Osteoglycin, a novel coordinator of bone and glucose homeostasis

Loh, 2015, Regulation of energy homeostasis by the NPY system, Trends in Endocrinology and Metabolism, 26, 125, 10.1016/j.tem.2015.01.003 Baldock, 2002, Hypothalamic Y2 receptors regulate bone formation, Journal of Clinical Investigation, 109, 915, 10.1172/JCI0214588 Lee, 2010, Critical role for Y1 receptors in mesenchymal progenitor cell differentiation and osteoblast activity, Journal of Bone and Mineral Research, 25, 1736, 10.1002/jbmr.61 Baldock, 2009, Neuropeptide Y knockout mice reveal a central role of NPY in the coordination of bone mass to body weight, PLoS One, 4, e8415, 10.1371/journal.pone.0008415 Lee, 2011, Osteoblast specific Y1 receptor deletion enhances bone mass, Bone, 48, 461, 10.1016/j.bone.2010.10.174 Matic, 2012, Bone-specific overexpression of NPY modulates osteogenesis, Journal of Musculoskeletal and Neuronal Interactions, 12, 209 Lee, 2015, NPY signaling in early osteoblasts controls glucose homeostasis, Molecular Metabolism, 4, 164, 10.1016/j.molmet.2014.12.010 Kalajzic, 2002, Use of type I collagen green fluorescent protein transgenes to identify subpopulations of cells at different stages of the osteoblast lineage, Journal of Bone and Mineral Research, 17, 15, 10.1359/jbmr.2002.17.1.15 Howell, 2003, Neuropeptide Y is neuroproliferative for post-natal hippocampal precursor cells, Journal of Neurochemistry, 86, 646, 10.1046/j.1471-4159.2003.01895.x Yang, 2014, Generating genetically modified mice using CRISPR/Cas-mediated genome engineering, Nature Protocols, 9, 1956, 10.1038/nprot.2014.134 Ran, 2013, Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity, Cell, 154, 1380, 10.1016/j.cell.2013.08.021 Yu, 2015, Two-year changes in bone density after Roux-en-Y gastric bypass surgery, Journal of Clinical Endocrinology & Metabolism, 100, 1452, 10.1210/jc.2014-4341 Awazawa, 2011, Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway, Cell Metabolism, 13, 401, 10.1016/j.cmet.2011.02.010 Maghrabi, 2015, Two-year outcomes on bone density and fracture incidence in patients with T2DM randomized to bariatric surgery versus intensive medical therapy, Obesity, 23, 2344, 10.1002/oby.21150 Irizarry, 2003, Summaries of Affymetrix GeneChip probe level data, Nucleic Acids Research, 31, e15, 10.1093/nar/gng015 Gautier, 2004, Affy–analysis of Affymetrix GeneChip data at the probe level, Bioinformatics, 20, 307, 10.1093/bioinformatics/btg405 Gentleman, 2004, Bioconductor: open software development for computational biology and bioinformatics, Genome Biology, 5, R80, 10.1186/gb-2004-5-10-r80 Ihaka, 1996, R: a language for data analysis and graphics, Journal of Computational & Graphical Statistics, 5, 299 Smyth, 2004, Linear models and empirical bayes methods for assessing differential expression in microarray experiments, Statistical Applications in Genetics and Molecular Biology, 3, 10.2202/1544-6115.1027 Subramanian, 2005, Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles, Proceedings of the National Academy of Sciences, 102, 15545, 10.1073/pnas.0506580102 Reich, 2006, GenePattern 2.0, Nature Genetics, 38, 500, 10.1038/ng0506-500 Shevchenko, 2006, In-gel digestion for mass spectrometric characterization of proteins and proteomes, Nature Protocols, 1, 2856, 10.1038/nprot.2006.468 Rappsilber, 2007, Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips, Nature Protocols, 2, 1896, 10.1038/nprot.2007.261 Cox, 2011, Andromeda: a peptide search engine integrated into the MaxQuant environment, Journal of Proteome Research, 10, 1794, 10.1021/pr101065j Zhang, 2010, Peripheral neuropeptide Y Y1 receptors regulate lipid oxidation and fat accretion, International Journal of Obesity, 34, 357, 10.1038/ijo.2009.232 Baldock, 2005, Hypothalamic control of bone formation: distinct actions of leptin and y2 receptor pathways, Journal of Bone and Mineral Research, 20, 1851, 10.1359/JBMR.050523 Lee, 2007, Endocrine regulation of energy metabolism by the skeleton, Cell, 130, 456, 10.1016/j.cell.2007.05.047 Mosialou, 2017, MC4R-dependent suppression of appetite by bone-derived lipocalin 2, Nature, 543, 385, 10.1038/nature21697 Jiang, 2003, Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing, Proceedings of the National Academy of Sciences of the U S A, 100, 7569, 10.1073/pnas.1332633100 Cao, 2015, Mimecan, a hormone abundantly expressed in adipose tissue, reduced food intake independently of leptin signaling, EBioMedicine, 2, 1718, 10.1016/j.ebiom.2015.09.044 Wei, 2015, Glucose uptake and Runx2 synergize to orchestrate osteoblast differentiation and bone formation, Cell, 161, 1576, 10.1016/j.cell.2015.05.029 Bentz, 1989, Purification and characterization of a unique osteoinductive factor from bovine bone, Journal of Biological Chemistry, 264, 20805, 10.1016/S0021-9258(19)47133-0 Ge, 2004, Bone morphogenetic protein-1/tolloid-related metalloproteinases process osteoglycin and enhance its ability to regulate collagen fibrillogenesis, Journal of Biological Chemistry, 279, 41626, 10.1074/jbc.M406630200 Tasheva, 2002, Mimecan/osteoglycin-deficient mice have collagen fibril abnormalities, Molecular Vision, 8, 407 Tanaka, 2012, Role of osteoglycin in the linkage between muscle and bone, Journal of Biological Chemistry, 287, 11616, 10.1074/jbc.M111.292193 Lee, 2017, Energy metabolism of the osteoblast: implications for osteoporosis, Endocrine Reviews, 38, 255, 10.1210/er.2017-00064 Kushwaha, 2017, Fatty acid metabolism by the osteoblast, Bone, 10.1016/j.bone.2017.08.024 Paic, 2009, Identification of differentially expressed genes between osteoblasts and osteocytes, Bone, 45, 682, 10.1016/j.bone.2009.06.010 Karl, 2008, Behavioural profile of a new mouse model for NPY deficiency, European Journal of Neuroscience, 28, 173, 10.1111/j.1460-9568.2008.06306.x Loh, 2017, Insulin controls food intake and energy balance via NPY neurons, Mol Metab, 6, 574, 10.1016/j.molmet.2017.03.013