Study of the oxidative metabolic function and chemotaxis of neutrophils from patients with cancer influenced by Selenium Yeast

Biological Trace Element Research - Tập 25 - Trang 201-209 - 1990
Huibi Xu1, Weide Mei2, Zhaoming Dong2, Baoliang Liao2
1Huazhong University of Science and Technology, Wuhan, People's Republic of China
2Anhui Medical University, Hefei, People’s Republic of China

Tóm tắt

The effects of Selenium Yeast (SY) given orally to patients with cancer on the oxidative metabolic function and chemotaxis of neutrophils were studied by Lumino-dependent Chemiluminescence (CL) assay and agarose plates assay, respectively. The results showed that the background CL and the peak value CL of neutrophils from patients with cancer 14 d after taking SY were, on the average, 4 and 1.2 times higher than those before taking SY. The chemotactic index (CI) and chemotactic differential (CD) increased in response to SY supplementation; the differences are statistically significant (p<0.01), and no corresponding differences could be seen in the control group (taking yeast).

Tài liệu tham khảo

F. Dallegri, G. Frumento, and F. Patrone, Immunology48, 273 (1983). D. English and J. N. Lukens, J. Immunol.130, 850 (1983). A. Lichtenstein,Cancer Res. 47, 2211 (1987). W. C. Willett, B. F. Polk, J. S. Morris, and M. J. Stampter,Lancet 2, 130 (1983). R. E. Serfass and H. E. Ganther,Nature 255, 640 (1975). A. Boyum, Scan. J. Clin. Lab. Invest.21, 97 (1968). M. E. Wilson, M. A. Trush, K. V. Dyke, J. M. Kyle, M. D. Mullett, and W. A. Neal,J. Immunol. Methods 23, 327 (1978). Chen Minxian and Qu Ping,Chin. J. Tumor 2, 19 (1980). Yu Wei and Liu Liann,J. Anhui Med. Univ. 22, 111 (1987). R. B. Barry (ed.),In Vitro Methods in Cell-mediated Tumor Immunity, Academic, London, 1976, p. 673. H. J. Thompson and P. J. Becol,J. Natl. Cancer. Inst. 65, 1269 (1980).