919, 10.1016/j.immuni.2014.11.011 Watson, 2015, The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy, Cell Host Microbe, 17, 811, 10.1016/j.chom.2015.05.004 Wu, 2013, Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA, Science, 339, 826, 10.1126/science.1229963 Yang, 2013, Novel function of Trim44 promotes an antiviral response by stabilizing VISA, J. Immunol., 190, 3613, 10.4049/jimmunol.1202507 Zhou, 2014, TRIM14 is a mitochondrial adaptor that facilitates retinoic acid-inducible gene-I-like receptor-mediated innate immune response, Proc. Natl. Acad. Sci. USA, 111, E245, 10.1073/pnas.1316941111