Tityus serrulatus venom – A lethal cocktail

Abbas, 2012 Almeida, 2002, Enzymes with gelatinolytic activity can be found in Tityus bahiensis and Tityus serrulatus venoms, Toxicon, 40, 1041, 10.1016/S0041-0101(02)00084-3 Alvarenga, 2012, Transcriptome analysis of the Tityus serrulatus scorpion venom gland, Open J. Genet., 2, 210, 10.4236/ojgen.2012.24027 Alves, 2013, Isolation, homology modeling and renal effects of a C-type natriuretic peptide from the venom of the Brazilian yellow scorpion (Tityus serrulatus), Toxicon, 74C, 19, 10.1016/j.toxicon.2013.07.016 Amaral, 1991, Electrocardiographic, enzymatic and echocardiographic evidence of myocardial damage after Tityus serrulatus scorpion poisoning, Am. J. Cardiol., 67, 655, 10.1016/0002-9149(91)90912-5 Amaral, 1993, Acute pulmonary edema after Tityus serrulatus scorpion sting in children, Am. J. Cardiol., 71, 242, 10.1016/0002-9149(93)90746-Y Amaral, 1994, Scorpion sting-induced pulmonary oedema: evidence of increased alveolocapillary membrane permeability, Toxicon, 32, 999, 10.1016/0041-0101(94)90378-6 Anderson, 2012 Andersson, 1995, Physiology of penile erection, Physiol. Rev., 75, 191, 10.1152/physrev.1995.75.1.191 Anele, 2015, How I treat priapism, Blood, 125, 3551, 10.1182/blood-2014-09-551887 Bahloul, 2005, Gastrointestinal manifestations in severe scorpion envenomation, Gastroenterol. Clin. Biol., 29, 1001, 10.1016/S0399-8320(05)88173-4 Bahloul, 2010, Nosocomial scorpion envenomation: an unusual mode of scorpion sting, Clin. Toxicol. (Phila), 48, 962, 10.3109/15563650.2010.533679 Bahloul, 2013, Pulmonary edema following scorpion envenomation: mechanisms, clinical manifestations, diagnosis and treatment, Int. J. Cardiol., 162, 86, 10.1016/j.ijcard.2011.10.013 Barão, 2008, Developmental effects of Tityus serrulatus scorpion venom on the rat offspring, Brain Res. Bull., 76, 499, 10.1016/j.brainresbull.2008.02.033 Bartholomew, 1976, Scorpion venom-induced enzyme secretion in rat pancreatic slices [proceedings], J. Physiol., 263, 256P Bawaskar, 2012, Scorpion sting: update, J. Assoc. Phys. India, 60, 46 Beeton, 2005, Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases, Mol. Pharmacol., 67, 1369, 10.1124/mol.104.008193 Bertazzi, 2003, Effects of Tityus serrulatus scorpion venom and its major toxin, TsTX-I on the complement system in vivo, Toxicon, 41, 501, 10.1016/S0041-0101(02)00391-4 Bomfim, 2005, Effects induced by Tityus serrulatus scorpion venom and its toxins TsTX-I and TsTX-V on the rat isolated retractor penis muscle, Pharmacology, 73, 190, 10.1159/000082804 Bordon, 2015, Scorpion venom research around the world: Tityus serrulatus Borges, 2000, Scorpion venom-induced neutrophilia is inhibited by a PAF receptor antagonist in the rat, J. Leukoc. Biol., 67, 515, 10.1002/jlb.67.4.515 Borja-Oliveira, 2009, Positive inotropic effects of Tityus cambridgei and T. serrulatus scorpion venoms on skeletal muscle, Comp. Biochem. Physiol. C Toxicol. Pharmacol., 149, 404, 10.1016/j.cbpc.2008.09.014 Bradding, 2009, The K+ channels K(Ca)3.1 and K(v)1.3 as novel targets for asthma therapy, Br. J. Pharmacol., 157, 1330, 10.1111/j.1476-5381.2009.00362.x Brunton, 2011 Bucaretchi, 1999, Effect of toxin-g from Tityus serrulatus scorpion venom on gastric emptying in rats, Braz. J. Med. Biol. Res., 32, 431, 10.1590/S0100-879X1999000400009 Bucaretchi, 2014, Clinical consequences of Tityus bahiensis and Tityus serrulatus scorpion stings in the region of Campinas, southeastern Brazil, Toxicon, 89, 17, 10.1016/j.toxicon.2014.06.022 Cain, 1999, Tumor necrosis factor-alpha and interleukin-1beta synergistically depress human myocardial function, Crit. Care Med., 27, 1309, 10.1097/00003246-199907000-00018 Carmo, 2015 Carmo, 2014, Molecular and functional characterization of metalloserrulases, new metalloproteases from the Tityus serrulatus venom gland, Toxicon, 90C, 45, 10.1016/j.toxicon.2014.07.014 Cecchini, 2006, Effects of Tityus serrulatus scorpion venom and its toxin TsTX-V on neurotransmitter uptake in vitro, Toxicol. Appl. Pharmacol., 217, 196, 10.1016/j.taap.2006.09.003 Cerni, 2014, Electrophysiological characterization of Ts6 and Ts7, K+ channel toxins isolated through an improved Tityus serrulatus venom purification procedure, Toxins (Basel), 6, 892, 10.3390/toxins6030892 Cerni, 2015, Isolation and characterization of Ts19 fragment II, a new long-chain potassium channel toxin from Tityus serrulatus venom, Peptides Chandy, 2004, K+ channels as targets for specific immunomodulation, Trends Pharmacol. Sci., 25, 280, 10.1016/j.tips.2004.03.010 Chippaux, 2008, Epidemiology of scorpionism: a global appraisal, Acta Trop., 107, 71, 10.1016/j.actatropica.2008.05.021 Clemente, 2002, Mechanisms underlying the structural alterations of the rat submandibular gland induced by Tityus serrulatus tityustoxin, Toxicon, 40, 731, 10.1016/S0041-0101(01)00273-2 Cologna, 2009, Tityus serrulatus scorpion venom and toxins: an overview, Protein Pept. Lett., 16, 920, 10.2174/092986609788923329 Cologna, 2011, Purification and characterization of Ts15, the first member of a new alpha-KTx subfamily from the venom of the Brazilian scorpion Tityus serrulatus, Toxicon, 58, 54, 10.1016/j.toxicon.2011.05.001 Cologna, 2012, Investigation of the relationship between the structure and function of Ts2, a neurotoxin from Tityus serrulatus venom, FEBS J., 279, 1495, 10.1111/j.1742-4658.2012.08545.x Comellas, 2003, Scorpion venom decreases lung liquid clearance in rats, Am. J. Respir. Crit. Care Med., 167, 1064, 10.1164/rccm.200207-688OC Corrêa, 1997, Biochemical and histopathological alterations induced in rats by Tityus serrulatus scorpion venom and its major neurotoxin tityustoxin-I, Toxicon, 35, 1053, 10.1016/S0041-0101(96)00219-X Couto, 1992, Effects of toxin Ts-gamma, purified from Tityus serrulatus scorpion venom, on the isolated rat atria, Toxicon, 30, 339, 10.1016/0041-0101(92)90874-5 Cruttenden, 2008, Reproductive toxic effects of Tityus serrulatus scorpion venom in rats, Reprod. Toxicol., 25, 497, 10.1016/j.reprotox.2008.04.011 Cruz, 1995, Programa de controle de surto de escorpião Tityus serrulatus, Lutz e mello 1922, no município de Aparecida, SP (Scorpiones, Buthidae), Rev. Soc. Bras. Med. Trop., 28, 123, 10.1590/S0037-86821995000200007 Cunha-Melo, 1983, Effects of purified scorpion toxin (tityustoxin) on gastric secretion in the rat, Toxicon, 21, 843, 10.1016/0041-0101(83)90073-9 Cupo, 2002, Cardiac troponin I release after severe scorpion envenoming by Tityus serrulatus, Toxicon, 40, 823, 10.1016/S0041-0101(02)00080-6 Cupo, 1994, Severe scorpion envenomation in Brazil. Clinical, laboratory and anatomopathological aspects, Rev. Inst. Med. Trop. Sao Paulo, 36, 67, 10.1590/S0036-46651994000100011 Cupo, 2007, Acute left ventricular dysfunction of severe scorpion envenomation is related to myocardial perfusion disturbance, Int. J. Cardiol., 116, 98, 10.1016/j.ijcard.2006.02.015 De Matos, 1997, Lung oedema induced by Tityus serrulatus scorpion venom in the rat, Comp. Biochem. Physiol. C Pharmacol. Toxicol. Endocrinol., 118, 143, 10.1016/S0742-8413(97)00086-8 De Sousa Alves, 2005, Renal effects and vascular reactivity induced by Tityus serrulatus venom, Toxicon, 46, 271, 10.1016/j.toxicon.2005.04.013 Deshpande, 2012, Non-cardiogenic mechanisms for the pulmonary edema induced by scorpion venom, Int. J. Cardiol., 157, 426, 10.1016/j.ijcard.2012.03.163 Di, 2014, History of study, updated checklist, distribution and key of scorpions (Arachnida: Scorpiones) from China, Zool. Res., 35, 3 Diniz, 1974, Effect of scorpion venom from Tityus serrulatus (Tityustoxin) on the acetylcholine release and fine structure of the nerve terminals, Experientia, 30, 1304, 10.1007/BF01945198 Dos Santos, 2014, Description of the male of Tityus kuryi Lourenço, 1997 and notes about males of Tityus stigmurus (Thorell, 1877) and Tityus serrulatus Lutz & Mello, 1922 (Scorpiones, Buthidae), Zookeys, 49, 10.3897/zookeys.435.6694 Ferreira, 1993, Peptide T, a novel bradykinin potentiator isolated from Tityus serrulatus scorpion venom, Toxicon, 31, 941, 10.1016/0041-0101(93)90253-F Fialho, 2011, Immune cells recruitment and activation by Tityus serrulatus scorpion venom, Toxicon, 58, 480, 10.1016/j.toxicon.2011.08.006 Fletcher, 1992, Characteristics of pancreatic exocrine secretion produced by venom from the Brazilian scorpion, Tityus serrulatus, Eur. J. Cell Biol., 58, 259 Fletcher, 2010, Vesicle-associated membrane protein (VAMP) cleavage by a new metalloprotease from the Brazilian scorpion Tityus serrulatus, J. Biol. Chem., 285, 7405, 10.1074/jbc.M109.028365 Fukuhara, 2003, Increased plasma levels of IL-1beta, IL-6, IL-8, IL-10 and TNF-alpha in patients moderately or severely envenomed by Tityus serrulatus scorpion sting, Toxicon, 41, 49, 10.1016/S0041-0101(02)00208-8 Galanter, 2012, Principles of nervous system physiology and pharmacology Garfield, 1986, Structural studies of innervation on nonpregnant rat uterus, Am. J. Physiol., 251, C41, 10.1152/ajpcell.1986.251.1.C41 Gomes, 2009, Experimental osteoporosis induced in female albino rats and its antagonism by Indian black scorpion (Heterometrus bengalensis C.L.Koch) venom, Toxicon, 53, 60, 10.1016/j.toxicon.2008.10.011 Gonzaga, 1979, Gastric secretion induced by scorpion toxin, Toxicon, 17, 316, 10.1016/0041-0101(79)90222-8 Gonçalves, 2003, Participation of Na(+) channels in the potentiation by Tityus serrulatus alpha-toxin TsTx-V of glucose-induced electrical activity and insulin secretion in rodent islet beta-cells, Toxicon, 41, 1039, 10.1016/S0041-0101(03)00086-2 Guidine, 2014, Brainstem structures are primarily affected in an experimental model of severe scorpion envenomation, Toxicol. Sci., 137, 147, 10.1093/toxsci/kft231 Guyton, 2012 Henriques, 1968, Effect of the venom of the scorpion Tityus serrulatus on adrenal gland catecholamines, Toxicon, 5, 175, 10.1016/0041-0101(68)90086-X Herweijer, 2014, Characterization of primary afferent spinal innervation of mouse uterus, Front. Neurosci., 8, 202, 10.3389/fnins.2014.00202 Herzig, 2004, Ontogenetic changes in Phoneutria nigriventer (Araneae, Ctenidae) spider venom, Toxicon, 44, 635, 10.1016/j.toxicon.2004.07.020 Horta, 2014, Molecular, immunologica*l, and biological characterization of Tityus serrulatus venom hyaluronidase: new insights into its role in envenomation, PLoS Negl. Trop. Dis., 8, e2693, 10.1371/journal.pntd.0002693 Isbister, 2014, Scorpion envenomation, N. Engl. J. Med., 371, 457, 10.1056/NEJMra1401108 Ismail, 1995, Scorpion envenomation syndrome, Toxicon, 33, 825, 10.1016/0041-0101(95)00005-7 Karnad, 1998, Haemodynamic patterns in patients with scorpion envenomation, Heart, 79, 485, 10.1136/hrt.79.5.485 Keely, 2011, Epithelial acetylcholine – a new paradigm for cholinergic regulation of intestinal fluid and electrolyte transport, J. Physiol., 589, 771, 10.1113/jphysiol.2010.204263 Klaassen, 2013 Lombet, 1984, Characterization, solubilization, affinity labeling and purification of the cardiac Na+ channel using Tityus toxin-gamma, Eur. J. Biochem., 141, 651, 10.1111/j.1432-1033.1984.tb08241.x Lourenço, 2002, Reproduction in scorpions, with special reference to parthenogenesis, Eur. Arachnol., 2000, 71 Lourenço, 2008, Parthenogenesis in scorpions: some history - new data, J. Venom Anim. Toxins Incl. Trop. Dis., 14, 19 Lourenço, 1999, Discovery of a sexual population of Tityus serrulatus, one of the morphs within the complex Tityus stigmurus (Scorpiones, Buthidae), J. Arachnol., 27, 154 Lutz, 1922, Cinco novos escorpiões brasileiros dos gêneros Tityus e Rhopalurus, Folha Méd., 3, 26 Maciel, 2014, Tityus serrulatus scorpion venom improves survival and lung inflammation in lethal sepsis induced by CLP in mice, Toxicon, 89, 1, 10.1016/j.toxicon.2014.06.018 Magalhães, 1999, Serum levels of cytokines in patients envenomed by Tityus serrulatus scorpion sting, Toxicon, 37, 1155, 10.1016/S0041-0101(98)00251-7 Marcussi, 2011 Melo, 2006, Effect of acid secretion blockade on acute gastric mucosal lesions induced by Tityus serrulatus scorpion toxin in anaesthetized rats, Toxicon, 48, 543, 10.1016/j.toxicon.2006.07.003 Mendonça, 1995, Effect of scorpion toxin from Tityus serrulatus on the contraction of the isolated rat uterus, Toxicon, 33, 355, 10.1016/0041-0101(94)00162-2 Miranda, 2015, The first description of cardiac magnetic resonance findings in a severe scorpion envenomation: is it a stress-induced (Takotsubo) cardiomyopathy like?, Am. J. Emerg. Med., 33, 862.e5, 10.1016/j.ajem.2014.12.044 Mouhat, 2008, Animal toxins acting on voltage-gated potassium channels, Curr. Pharm. Des., 14, 2503, 10.2174/138161208785777441 Nencioni, 2000, Neurotoxic effects of three fractions isolated from Tityus serrulatus scorpion venom, Pharmacol. Toxicol., 86, 149, 10.1034/j.1600-0773.2000.d01-28.x Neto, 2012, Tityus serrulatus venom and its toxins Ts1 and Ts5 increase cytosolic Ca2+ concentration in isolated vascular smooth muscle cells, J. Biophys. Chem., 3, 287 NIH, 2012 Nishioka, 1993, Scorpion sting on the penis, J. Urol., 150, 1501 Novaes, 1982, Effect of purified scorpion toxin (tityustoxin) on the pancreatic secretion of the rat, Toxicon, 20, 847, 10.1016/0041-0101(82)90072-1 Nunan, 2003, Effect of age on body distribution of Tityustoxin from Tityus serrulatus scorpion venom in rats, Life Sci., 73, 319, 10.1016/S0024-3205(03)00264-9 Oliveira, 2013, Another record of significant regional variation in toxicity of Tityus serrulatus venom in Brazil: a step towards understanding the possible role of sodium channel modulators, Toxicon, 73C, 33, 10.1016/j.toxicon.2013.06.021 Olsson, 2011, Autonomic control of gut motility: a comparative view, Auton. Neurosci., 165, 80, 10.1016/j.autneu.2010.07.002 Ortiz, 2015, Scorpion venom components as potential candidates for drug development, Toxicon, 93, 125, 10.1016/j.toxicon.2014.11.233 Pandey, 2007, Aprotinin reverses ECG abnormalities induced by Mesobuthus tamulus concanesis, Pocock venom in adult rats, Indian J. Exp. Biol., 45, 949 Paneque Peres, 2009, Effects of Tityus serrulatus scorpion venom on lung mechanics and inflammation in mice, Toxicon, 53, 779, 10.1016/j.toxicon.2009.02.002 Panga, 2008, Activation of spinal ERK signaling pathway contributes to pain-related responses induced by scorpion Buthus martensi Karch venom, Toxicon, 51, 994, 10.1016/j.toxicon.2008.01.005 Peigneur, 2015, A gamut of undiscovered electrophysiological effects produced by Tityus serrulatus toxin 1 on Na-type isoforms, Neuropharmacology, 95, 269, 10.1016/j.neuropharm.2015.03.027 Pessini, 2001, A hyaluronidase from Tityus serrulatus scorpion venom: isolation, characterization and inhibition by flavonoids, Toxicon, 39, 1495, 10.1016/S0041-0101(01)00122-2 Pessini, 2003, Time course of acute-phase response induced by Tityus serrulatus venom and TsTX-I in mice, Int. Immunopharmacol., 3, 765, 10.1016/S1567-5769(03)00078-X Petricevich, 2002, Effect of Tityus serrulatus venom on cytokine production and the activity of murine macrophages, Mediat. Inflamm., 11, 23, 10.1080/09629350210308 Pinto, 2010, Hematological and biochemical profiles of rats submitted to experimental poisoning with Tityus serrulatus venom, Arq. Bras. Med. Vet. Zootec., 62, 350, 10.1590/S0102-09352010000200015 Pipelzadeh, 2007, An epidemiological and a clinical study on scorpionism by the Iranian scorpion Hemiscorpius lepturus, Toxicon, 50, 984, 10.1016/j.toxicon.2007.07.018 Possani, 1991, Discharge effect on pancreatic exocrine secretion produced by toxins purified from Tityus serrulatus scorpion venom, J. Biol. Chem., 266, 3178, 10.1016/S0021-9258(18)49971-1 Pucca, 2011, Experimental Tityus serrulatus scorpion envenomation: age- and sex-related differences in symptoms and mortality in mice, J. Venom Anim. Toxins Incl. Trop. Dis., 17, 325, 10.1590/S1678-91992011000300013 Pucca, 2012, Serrumab: a human monoclonal antibody that counters the biochemical and immunological effects of Tityus serrulatus venom, J. Immunotoxicol., 9, 173, 10.3109/1547691X.2011.649220 Pucca, 2014, Influence of post-starvation extraction time and prey-specific diet in Tityus serrulatus scorpion venom composition and hyaluronidase activity, Toxicon, 90, 326, 10.1016/j.toxicon.2014.08.064 Pucca, 2014, Serrumab: a novel human single chain-fragment antibody with multiple scorpion toxin-neutralizing capacities, J. Immunotoxicol., 11, 133, 10.3109/1547691X.2013.809175 Pucca, 2015, Revealing the function and the structural model of Ts4: insights into the “non-toxic” toxin from Tityus serrulatus venom, Toxins (Basel), 7, 2534, 10.3390/toxins7072534 Pucca, 2015, Scorpionism and dangerous species of Brazil Pucca, 2015, Electrophysiological characterization of the first Tityus serrulatus alpha-like toxin, Ts5: evidence of a pro-inflammatory toxin on macrophages, Biochimie, 115, 8, 10.1016/j.biochi.2015.04.010 Rahmani, 2012, Symptom patterns in adult patients stung by scorpions with emphasis on coagulopathy and hemoglubinuria, J. Venom Anim. Toxins Incl. Trop. Dis., 18, 427, 10.1590/S1678-91992012000400011 Ranabir, 2011, Stress and hormones, Indian J. Endocrinol. Metab., 15, 18, 10.4103/2230-8210.77573 Revelo, 1996, Body distribution of Tityus serrulatus scorpion venom in mice and effects of scorpion antivenom, Toxicon, 34, 1119, 10.1016/0041-0101(96)00074-8 Ribeiro, 2010, Biochemical profile of dogs experimentally envenomed with Tityus serrulatus scorpion venom, Toxicon, 55, 1125, 10.1016/j.toxicon.2010.01.001 Rogowski, 1994, Tityustoxin K alpha blocks voltage-gated noninactivating K+ channels and unblocks inactivating K+ channels blocked by alpha-dendrotoxin in synaptosomes, Proc. Natl. Acad. Sci. U. S. A., 91, 1475, 10.1073/pnas.91.4.1475 Roncolato, 2015, Phage display as a novel promising antivenom therapy: a review, Toxicon, 93, 79, 10.1016/j.toxicon.2014.11.001 Sampaio, 1996, Isolation of toxin TsTX-VI from Tityus serrulatus scorpion venom. Effects on the release of neurotransmitters from synaptosomes, Biochem. Mol. Biol. Int., 39, 729 Sampaio, 1997, TsTX-VII, a new toxin from Tityus serrulatus scorpion venom able to induce the release of neurotransmitters from rat brain synaptosomes not blocked by tetrodotoxin, Biochem. Mol. Biol. Int., 41, 1255 Sandoval, 2002, TsTx toxin isolated from Tityus serrulatus scorpion venom-induced spontaneous recurrent seizures and mossy fiber sprouting, Epilepsia, 43, 36, 10.1046/j.1528-1157.43.s.5.24.x Sandoval, 2003, TSII toxin isolated from Tityus serrulatus scorpion venom: behavioral, electroencephalographic, and histopathologic studies, Brain Res. Bull., 62, 165, 10.1016/j.brainresbull.2003.09.006 Saucedo, 2012, New tricks of an old pattern structural versatility of scorpion toxins with common cysteine spacing, J. Biol. Chem., 287, 12321, 10.1074/jbc.M111.329607 Savino, 1985, Effects of tityustoxin on the rat isolated tail artery, Acta Physiol. Pharmacol. Latinoam., 35, 119 Sherwood, 2015 Silva, 2015, The role of dorsomedial hypotalamus ionotropic glutamate receptors in the hypertensive and tachycardic responses evoked by Tityustoxin intracerebroventricular injection, Neurotoxicology, 47, 54, 10.1016/j.neuro.2014.12.006 Silveira, 1991, Effects of Tityus serrulatus scorpion venom and one of its purified toxins (toxin gamma) on the isolated guinea-pig heart, Comp. Biochem. Physiol. C, 98, 329, 10.1016/0742-8413(91)90213-D Sninsky, 1986, Effect of lidamidine hydrochloride and loperamide on gastric emptying and transit of the small intestine. A double-blind study, Gastroenterology, 90, 68, 10.1016/0016-5085(86)90076-4 Sofer, 1994, Scorpion envenomation and antivenom therapy, J. Pediatr., 124, 973, 10.1016/S0022-3476(05)83196-8 Teixeira, 1998, Effect of Tityus serrulatus scorpion venom on the rabbit isolated corpus cavernosum and the involvement of NANC nitrergic nerve fibres, Br. J. Pharmacol., 123, 435, 10.1038/sj.bjp.0701623 Teixeira, 2001, Evidence for a direct action of Tityus serrulatus scorpion venom on the cardiac muscle, Toxicon, 39, 703, 10.1016/S0041-0101(00)00200-2 Teixeira, 2001, Nonadrenergic, noncholinergic relaxation of human isolated corpus cavernosum induced by scorpion venom, Urology, 57, 816, 10.1016/S0090-4295(00)01047-5 Teixeira, 2004, Nitric oxide release from human corpus cavernosum induced by a purified scorpion toxin, Urology, 63, 184, 10.1016/S0090-4295(03)00785-4 Toda, 2005, Nitric oxide and penile erectile function, Pharmacol. Ther., 106, 233, 10.1016/j.pharmthera.2004.11.011 Toppa, 1998, Effect of Tityus serrulatus scorpion toxin on serum gastrin levels in anaesthetized rat, Toxicon, 36, 1833, 10.1016/S0041-0101(98)00093-2 Troncon, 2000, Inhibition of gastric emptying and intestinal transit in anesthetized rats by a Tityus serrulatus scorpion toxin, Braz. J. Med. Biol. Res., 33, 1053, 10.1590/S0100-879X2000000900010 Van Der Meijden, 2015, Variability in venom volume, flow rate and duration in defensive stings of five scorpion species, Toxicon, 100, 60, 10.1016/j.toxicon.2015.04.011 Van Fraga, 2015, Effects of tityustoxin on cerebral inflammatory response in young rats, Neurosci. Lett., 588, 24, 10.1016/j.neulet.2014.12.044 Vasconcelos, 2004, Insulin-like effects of Bauhinia forficata aqueous extract upon Tityus serrulatus scorpion envenoming, J. Ethnopharmacol., 95, 385, 10.1016/j.jep.2004.08.006 Vasconcelos, 2005, Effects of voltage-gated Na+ channel toxins from Tityus serrulatus venom on rat arterial blood pressure and plasma catecholamines, Comp. Biochem. Physiol. C Toxicol. Pharmacol., 141, 85, 10.1016/j.cca.2005.05.012 Venancio, 2013, Enzymatic properties of venoms from Brazilian scorpions of Tityus genus and the neutralisation potential of therapeutical antivenoms, Toxicon, 69, 180, 10.1016/j.toxicon.2013.02.012 Verano-Braga, 2008, Tityus serrulatus hypotensins: a new family of peptides from scorpion venom, Biochem. Biophys. Res. Commun., 371, 515, 10.1016/j.bbrc.2008.04.104 Verano-Braga, 2010, Structure–function studies of Tityus serrulatus Hypotensin-I (TsHpt-I): a new agonist of B2 kinin receptor, Toxicon, 56, 1162, 10.1016/j.toxicon.2010.04.006 Wulff, 2003, The voltage-gated Kv1.3 K(+) channel in effector memory T cells as new target for MS, J. Clin. Investig., 111, 1703, 10.1172/JCI16921 Wulff, 2009, Voltage-gated potassium channels as therapeutic targets, Nat. Rev. Drug Discov., 8, 982, 10.1038/nrd2983 Yatani, 1988, Effects of new world scorpion toxins on single-channel and whole cell cardiac sodium currents, Am. J. Physiol., 254, H443 Zoccal, 2011, Tityus serrulatus venom and toxins Ts1, Ts2 and Ts6 induce macrophage activation and production of immune mediators, Toxicon, 57, 1101, 10.1016/j.toxicon.2011.04.017 Zoccal, 2013, Ts6 and Ts2 from Tityus serrulatus venom induce inflammation by mechanisms dependent on lipid mediators and cytokine production, Toxicon, 61, 1, 10.1016/j.toxicon.2012.10.002 Zoccal, 2014, TLR2, TLR4 and CD14 recognize venom-associated molecular patterns from Tityus serrulatus to induce macrophage-derived inflammatory mediators, PLoS One, 9, e88174, 10.1371/journal.pone.0088174 Zoccal, 2015, PPAR-gamma activation by Tityus serrulatus venom regulates lipid body formation and lipid mediator production, Toxicon, 93, 90, 10.1016/j.toxicon.2014.11.226 Zuliani, 2013, Tityus serrulatus venom increases vascular permeability in selected airway tissues in a mast cell-independent way, Exp. Toxicol. Pathol., 65, 229, 10.1016/j.etp.2011.08.010