Nano neodymium oxide induces massive vacuolization and autophagic cell death in non-small cell lung cancer NCI-H460 cells

Ferreira, 2000, Chemotherapy triggers apoptosis in a caspase-8-dependent and mitochondria-controlled manner in the non-small cell lung cancer cell line NCI-H460, Cancer Res., 60, 7133 Fukuoka, 2003, Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer, J. Clin. Oncol., 21, 2237, 10.1200/JCO.2003.10.038 AS, 2004, Autophagy in human tumors: cell survival or death?, Cell Death Differ., 11, 1046, 10.1038/sj.cdd.4401445 Baehrecke, 2005, Autophagy: dual roles in life and death?, Nat. Rev. Mol. Cell Biol., 6, 505, 10.1038/nrm1666 Broker, 2005, Cell death independent of caspases: a review, Clin. Cancer Res., 11, 3155, 10.1158/1078-0432.CCR-04-2223 Klionsky, 2005, Autophagy, Curr. Biol., 15, R282, 10.1016/j.cub.2005.04.013 Qu, 2003, Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene, J. Clin. Invest., 112, 1809, 10.1172/JCI20039 Shunji Chi, 1999, Oncogenic ras triggers cell suicide through the activation of a caspase-independent cell death program in human cancer cells, Oncogene, 18, 2281, 10.1038/sj.onc.1202538 Paglin, 2001, A Novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles, Cancer Res., 61, 439 Takao Kanzawa, 2005, Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3, Oncogene, 24, 980, 10.1038/sj.onc.1208095 Daido, 2004, Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells, Cancer Res., 64, 4286, 10.1158/0008-5472.CAN-03-3084 Kanzawa, 2004, Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells, Cell Death Differ., 11, 448, 10.1038/sj.cdd.4401359 Cristina Go’mez-Santos, 2003, Dopamine induces autophagic cell death and alpha-synuclein increase in human neuroblastoma SH-SY5Y cells, J. Neurosci. Res., 73, 341, 10.1002/jnr.10663 Pazit Tal-Or, 2003, Neuregulin promotes autophagic cell death of prostate cancer cells, Prostate, 55, 147, 10.1002/pros.10200 Shao, 2004, Apoptotic and autophagic cell death induced by histone deacetylase inhibitors, Proc. Natl. Acad. Sci. USA, 101, 18030, 10.1073/pnas.0408345102 Lizon, 1999, Chemical toxicity of some actinides and lanthanides towards alveolar macrophages: an in vitro study, Int. J. Radiat. Biol., 75, 1459, 10.1080/095530099139322 Ji, 2000, The suppression effect of light rare earth elements on proliferation of two cancer cell lines, Biomed. Environ. Sci., 13, 287 Dai, 2002, Effects of rare earth compounds on growth and apoptosis of leukemic cell lines, In Vitro Cell Dev. Biol. Anim., 38, 373, 10.1290/1071-2690(2002)038<0373:EORECO>2.0.CO;2 Pajonk, 2002, The Human immunodeficiency virus (HIV)-1 protease inhibitor saquinavir inhibits proteasome function and causes apoptosis and radiosensitization in non-HIV-associated human cancer cells, Cancer Res., 62, 5230 Chen, 2005, Ciglitazone-induced cellular anti-proliferation increases p27kip1 protein levels through both increased transcriptional activity and inhibition of proteasome degradation, Cell. Signal., 17, 809, 10.1016/j.cellsig.2004.11.002 Saeki, 2000, Bcl-2 down-regulation causes autophagy in a caspase-independent manner in human leukemic HL60 cells, Cell Death Differ., 7, 1263, 10.1038/sj.cdd.4400759 Piacentini, 2003, Does prothymosin act as molecular switch between apoptosis and autophagy?, Cell Death Differ., 10, 937, 10.1038/sj.cdd.4401282 Boya, 2005, Inhibition of macroautophagy triggers apoptosis, Mol. Cell. Biol., 25, 1025, 10.1128/MCB.25.3.1025-1040.2005 Butler, 2000, Nonapoptotic cell death associated with S-phase arrest of prostate cancer cells via the peroxisome proliferator-activated receptor {gamma} ligand, 15-deoxy-{delta}12,14- prostaglandin J2, Cell Growth Differ., 11, 49 Opipari, 2004, Resveratrol-induced autophagocytosis in ovarian cancer cells, Cancer Res., 64, 696, 10.1158/0008-5472.CAN-03-2404 Ellington, 2005, Induction of macroautophagy in human colon cancer cells by soybean B-group triterpenoid saponins, Carcinogenesis, 26, 159, 10.1093/carcin/bgh297 Teicher, 1999, The proteasome inhibitor PS-341 in cancer therapy, Clin. Cancer Res., 5, 2638 Stefanis, 2001, Expression of a53t mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death, J. Neurosci., 21, 9549, 10.1523/JNEUROSCI.21-24-09549.2001 Webb, 2003, {alpha}-Synuclein is degraded by both autophagy and the proteasome, J. Biol. Chem., 278, 25009, 10.1074/jbc.M300227200 Alexiou, 2000, Locoregional cancer treatment with magnetic drug targeting, Cancer Res., 60, 6641