Naive T cells: The crux of cellular immune aging?

Agrawal, 2008, Biology of dendritic cells in aging, J. Clin. Immunol., 28, 14, 10.1007/s10875-007-9127-6

Ahmed, 2009, Clonal expansions and loss of receptor diversity in the naive CD8 T cell repertoire of aged mice, J. Immunol., 182, 784, 10.4049/jimmunol.182.2.784

Brien, 2009, Key role of T cell defects in age-related vulnerability to West Nile virus, J. Exp. Med., 206, 2735, 10.1084/jem.20090222

Cicin-Sain, 2007, Dramatic increase in naive T cell turnover is linked to loss of naive T cells from old primates, Proc. Natl. Acad. Sci. U. S. A., 104, 19960, 10.1073/pnas.0705905104

Cicin-Sain, 2010, Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates, J. Immunol., 184, 6739, 10.4049/jimmunol.0904193

Decman, 2012, Defective CD8 T cell responses in aged mice are due to quantitative and qualitative changes in virus-specific precursors, J. Immunol., 188, 1933, 10.4049/jimmunol.1101098

den Braber, 2012, Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans, Immunity, 36, 288, 10.1016/j.immuni.2012.02.006

Douek, 1998, Changes in thymic function with age and during the treatment of HIV infection, Nature, 396, 690, 10.1038/25374

Fagnoni, 2000, Shortage of circulating naive CD8(+) T cells provides new insights on immunodeficiency in aging, Blood, 95, 2860, 10.1182/blood.V95.9.2860.009k35_2860_2868

Ferrando-Martinez, 2010, A reliable and simplified sj/beta-TREC ratio quantification method for human thymic output measurement, J. Immunol. Methods, 352, 111, 10.1016/j.jim.2009.11.007

Ferrando-Martinez, 2011, Age-related deregulation of naive T cell homeostasis in elderly humans, Age (Dordr.), 33, 197, 10.1007/s11357-010-9170-8

Ferrando-Martinez, 2013, Thymic function failure and C-reactive protein levels are independent predictors of all-cause mortality in healthy elderly humans, Age (Dordr.), 35, 251, 10.1007/s11357-011-9341-2

Ferreira, 2000, Differential survival of naive CD4 and CD8 T cells, J. Immunol., 165, 3689, 10.4049/jimmunol.165.7.3689

Foulds, 2002, Cutting edge: CD4 and CD8 T cells are intrinsically different in their proliferative responses, J. Immunol., 168, 1528, 10.4049/jimmunol.168.4.1528

Goronzy, 2013, Understanding immunosenescence to improve responses to vaccines, Nat. Immunol., 14, 428, 10.1038/ni.2588

Griffiths, 2013, Age-associated increase of low-avidity cytomegalovirus-specific CD8+ T cells that re-express CD45RA, J. Immunol., 190, 5363, 10.4049/jimmunol.1203267

Homann, 2001, Differential regulation of antiviral T-cell immunity results in stable CD8+ but declining CD4+ T-cell memory, Nat. Med., 7, 913, 10.1038/90950

Jiang, 2013, Intrinsic defects in CD8 T cells with aging contribute to impaired primary antiviral responses, Exp. Gerontol., 48, 579, 10.1016/j.exger.2013.02.027

Johnson, 2012, Peripheral selection rather than thymic involution explains sudden contraction in naive CD4 T-cell diversity with age, Proc. Natl. Acad. Sci. U. S. A., 109, 21432, 10.1073/pnas.1209283110

Khan, 2004, Herpesvirus-specific CD8 T cell immunity in old age: cytomegalovirus impairs the response to a coresident EBV infection, J. Immunol., 173, 7481, 10.4049/jimmunol.173.12.7481

Kilpatrick, 2008, Homeostasis of the naive CD4+ T cell compartment during aging, J. Immunol., 180, 1499, 10.4049/jimmunol.180.3.1499

Koch, 2006, Human cytomegalovirus infection and T cell immunosenescence: a mini review, Mech. Ageing Dev., 127, 538, 10.1016/j.mad.2006.01.011

Kohler, 2009, Life after the thymus: CD31+ and CD31− human naive CD4+ T-cell subsets, Blood, 113, 769, 10.1182/blood-2008-02-139154

Lachmann, 2012, Polyfunctional T cells accumulate in large human cytomegalovirus-specific T cell responses, J. Virol., 86, 1001, 10.1128/JVI.00873-11

Larbi, 2011, Impact of age on T cell signaling: a general defect or specific alterations?, Ageing Res. Rev., 10, 370, 10.1016/j.arr.2010.09.008

Lelic, 2012, The polyfunctionality of human memory CD8+ T cells elicited by acute and chronic virus infections is not influenced by age, PLoS Pathog., 8, e1003076, 10.1371/journal.ppat.1003076

Li, 2012, Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity, Nat. Med., 18, 1518, 10.1038/nm.2963

Li, 2012, Age-associated alterations in CD8alpha+ dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium, Aging Cell, 11, 968, 10.1111/j.1474-9726.2012.00867.x

Linton, 2004, Age-related changes in lymphocyte development and function, Nat. Immunol., 5, 133, 10.1038/ni1033

Marzo, 2005, Initial T cell frequency dictates memory CD8+ T cell lineage commitment, Nat. Immunol., 6, 793, 10.1038/ni1227

McElhaney, 2005, The unmet need in the elderly: designing new influenza vaccines for older adults, Vaccine, 23, S10, 10.1016/j.vaccine.2005.04.019

Mirza, 2011, Comparative kinetic analyses of gene profiles of naive CD4+ and CD8+ T cells from young and old animals reveal novel age-related alterations, Aging Cell, 10, 853, 10.1111/j.1474-9726.2011.00730.x

Moretto, 2008, Aging mice exhibit a functional defect in mucosal dendritic cell response against an intracellular pathogen, J. Immunol., 181, 7977, 10.4049/jimmunol.181.11.7977

Naylor, 2005, The influence of age on T cell generation and TCR diversity, J. Immunol., 174, 7446, 10.4049/jimmunol.174.11.7446

Nikolich-Zugich, 2008, Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections, Nat. Rev. Immunol., 8, 512, 10.1038/nri2318

Obar, 2008, Endogenous naive CD8+ T cell precursor frequency regulates primary and memory responses to infection, Immunity, 28, 859, 10.1016/j.immuni.2008.04.010

Obar, 2011, Pathogen-induced inflammatory environment controls effector and memory CD8+ T cell differentiation, J. Immunol., 187, 4967, 10.4049/jimmunol.1102335

Ouyang, 2004, Dysfunctional CMV-specific CD8(+) T cells accumulate in the elderly, Exp. Gerontol., 39, 607, 10.1016/j.exger.2003.11.016

Prelog, 2009, Thymectomy in early childhood: significant alterations of the CD4(+)CD45RA(+)CD62L(+) T cell compartment in later life, Clin. Immunol., 130, 123, 10.1016/j.clim.2008.08.023

Rudd, 2011, Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions, Proc. Natl. Acad. Sci. U. S. A., 108, 13694, 10.1073/pnas.1107594108

Sadighi Akha, 2005, Signal transduction in the aging immune system, Curr. Opin. Immunol., 17, 486, 10.1016/j.coi.2005.07.004

Sauce, 2009, Evidence of premature immune aging in patients thymectomized during early childhood, J. Clin. Invest., 119, 3070, 10.1172/JCI39269

Sauce, 2012, Lymphopenia-driven homeostatic regulation of naive T cells in elderly and thymectomized young adults, J. Immunol., 189, 5541, 10.4049/jimmunol.1201235

Sempowski, 2002, T cell receptor excision circle assessment of thymopoiesis in aging mice, Mol. Immunol., 38, 841, 10.1016/S0161-5890(01)00122-5

Smithey, 2011, Increased apoptosis, curtailed expansion and incomplete differentiation of CD8+ T cells combine to decrease clearance of L. monocytogenes in old mice, Eur. J. Immunol., 41, 1352, 10.1002/eji.201041141

Valkenburg, 2012, Early priming minimizes the age-related immune compromise of CD8(+) T cell diversity and function, PLoS Pathog., 8, e1002544, 10.1371/journal.ppat.1002544

Wikby, 1998, Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study, Mech. Ageing Dev., 102, 187, 10.1016/S0047-6374(97)00151-6

Yager, 2008, Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus, J. Exp. Med., 205, 711, 10.1084/jem.20071140