Cannabinoids and prefrontal cortical function: Insights from preclinical studies

Acquas, 2001, δ9-Tetrahydrocannabinol enhances cortical and hippocampal acetylcholine release in vivo: a microdialysis study, Eur. J. Pharmacol., 419, 155, 10.1016/S0014-2999(01)00967-0 Allison, C., Brett, R., Pratt, J., 2004. Deficits in a rodent attentional set shift task induced by repeated THC administration. Program no 690.3. 2004 Abstract Viewer/Itinerary Planner. Society for Neuroscience. Amen, 1998, High resolution brain SPECT imaging of marijuana smokers with AD/HD, J. Psychoactive Drugs, 30, 209, 10.1080/02791072.1998.10399692 Arguello, 2004, Cannabinoid CB1 receptor-mediated impairment of visuospatial attention in the rat, Psychopharmacology (Berl), 177, 141, 10.1007/s00213-004-1953-0 Beltramo, 2000, Carrier-mediated transport and enzymatic hydrolysis of the endogenous cannabinoid 2-arachidonylglycerol, Neuroreport, 11, 1231, 10.1097/00001756-200004270-00018 Bergson, 1995, Regional, cellular, and subcellular variations in the distribution of D1 and D5 dopamine receptors in primate brain, J. Neurosci., 15, 7821, 10.1523/JNEUROSCI.15-12-07821.1995 Birrell, 2000, Medial prefrontal cortex mediates perceptual attention set shifting in the rat, J. Neurosci., 20, 4320, 10.1523/JNEUROSCI.20-11-04320.2000 Bisogno, 1999, Brain regional distribution of endocannabinoids: implications for their biosynthesis and biological function, Biochem. Biophys. Res. Commun., 256, 377, 10.1006/bbrc.1999.0254 Block, 1993, Effects of chronic marijuana use on human cognition, Psychopharmacology (Berl), 110, 219, 10.1007/BF02246977 Block, R.I., O'Leary, D.S., Hichwa, R.D., Augustinak, J.C., Boles Ponto, L.L., Ghoneim, M.M., Ardnt, S.V., Ehrhardt, J.C., Yuh, W.T.C., Hurtig, R.R., Watkins, G.L., Hall, J.A., Nathan, P.E., Maktabi, M.A., Smith, L.A., Andreasen, N.C., 1999. Effects of chronic marijuana use on regional cerebral blood flow during recall. Society for Neuroscience Abstracts 25, 831.812. Block, 2002, Effects of frequent marijuana use on memory-related regional cerebral blood flow, Pharmacol. Biochem. Behav., 72, 237, 10.1016/S0091-3057(01)00771-7 Bolla, 2002, Dose-related neurocognitive effects of marijuana use, Neurology, 59, 1337, 10.1212/01.WNL.0000031422.66442.49 Braida, 2000, Cannabinoid-induced working memory impairment is reversed by a second generation cholinesterase inhibitor in rats, Neuroreport, 11, 2025, 10.1097/00001756-200006260-00044 Brett, 2001, Delta 9-tetrahydrocannabinol-induced alterations in limbic system glucose use in the rat, Neuroreport, 12, 3573, 10.1097/00001756-200111160-00040 Brodkin, 1997, SR141716A antagonizes the disruptive effects of cannabinoid ligands on learning in rats, J. Pharmacol. Exp. Ther., 282, 1526 Brown, 2002, Rodent models of prefrontal cortical function, Trends Neurol. Sci., 25, 340, 10.1016/S0166-2236(02)02164-1 Bukoski, 2002, CB(1) receptor antagonist SR141716A inhibits Ca(2+)-induced relaxation in CB(1) receptor-deficient mice, Hypertension, 39, 251, 10.1161/hy0202.102702 Burk, 2001, Effects of intralaminar thalamic lesions on sensory attention and motor intention in the rat: a comparison with lesions involving frontal cortex and hippocampus, Behav. Brain. Res., 123, 49, 10.1016/S0166-4328(01)00202-9 Campbell, 1986, delta 9-Tetrahydrocannabinol differentially affects sensory-evoked potentials in the rat dentate gyrus, J. Pharmacol. Exp. Ther., 239, 936 Campbell, 1986, Effects of delta 9-tetrahydrocannabinol on sensory-evoked discharges of granule cells in the dentate gyrus of behaving rats, J. Pharmacol. Exp. Ther., 239, 941 Chen, 1990, D9-Tetrahydrocannabinol enhances presynaptic dopamine efflux in medial prefrontal cortex, Eur. J. Pharmacol., 190, 259, 10.1016/0014-2999(90)94136-L Christakou, 2001, Functional disconnection of a prefrontal cortical-dorsal striatal system disrupts choice reaction time performance: implications for attentional function, Behav. Neurosci., 115, 812, 10.1037/0735-7044.115.4.812 Chudasama, 2003, Dissociable aspects of performance on the 5-choice serial reaction time task following lesions of the dorsal anterior cingulate, infralimbic and orbitofrontal cortex in the rat: differential effects on selectivity, impulsivity and compulsivity, Behav. Brain. Res., 146, 105, 10.1016/j.bbr.2003.09.020 Clark, 2004, The neuropsychology of ventral prefrontal cortex: Decision making and reversal learning, Brain Cogn., 55, 41, 10.1016/S0278-2626(03)00284-7 Clarke, 2004, Cognitive inflexibility after prefrontal serotonin depletion, Science, 304, 878, 10.1126/science.1094987 Clarke, 2005, Prefrontal serotonin depletion affects reversal learning but not attentional set shifting, J. Neurosci., 25, 532, 10.1523/JNEUROSCI.3690-04.2005 Cravatt, 1996, Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides, Nature, 384, 83, 10.1038/384083a0 Dalley, 2001, Distinct changes in cortical acetylcholine and noradrenaline efflux during contingent and noncontingent performance of a visual attention task, J. Neurosci., 21, 4908, 10.1523/JNEUROSCI.21-13-04908.2001 Dalley, 2004, Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates, Neurosci. Biobehav. Rev., 28, 771, 10.1016/j.neubiorev.2004.09.006 Deadwyler, 1990, The effects of delta-9-THC on mechanisms of learning and memory, NIDA Res. Monogr., 97, 79 Dean, 2001, Studies on [3H]CP-55940 binding in the human central nervous system: regional specific changes in density of cannabinoid-1 receptors associated with schizophrenia and cannabis use, Neuroscience, 103, 9, 10.1016/S0306-4522(00)00552-2 Delatour, 1999, Lesions of the prelimbic-infralimbic cortices in rats do not disrupt response selection processes but induce delay-dependent deficits: evidence for a role in working memory?, Behav. Neurosci., 113, 941, 10.1037/0735-7044.113.5.941 Devane, 1988, Determination and characterisation of a cannabinoid receptor in the rat brain, Mol. Pharmacol., 34, 604 Devane, 1992, Isolation and structure of a brain constituent that binds to the cannabinoid receptor, Science, 258, 1946, 10.1126/science.1470919 Di Marzo, 2000, Enhancement of anandamide formation in the limbic forebrain and reduction of endocannabinoid contents in the striatum of delta 9-tetrahydrocannabinol-tolerant rats, J. Neurochem., 74, 1627, 10.1046/j.1471-4159.2000.0741627.x Di Marzo, 2000, Neurobehavioural activity of N-vanillyl-arachidonyl-amide, Eur. J. Pharmacol., 406, 363, 10.1016/S0014-2999(00)00687-7 Di Marzo, 2000, Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease, FASEB J., 14, 1432, 10.1096/fj.14.10.1432 Diana, 2004, Endocannabinoid-mediated short term synaptic plasticity:depolarisation-induced suppression of inhibition (DSI) and depolarisation-induced suppression of DSE, Br. J. Pharmacol., 142, 9, 10.1038/sj.bjp.0705726 Diana, 1998, Increase in meso-prefrontal dopaminergic activity after stimulation of CB1 receptors by cannabinoids, Eur. J. Neurosci., 10, 2825, 10.1111/j.1460-9568.1998.00292.x Dias, 1996, Dissociation in prefrontal cortex of affective and attentional shifts, Nature, 380, 69, 10.1038/380069a0 Dias, 1996, Primate analogue of the wisconsin card sorting test: effects of excitotoxic lesions of the prefrontal cortex in the marmoset, Behav. Neurosci., 110, 872, 10.1037/0735-7044.110.5.872 Dias, 1997, Dissociable forms of inhibitory control within prefrontal cortex with an analog of the wisconsin card sort test: restriction to novel situations and independence from ‘on-line’ processing, J. Neurosci., 17, 9285, 10.1523/JNEUROSCI.17-23-09285.1997 Doyere, 1993, Long-term potentiation of hippocampal afferents and efferents to prefrontal cortex: implications for associative learning, Neuropsychologia, 31, 1031, 10.1016/0028-3932(93)90031-T Egerton, 2001, Differential dose effects of g-tetrahydrocannabinol on behaviour and gene expression, Behavioural pharmacology 12, s33 Egerton, 2005, Acute Delta(9)-Tetrahydrocannabinol-induced deficits in reversal learning: neural correlates of affective inflexibility, Neuropsychopharmacology, 30, 1895, 10.1038/sj.npp.1300715 Egertova, 2003, Comparative analysis of fatty acid amide hydrolase and CB(1) cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling, Neuroscience, 119, 481, 10.1016/S0306-4522(03)00145-3 Eichenbaum, 1996, Functional organization of the hippocampal memory system, Proc. Natl Acad. Sci. USA, 93, 13500, 10.1073/pnas.93.24.13500 Eldreth, 2004, Abnormal brain activity in prefrontal regions in abstinent marijuana users, Neuroimage, 23, 914, 10.1016/j.neuroimage.2004.07.032 Everitt, 1997, Central cholinergic systems and cognition, Ann. Rev. Psychol., 48, 649, 10.1146/annurev.psych.48.1.649 Fadda, 2004, Differential effects of THC- or CBD-rich cannabis extracts on working memory in rats, Neuropharmacology, 47, 1170, 10.1016/j.neuropharm.2004.08.009 Fellows, 2003, Ventromedial frontal cortex mediates affective shifting in humans: evidence from a reversal learning paradigm, Brain, 126, 1830, 10.1093/brain/awg180 Ferrari, 1999, Learning impairment produced in rats by the cannabinoid agonist HU 210 in a water-maze task, Pharmacol. Biochem. Behav., 64, 555, 10.1016/S0091-3057(99)00106-9 Ferraro, 2001, The cannabinoid receptor agonist WIN 55,212-2 regulates glutamate transmission in rat cerebral cortex: an in vivo and in vitro study, Cereb. Cortex, 11, 728, 10.1093/cercor/11.8.728 Fletcher, 1996, Cognitive correlates of long-term cannabis use in costa rican men, Arch. Gen. Psychiatry, 53, 1051, 10.1001/archpsyc.1996.01830110089011 Floresco, 1996, Differential effects of lidocaine infusions into the ventral CA1/subiculum or the nucleus accumbens on the acquisition and retention of spatial information, Behav. Brain. Res., 81, 163, 10.1016/S0166-4328(96)00058-7 Floresco, 1997, Selective roles for hippocampal, prefrontal cortical, and ventral striatal circuits in radial-arm maze tasks with or without a delay, J. Neurosci., 17, 1880, 10.1523/JNEUROSCI.17-05-01880.1997 Freedland, 2002, Dose-dependent effects of delta9-tetrahydrocannabinol on rates of local cerebral glucose utilization in rat, Synapse, 45, 134, 10.1002/syn.10089 Fuster, 1991, The prefrontal cortex and its relation to behavior, Prog. Brain. Res., 87, 201, 10.1016/S0079-6123(08)63053-8 Gellman, 1993, Pyramidal cells in piriform cortex receive a convergence of inputs from monoamine activated GABAergic interneurons, Brain Res., 600, 63, 10.1016/0006-8993(93)90402-9 Gessa, 1998, Cannabinoids activate mesolimbic dopamine neurons by an action on cannabinoid CB1 receptors, Eur. J. Pharmacol., 341, 39, 10.1016/S0014-2999(97)01442-8 Gessa, 1998, Cannabinoids decrease acetylcholine release in the medial-prefrontal cortex and hippocampus, reversal by SR 141716A, Eur. J. Pharmacol., 355, 119, 10.1016/S0014-2999(98)00486-5 Gioanni, 1998, Alpha1-adrenergic, D1, and D2 receptors interactions in the prefrontal cortex: implications for the modality of action of different types of neuroleptics, Synapse, 30, 362, 10.1002/(SICI)1098-2396(199812)30:4<362::AID-SYN3>3.0.CO;2-W Glass, 1997, Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain, Neuroscience, 77, 299, 10.1016/S0306-4522(96)00428-9 Godbout, 1991, Inhibitory influence of mesocortical dopaminegic neurons on their target cells: electrophysiological and pharmacological characterization, J. Pharmacol. Exp. Ther., 258, 728 Goldman-Rakic, 1987, Motor control function of the prefrontal cortex, Ciba Found. Symp., 132, 187 Goldman-Rakic, 1996, Regional and cellular fractionation of working memory, Proc. Natl Acad. Sci. USA, 93, 13473, 10.1073/pnas.93.24.13473 Goldman-Rakic, 1989, Dopamine synaptic complex with pyramidal neurons in primate cerebral cortex, Proc. Natl Acad. Sci. USA, 86, 9015, 10.1073/pnas.86.22.9015 Goldman-Rakic, 1992, The prefrontal cortex and internally generated motor acts, Curr. Opin. Neurobiol., 2, 830, 10.1016/0959-4388(92)90141-7 Goldstein, 1994, The NMDA glycine site antagonist (+)-HA966 selectively regulates conditioned stress-induced metabolic activation of the mesoprefrontal dopamine but not serotonin systems: a behavioural, neuroendocrine and neurochemical study in the rat, J. Neurosci., 14, 4937, 10.1523/JNEUROSCI.14-08-04937.1994 Granon, 2000, Enhanced and impaired attentional performance after infusion of D1 dopaminergic receptor agents into rat prefrontal cortex, J. Neurosci., 20, 1208, 10.1523/JNEUROSCI.20-03-01208.2000 Griffin, 1998, Evaluation of cannabinoid receptor agonists and antagonists using the guanosine-5′-O-(3-[35S]thio)-triphosphate binding assay in rat cerebellar membranes, J. Pharmacol. Exp. Ther., 285, 553 Groenewegen, 2000, The prefrontal cortex and the integration of sensory, limbic and autonomic function, Prog. Brain Res., 126, 3, 10.1016/S0079-6123(00)26003-2 Hajos, 2002, Distinct cannabinoid sensitive receptors regulate hippocampal excitation and inhibition, Chem. Phys. Lipids, 121, 73, 10.1016/S0009-3084(02)00149-4 Hampson, 1999, Role of cannabinoid receptors in memory storage, Neurobiol. Dis., 5, 474, 10.1006/nbdi.1998.0223 Hampson, 1999, Cannabinoids, hippocampal function and memory, Life Sci., 65, 715, 10.1016/S0024-3205(99)00294-5 Hampson, 2000, Cannabinoids reveal the necessity of hippocampal neural encoding for short term memory in rats, J. Neurosci., 20, 8932, 10.1523/JNEUROSCI.20-23-08932.2000 Hampson, 1998, Dual effects of anandamide on NMDA receptor-mediated responses and neurotransmission, J. Neurochem., 70, 671, 10.1046/j.1471-4159.1998.70020671.x Herkenham, 1992, Cannabinoid receptor localisation in brain: relationship to motor and reward systems, Ann. NY Acad. Sci., 654, 19, 10.1111/j.1749-6632.1992.tb25953.x Herkenham, 1990, Cannabiniod receptor localisation in brain, Proc. Natl Acad. Sci. USA, 87, 1932, 10.1073/pnas.87.5.1932 Herkenham, 1991, Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study, J. Neurosci., 11, 563, 10.1523/JNEUROSCI.11-02-00563.1991 Heyser, 1993, Effects of delta-9-tetrahydrocannabinol on delayed match to sample performance in rats: alterations in short-term memory associated with changes in task-specific firing of hippocampal cells, J. Pharm. Exp. Ther., 264, 294 Hill, 2004, Prolonged cannabinoid treatment results in spatial working memory deficits and impaired long-term potentiation in the CA1 region of the hippocampus in vivo, Eur. J. Neurosci., 20, 859, 10.1111/j.1460-9568.2004.03522.x Howlett, 1988, Nonclassical cannabinoid analgetics inhibit adenylate cyclase: development of a cannabinoid receptor model, Mol. Pharmacol., 33, 297 Hugund, 2004, Upregulation of CB1 receptors and agonist-stimulated [35S]GTPgS binding in the prefrontal cortex of depressed suicide victims, Mol. Psychiatry, 9, 184, 10.1038/sj.mp.4001376 Ilan, 2004, Effects of marijuana on neurophysiological signals of working and episodic memory, Psychopharmacology (Berl), 176, 214, 10.1007/s00213-004-1868-9 Inui, 2004, The serotonin1A receptor agonist 8-OHDPAT reverses delta 9-tetrahydrocannabinol-induced impairment of spatial memory and reduction of acetylcholine release in the dorsal hippocampus in rats, Neurotox. Res., 6, 153, 10.1007/BF03033218 Izaki, 2001, Effects of rat medial prefrontal cortex temporal inactivation on a delayed alternation task, Neurosci. Lett., 315, 129, 10.1016/S0304-3940(01)02366-7 Jentsch, 1999, Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli, Psychopharmacology (Berl), 146, 373, 10.1007/PL00005483 Jentsch, 1997, Delta 9-tetrahydrocannabinol increases prefrontal cortical catecholaminergic utilization and impairs spatial working memory in the rat: blockade of dopaminergic effects with HA966, Neuropsychopharmacology, 16, 426, 10.1016/S0893-133X(97)00018-3 Jentsch, 1998, Repeated exposure to δ9-tetrahydrocannabinol reduces prefrontal cortical dopamine metabolism in the rat, Neurosci. Lett., 246, 169, 10.1016/S0304-3940(98)00254-7 Jentsch, 1998, α-Noradrenergic receptor modulation of the phencyclidine- and δ9-tetrahydrocannabinol- induced increases in dopamine utilization in rat prefrontal cortex, Synapse, 28, 21, 10.1002/(SICI)1098-2396(199801)28:1<21::AID-SYN3>3.0.CO;2-E Jones, 1972, Limbic lesions and the problem of stimulus—reinforcement associations, Exp. Neurol., 36, 362, 10.1016/0014-4886(72)90030-1 Kanayama, 2004, Spatial working memory in heavy cannabis users: a functional magnetic resonance imaging study, Psychopharmacology (Berl), 176, 239, 10.1007/s00213-004-1885-8 Katona, 1999, Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons, J. Neurosci., 19, 4544, 10.1523/JNEUROSCI.19-11-04544.1999 Kesner, 1996, Prefrontal cortex and working memory for spatial response, spatial location, and visual object information in the rat, Cereb. Cortex, 6, 311, 10.1093/cercor/6.2.311 Laroche, 2000, Plasticity at hippocampal to prefrontal cortex synapses: dual roles in working memory and consolidation, Hippocampus, 10, 438, 10.1002/1098-1063(2000)10:4<438::AID-HIPO10>3.0.CO;2-3 Law-Tho, 1994, Dopamine modulation of synaptic transmission in rat prefrontal cortex: an in vitro electrophysiological study, Neurosci. Res., 21, 151, 10.1016/0168-0102(94)90157-0 Lee, 2003, Differential roles of dorsal hippocampal subregions in spatial working memory with short versus intermediate delay, Behav. Neurosci., 117, 1044, 10.1037/0735-7044.117.5.1044 Lee, 2003, Time-dependent relationship between the dorsal hippocampus and the prefrontal cortex in spatial memory, J. Neurosci., 23, 1517, 10.1523/JNEUROSCI.23-04-01517.2003 Lehmann, 2001, 192 IgG saporin-induced lesions of the basal forebrain: effects on attention as assessed by the 5-choice serial reaction time task, Behav. Pharmacol., 12, S58 Lichtman, 2000, SR 141716A enhances spatial memory as assessed in a radial-arm maze task in rats, Eur. J. Pharmacol., 404, 175, 10.1016/S0014-2999(00)00615-4 Lichtman, 1996, δ9-Tetrahydrocannabinol impairs spatial memory through a cannabinoid receptor mechanism, Psychopharmacology, 126, 125, 10.1007/BF02246347 Lichtman, 1995, Systemic or intrahippocampal cannabinoid administration impairs spatial memory in rats, Psychopharmacology (Berl), 119, 282, 10.1007/BF02246292 Lichtman, 2002, Endocannabinoids in cognition and dependence, Prostaglandins Leukot. Essent. Fatty Acids, 66, 269, 10.1054/plef.2001.0351 Lundqvist, 2005, Cognitive consequences of cannabis use: comparison with abuse of stimulants and heroin with regard to attention, memory and executive functions, Pharmacol. Biochem. Behav., 81, 319, 10.1016/j.pbb.2005.02.017 Lundqvist, 2001, Frontal lobe dysfunction in long-term cannabis users, Neurotoxicol. Teratol., 23, 437, 10.1016/S0892-0362(01)00165-9 Macavoy, 1975, Divided attention performance of cannabis users and non-users following cannabis and alcohol, Psychopharmacologia, 44, 147, 10.1007/BF00421001 Mailleux, 1992, Distribution of neuronal cannabinoid receptors in the adult rat brain: a comparative receptor binding radioautography and in situ hybridisation histochemistry, Neuroscience, 48, 655, 10.1016/0306-4522(92)90409-U Mailleux, 1994, Activation of multiple transcription factor genes by tetrahydrocannabinol in rat forebrain, Neuroreport, 5, 1265, 10.1097/00001756-199406020-00028 Mallet, 1998, The cannabinoid CB1 receptor antagonist SR141716A attenuates the memory impairment produced by delta9-tetrahydrocannabinol or anandamide, Psychopharmacology (Berl), 140, 11, 10.1007/s002130050733 Mansbach, 1996, Effects of the cannabinoid CB1 receptor antagonist SR141716A on the behaviour of pigeons and rats, Psychopharmacology (Berl), 124, 315, 10.1007/BF02247436 Margulies, 1991, Tetrahydrocannabinol alters cerebral metabolism in a biphasic, dose-dependent manner in rat brain, J. Pharmacol., 202, 373 Marsicano, 1999, Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations of the adult mouse forebrain, Eur. J. Neurosci, 11, 4213, 10.1046/j.1460-9568.1999.00847.x Marsicano, 2002, The endogenous cannabinoid system controls extinction of aversive memories, Nature, 418, 530, 10.1038/nature00839 Mathew, 1992, The effects of marijuana on cerebral blood flow and metabolism Mathew, 1993, Acute changes in cerebral blood flow after smoking marijuana, Life Sci., 52, 757, 10.1016/0024-3205(93)90239-Y Mathew, 1997, Marijuana intoxication and brain activation in marijuana smokers, Life Sci., 60, 2075, 10.1016/S0024-3205(97)00195-1 Mathew, 2002, Time course of tetrahydrocannabinol-induced changes in regional cerebral blood flow measured with positron emission tomography, Psychiatry Res., 116, 173, 10.1016/S0925-4927(02)00069-0 Mato, 2004, Influence of age, postmortem delay and freezing storage period on cannabinoid receptor density and functionality in human brain, Neuropharmacology, 46, 716, 10.1016/j.neuropharm.2003.11.004 Matsuda, 1993, Localization of cannabinoid receptor mRNA in rat brain, J. Comp. Neurol., 327, 535, 10.1002/cne.903270406 McAlonan, 2003, Orbital prefrontal cortex mediates reversal learning and not attentional set shifting in the rat, Behav. Brain. Res., 146, 97, 10.1016/j.bbr.2003.09.019 McGaughy, 2002, Selective behavioural and neurochemical effects of cholinergic lesions produced by intrabasalis infusions of 192 IgG-saporin on attentional performance in a five-choice serial treaction time task, J. Neurosci., 22, 1905, 10.1523/JNEUROSCI.22-05-01905.2002 Mechoulam, 1995, Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors, Biochem. Pharmacol., 50, 83, 10.1016/0006-2952(95)00109-D Melis, 2004, Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in dopamine neurones, J. Neurosci., 24, 10707, 10.1523/JNEUROSCI.3502-04.2004 Miller, 1983, Cannabis: effects on memory and the cholinergic limbic system, Psychol. Bull., 93, 441, 10.1037/0033-2909.93.3.441 Mishima, 2001, Characteristics of learning and memory impairment induced by delta9-tetrahydrocannabinol in rats, Jpn. J. Pharmacol., 87, 297, 10.1254/jjp.87.297 Mishima, 2002, Involvement of reduced acetylcholine release in delta9-tetrahydrocannabinol-induced impairment of spatial memory in the 8-arm radial maze, Life Sci., 72, 397, 10.1016/S0024-3205(02)02274-9 Misner, 1999, Mechanism of cannabinoid effects on long-term potentiation and depression in hippocampal CA1 neurons., J. Neurosci., 19, 6795, 10.1523/JNEUROSCI.19-16-06795.1999 Miyamoto, 1995, Effect of repeated administration of delta 9-tetrahydrocannabinol on delayed matching-to-sample performance in rats, Neurosci. Lett., 201, 139, 10.1016/0304-3940(95)12189-7 Miyamoto, 1996, Roles of dopamine D1 receptors in D9-tetrahydrocannabinol — induced expression of Fos protein in the rat brain, Brain Res., 710, 234, 10.1016/0006-8993(95)01352-0 Molina-Holgado, 1995, Effect of delta 9-tetrahydrocannabinol on short-term memory in the rat, Physiol. Behav., 57, 177, 10.1016/0031-9384(94)00201-F Morgan, 1989, Stimulus-transcription coupling: immediate-early genes, Trends Neurol. Sci., 12, 459, 10.1016/0166-2236(89)90096-9 Morgan, 1993, Extinction of emotional learning: contribution of medial prefrontal cortex, Neurosci. Lett., 163, 109, 10.1016/0304-3940(93)90241-C Morris, 1984, Developments of a water-maze procedure for studying spatial learning in the rat, J. Neurosci. Methods, 11, 47, 10.1016/0165-0270(84)90007-4 Morrow, 1999, An antisense oligonucleotide reverses the footshock-induced expression of Fos in the rat medial prefrontal cortex and the subsequent expression of conditioned fear-induced immobility, J. Neurosci., 19, 5666, 10.1523/JNEUROSCI.19-13-05666.1999 Mrzljak, 1996, Localization of dopamine D4 receptors in GABAergic neurons of the primate brain, Nature, 381, 245, 10.1038/381245a0 Muir, 1996, The cerebral cortex of the rat and visual attentional function: dissociable effects of mediofrontal, cingulate, anterior dorsolateral, and parietal cortex lesions on a five-choice serial reaction time task, Cereb. Cortex, 6, 470, 10.1093/cercor/6.3.470 Murphy, 1996, Increased dopamine turnover in the prefrontal cortex impairs spatial working memory in rats and monkeys, Proc. Natl Acad. Sci. USA, 93, 1329, 10.1073/pnas.93.3.1325 Murphy, 1996, Dopamine and spatial working memory in rats and monkeys: pharmacological reversal of stress-induced impairment, J. Neurosci., 93, 1325 Nakamura, 1991, Reversible effects of acute and long-term administration of delta-9-tetrahydrocannabinol (THC) on memory in the rat, Drug Alcohol Depend., 28, 167, 10.1016/0376-8716(91)90072-7 Nakazi, 2000, Inhibition of serotonin release in the mouse brain via presynaptic cannabinoid CB1 receptors, Naunyn-Schmiedeberg's Arch. Pharmacol., 361, 19, 10.1007/s002109900147 Nava, 2000, D2 dopamine receptors enable δ9-tetrahydrocannabinol induced memory impairment and reduction of hippocampal extracellular acetylcholine concentration, Br. J. Pharmacol., 130, 1201, 10.1038/sj.bjp.0703413 Nava, 2001, Effects of chronic Delta(9)-tetrahydrocannabinol treatment on hippocampal extracellular acetylcholine concentration and alternation performance in the T-maze, Neuropharmacology, 41, 392, 10.1016/S0028-3908(01)00075-2 Nelson, 1998, Behavior in mice with targeted disruption of single genes, Neurosci. Biobeh. Rev., 22, 453, 10.1016/S0149-7634(97)00053-5 Newman, 1999, Binding across time: the selective gating of frontal and hippocampal systems modulating working memory and attentional states, Conscious. Cogn., 8, 196, 10.1006/ccog.1999.0392 O'Leary, 2000, Acute marijuana effects on rCBF and cognition: a PET study, Neuroreport, 11, 3835, 10.1097/00001756-200011270-00047 O'Leary, 2002, Effects of smoking marijuana on brain perfusion and cognition, Neuropsychopharmacology, 26, 802, 10.1016/S0893-133X(01)00425-0 Olton, 1987, The radial arm maze as a tool in behavioral pharmacology, Physiol. Behav., 40, 793, 10.1016/0031-9384(87)90286-1 Ongur, 2000, The organization of networks within the orbital and medial prefrontal cortex of rats, monkeys and humans, Cereb. Cortex, 10, 206, 10.1093/cercor/10.3.206 Owen, 1991, Extra-dimensional versus intra-dimensional set shifting performance following frontal lobe excisions, temporal lobe excisions or amygdalo-hippocampectomy in man, Neuropsychologia, 29, 993, 10.1016/0028-3932(91)90063-E Pan, 1998, SR 141716A acts as an inverse agonist to increase neuronal voltage-dependent Ca2+ currents by reversal of tonic CB1 cannabinoid receptor activity, Mol. Pharmacol., 54, 1064, 10.1124/mol.54.6.1064 Passetti, 2000, Increased acetylcholine release in the rat medial prefrontal cortex during performance of a visual attention task, Eur. J. Neurosci., 12, 3051, 10.1046/j.1460-9568.2000.00183.x Pirot, 1992, Inhibitory effects of ventral tegmental area stimulation on the activity of prefrontal cortical neurons: evidence for the involvement of both dopaminergic and GABAergic components, Neuroscience, 49, 857, 10.1016/0306-4522(92)90362-6 Pistis, 2001, Effects of cannabinoids on prefrontal neuronal responses to ventral tegmental area stimulation, Eur. J. Neurosci., 14, 96, 10.1046/j.0953-816x.2001.01612.x Pistis, 2002, Delta(9)-tetrahydrocannabinol decreases extracellular GABA and increases extracellular glutamate and dopamine levels in the rat prefrontal cortex: an in vivo microdialysis study, Brain. Res., 948, 155, 10.1016/S0006-8993(02)03055-X Pope, 1996, The residual cognitive effects of heavy marijuana use in college students, JAMA, 275, 521, 10.1001/jama.275.7.521 Pope, 2001, Neuropsychological performance in long-term cannabis users, Arch. Gen. Psychiatry, 58, 909, 10.1001/archpsyc.58.10.909 Porcella, 1998, δ9-Tetrahydrocannabinol increases sequence-specific AP-1 DNA-binding activity and Fos-related antigens in the rat brain, Eur. J. Neurosci., 10, 1743, 10.1046/j.1460-9568.1998.00175.x Porter, 2000, A comparison of the effects of hippocampal or prefrontal cortical lesions on three versions of delayed non-matching-to-sample based on positional or spatial cues, Behav. Brain Res., 109, 69, 10.1016/S0166-4328(99)00161-8 Presburger, 1999, Spatial signal detection in rats is differentially disrupted by delta-9-tetrahydrocannabinol, scopolamine, and MK-801, Behav. Brain Res., 99, 27, 10.1016/S0166-4328(98)00065-5 Preuss, 1995, Do rats have a prefrontal cortex? The Rose-Woolsey-Akert program reconsidered, J. Cogn. Res., 7, 1 Ragozzino, 2002, The effects of dopamine D(1) receptor blockade in the prelimbic-infralimbic areas on behavioral flexibility, Learn. Mem., 9, 18, 10.1101/lm.45802 Ragozzino, 1998, The effects of muscarinic cholinergic receptor blockade in the rat anterior cingulate and prelimbic/infralimbic cortices on spatial working memory, Neurobiol. Learn. Mem., 113, 32 Reibaud, 1999, Enhancement of memory in CB1 receptor knock-out mice, Eur. J. Pharmacol., 379, R1, 10.1016/S0014-2999(99)00496-3 Retaux, 1991, Synergism between D1 and D2 dopamine receptors in the inhibition of the evoked release of [3H]GABA in the rat prefrontal cortex, Neuroscience, 43, 323, 10.1016/0306-4522(91)90296-Z Rinaldi-Carmona, 1994, SR 141716A, a potent and selective antagonist of the brian cannabinoid receptor, FEBS Lett., 350, 240, 10.1016/0014-5793(94)00773-X Robbins, 2000, Chemical neuromodulation of frontal-executive functions in humans and other animals, Exp. Brain. Res., 133, 130, 10.1007/s002210000407 Roberts, 1992, A specific form of cognitive rigidity following excitotoxic lesions of the basal forebrain in monkeys, Neuroscience, 47, 251, 10.1016/0306-4522(92)90241-S Roberts, 1994, 6-Hydroxydopamine lesions of the prefrontal cortex in monkeys enhance performance on an analog of the wisconin card sort test: possible interactions with subcortical dopamine, J. Neurosci., 14, 2531, 10.1523/JNEUROSCI.14-05-02531.1994 Rogers, 1999, Tryptophan depletion impairs stimulus-reward learning while methylphenidate disrupts attentional control in healthy young adults: implications for the monoaminergic basis of impulsive behaviour, Psychopharmacology (Berl), 146, 482, 10.1007/PL00005494 Rogers, 1999, Dissociable deficits in decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan—depleted normal volunteers: Evidence for monoaminergic mechanisms, Neuropsychopharmacology, 20, 322, 10.1016/S0893-133X(98)00091-8 Rolls, 1994, Emotion-related learning in patients with social and emotional changes associated with frontal lobe damage, J. Neurol. Neurosurg. Psychiatry, 57, 1518, 10.1136/jnnp.57.12.1518 Rose, 1948, The orbitofrontal cortex and its connections with the mediodorsal nucleus in rabbit, sheep and cat, Res. Publ. Assoc. Nerv. Ment. Dis., 27, 210 Sarter, 2004, Animal cognition: defining the issues, Neurosci. Biobehav. Rev., 28, 645, 10.1016/j.neubiorev.2004.09.005 Schulze, 1988, Acute effects of delta-9-tetrahydrocannabinol in rhesus monkeys as measured by performance in a battery of complex operant tests, J. Pharmacol. Exp. Ther., 245, 178 Schwartz, 1989, Short-term memory impairment in cannabis-dependent adolescents, Am. J. Disord. Child., 143, 1214 Seamans, 2004, The principal features and mechanisms of dopamine modulation in the prefrontal cortex, Prog. Neurobiol., 74, 1, 10.1016/j.pneurobio.2004.05.006 Seamans, 1998, D1 receptor modulation of hippocampal-prefrontal cortical circuits integrating spatial memory with executive functions in the rat, J. Neurosci., 18, 1613, 10.1523/JNEUROSCI.18-04-01613.1998 Selley, 1996, Cannabinoid receptor stimulation of guanosine-5′-O-(3-[35S]thio)triphosphate binding in rat brain membranes, Life Sci., 59, 659, 10.1016/0024-3205(96)00347-5 Shah, 2004, Detection of cannabinoid agonist evoked increase in BOLD contrast in rats using functional magnetic resonance imaging, Neuropharmacology, 46, 379, 10.1016/j.neuropharm.2003.09.023 Shen, 1996, Cannabinoid receptor agonists inhibit glutamatergic synaptic transmission in rat hippocampal cultures, J. Neurosci., 16, 4322, 10.1523/JNEUROSCI.16-14-04322.1996 Solowij, 1995, Do cognitive impairments recover following cessation of cannabis use?, Life Sci., 56, 2119, 10.1016/0024-3205(95)00197-E Solowij, 1995, Differential impairments of selective attention due to frequency and duration of cannabis use, Biol. Psychiatry, 37, 731, 10.1016/0006-3223(94)00178-6 Solowij, 2002, Does marijuana use cause long-term cognitive deficits?, JAMA, 287, 2653 Stam, 1989, Influence of the mesocortical dopaminergic system on activity, food hoarding, social-agonistic behavior, and spatial delayed alternation in male rats, Behav. Neurosci., 103, 24, 10.1037/0735-7044.103.1.24 Sugiura, 1995, 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain, Biochem. Biophys. Res. Commun., 215, 89, 10.1006/bbrc.1995.2437 Tanda, 1997, Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common μ1 opioid receptor mechanism, Science, 276, 2048, 10.1126/science.276.5321.2048 Terranova, 1996, Improvement of memory in rodents by the selective CB1 cannabinoid receptor antagonist, SR141716, Psychopharmacology (Berl), 126, 165, 10.1007/BF02246352 Thomas, 1997, Fatty acid amide hydrolase, the degradative enzyme for anandamide and oleamide, has selective distribution in neurons within the rat central nervous system, J. Neurosci. Res., 50, 1047, 10.1002/(SICI)1097-4547(19971215)50:6<1047::AID-JNR16>3.0.CO;2-1 Trettel, 2002, Cannabinoids depress inhibitory synaptic inputs received by layer 2/3 pyramial neurons in the neocortex, J. Neurophysiol., 88, 534, 10.1152/jn.2002.88.1.534 Tsou, 1998, Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system, Neuroscience, 832, 393, 10.1016/S0306-4522(97)00436-3 Tsou, 1999, Fatty acid amide hydrolase is located preferentially in large neurons in rat central nervous system as revealed by immunohistochemistry, Neurosci. Lett., 254, 137, 10.1016/S0304-3940(98)00700-9 Tzavara, 2003, The CB1 receptor antagonist SR141716A selectively increases monoaminergic neurotransmission in the medial prefrontal cortex: implications for therapeutic actions, Br. J. Pharmacol., 138, 544, 10.1038/sj.bjp.0705100 Tzschentke, 2001, Pharmacology and behavioural pharmacology of the mesocortical dopamine system, Prog. Neurobiol., 63, 241, 10.1016/S0301-0082(00)00033-2 Ueda, 1998, A hydrolase enzyme inactivating endogenous ligands for cannabinoid receptors, J. Med. Invest., 45, 27 Uylings, 1990, Qualitative and quantitative comparison of the prefrontal cortex in rat and in primates, including humans, Prog. Brain Res., 85, 31, 10.1016/S0079-6123(08)62675-8 van Eden, 1987, Immunocytochemical localization of dopamine in the prefrontal cortex of the rat at the light and electron microscopical level, Neuroscience, 22, 849, 10.1016/0306-4522(87)92964-2 Varvel, 2002, Evaluation of CB1 receptor knockout mice in the morris water maze, J. Pharmacol. Exp. Ther., 301, 915, 10.1124/jpet.301.3.915 Varvel, 2001, Differential effects of delta 9-THC on spatial reference and working memory in mice, Psychopharmacology (Berl), 157, 142, 10.1007/s002130100780 Varvel, 2005, Disruption of CB(1) receptor signaling impairs extinction of spatial memory in mice, Psychopharmacology (Berl), 179, 863, 10.1007/s00213-004-2121-2 Verrico, 2003, Persistent and anatomically selective reduction in prefrontal cortical dopamine metabolism after repeated, intermittent cannabinoid administration to rats, Synapse, 49, 61, 10.1002/syn.10215 Verrico, 2004, Repeated, intermittent delta(9)-tetrahydrocannabinol administration to rats impairs acquisition and performance of a test of visuospatial divided attention, Neuropsychopharmacology, 29, 522, 10.1038/sj.npp.1300316 Volkow, 2000, Addiction, a disease of compulsion and drive: involvement of the orbitofrontal cortex, Cereb. Cortex, 10, 318, 10.1093/cercor/10.3.318 Volkow, 1996, Brain glucose metabolism in chronic marijuana users at baseline and during marijuana intoxication, Psychiatry Res.: Neuroimaging, 67, 29, 10.1016/0925-4927(96)02817-X Wall, 2001, The hippocampal formation—orbitomedial prefrontal cortex circuit in the attentional control of active memory, Behav. Brain Res., 127, 99, 10.1016/S0166-4328(01)00355-2 Whitlow, 2002, Metabolic mapping of the time-dependent effects of delta 9-tetrahydrocannabinol administration in the rat, Psychopharmacology (Berl), 161, 129, 10.1007/s00213-002-1001-x Winsauer, 1999, Cannabinoid ligands and their effects on learning and performance in rhesus monkeys, Behav. Pharmacol., 10, 497, 10.1097/00008877-199909000-00008 Winstanley, 2004, Fractionating impulsivity: contrasting effects of central 5-HT depletion on different measures of impulsive behavior, Neuropsychopharmacology, 29, 1331, 10.1038/sj.npp.1300434 Zahrt, 1997, Supranormal stimulation of D1 dopamine receptors in the rodent prefrontal cortex impairs spatial working memory performance, J. Neurosci., 17, 8528, 10.1523/JNEUROSCI.17-21-08528.1997 Zimmerberg, 1971, Impairment of recent memory by marihuana and THC in rhesus monkeys, Nature, 233, 343, 10.1038/233343a0