Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

Cell - Tập 133 - Trang 235-249 - 2008
Yumiko Imai1, Keiji Kuba1,2, G. Greg Neely1, Rubina Yaghubian-Malhami1, Thomas Perkmann3, Geert van Loo4, Maria Ermolaeva4,5, Ruud Veldhuizen6, Y.H. Connie Leung7, Hongliang Wang8, Haolin Liu8, Yang Sun8, Manolis Pasparakis4,5, Manfred Kopf9, Christin Mech10, Sina Bavari10, J.S. Malik Peiris7, Arthur S. Slutsky11,12, Shizuo Akira13, Malin Hultqvist14
1IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr. Bohrgasse 3, A-1030 Vienna, Austria
2Medical Research Institute, Tokyo Medical and Dental University, Kandasurugadai 2-3-10, Chiyoda-ku, Tokyo 101-0062, Japan
3CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences and Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria
4European Molecular Biology Laboratory (EMBL), Mouse Biology Unit, Via Ramarini 32, Monterotondo-Scalo, Rome 00016, Italy
5Institute for Genetics, University of Cologne, Zülpicher Str. 47, D-50674 Cologne, Germany
6Lawson Health Research Institute, Departments of Medicine and Physiology and Pharmacology, The University of Western Ontario, London Ontario, N6A 4V2, Canada
7Department of Microbiology, University of Hong Kong, SAR
8National Key Laboratory of Medical Molecular Biology, School of Basic Medicine Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100005, China
9Molecular Biomedicine, Swiss Federal Institute of Technology, Wagistrasse 27, CH-8952 Zürich-Schlieren, Switzerland
10US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21701, USA
11Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto M5B 1W8, Canada
12Department of Critical Care, St. Michael's Hospital, University of Toronto, Toronto M5B 1W8, Canada
13Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan
14Medical Inflammation Research, MBB, Karolinska Institutet, Stockholm, Sweden and Medical Inflammation Research BMC I11 Lund, Sweden

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