Inhibition of macroautophagy by bafilomycin A1 lowers proliferation and induces apoptosis in colon cancer cells

Meijer, 2004, Regulation and role of autophagy in mammalian cells, Int. J. Biochem. Cell Biol., 36, 2445, 10.1016/j.biocel.2004.02.002

Mizushima, 2008, Autophagy fights disease through cellular self-digestion, Nature, 451, 1069, 10.1038/nature06639

Scarlatti, 2009, Does autophagy have a license to kill mammalian cells?, Cell Death Differ., 16, 12, 10.1038/cdd.2008.101

Mortimore, 1983, Quantitative correlation between proteolysis and macro- and microautophagy in mouse hepatocytes during starvation and refeeding, Proc. Natl. Acad. Sci. USA, 80, 2179, 10.1073/pnas.80.8.2179

Shacka, 2008, The autophagy-lysosomal degradation pathway: role in neurodegenerative disease and therapy, Front. Biosci., 13, 718, 10.2741/2714

Maiuri, 2009, Control of autophagy by oncogenes and tumor suppressor genes, Cell Death Differ., 16, 87, 10.1038/cdd.2008.131

Levine, 2008, Autophagy in the pathogenesis of disease, Cell, 132, 27, 10.1016/j.cell.2007.12.018

Bialik, 2008, Autophagy and tumor suppression: recent advances in understanding the link between autophagic cell death pathways and tumor development, Adv. Exp. Med. Biol., 615, 177, 10.1007/978-1-4020-6554-5_9

Amaravadi, 2008, Autophagy-induced tumor dormancy in ovarian cancer, J. Clin. Invest., 118, 3837

Ahn, 2007, Expression of beclin-1, an autophagy-related protein, in gastric and colorectal cancers, APMIS, 115, 1344, 10.1111/j.1600-0463.2007.00858.x

Yoshioka, 2008, LC3, an autophagosome marker, is highly expressed in gastrointestinal cancers, Int. J. Oncol., 33, 461

Marshansky, 2008, The V-type H+-ATPase in vesicular trafficking: targeting, regulation and function, Curr. Opin. Cell Biol., 20, 415, 10.1016/j.ceb.2008.03.015

Gagliardi, 1999, Chemistry and structure activity relationships of bafilomycin A1, a potent and selective inhibitor of the vacuolar H+-ATPase, Curr. Med. Chem., 6, 1197, 10.2174/0929867306666220401184707

Shacka, 2006, Autophagy, bafilomycin, cell death: the “a-B-cs” of plecomacrolide-induced neuroprotection, Autophagy, 2, 228, 10.4161/auto.2703

Rubinsztein, 2006, The roles of intracellular protein-degradation pathways in neurodegeneration, Nature, 443, 780, 10.1038/nature05291

Goldberg, 2003, Protein degradation and protection against misfolded or damaged proteins, Nature, 426, 895, 10.1038/nature02263

Wu, 2008, Bone morphogenetic protein signalling is required for the anti-mitogenic effect of the proteasome inhibitor MG-132 on colon cancer cells, Br. J. Pharmacol., 154, 632, 10.1038/bjp.2008.115

Wu, 2008, Proteasome inhibitor MG-132 lowers gastric adenocarcinoma TMK1 cell proliferation via bone morphogenetic protein signaling, Biochem. Biophys. Res. Commun., 371, 209, 10.1016/j.bbrc.2008.04.059

Tobinai, 2007, Proteasome inhibitor, bortezomib, for myeloma and lymphoma, Int. J. Clin. Oncol., 12, 318, 10.1007/s10147-007-0695-5

Paglin, 2001, A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles, Cancer Res., 61, 439

Kabeya, 2000, LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing, EMBO J., 19, 5720, 10.1093/emboj/19.21.5720

Backer, 2008, The regulation and function of Class III PI3Ks: novel roles for Vps34, Biochem. J., 410, 1, 10.1042/BJ20071427

Petiot, 2000, Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells, J. Biol. Chem., 275, 992, 10.1074/jbc.275.2.992

Serova, 2008, Effects of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells, Mol. Cancer Ther., 7, 915, 10.1158/1535-7163.MCT-07-2060

Thoms, 2007, P38-mediated inactivation of cyclin D1/cyclin-dependent kinase 4 stimulates nucleolar translocation of RelA and apoptosis in colorectal cancer cells, Cancer Res., 67, 1660, 10.1158/0008-5472.CAN-06-1038

Yamamoto, 1998, Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells, Cell Struct. Funct., 23, 33, 10.1247/csf.23.33

Lum, 2005, Autophagy in metazoans: cell survival in the land of plenty, Nat. Rev. Mol. Cell Biol., 6, 439, 10.1038/nrm1660

Fung, 2008, Induction of autophagy during extracellular matrix detachment promotes cell survival, Mol. Biol. Cell, 19, 797, 10.1091/mbc.E07-10-1092

Abedin, 2007, Autophagy delays apoptotic death in breast cancer cells following DNA damage, Cell Death Differ., 14, 500, 10.1038/sj.cdd.4402039

Thorburn, 2008, Apoptosis and autophagy: regulatory connections between two supposedly different processes, Apoptosis, 13, 1, 10.1007/s10495-007-0154-9

Yang, 2008, Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer’s disease, Am. J. Pathol., 173, 665, 10.2353/ajpath.2008.071176

Park, 2007, A human scFv antibody against TRAIL receptor 2 induces autophagic cell death in both TRAIL-sensitive and TRAIL-resistant cancer cells, Cancer Res., 67, 7327, 10.1158/0008-5472.CAN-06-4766

Kim, 2008, Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer, Autophagy, 4, 659, 10.4161/auto.6058