Development of a lipoplex-type mRNA carrier composed of an ionizable lipid with a vitamin E scaffold and the KALA peptide for use as an ex vivo dendritic cell-based cancer vaccine

Banchereau, 1998, Dendritic cells and the control of immunity, Nature, 392, 245, 10.1038/32588 Guermonprez, 2002, Antigen presentation and T cell stimulation by dendritic cells, Annu. Rev. Immunol., 20, 621, 10.1146/annurev.immunol.20.100301.064828 Turnis, 2010, Enhancement of dendritic cells as vaccines for cancer, Immunotherapy, 2, 847, 10.2217/imt.10.56 Anguille, 2014, Clinical use of dendritic cells for cancer therapy, Lancet Oncol., 15, e257, 10.1016/S1470-2045(13)70585-0 Palucka, 2016, Diversity and collaboration for effective immunotherapy, Nat. Med., 22, 1390, 10.1038/nm.4249 Ulmer, 2012, RNA-based vaccines, Vaccine, 30, 4414, 10.1016/j.vaccine.2012.04.060 Guo, 2013, Therapeutic cancer vaccines: past, present, and future, Adv. Cancer Res., 119, 421, 10.1016/B978-0-12-407190-2.00007-1 Akita, 2013, A neutral envelope-type nanoparticle containing pH-responsive and SS-cleavable lipid-like material as a carrier for plasmid DNA, Adv. Healthcare Mater., 2, 1120, 10.1002/adhm.201200431 Akita, 2015, A neutral lipid envelope-type nanoparticle composed of a pH-activated and vitamin E-scaffold lipid-like material as a platform for a gene carrier targeting renal cell carcinoma, J. Control. Release, 200, 97, 10.1016/j.jconrel.2014.12.029 Akita, 2015, Molecular tuning of a vitamin E-scaffold pH-sensitive and reductive cleavage lipid-like material for accelerated in vivo hepatic siRNA delivery, ACS Biomater. Sci. Eng., 1, 11, 10.1021/acsbiomaterials.5b00203 Tanaka, 2018, In vivo introduction of mRNA encapsulated in lipid nanoparticles to brain neuronal cells and astrocytes via intracerebroventricular administration, Mol. Pharm., 15, 2060, 10.1021/acs.molpharmaceut.7b01084 Togashi, 2018, A hepatic pDNA delivery system based on an intracellular environment sensitive vitamin E-scaffold lipid-like material with the aid of an anti-inflammatory drug, J. Control. Release, 279, 262, 10.1016/j.jconrel.2018.04.022 Kawai, 2018, DNA-loaded nano-adjuvant formed with a vitamin E-scaffold intracellular environmentally-responsive lipid-like material for cancer immunotherapy, Nanomedicine, 14, 2587, 10.1016/j.nano.2018.08.006 Furuhata, 2006, Intracellular delivery of proteins in complexes with oligoarginine-modified liposomes and the effect of oligoarginine length, Bioconjug. Chem., 17, 935, 10.1021/bc060034h Nakamura, 2008, Efficient MHC class I presentation by controlled intracellular trafficking of antigens in octaarginine-modified liposomes, Mol. Ther., 16, 1507, 10.1038/mt.2008.122 Miura, 2015, A KALA-modified lipid nanoparticle containing CpG-free plasmid DNA as a potential DNA vaccine carrier for antigen presentation and as an immune-stimulative adjuvant, Nucleic Acids Res., 43, 1317, 10.1093/nar/gkv008 Miura, 2017, Identification and evaluation of the minimum unit of a KALA peptide required for gene delivery and immune activation, J. Pharm. Sci., 106, 3113, 10.1016/j.xphs.2017.05.014 Shaheen, 2011, KALA-modified multi-layered nanoparticles as gene carriers for MHC class-I mediated antigen presentation for a DNA vaccine, Biomaterials, 32, 6342, 10.1016/j.biomaterials.2011.05.014 Miura, 2017, Modifying antigen-encapsulating liposomes with KALA facilitates MHC class I antigen presentation and enhances anti-tumor effects, Mol. Ther., 25, 1003, 10.1016/j.ymthe.2017.01.020 Masuda, 2011, Microscale phosphoproteome analysis of 10,000 cells from human cancer cell lines, Anal. Chem., 83, 7698, 10.1021/ac201093g Sugiyama, 2007, Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications, Mol. Cell. Proteomics, 6, 1103, 10.1074/mcp.T600060-MCP200 Shoji, 2015, Bakuchiol is a phenolic isoprenoid with novel enantiomer-selective anti-influenza a virus activity involving Nrf2 activation, J. Biol. Chem., 290, 28001, 10.1074/jbc.M115.669465 Yang, 2004, Persistent toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance, Nat. Immunol., 5, 508, 10.1038/ni1059 Hama, 2007, Quantitative and mechanism-based investigation of post-nuclear delivery events between adenovirus and lipoplex, Nucleic Acids Res., 35, 1533, 10.1093/nar/gkl1165 Janeway, 1989, Approaching the asymptote? Evolution and revolution in immunology, Cold Spring Harb. Symp. Quant. Biol., 54, 1, 10.1101/SQB.1989.054.01.003 Atreya, 2000, Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo, Nat. Med., 6, 583, 10.1038/75068 Le Bon, 2003, Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon, Nat. Immunol., 4, 1009, 10.1038/ni978 Steinman, 2006, Dendritic cells: translating innate to adaptive immunity, Curr. Top. Microbiol. Immunol., 311, 17 Nakase, 2004, Cellular uptake of arginine-rich peptides: roles for macropinocytosis and actin rearrangement, Mol. Ther., 10, 1011, 10.1016/j.ymthe.2004.08.010 Sato, 2012, A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo, J. Control. Release, 163, 267, 10.1016/j.jconrel.2012.09.009 Liu, 2004, The role of calpain in oncotic cell death, Annu. Rev. Pharmacol. Toxicol., 44, 349, 10.1146/annurev.pharmtox.44.101802.121804 Schweizer, 2006, New consensus nomenclature for mammalian keratins, J. Cell Biol., 174, 169, 10.1083/jcb.200603161 Olson, 2008, Applications for ROCK kinase inhibition, Curr. Opin. Cell Biol., 20, 242, 10.1016/j.ceb.2008.01.002 Martineau, 2008, Poly(A)-binding protein-interacting protein 1 binds to eukaryotic translation initiation factor 3 to stimulate translation, Mol. Cell. Biol., 28, 6658, 10.1128/MCB.00738-08 Martineau, 2014, Control of Paip1-eukayrotic translation initiation factor 3 interaction by amino acids through S6 kinase, Mol. Cell. Biol., 34, 1046, 10.1128/MCB.01079-13