An emerging direction in glucagon-based therapy

Cell Metabolism - Tập 34 - Trang 1615-1616 - 2022
Yan Chen1, Dehua Yang2,3, Ming-Wei Wang1,3
1Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China
2The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
3Research Center for Deepsea Bioresources, Sanya, Hainan 572025, China

Tài liệu tham khảo

Coskun, 2022, LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: from discovery to clinical proof of concept, Cell Metab., 34, 1234, 10.1016/j.cmet.2022.07.013 Muller, 2017, The new biology and pharmacology of glucagon, Physiol. Rev., 97, 721, 10.1152/physrev.00025.2016 Nahra, 2021, Effects of cotadutide on metabolic and hepatic parameters in adults with overweight or obesity and type 2 diabetes: a 54-week randomized phase 2b study, Diabetes Care, 44, 1433, 10.2337/dc20-2151 Patil, 2020, Glucagon-based therapy: past, present and future, Peptides, 127, 10.1016/j.peptides.2020.170296 Sekar, 2022, Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes, Cell Metab., 34, 1824, 10.1016/j.cmet.2022.09.022 Sutkeviciute, 2020, Structural insights into emergent signaling modes of G protein-coupled receptors, J. Biol. Chem., 295, 11626, 10.1074/jbc.REV120.009348